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Elsevier

Libros en Ciencias de la Vida

  • Synuclein and the Coelacanth

    The Molecular and Evolutionary Origins of Parkinson's Disease
    • 1 Edición
    • James M. Gruschus
    • Inglés
    Most neurodegenerative diseases have animal parallels such as Alzheimer’s in chimpanzees, multiple sclerosis in macaques, Lou Gehrig’s disease in dogs, but nothing like Parkinson’s has ever been seen in any species but humans. Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson's Disease delves into the causes of Parkinson’s disease and how the evolution of the human brain has left us uniquely vulnerable. Genetic risk factors, environmental toxins, and neuroanatomy are woven together in a multidisciplinary discussion that ranges from subatomic physics to socioeconomics. Connections between neurodegenerative disease, neural pathways, and innate immunity are explored. Finally, the author discusses new therapeutic agents are being developed that hope to go beyond just treating the symptoms of Parkinson’s and actually halt the disease.

  • Recent Advances in iPSCs for Therapy

    • 1 Edición
    • Alexander Birbrair
    • Inglés
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSCs for Therapy, Volume 3 addresses the use of induced pluripotent stem cells for therapy of several disorders. The volume teaches the reader about the biology of induced pluripotent stem cells and their possible use as cell therapy. Remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs for therapy of multiple diseases, such as: hair loss disorders, Parkinson’s disease, Huntington’s disease, ischemic stroke, Alzheimer’s disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more. The volume is written for researchers and scientists interested in cell therapy, stem cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

  • Androgens in Women: Too Much, Too Little, Just Right, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1 Edición
    • Volumen 50-1
    • Margaret E. Wierman
    • Inglés
    Guest edited by Dr. Margaret E. Wierman, this issue of Endocrinology and Metabolism Clinics will cover several key areas of interest related to Androgens in Women. This issue is one of four selected each year by our series Consulting Editor, Dr. Adriana Ioachimescu. Articles in this issue include but are not limited to: Hyperandrogenic Anovulation: Differential Diagnosis and Evaluation, Diagnosis of Polycystic Ovary Syndrome, Polycystic Ovary Syndrome: Ontogeny in Adolescence, Fertility Issues in Polycystic Ovarian Disease: A Systematic Approach, Management of Women with PCOS during Pregnancy, Genetics of PCOS, Cardiometabolic Risk in PCOS: Current Guidelines, Non Classical Congenital Adrenal Hyperplasia, Post-menopausal Hyperandrogenism: Evaluation and Treatment Strategies, Sexual Dysfunction in Women, Use of Testosterone in Postmenopausal women, Risks of Testosterone Therapy in Women, Non-Classic Congenital Adrenal Hyperplasia, and more.

  • 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance Part A

    • 1 Edición
    • Volumen 259
    • Inglés
    5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance, Part B, Volume 260 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Serotonin-noradrenal... interactions, Electrophysiological and neurochemical evidence for an interaction of serotonin on noradrenergic neurons, Serotonin and cannabinoid system, 5-HT/CB interaction in the CNS in health and disease, Serotonin2A receptors and Cannabinoids, CB1/5-HT/GABA in food intake, A close interaction between serotonergic system and BDNF in the mechanism of action of antidepressant, 5-HT/ Ach, Interaction of 5-HT2A/2C ligands and nicotine, and more.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 166
    • Donald L. Sparks
    • Inglés
    Advances in Agronomy, Volume 166, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

  • Aminoff's Neurology and General Medicine

    • 6 Edición
    • Michael J. Aminoff + 1 más
    • Inglés
    Aminoff’s Neurology and General Medicine, Sixth Edition is the standard and classic reference providing comprehensive coverage of the relationship between neurologic practice and general medicine. As neurologists are asked to consult on general medical conditions, this reference provides an authoritative tool linking general medical conditions to specific neurologic issues and disorders. This is also a valuable tool for the general practitioner seeking to understand the neurologic aspects of their medical practice. Completely revised with new chapters covering neurologic complications of immunotherapies, headache and general medical disorders, back and neck pain in general medical disorders, swallowing and speech disorders, and neurological changes in the elderly, this new edition will again be the go-to reference for both neurologists and general practitioners.

  • Nutraceuticals

    Efficacy, Safety and Toxicity
    • 2 Edición
    • Ramesh C. Gupta + 2 más
    • Inglés
    Nutraceuticals: Efficacy, Safety and Toxicity, Second Edition, brings together everything that is currently known about nutraceuticals and their potential toxic effects. The book introduces readers to nutraceuticals, herbal medicines, Ayurvedic medicines, prebiotics, probiotics, adaptogens, and their uses and specific applications. This essential reference discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered. Completely revised and updated, this updated edition provides toxicologists, pharmacologists, pharmaceutical scientists, and those interested in medicinal plants and natural products with a comprehensive overview of the most effective tools upon which to evaluate the safety and toxicity of nutraceuticals, prebiotics, probiotics and alternative medicines.

  • Sex differences in Cardiac Diseases

    Pathophysiology, Presentation, Diagnosis and Management
    • 1 Edición
    • Niti R. Aggarwal + 1 más
    • Inglés
    Significant biological differences exist between men and women that contribute to sex-specific differences in cardiovascular disease (CVD) risk factors, pathophysiology, presentation, response to therapy, and prognosis. It is essential for clinicians to be cognizant of these sex-specific differences in order to reduce the disparity in diagnosis and management of cardiovascular diseases in both genders.Sex Differences in Cardiac Disease provides a timely review of the contemporary data on these sex-specific differences in pathophysiology, clinical presentation, diagnostic evaluation, and management of cardiovascular diseases that fills a void for clinicians in practice and training. With contributions from renowned experts in the field and guideline writers, the text provides a state-of-the-art review of each topic encompassing the full spectrum of CVD in men and women. Sex-specific guideline-based recommendations are highlighted when available. Tailored to meet the needs of the busy clinicians and researchers, this text provides concise practical data to care for men and women at risk for or with CVD. The book serves as an essential resource for researchers, cardiologists, obstetricians, gynecologists, internists, family practitioners, nurse practitioners and physician assistants, and respective trainees who treat men and women with CVD.

  • Turmeric and Curcumin for Neurodegenerative Diseases

    • 1 Edición
    • Magisetty Obulesu
    • Inglés
    Turmeric and Curcumin for Neurodegenerative Diseases examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strategies to circumvent Alzheimer’s Disease, Parkinson’s, and liver diseases. With neurodegenerative and liver diseases posing a serious threat to health care systems worldwide, this book addresses how existing nanotechnology and therapeutic strategies have not been as successful in their treatment. In addition to discussing drawbacks, possible future perspectives to overcome these challenges are also examined. Chapters also focus on therapeutic efficacy and drug delivery systems, providing readers with a full summary of research in this field in one handy reference.

  • Agricultural Waste Diversity and Sustainability Issues

    Sub-Saharan Africa as a Case Study
    • 1 Edición
    • Peter Onu + 1 más
    • Inglés
    Agricultural Waste Diversity and Sustainability Issues: Sub Saharan Africa as Case Study presents solutions for overcoming limitations, guiding developmental processes, and improving knowledge transfer in agricultural waste management and development. The book gives considerable attention to treatment and conversion, with best management practices involving the reduction and elimination of waste volume in its various forms, sectors and streams. Sections cover waste management in the agriculture and food sector, including methodological approaches in waste preparation and processes, the most important energy generation techniques and strategies, and best practices, management, sustainability, associated technologies, accountability, communications, and involvement surrounding diverse stakeholders. Agricultural Waste Diversity and Sustainability Issues: Sub Saharan Africa as Case Study illustrates the use of mathematical models to minimize operational cost in agro-waste management processes and discusses the application of eco-efficiency. Ultimately, the book focuses on the prospect of agro-wastes management and risk associated in the sub-Saharan African region, including Nigeria, Uganda, and South Africa as case studies.

  • Plant metabolomics in full swing

    • 1 Edición
    • Volumen 98
    • Inglés
    Plant Metabolics, Volume 98, the latest release in the Advances in Botanical Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of intriguing topics, including Developmental metabolomics to decipher and improve fleshy fruit quality, Specialized metabolites in seeds, Untangling plant immune responses through metabolomics, Plant metabolomics to the benefit of crop protection and growth stimulation, Metabolomics in plant-microbe interactions in the roots, A practical guide to implementing metabolomics in plant ecology and biodiversity research, Plant metabolomics and breeding, Plant genome-scale metabolic networks, Metabolite imaging by mass spectrometry: A new discovery tool, MS- and NMR-metabolomic tools for the discrimination of wines: Applications for authenticity

  • The Cancer Stem Cell Niche

    • 1 Edición
    • Volumen 5
    • Susie Nilsson
    • Inglés
    The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche.

  • An Introduction to Hypergeometric, Supertrigonometric, and Superhyperbolic Functions

    • 1 Edición
    • Xiao-Jun Yang
    • Inglés
    An Introduction to Hypergeometric, Supertigonometric, and Superhyperbolic Functions gives a basic introduction to the newly established hypergeometric, supertrigonometric, and superhyperbolic functions from the special functions viewpoint. The special functions, such as the Euler Gamma function, the Euler Beta function, the Clausen hypergeometric series, and the Gauss hypergeometric have been successfully applied to describe the real-world phenomena that involve complex behaviors arising in mathematics, physics, chemistry, and engineering.

  • Inborn Errors of Immunity

    A Practical Guide
    • 1 Edición
    • Asghar Aghamohammadi + 3 más
    • Inglés
    Awareness among clinicians about PIDs, which consist of more than 400 different entities, plays an important role in ensuring that patients receive a timely diagnosis. Furthermore, clinicians who are educated about PIDs can give their patients access to optimal management of their condition, thus helping the patient achieve a better quality-of-life and long-term prognosis. Inborn Errors of Immunity: A Practical Guide provides the most up-to-date information for busy students, nurses, clinical residents, practicing physicians, and even basic researchers. Readers will benefit from a well-structured breakdown of complicated PID diseases, including approaches to their clinical signs/symptoms and immunologic/laborato... findings.

  • Plant Breeding and Cultivar Development

    • 1 Edición
    • D. P. Singh + 2 más
    • Inglés
    Plant Breeding and Cultivar Development features an optimal balance between classical and modern tools and techniques related to plant breeding. Written for a global audience and based on the extensive international experience of the authors, the book features pertinent examples from major and minor world crops. Advanced data analytics (machine learning), phenomics and artificial intelligence are explored in the book's 28 chapters that cover classical and modern plant breeding. By presenting these advancements in specific detail, private and public sector breeding programs will learn about new, effective and efficient implementation. The insights are clear enough that non-plant breeding majoring students will find it useful to learn about the subject, while advanced level students and researchers and practitioners will find practical examples that help them implement their work.

  • The Design and Development of Novel Drugs and Vaccines

    Principles and Protocols
    • 1 Edición
    • Tarun Kumar Bhatt + 1 más
    • Inglés
    The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval.

  • Transport Proteins

    • 1 Edición
    • Volumen 123
    • Inglés
    Transport Proteins, Volume 123, provides the latest information on the two major groups of transport proteins, those that carry molecules to different locations within a cell or organism and those that carry molecules across otherwise impermeable membranes. Chapters in the updated release include Biology of Iron Transport: Ferroportin, Transport of transition metals across biological membranes, The effect of sport and physical activity on transport proteins: implications for cancer prevention and control, Structural rearrangement in polyketide synthase for improvement its bio-physicochemical properties, Autophagy Proteins and its Homeostasis in Cellular Environment, and much more.

  • Stem Cells

    Scientific Facts and Fiction
    • 3 Edición
    • Christine L. Mummery + 3 más
    • Inglés
    Stem Cells: Scientific Facts and Fiction, Third Edition, provides a state-of-the-art overview on the field of stem cells and their current applications. The book incorporates the history and firsthand commentaries in the field from clinical and research leaders, covering interesting topics of note, including the first clinical trials to treat Parkinson disease, macular degeneration, and corneal replacement, the cloning of monkeys, the organoid field, and CRISPR-edited genomics. In addition, coverage of adult, embryonic stem cells and iPS cells is included. This new edition distinguishes itself from the multiplicity of websites about stem cells with a broad view of the field.

  • Linkers in Biomacromolecules

    • 1 Edición
    • Volumen 647
    • Inglés
    Linkers in Biomacromolecules, Volume 647 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New sections in this updated release include chapters devoted to ser-gly linkers + models, sergGly- EAAAK linkers, Effect of crowding on linker behavior, Protathether. Experimental approach to quickly test different linkers in fusion proteins, Linkers in enzyme fusions/cascade catalysis, Linker dependence of avidity in multivalent interactions between disordered proteins, ER/K α-helix linker, The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein design, Linker design in protein-based nanostructures, and much more. Linkers in Biomacromolecules, Volume 647 in the Methods in Enzymology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. New sections in this updated release include chapters devoted to ser-gly linkers + models, sergGly- EAAAK linkers, Effect of crowding on linker behavior, Protathether. Experimental approach to quickly test different linkers in fusion proteins, Linkers in enzyme fusions/cascade catalysis, Linker dependence of avidity in multivalent interactions between disordered proteins, ER/K α-helix linker, The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein design, Linker design in protein-based nanostructures, and much more.

  • Endothelial Signaling in Vascular Dysfunction and Disease

    From Bench to Bedside
    • 1 Edición
    • Shampa Chatterjee
    • Inglés
    Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable. This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease.

  • Food Technology Disruptions

    • 1 Edición
    • Charis M. Galanakis
    • Inglés
    Food Technology Disruptions covers the latest disruptions in the food industry, such as the Internet of Things, digital technologies, modern applications like 3D printing, bacterial sensors in food packaging, electronic noses for food authentication, and artificial intelligence. With additional discussions on innovative distribution and delivery of food and consumer acceptance of food disruptions, this book is an essential resource for food scientists, technologists, engineers, agriculturalists, chemists, product developers, researchers, academics and professionals working in the food industry. While innovations play an important role in food production, disruptive technologies are a revolutionary type of innovation that can displace an established technology and shake up the industry...or create a completely new industry. Currently, digital technologies and smart applications lead innovations in the food sector in order to optimize the food supply chain and to develop and deliver tailor-made food products to consumers with new eating habits.

  • Himalayan Medicinal Plants

    Advances in Botany, Production & Research
    • 1 Edición
    • Nikhil Malhotra + 1 más
    • Inglés
    The Himalayan Region is a mega hot spot for biological diversity. It supports over 1,748 plants species of known medicinal value. This title focuses on origin and distribution of Himalayan herbs, their medicinal potential, industrial significance, and research advancements pertaining to molecular breeding and omics-based approaches.

  • Inhaled Medicines

    Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches
    • 1 Edición
    • Stavros Kassinos + 3 más
    • Inglés
    Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments.

  • Aromatic Herbs in Food

    Bioactive Compounds, Processing, and Applications
    • 1 Edición
    • Charis M. Galanakis
    • Inglés
    Aromatic Herbs in Food: Bioactive Compounds, Processing, and Applications thoroughly explores three critical dimensions: properties of bioactive compounds, recovery and applications. The book covers the most trending topics in herbs’ applications, putting emphasis on the health components of spices and herbs, their culinary use, their application for the treatment of functional gastrointestinal disorders, quality and safety requirements for usage in foods, processing, extraction technologies, green extraction technologies, encapsulation of recovered bioactives, applications and interactions with food components, applications as food supplements for weight loss, usage in active food packaging, the applications of rosemary and sage extracts, and much more. This book is ideal for food scientists, technologists, engineers and chemists working in the whole food science field. In addition, nutrition researchers working on food applications and food processing will find the content very valuable.

  • Introduction to Forestry and Natural Resources

    • 2 Edición
    • Donald L. Grebner + 3 más
    • Inglés
    Introduction to Forestry and Natural Resources, Second Edition, presents a broad, completely updated overview of the profession of forestry. The book details several key fields within forestry, including forest management, economics, policy, utilization and forestry careers. Chapters deal specifically with forest regions of the world, landowners, forest products, wildlife habitats, tree anatomy and physiology, and forest disturbances and health. These topics are ideal for undergraduate introductory courses and include numerous examples and questions for students to ponder. There is also a section dedicated to forestry careers. Unlike other introductory forestry texts, which focus largely on forest ecology rather than practical forestry concepts, this book encompasses the economic, ecological and social aspects, thus providing a uniquely balanced text. The wide range of experience of the contributing authors equips them especially well to identify missing content from other texts in the area and address topics currently covered in corresponding college courses.

  • Inflammation and Natural Products

    • 1 Edición
    • Sreeraj Gopi + 3 más
    • Inglés
    Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 111
    • Inglés
    Advances in Parasitology, Volume 111, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history. Chapters in this update include Taking the strain out of onchocerciasis: a reanalysis of blindness and transmission data does not support the existence of a savanna blinding strain of onchocerciasis in West Africa, Enterocytozoon bieneusi of animals, Taenia solium taeniasis/cysticerco... Genomic analysis reveals predominant clonality and progressive evolution at all evolutionary scales in eukaryotic pathogens, HTLV-I and Strongyloides: the worm lurking beneath, and more.

  • Expansion Microscopy for Cell Biology

    • 1 Edición
    • Volumen 161
    • Inglés
    Expansion Microscopy for Cell Biology, Volume 161 in the Methods in Cell Biology series, compiles recent developments in expansion microscopy techniques (Pro-ExM, U-ExM, Ex-STED, X10, Ex-dSTORM, etc.) and their applications in cell biology, ranging from mitosis, centrioles or nuclear pore complex to plant cell, bacteria, Drosophila or neurons. Chapters in this new release include Protein-retention Expansion Microscopy: Improved Sub-cellular Imaging Resolution through Physical Specimen Expansion, Ultrastructure Expansion Microscopy (U-ExM), Expansion STED microscopy (ExSTED), Simple multi-color super-resolution by X10 microscopy, Expansion microscopy imaging of various neuronal structures, Mapping the neuronal cytoskeleton using expansion microscopy, Mechanical expansion microscopy, and much more.

  • Translational Biotechnology

    A Journey from Laboratory to Clinics
    • 1 Edición
    • Yasha Hasija
    • Inglés
    Translational Biotechnology: A Journey from Laboratory to Clinics presents an integrative and multidisciplinary approach to biotechnology to help readers bridge the gaps between fundamental and functional research. The book provides state-of-the-art and integrative views of translational biotechnology by covering topics from basic concepts to novel methodologies. Topics discussed include biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, and system and synthetic biology. Additional sections cover drug discovery, precision medicine and the socioeconomic impact of translational biotechnology. This book is valuable for bioinformaticians, biotechnologists, and members of the biomedical field who are interested in learning more about this promising field.

  • Prof. of Drug Substances, Excipients and Related Methodology

    • 1 Edición
    • Volumen 46
    • Abdulrahman Al-Majed
    • Inglés
    Profiles of Drug Substances, Excipients, and Related Methodology, Volume 46 contains comprehensive profiles of five drug compounds: Darunavir, Bisoprolol, Betaxolol, Rabeprazole and Irbesartan. In addition, the work contains a chapter reviewing Bioassay Methods and Their Applications in Herbal Drug Research. The comprehensive reviews in the book cover all aspects of drug development and the formulation of drugs, helping readers understand how the drug development community remains essential to all phases of pharmaceutical development. In addition, this work answers why such profiles are of immeasurable importance to workers in the field. The scope of the Profiles series encompasses review articles and database compilations that fall within one or more of the following five broad categories: Physical Profiles of Drug Substances and Excipients, Analytical Profiles of Drug Substances and Excipients, ADME Profiles of Drug Substances and Excipients, Methodology Related to the Characterization of Drug Substances and Excipients, and Methods of Chemical Synthesis.

  • Organ Repair and Regeneration

    Preserving Organs in the Regenerative Medicine Era
    • 1 Edición
    • Giuseppe Orlando + 1 más
    • Inglés
    Organ Repair and Regeneration: Preserving Organs in the Regenerative Medicine Era encompasses updates on all organs, from the kidneys, to the lungs, liver, pancreas, intestines, and beyond. Chapters cover the pathophysiology of ischemia-reperfusion... repairing organs with MSC, repairing cardiac allografts in situ, and much more. The book conceptualizes the idea that the modern approach to organ preservation is ante literam, a form of organ repair and regeneration which, per se, is referred to as a field of health sciences under the umbrella of regenerative medicine. This book demonstrates the merging of regenerative medicine and organ transplantation.

  • Eutectic Solvents and Stress in Plants

    • 1 Edición
    • Volumen 97
    • Inglés
    Eutectic Solvents and Stress in Plants, Volume 97 in the Advances in Botanical Research series, highlights new advances in the field, with this new volume presenting interesting chapters surrounding NADES: from simple systems to complex colloidal mixtures, DES nanostructures with water, micelle and DES interaction, Dissolving proteins protein physics, Enzyme reactions in NADES, Protection against oxidation of metabolites, stability food, DES for pharmaceutical preparations, Cosmetics, Metabolons and bio-condensates: the essence of plant plasticity and the key elements in development of green production systems, Immediate in the whole plant during extreme conditions metabolomics, NADES in sees spores, and much more.

  • Epigenetics

    • 1 Edición
    • Volumen 156
    • Inglés
    Epigenetics, Volume 151, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of comprehensive topics, including Histone modifications in Alcohol use disorder, Non-coding RNAs: Regulators of alcohol actions, Epigenetics and Neuroinflammation in Psychiatric disorders, DNA methylation and Neurodevelopmental disease, Epigenetic inheritance in substance use disorders, THC, Epigenetics and schizophrenia, and more.

  • Cancer

    Oxidative Stress and Dietary Antioxidants
    • 2 Edición
    • Victor R. Preedy + 1 más
    • Inglés
    Cancer: Oxidative Stress and Dietary Antioxidants, Second Edition, covers the science of oxidative stress in cancer and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor-mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component. Other sections cover new organ site tumors—skin and liver cancer, the role of polymorphisms, cytochrome p450s, COX gene, fatty acids, apoptosis, T cells and mitochondria, prevention/protectio... with anthocyanins, esculetin, nanoparticles, and more. This book is a valuable resource for cancer researchers, oncologists, nutritionists and other members of the biomedical field who are interested in enhancing treatment outcome, improving the quality of life of patients, and developing new treatments in the fight against cancer.

  • Liquid-Liquid Phase Coexistence and Membraneless Organelles

    • 1 Edición
    • Volumen 646
    • Inglés
    Methods in Enzymology, Volume 646, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Methods for Studying RNA condensation/granule... in vitro, RNA Dynamics in Intracellular Condensates, Methods for Viscoelastic Characterization of Liquid and Gel Condensates, Incorporating Proteins into Complex Coacervates, Methods for Study of Liquid-Liquid Phase Coexistence in Proximity to Lipid Membranes, Preparation of and Solute Partitioning in Multiphase Coacervates, Reversible photocontrol of DNA coacervation, Enzymatic Control over Coacervation, and much more.

  • Molecular Biology of Neurodegenerative Diseases: Visions for the Future - Part B

    • 1 Edición
    • Volumen 177
    • Inglés
    Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Part B, Volume 177 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, and more.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 100
    • Gregory S. Makowski
    • Inglés
    Advances in Clinical Chemistry, Volume 100, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with chapters in this new release focusing on Chimeric RNAs in cancer, Pathophysiologic landscape of osteoarthritis, Advances in lung cancer biomarkers: The role of (metal-) metabolites and selenoproteins, Advances in cerebral palsy biomarkers, Cytokines in psoriasis, Biochemical analysis of oral fluids for disease detection, and more.

  • Toxicological Evaluation of Electronic Nicotine Delivery Products

    • 1 Edición
    • Manuel C. Peitsch + 1 más
    • Inglés
    Toxicological Evaluation of Electronic Nicotine Delivery Products　(ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them.　This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 165
    • Inglés
    Advances in Agronomy, Volume 165, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors, with this release including chapters on Urban Anthropogenic Soils – A Review, Epichloe spp. And Serendipita indica Endophytic Fungi: Functions in Plant-Soil Relations, Heating Up a Cold Case: Applications of Analytical Pyrolysis GC/MS to Assess Molecular Biomarkers in Peat, The problem with “Apparent Electrical Conductivity” in Soil Electromagnetic Induction Studies, and more.

  • Regenerated Organs

    Future Perspectives
    • 1 Edición
    • Chandra P. Sharma
    • Inglés
    Regenerated Organs: Future Perspectives provides the translational-resear... aspects, currently lacking in existing literature, in this rapidly-moving field. The book is divided into six sections: Engineering Approaches, Cardiovascular System, Musculoskeletal Regeneration, Regenerative Neuroscience, Respiratory Research, a Future Outlook and Conclusions. Each chapter is multi-authored by international experts in each area. The book's primary audience is academic faculty and those in industry interested in translational research in regenerative medicine and tissue engineering. Additionally, this book is ideal for graduate students in the field.

  • The Microbiome in Prenatal and Neonatal Life

    • 1 Edición
    • Josef Neu
    • Inglés
    The Microbiome in Prenatal and Neonatal Life clarifies that the microbiome in the maternal fetal unit and immediate changes that occur as new microbes are acquired postnatally play major roles in subsequent health and disease. Rapidly developing technologies for multi-omic analyses and systems biology are shifting paradigms in both scientific knowledge and clinical care with regard to this topic. In essence, we are changing the idea that newborns emerge from sterile environments. As such, in-utero colonization may have impacts on the development of immunity and metabolism that, with epigenetic modifications, will lead to diseases in later life. In addition, the microbial profile that develops during and after birth depends on mode of delivery, type of feeding (human milk versus formula), and various other environmental factors to which the newborn is exposed.

  • Plant Virus-Host Interaction

    Molecular Approaches and Viral Evolution
    • 2 Edición
    • R.K. Gaur + 3 más
    • Inglés
    Plant Virus-Host Interaction: Molecular Approaches and Viral Evolution, Second Edition, provides comprehensive coverage of molecular approaches for virus-host interaction. The book contains cutting-edge research in plant molecular virology, including pathogenic viroids and transport by insect vectors, interference with transmission to control viruses, synergism with pivotal coverage of RNA silencing, and the counter-defensive strategies used by viruses to overcome the silencing response in plants. This new edition introduces new, emerging proteins involved in host-virus interactions and provides in-depth coverage of plant virus genes’ interactions with host, localization and expression. With contributions from leading experts, this is a comprehensive reference for plant virologists, molecular biologists and others interested in characterization of plant viruses and disease management.

  • Brain Oscillations, Synchrony and Plasticity

    Basic Principles and Application to Auditory-Related Disorders
    • 1 Edición
    • Jos J. Eggermont
    • Inglés
    Brain Oscillations, Synchrony and Plasticity: Basic Principles and Application to Auditory-Related Disorders discusses the role of brain oscillations, especially with respect to the auditory system and how those oscillations are measured, change over the lifespan, and falter leading to a variety of psychiatric and neurological disorders. The book begins with a description of these cortical rhythm oscillations and how they function in both the normal and pathological brain. It explains how these oscillations are important to auditory, executive and attention brain networks and how they relate to the development, production and deterioration of speech and language. In addition, treatment of malfunctioning cortical rhythms are reviewed using neuromodulation, such as transcranial magnetic, direct current, random noise, and alternating current stimulation, as well as focused ultrasound. The book concludes by describing the potential role of oscillations in dyslexia, autism, schizophrenia and Alzheimer’s disease.

  • Dual Antiplatelet Therapy for Coronary and Peripheral Arterial Disease

    • 1 Edición
    • Sorin Brener
    • Inglés
    Dual Antiplatelet Therapy for Coronary and Peripheral Arterial Disease is a complete reference containing updated information on the advantages and disadvantages of dual antiplatelet therapy, its duration, composition and anticipated changes. The basis for DAPT in arterial disease is discussed, allowing readers to understand platelet physiology and its relevance to ischemic events. Data on shorter than usual duration of DAPT, and on extended therapy beyond the recommendation of current guidelines is presented in great detail, summarizing a large body of evidence into concrete, relevant recommendation that is readily adaptable by practicing clinicians. A clinically relevant and updated compendium of data pertaining to this field is also presented, as well as the anticipated trends and innovations likely to occur in the next 3-5 years.

  • Handbook of Analytical Quality by Design

    • 1 Edición
    • Sarwar Beg + 3 más
    • Inglés
    Handbook of Analytical Quality by Design addresses the steps involved in analytical method development and validation in an effort to avoid quality crises in later stages. The AQbD approach significantly enhances method performance and robustness which are crucial during inter-laboratory studies and also affect the analytical lifecycle of the developed method. Sections cover sample preparation problems and the usefulness of the QbD concept involving Quality Risk Management (QRM), Design of Experiments (DoE) and Multivariate (MVT) Statistical Approaches to solve by optimizing the developed method, along with validation for different techniques like HPLC, UPLC, UFLC, LC-MS and electrophoresis. This will be an ideal resource for graduate students and professionals working in the pharmaceutical industry, analytical chemistry, regulatory agencies, and those in related academic fields.

  • New Paradigms in Computational Modeling and Its Applications

    • 1 Edición
    • Snehashish Chakraverty
    • Inglés
    In general, every problem of science and engineering is governed by mathematical models. There is often a need to model, solve and interpret the problems one encounters in the world of practical problems. Models of practical application problems usually need to be handled by efficient computational models. New Paradigms in Computational Modeling and Its Applications deals with recent developments in mathematical methods, including theoretical models as well as applied science and engineering. The book focuses on subjects that can benefit from mathematical methods with concepts of simulation, waves, dynamics, uncertainty, machine intelligence, and applied mathematics. The authors bring together leading-edge research on mathematics combining various fields of science and engineering. This perspective acknowledges the inherent characteristic of current research on mathematics operating in parallel over different subject fields. New Paradigms in Computational Modeling and Its Applications meets the present and future needs for the interaction between various science and technology/engineeri... areas on the one hand and different branches of mathematics on the other. As such, the book contains 13 chapters covering various aspects of computational modeling from theoretical to application problems. The first six chapters address various problems of structural and fluid dynamics. The next four chapters include solving problems where the governing parameters are uncertain regarding fuzzy, interval, and affine. The final three chapters will be devoted to the use of machine intelligence in artificial neural networks.

  • Calcium Transport Elements in Plants

    • 1 Edición
    • Santosh Kumar Upadhyay
    • Inglés
    Calcium Transport Elements in Plants discusses the role of calcium in plant development and stress signaling, the mechanism of Ca2+ homeostasis across plant membranes, and the evolution of Ca2+/cation antiporter (CaCA) superfamily proteins. Additional sections cover genome-wide analysis of Annexins and their roles in plants, the roles of calmodulin in abiotic stress responses, calcium transport in relation to plant nutrition/biofortifi... and much more. Written by leading experts in the field, this title is an essential resource for students and researchers that need all of the information on calcium transport elements in one place. Calcium transport elements are involved in various structural, physiological and biochemical processes or signal transduction pathways in response to various abiotic and biotic stimuli. Development of high throughput sequencing technology has favored the identification and characterization of numerous gene families in plants in recent years, including the calcium transport elements.

  • Peripartum Cardiomyopathy

    From Pathophysiology to Management
    • 1 Edición
    • Karen Sliwa
    • Inglés
    Peripartum Cardiomyopathy: From Pathophysiology to Management covers the pathophysiology and the heterogenous mode of presentation of PPCM to assist in risk stratification and provide a guide for the acute and long-term management of women affected by this serious condition. Each chapter provides structured figures and practical algorithms as well as prints of electrocardiograms, echocardiographic, MRI images and several case studies throughout. This title is a must have reference for those doing basic research in this area as well as all healthcare providers caring for peripartum women, including obstetricians, general physicians, cardiologists, intensivists, as well as nurses caring for heart failure patients.

  • Skeletal Trauma

    A Mechanism-Based Approach of Imaging
    • 1 Edición
    • Guillaume Bierry
    • Inglés
    A key to being confident in the evaluation of skeletal trauma imaging is to rely on the identification of mechanism-specific traumatic features. Indeed, for each mechanism of injury applied to a particular part of the skeleton, the latter can only present predefined traumatic injuries: this is a pattern of injuries.The recognition of such a pattern of imaging allows the reader to determine the injuring mechanism and look for damages of lesser expression (or even invisible damages) that are common to the identified mechanism. In becoming more familiar with those mechanisms, the readers can deal with trauma imaging more efficiently and directly focus on findings relevant for further management.Skeletal Trauma: A Mechanism-Based Approach of Imaging aims to combine the knowledge of both radiologists and surgeons to propose a mechanism-based approach to imaging in skeletal trauma. Along 15 chapters covering every part of the skeleton, with more than 900 figures, this book reviews the anatomy, standard radiologic views, and imaging findings of skeletal trauma. Over 200 original schemas invite the reader to understand the imaging features and determine the injuring mechanism.

  • Therapeutic Strategies to Overcome ALK Resistance in Cancer

    • 1 Edición
    • Volumen 13
    • Luc Friboulet
    • Inglés
    Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment.

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