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Elsevier

Libros en Ciencias de la Vida

  • Toxoplasma Gondii

    The Model Apicomplexan - Perspectives and Methods
    • 3 Edición
    • Louis M. Weiss + 1 más
    • Inglés
    Toxoplasma gondii: The Model Apicomplexan - Perspectives and Methods, Third Edition, reflects significant advances in the field in the last five years, including new information on the genomics, epigenomics and proteomics of T. gondii, along with a new understanding of the population biology and genetic diversity of this organism. This edition expands information on the effects of T. gondii on human psychiatric disease and new molecular techniques, such as CAS9/CSPR. T gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

  • Biscuit, Cookie and Cracker Process and Recipes

    • 1 Edición
    • Glyn Barry Sykes + 1 más
    • Inglés
    Biscuit, Cookie and Cracker Process and Recipes: A practical reference for a wide range of recipes and production information for crackers, snack crackers, semi-sweet biscuits, short doughs, cookies and sandwich biscuits. These recipes have been developed in Europe, Asia, Australia, North America and South America. Beginning with an explanation of the production process and formulations, this book provides easy-access information for developing new biscuits, cookies and crackers for international markets. All the process details, formulations, technical information are based on the notes and files of the late Glyn Sykes. Glyn gained wide experience over a working lifetime in the biscuit baking industry, working with over fifty biscuit manufacturers world-wide. Glyn Sykes family have made the information available for the new book, which is a valuable reference for professionals in the biscuit baking industry and students in the food technology field.

  • Tumor Immunology and Immunotherapy - Integrated Methods Part A

    • 1 Edición
    • Volumen 635
    • Inglés
    Tumor Immunology and Immunotherapy Integrated Methods - Part A, Volume 635 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Specific chapters to this release include Deconvolution of the immunological contexture of mouse tumors with multiplexed immunohistochemistry... High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers, Multiplex assay by IHC for melanoma tumor microenvironment evaluation, Characterization of the tumor immune microenvironment by multispectral image analysis of multiplex immunofluorescence images, Phenotyping of immune cells in situ using multispectral imaging quantification, and much more.

  • Giardia and Giardiasis - Part B

    • 1 Edición
    • Volumen 107
    • Inglés
    Giardia and Giardiasis Volume 107-Part B, in the Advances in Parasitology series, is dedicated to aspects of cytoskeletal structure of this parasite with an emphasis on insights of new components and their function in trophozoites. Further, microtubule function and its critical involvement in motility, attachment, mitosis and cell division as well as in transitions between developmental stages are reviewed. Also a comprehensive revision in the progress of tools to explore and understand the functional biology of Giardia, its coding and non-coding genes, features and cellular and molecular biology is contained in this volume. Additionally, an exciting perspective on the interactions between Giardia and intestinal epithelial cell by reviewing transcriptomic and proteomic investigations is included along with a state-of-the art of the understanding pathophysiology of giardiasis and of how Giardia can cause post-infectious and extra-intestinal complications. A complete review of current knowledge including commonly prescribed drugs, causes of therapeutic fails, drug resistance mechanisms, strategies for the discovery of new agents for alternative drug therapies is covered.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 95
    • Inglés
    Advances in Clinical Chemistry, Volume 95, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release including sections on Advances in diagnostic microfluidics, Vascular and valvular calcification biomarkers, Long noncoding RNAs in cancer: From discovery to therapeutic targets, Exosomes of male reproduction, Tryptophan in health and disease, Biochemistry of blood platelet activation, and the beneficial role of plant oils in cardiovascular diseases.

  • Systems Simulation and Modeling for Cloud Computing and Big Data Applications

    • 1 Edición
    • Dinesh Peter + 1 más
    • Inglés
    Systems Simulation and Modelling for Cloud Computing and Big Data Applications provides readers with the most current approaches to solving problems through the use of models and simulations, presenting SSM based approaches to performance testing and benchmarking that offer significant advantages. For example, multiple big data and cloud application developers and researchers can perform tests in a controllable and repeatable manner. Inspired by the need to analyze the performance of different big data processing and cloud frameworks, researchers have introduced several benchmarks, including BigDataBench, BigBench, HiBench, PigMix, CloudSuite and GridMix, which are all covered in this book. Despite the substantial progress, the research community still needs a holistic, comprehensive big data SSM to use in almost every scientific and engineering discipline involving multidisciplinary research. SSM develops frameworks that are applicable across disciplines to develop benchmarking tools that are useful in solutions development.

  • The Electronic Health Record

    Ethical Considerations
    • 1 Edición
    • Eike-Henner W. Kluge
    • Inglés
    The Electronic Health Record: Ethical Considerations analyses the ethical issues that surround the construction, maintenance, storage, use, linkage, manipulation and communication of electronic health records. Its purpose is to provide ethical guidance to formulate and implement policies at the local, national and global level, and to provide the basis for global certification in health information ethics. Electronic health records (EHRs) are increasingly replacing the use of paper-based records in the delivery of health care. They are integral to providing eHealth, telehealth, mHealth and pHealth - all of which are increasingly replacing direct and personal physician-patient interaction - as well as in the developing field of artificial intelligence and expert systems in health care. The book supplements considerations that are raised by national and international regulations dealing with electronic records in general, for instance the General Data Protection Regulation of the European Union. This book is a valuable resource for physicians, health care administrators and workers, IT service providers and several members of biomedical field who are interested in learning more about how to ethically manage health data.

  • Cognitive Biases in Health and Psychiatric Disorders

    Neurophysiological Foundations
    • 1 Edición
    • Tatjana Aue + 1 más
    • Inglés
    Cognitive Biases in Health and Psychiatric Disorders: Neurophysiological Foundations focuses on the neurophysiological basis of biases in attention, interpretation, expectancy and memory. Each chapter includes a review of each specific bias, including both positive and negative information in both healthy individuals and psychiatric populations. This book provides readers with major theories, methods used in investigating biases, brain regions associated with the related bias, and autonomic responses to specific biases. Its end goal is to provide a comprehensive overview of the neural, autonomic and cognitive mechanisms related to processing biases.

  • Food and Society

    • 1 Edición
    • Mark Gibson
    • Inglés
    Food and Society provides a broad spectrum of information to help readers understand how the food industry has evolved from the 20th century to present. It includes information anyone would need to prepare for the future of the food industry, including discussions on the drivers that have, and may, affect food supplies. From a historical perspective, readers will learn about past and present challenges in food trends, nutrition, genetically modified organisms, food security, organic foods, and more. The book offers different perspectives on solutions that have worked in the past, while also helping to anticipate future outcomes in the food supply. Professionals in the food industry, including food scientists, food engineers, nutritionists and agriculturalists will find the information comprehensive and interesting. In addition, the book could even be used as the basis for the development of course materials for educators who need to prepare students entering the food industry.

  • Neutron Crystallography in Structural Biology

    • 1 Edición
    • Volumen 634
    • Inglés
    Neutron Crystallography in Structural Biology, Volume 634, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this updated release include Fundamentals of neutron crystallography in structural biology, Large crystal growth for neutron protein crystallography, Prospects for membrane protein crystals in NMX, IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor, The macromolecular neutron diffractometer at the spallation neutron source, Current status and near future plan of neutron protein crystallography at J-PARC, Neutron macromolecular crystallography at the European spallation source, and much more.

  • Risk Factors for Psychosis

    Paradigms, Mechanisms, and Prevention
    • 1 Edición
    • Andrew Thompson + 1 más
    • Inglés
    Risk Factors for Psychosis: Paradigms, Mechanisms, and Prevention combines the related, but disparate research endeavors into a single text that considers all risk factors for psychosis, including biological, psychological and environmental factors. The book also introduces the ethics and current treatment evidence that attempts to ameliorate risk or reduce the number of individuals with risk factors developing a psychotic disorder. Finally, the book highlights new research paradigms that will further enhance the field in the future. Psychotic disorders affect more than 50 million people worldwide, creating a devastating effect on lives and causing major financial and emotional impact on families and on society as a whole. The search for risk factors for psychosis has developed rapidly over the past decades, invigorated by changes in the thinking about the malleability and treatability of psychotic disorders. The paradigms for investigating psychosis risk have developed, often in parallel, but there has been no book to date that has summarized and synthesized the current approaches.

  • Drying Atlas

    Drying Kinetics and Quality of Agricultural Products
    • 1 Edición
    • Werner Muhlbauer + 1 más
    • Inglés
    Drying Atlas: Drying Kinetics and Quality of Agricultural Products provides, in a condensed and systematic way, specific insights on the drying-relevant properties and coefficients of over 40 agricultural products. It also presents information about the production methods that influence the drying process, the quality of the dried product, the official quality standards of the products, and the design principles and operating characteristics of drying systems that are widely used in the postharvest processing and food industry. Available books on drying technology mainly focus on drying theory and simulation of drying processes. This book offers systematic information on the impact of other important parameters, such as relative humidity, air flow rate, mechanical, thermal and chemical pre-treatment, and drying mode for specific products. It is a unique and valuable reference for scientists and engineers who want to focus on industrial drying applications and dryers, as well as graduate and post-graduate students in postharvest technology and drying.

  • The Neuroscience of Meditation

    Understanding Individual Differences
    • 1 Edición
    • Yi-Yuan Tang + 1 más
    • Inglés
    The Neuroscience of Meditation: Understanding Individual Differences explores the individual differences in learning and practicing meditation, while also providing insights on how to learn and practice effectively. The book comprehensively covers the research in brain areas and networks that mediate the positive effects of meditation upon physical and mental health. Though it examines how people differ in how they learn and practice meditation, it underscores how underlying mechanisms differ in learning and practicing meditation and how they remain unclear to researchers. This book addresses the research gap and explores the brain science behind meditation.

  • Microbiomics

    Dimensions, Applications, and Translational Implications of Human and Environmental Microbiome Research
    • 1 Edición
    • Inglés
    Microbiomics: Dimensions, Applications, and Translational Implications of Human and Environmental Microbiome Research describes a new, holistic approach to microbiomics. International experts provide in-depth discussion of current research methods for studying human, environmental, viral and fungal microbiomes, as well as the implications of new discoveries for human health, nutrition, disease, cancer research, probiotics and in the food and agricultural industries. Distinct chapters covering culturomics and sub-microbiomes, such as the viriome and mycetobiome, provide an integrative framework for the expansion of microbiomics into new areas of application, as well as crosspollination between research areas. Detailed case studies include the use of microbiomics to develop natural products with antimicrobial properties, microbiomic enhancements in food and beverage technology, microbes for bioprotection and biopreservation, microbial tools to reduce antibiotic resistance, and maintenance and cultivation of human microbial communities.

  • GPCR Signaling in Cancer

    • 1 Edición
    • Volumen 145
    • Inglés
    GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in cancer, Emerging GPCR signaling pathways in cancer, and more. G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics.

  • Pharmacological Advances in Natural Product Drug Discovery

    • 1 Edición
    • Volumen 87
    • Inglés
    Pharmacological Advances in Natural Product Drug Discovery, Volume 87 in the Advances in Pharmacology series, presents the latest pharmacological research progresses of 8 medicinal compounds from natural products, including salvianolic acid, tanshinone, paeonol, chlorogenic acid, astragaloside, icariin, ganoderan, and febrifugine. Specific chapters to this new release include Potential Role of Paeonol on Atherosclerosis Related Cells, A Review on Salvianolic Acid, Pharmacological Advances of Tanshinones, the Natural Product of Salvia Miltiorrhiza, Pharmacological Action and Potential Targets Analysis of Major Pharmacological Effects of Chlorogenic Acid, Modern TCM: Identifying and Defining the "Medicinal Mix", Pharmacological Advances in Astragaloside IV Derived from Astragalus Membranaceus, and much more.

  • Inflammatory Disorders - Part B

    • 1 Edición
    • Volumen 120
    • Inglés
    Inflammatory Disorders - Part B, Volume 120 explores inflammation in the immune system and how the body’s own cells or tissues may cause abnormal inflammation, thus resulting in chronic pain, redness, swelling, stiffness, and damage to normal tissues. Chapters in this updated volume include Proteins in monogenic autoinflammatory disorders, Virulence factors and their roles in periodontal disease pathogenesis, Role of Heat shock proteins in Inflammatory disorder Rheumatoid Arthritis, Novel targeted therapies for Crohn's disease: Recent progress and future perspectives, Dietary plant flavonoids in prevention of obesity and diabetes, Small RNAs in allergic diseases, Inflammation and inflammasome during ageing and age-related diseases, and more.

  • A Beginner's Guide to Data Agglomeration and Intelligent Sensing

    • 1 Edición
    • Amartya Mukherjee + 2 más
    • Inglés
    A Beginners Guide to Data Agglomeration and Intelligent Sensing provides an overview of the Sensor Cloud Platform, Converge-casting, and Data Aggregation in support of intelligent sensing and relaying of information. The book begins with a brief introduction on sensors and transducers, giving readers insight into the various types of sensors and how one can work with them. In addition, it gives several real-life examples to help readers properly understand concepts. An overview of concepts such as wireless sensor networks, cloud platforms, and device-to-cloud and sensor cloud architecture are explained briefly, as is data gathering in wireless sensor networks and aggregation procedures. Final sections explore how to process gathered data and relay the data in an intelligent way, including concepts such as supervised and unsupervised learning, software defined networks, sensor data mining and smart systems.

  • Plant Small RNA

    Biogenesis, Regulation and Application
    • 1 Edición
    • Praveen Guleria + 1 más
    • Inglés
    Plant Small RNA: Biogenesis, Regulation and Application describes the biosynthesis of small RNA in plant systems. With an emphasis on the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival, this books presents the basics and most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology. In addition, it emphasizes the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival. Final sections cover the most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology.

  • BEST

    Implementing Career Development Activities for Biomedical Research Trainees
    • 1 Edición
    • Lorena Infante Lara + 2 más
    • Inglés
    BEST: Implementing Career Development Activities for Biomedical Research Trainees provides an instructional guide for institutions wanting to create, supplement or improve their career and professional development offerings. Each chapter provides an exclusive perspective from an administrator from the 17 Broadening Experiences in Scientific Training (BEST) institutions. The book can aid institutions who train graduate students in a variety of careers by teaching faculty and staff how to create and implement career development programming, how to highlight the effectiveness of offerings, how to demonstrate that creating a program from scratch is doable, and how to inform faculty and staff on getting institutional buy-in. This is a must-have for graduate school deans and faculty and staff who want to implement and institutionalize career development programing at their institutions. It is also ideal for graduate students and postdocs.

  • An Introduction to Interdisciplinary Toxicology

    From Molecules to Man
    • 1 Edición
    • Carey N. Pope + 1 más
    • Inglés
    An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from “simple” molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are also included. The book allows students to concurrently learn concepts in both biomedical and environmental toxicology fields, thus better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology.

  • Genome Engineering via CRISPR-Cas9 System

    • 1 Edición
    • Vijai Singh + 1 más
    • Inglés
    Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields.

  • Advances in Immunology in China - Part B

    • 1 Edición
    • Volumen 145
    • Inglés
    Advances in Immunology in China - Part B, Volume 145, the latest release in the Advances in Immunology series, presents the latest release in a long-established and highly respected publication. The book includes current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release focusing on advances in immunology in China.

  • Functional and Preservative Properties of Phytochemicals

    • 1 Edición
    • Bhanu Prakash
    • Inglés
    Functional and Preservative Properties of Phytochemicals examines the potential of plant-based bioactive compounds as functional food ingredients and preservative agents against food-spoiling microbes and oxidative deterioration. The book provides a unified and systematic accounting of plant-based bioactive compounds by illustrating the connections among the different disciplines, such as food science, nutrition, pharmacology, toxicology, combinatorial chemistry, nanotechnology and biotechnological approaches. Chapters present the varied sources of raw materials, biochemical properties, metabolism, health benefits, preservative efficacy, toxicological aspect, safety and Intellectual Property Right issue of plant-based bioactive compounds. Written by authorities within the field, the individual chapters of the book are organized according to the following practical and easy to consult format: introduction, chapter topics and text, conclusions (take-home lessons), and references cited for further reading.

  • Advances in Cyanobacterial Biology

    • 1 Edición
    • Prashant Kumar Singh + 3 más
    • Inglés
    Advances in Cyanobacterial Biology presents the novel, practical, and theoretical aspects of cyanobacteria, providing a better understanding of basic and advanced biotechnological application in the field of sustainable agriculture. Chapters have been designed to deal with the different aspects of cyanobacteria including their role in the evolution of life, cyanobacterial diversity and classification, isolation, and characterization of cyanobacteria through biochemical and molecular approaches, phylogeny and biogeography of cyanobacteria, symbiosis, Cyanobacterial photosynthesis, morphological and physiological adaptation to abiotic stresses, stress-tolerant cyanobacterium, biological nitrogen fixation. Other topics include circadian rhythms, genetics and molecular biology of abiotic stress responses, application of cyanobacteria and cyanobacterial mats in wastewater treatments, use as a source of novel stress-responsive genes for development of stress tolerance and as a source of biofuels, industrial application, as biofertilizer, cyanobacterial blooms, use in Nano-technology and nanomedicines as well as potential applications. This book will be important for academics and researchers working in cyanobacteria, cyanobacterial environmental biology, cyanobacterial agriculture and cyanobacterial molecular biologists.

  • Aquaporin Regulation

    • 1 Edición
    • Volumen 112
    • Gerald Litwack
    • Inglés
    Aquaporin Regulation, Volume 112, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters highlighting Perspectives on the evolution of aquaporin superfamily, Structure and dynamics of aquaporin-1, Selectivity and Transport in Aquaporins from Molecular Simulation Studies, Aquaporin regulation in metabolic organs, Phosphorylation of human AQP2 and its role in trafficking, Regulation of Aquaporin-2 by RNA Interference, Aquaporin Regulation: Lessons from Secretory Vesicles, CFTR Regulation of Aquaporin-mediated Water Transport, Glucocorticoid Gene Regulation of Aquaporin-7, and much more.

  • Protein Homeostasis Diseases

    Mechanisms and Novel Therapies
    • 1 Edición
    • Angel L. Pey
    • Inglés
    Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-functi... and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders.

  • Controlled and Modified Atmospheres for Fresh and Fresh-Cut Produce

    • 1 Edición
    • Maria Isabel Gil + 1 más
    • Inglés
    Controlled and Modified Atmospheres for Fresh and Fresh-Cut Produce is the ultimate reference book of CA/MA recommendations for selected commodities. It includes the basic knowledge of physiology and technologies to the current application of recommended CA/MAP conditions for fresh and fresh-cut fruits and vegetables. For each commodity, a summary with requirements and recommendations is presented. The book is divided into three parts, with each focusing on different aspects of CA/MA, including fundamental topics on the physiological and quality effects of CA and MAP for fresh and fresh-cut fruits and vegetables, optimal CA/MAP conditions and recommendations, and optimal conditions for fresh-cut fruits and vegetables.

  • Preclinical Research in Down Syndrome: Insights for Pathophysiology and Treatments

    • 1 Edición
    • Volumen 251
    • Inglés
    Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more.

  • Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C

    • 1 Edición
    • Volumen 633
    • Inglés
    Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C, Volume 633, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial. This release includes sections on Next generation probes for molecular imaging in cells, Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin-4-fluorescein... Converting avidin to bind ligands other than biotin, especially steroids, Chemoenzymatic Labeling Strategy, Engineered Siderophores, Small molecules to inhibit bacterial population behavior, NMR tube bioreactor, Small molecule controlled RAS activation system, Small molecule regulated Cas9, the Design and application of synthetic receptors, and much more.

  • Second Generation Cell and Gene-Based Therapies

    Biological Advances, Clinical Outcomes and Strategies for Capitalisation
    • 1 Edición
    • Alain Vertes + 3 más
    • Inglés
    Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products.The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals.

  • 100 Years of Human Chorionic Gonadotropin

    Reviews and New Perspectives
    • 1 Edición
    • Laurence A. Cole + 1 más
    • Inglés
    100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world’s leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule.

  • Advances in Food and Nutrition Research

    • 1 Edición
    • Volumen 91
    • Fidel Toldra
    • Inglés
    Approx.322 pages

  • Handbook of Research on Blockchain Technology

    • 1 Edición
    • Saravanan Krishnan + 5 más
    • Inglés
    Handbook of Research on Blockchain Technology presents the latest information on the adaptation and implementation of Blockchain technologies in real world business, scientific, healthcare and biomedical applications. The book's editors present the rapid advancements in existing business models by applying Blockchain techniques. Novel architectural solutions in the deployment of Blockchain comprise the core aspects of this book. Several use cases with IoT, biomedical engineering, and smart cities are also incorporated. As Blockchain is a relatively new technology that exploits decentralized networks and is used in many sectors for reliable, cost-effective and rapid business transactions, this book is a welcomed addition on existing knowledge. Financial services, retail, insurance, logistics, supply chain, public sectors and biomedical industries are now investing in Blockchain research and technologies for their business growth. Blockchain prevents double spending in financial transactions without the need of a trusted authority or central server. It is a decentralized ledger platform that facilitates verifiable transactions between parties in a secure and smart way.

  • Prognostic and Therapeutic Applications of RKIP in Cancer

    • 1 Edición
    • Benjamin Bonavida + 1 más
    • Inglés
    Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression in cancer open a novel era of new therapeutics and their potential in the treatment of highly resistant cancers and metastases. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students.

  • Evidence-informed Approaches for Managing Dementia Transitions

    Riding the Waves
    • 1 Edición
    • Linda Garcia + 2 más
    • Inglés
    Evidence-Informed Approaches for Managing Dementia Transitions provides evidence-informed approaches and future directions for supporting a higher quality of life for people living with dementia. Through a person-centered lens, this book equips care providers to better help people living with dementia align their expectations and hopes with the trajectories they can expect in their journey. It highlights the various transitions that those with dementia will experience and describes best practices for optimal adjustment to each. Topics covered include problem identification, driving cessation, loss of financial autonomy, acute hospital admission, moving to assisted living residences and long term care homes, and palliative and end of life care. This is a must have reference for researchers, clinicians, and mental health professionals (psychologists, counsellors, social workers, mental health nurses) as well as policy makers and other health and social care providers working with individuals with dementia.

  • Delivery of Drugs

    Volume 2: Expectations and Realities of Multifunctional Drug Delivery Systems
    • 1 Edición
    • Ranjita Shegokar
    • Inglés
    Delivery of Drugs: Expectations and Realities of Multifunctional Drug Delivery Systems, Volume Two examines the formulation of micro-nanosized drug delivery systems and recaps opportunities for using physical methods to improve efficacy via mechano-, electroporation. The book highlights innovative delivery methods like PIPAC, including discussions on the regulatory aspects of complex injectables. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects.This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stakeholders. This level of discussion makes it a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about the status of drug delivery systems.

  • Regulation of Nitrogen-Fixing Symbioses in Legumes

    • 1 Edición
    • Volumen 94
    • Inglés
    The Nitrogen-Fixing Legume-Rhizobium Symbiosis, Volume 94, the latest release in the Advances in Botanical Research series, highlights new advances in the field, with this new volume presenting interesting chapters on The diversity of legume-rhizobium symbioses, Parasponia; an evolutionary outlier of rhizobium symbiosis, Rhizobium diversity in the light of evolution, Genomes of rhizobia, Gene regulation by extracytoplasmic function (ECF) sigma factors in alpha-rhizobia, Early symbiotic signaling between Plant and Bacteria, Rhizobia infection, a journey to the inside of plant cells, Differentiation of symbiotic nodule cells and their rhizobium endosymbionts, Nodule Organogenesis, Nitrogen Fixation by the Legume-Rhizobium Symbiosis, and much more.

  • Sustainability of the Food System

    Sovereignty, Waste, and Nutrients Bioavailability
    • 1 Edición
    • Noelia Betoret + 1 más
    • Inglés
    Sustainability of the Food System: Sovereignty, Waste, and Nutrients Bioavailability addresses the concept of global sustainability, focusing on three key areas of action within the food production system: food sovereignty, environmentally friendly food processes, and food technologies that increase the bioavailability of bioactive compounds. The book defines key concepts in the food production system and provides examples of specific and tailored actions that contribute to global sustainability. Sustainability of the Food System: Sovereignty, Waste, and Nutrients Bioavailability will serve as a welcomed resource for food scientists and technologists, agriculturists, agronomic engineers, food engineers, environmental technologists, nutritionists, and post-graduate students studying bioresource technology and sustainability.

  • On Call Neurology

    On Call Series
    • 4 Edición
    • Stephan A. Mayer + 1 más
    • Inglés
    Ideal for any on-call professional, resident, or medical student, this popular reference covers the common problems you’ll encounter while on call in the hospital. On Call Neurology, 4th Edition, by Drs. Randolph S. Marshall and Stephan A. Mayer, fits perfectly in your pocket, ready to provide key information in time-sensitive, challenging situations. You’ll gain speed, skill, and knowledge with every call - from diagnosing a difficult or life-threatening situation to prescribing the right medication.

  • Parkinson’s Disease Therapeutics

    Emphasis on Nanotechnological Advances
    • 1 Edición
    • Magisetty Obulesu
    • Inglés
    Parkinson’s Disease Therapeutics: Emphasis on Nanotechnological Advances presents the latest information on the second most common neurodegenerative disorder in the elderly. Despite remarkable progress in various PD therapeutics, such as microRNAs and brain drug delivery systems, a few limitations impede their success. This book sheds light on the pros and cons of recently developed novel therapeutics. Very few books have highlighted the protective efficacy of natural products, antioxidants, and biomaterial design for other diseases.

  • Introduction to the Chemistry of Food

    • 1 Edición
    • Michael Zeece
    • Inglés
    Introduction to the Chemistry of Food describes the molecular composition of food and the chemistry of its components. It provides students with an understanding of chemical and biochemical reactions that impact food quality and contribute to wellness. This innovative approach enables students in food science, nutrition and culinology to better understand the role of chemistry in food. Specifically, the text provides background in food composition, demonstrates how chemistry impacts quality, and highlights its role in creating novel foods. Each chapter contains a review section with suggested learning activities. Text and supplemental materials can be used in traditional face-to-face, distance, or blended learning formats.

  • Tumor Immunology and Immunotherapy - Cellular Methods Part B

    • 1 Edición
    • Volumen 632
    • Inglés
    Tumor Immunology and Immunotherapy – Cellular Methods Part B, Volume 632, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered include Quantitation of calreticulin exposure associated with immunogenic cell death, Side-by-side comparisons of flow cytometry and immunohistochemistry for detection of calreticulin exposure in the course of immunogenic cell death, Quantitative determination of phagocytosis by bone marrow-derived dendritic cells via imaging flow cytometry, Cytofluorometric assessment of dendritic cell-mediated uptake of cancer cell apoptotic bodies, Methods to assess DC-dependent priming of T cell responses by dying cells, and more.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 160
    • Donald L. Sparks
    • Inglés
    Advances in Agronomy continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied and exemplary of the abundant subject matter addressed by this long-running serial.

  • Handbook of Natural Fibres

    Volume 2: Processing and Applications
    • 2 Edición
    • Ryszard M. Kozlowski + 1 más
    • Inglés
    The Handbook of Natural Fibres: Volume Two, Processing and Applications, Second Edition provides detailed coverage of the latest processing techniques and industrial applications of a wide range of natural fibers. Natural fibrous resources, both lignocellulosic and protein ones, are renewable, biodegradable, and nontoxic, making them an important source of sustainable textile solutions. A broad range of sources of natural fibers are covered in the book, including flax, hemp, bast, jute, coir, linen, cotton and silk. This wealth of expert information provides a uniquely detailed reference for the processing, characterization, selection and application of natural fibers.

  • Saffron

    The Age-Old Panacea in a New Light
    • 1 Edición
    • Maryam Sarwat + 1 más
    • Inglés
    Saffron: The Age-Old Panacea in a New Light is the first book to detail the functions and effect of saffron in medicinal situations. This book explores the medicinal aspects of saffron and the effect saffron imparts on various diseases of the central nervous system, cardiovascular system, digestive system, locomotor system, urogenital system, eye, skin, and immune system, along with their mechanism of action. This perpetual bulb found mainly in Asia and Europe, Iran, India and Mediterranean countries has been shown to reduce seizures, delay convulsions, and as a neuroprotective agent against cerebral ischemia, brain damage, and Alzheimer's and Parkinson's disease. In addition, it also reduces depression, hypnosis and anxiety and enhances learning and memory skills.

  • Inflammatory Disorders - Part A

    • 1 Edición
    • Volumen 119
    • Rossen Donev
    • Inglés
    Inflammation is a biological response triggered by different stimuli that has in the body a potentially damaging effect. In certain conditions, such as injury or infection, inflammation is a normal, healthy response. However, inflammatory disorders that result in the immune system attacking the body’s own cells or tissues may cause abnormal inflammation, which results in chronic pain, redness, swelling, stiffness, and damage to normal tissues. Mechanisms involved in promoting a number of different inflammatory disorders and their targeting for therapeutic benefit have been one of the hottest topics in last few decades. The two consecutive volumes (119 and 120) dedicated to this subject cover a wide spectrum of inflammatory disorders, mechanisms that are believed to cause them and different strategies for managing the inflammatory diseases.

  • Molecular Evolutionary Models in Drug Discovery

    • 1 Edición
    • Juan Bueno
    • Inglés
    Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings.

  • Technology in Diabetes, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1 Edición
    • Volumen 49-1
    • Grazia Aleppo
    • Inglés
    This issue of Endocrinology and Metabolism Clinics, guest edited by Dr. Grazia Aleppo, will cover key topics in Technology in Diabetes. This issue is one of four selected each year by our series consulting editor, Dr. Adriana G. Ioachimescu. Topics discussed in this issue will include: Evolution of Diabetes Technology, Diabetes Technology in children, Diabetes Technology in adults with type 1 and type 2 Diabetes, Benefits and challenges of Diabetes Technology use in older adults, Integration of Diabetes Technology in Clinical Practice, Diabetes Technology in the inpatient setting for management of hyperglycemia, Standardization of CGM reports, Diabetes Technology and Exercise, Psychosocial Aspects of Diabetes Technology use, Automated insulin delivery, and Glucagon, among others.

  • Handbook of the Behavioral Neurobiology of Serotonin

    • 2 Edición
    • Volumen 31
    • Inglés
    Handbook of the Behavioral Neurobiology of Serotonin, Second Edition, builds on the success of the first edition by continuing to provide a detailed and comprehensive overview of the many facets of behavioral serotonin research. The text expands on the two key topics, behavioral control (sensory processing, ultrasonic vocalization, and melatonin and sleep control) and psychiatric disorders, including its role on psychostimulant abuse and addiction. The new edition includes two new sections on the serotonin systems interactions and the involvement of serotonin in neurological disorders and associated treatment. Serotonin is a major neurotransmitters in the serotonergic system which one of the best studied and understood transmitter systems. Both are critically involved in the organization of all behaviors and in the regulation of emotion and mood.

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