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Elsevier

Libros en Neurociencia

  • Methods in Neurosciences

    Quantitative and Qualitative Microscopy
    • 1 Edición
    • Volumen 3
    • P. Michael Conn
    • Inglés
    Because of the significance of morphology and cellular communication unique to the functioning and interdependence of neural systems, many of the advances in the neurosciences rely on classic as well as new microscopy techniques.

  • The Mathematical Brain Across the Lifespan

    • 1 Edición
    • Volumen 227
    • Inglés
    The Mathematical Brain Across the Lifespan is the latest volume in the Progress in Brain Research series that focuses on new trends and developments. This established international series examines major areas of basic and clinical research within the neurosciences, as well as popular and emerging subfields.

  • Mechanisms of Sensory Working Memory

    Attention and Perfomance XXV
    • 1 Edición
    • Pierre Jolicoeur + 2 más
    • Inglés
    Mechanisms of Sensory Working Memory: Attention and Performance XXV provides an update on research surrounding the memory processes that are crucial for many facets of cognitive processing and experience, with new coverage of emerging areas of study, including a new understanding of working memory for features of stimuli devoid of verbal, phonological, or long-term memory content, such as memory for simple visual features (e.g., texture or color), simple auditory features (e.g., pitch), or simple tactile features (e.g., vibration frequency), now called sensory memory to distinguish from verbal memory. This contemporary focus on sensory memory is just beginning, and this collection of original contributions provides a foundational reference for the study mechanisms of sensory memory. Students, scholars, and researchers studying memory mechanisms and processes in cognitive neuroscience, cognitive science, neuroscience, and psychology will find this book of great value to their work.

  • Neurobiology of Epilepsy

    From Genes to Networks
    • 1 Edición
    • Volumen 226
    • Inglés
    Neurobiology of Epilepsy: From Genes to Networks is the latest volume in the Progress in Brain Research series that focuses on new trends and developments. This established international series examines major areas of basic and clinical research within the neurosciences, as well as popular and emerging subfields.

  • Sport and Exercise Psychology Research

    From Theory to Practice
    • 1 Edición
    • Markus Raab + 4 más
    • Inglés
    Sport and Exercise Psychology Research: From Theory to Practice provides a comprehensive summary of new research in sport and exercise psychology from worldwide researchers. Encompassing theory, research, and applications, the book is split into several themed sections. Section 1 discusses basic antecedents to performance including fitness, practice, emotion, team dynamics, and more. Section 2 identifies factors influencing individual performance. Section 3 discusses applied sport psychology for athletes and coaches, and section 4 includes approaches from exercise psychology on motivation and well-being. The book includes a mix of award winning researchers from the European Sport Psychology Association, along with top researchers from the U.S. to bring an international overview to sport psychology.

  • Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

    • 1 Edición
    • Thomas Lehner + 2 más
    • Inglés
    This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders.

  • Developing Therapeutics for Alzheimer's Disease

    Progress and Challenges
    • 1 Edición
    • Michael S. Wolfe
    • Inglés
    Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics.

  • The Gut-Brain Axis

    Dietary, Probiotic, and Prebiotic Interventions on the Microbiota
    • 1 Edición
    • Niall Hyland + 1 más
    • Inglés
    The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota examines the potential for microbial manipulation as a therapeutic avenue in central nervous system disorders in which an altered microbiota has been implicated, and explores the mechanisms, sometimes common, by which the microbiota may contribute to such disorders.

  • Translational Neuroimmunology in Multiple Sclerosis

    From Disease Mechanisms to Clinical Applications
    • 1 Edición
    • Ruth Arnon + 1 más
    • Inglés
    Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon—such as neuroprotective strategies, stem cells, and repair promotion—are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development.

  • Pediatric Brain Stimulation

    Mapping and Modulating the Developing Brain
    • 1 Edición
    • Adam Kirton + 1 más
    • Inglés
    Pediatric Brain Stimulation: Mapping and Modulating the Developing Brain presents the latest on this rapidly expanding field that has seen an exponential growth in publications over the past 10 years. Non-invasive modalities like TMS can painlessly map and measure complex neurophysiology in real patients. Neuromodulatory applications like rTMS and tDCS carry increasingly proven therapeutic applications. Rapidly advancing technological methodologies are increasing opportunities and indications. Despite all these benefits, applications in the more plastic developing brains of children are only just emerging. This book provides a comprehensive overview of brain stimulation in children. Chapters include Transcranial Magnetic Stimulation (TMS) fundamentals, brain stimulation in pediatric neurological conditions, and invasive brain stimulation. The main audience for this research will be those interested in applying brain stimulation technologies to advance clinical research and patient care, although a wide variety of clinicians and scientist will find this to be a valuable reference on brain stimulation with specific chapters on a variety of conditions.

  • Functional Neuromarkers for Psychiatry

    Applications for Diagnosis and Treatment
    • 1 Edición
    • Juri D. Kropotov
    • Inglés
    Functional Neuromarkers for Psychiatry explores recent advances in neuroscience that have allowed scientists to discover functional neuromarkers of psychiatric disorders. These neuromarkers include brain activation patterns seen via fMRI, PET, qEEG, and ERPs. The book examines these neuromarkers in detail—what to look for, how to use them in clinical practice, and the promise they provide toward early detection, prevention, and personalized treatment of mental disorders. The neuromarkers identified in this book have a diagnostic sensitivity and specificity higher than 80%. They are reliable, reproducible, inexpensive to measure, noninvasive, and have been confirmed by at least two independent studies. The book focuses primarily on the analysis of EEG and ERPs. It elucidates the neuronal mechanisms that generate EEG spontaneous rhythms and explores the functional meaning of ERP components in cognitive tasks. The functional neuromarkers for ADHD, schizophrenia, and obsessive-compulsive disorder are reviewed in detail. The book highlights how to use these functional neuromarkers for diagnosis, personalized neurotherapy, and monitoring treatment results.

  • Congenital Heart Disease and Neurodevelopment

    Understanding and Improving Outcomes
    • 1 Edición
    • Christopher McCusker + 1 más
    • Inglés
    Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes brings together the work of leading researchers from the U.K., Europe, and the U.S. to provide a comprehensive examination of the causes, risks, and neurodevelopmental and psychological outcomes in children with congenital heart disease. The book includes longitudinal studies which have tracked outcomes from birth through late childhood and explores the emergent phenotype and etiologies, risk, and protective factors that strengthen proposed models. Medical and surgical advances have meant that greater numbers of children with even the most severe congenital heart disease (CHD) now survive well into adulthood. Studies over the past 20 years have suggested certain neurodevelopmental and psychological features are common, with clinical interventions being internationally articulated. The U.K. Belfast Center has developed and evaluated unique early intervention programs to circumvent the common problems discerned and promote optimal adjustment and outcomes. The first edition of Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes describes these programs in detail and outlines promising results obtained by researchers worldwide. Such interventions, together with the U.S. consensus statement (Circulation, 2012) on neurodevelopmental screening, hold great promise for clinical interventions.

  • Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

    • 1 Edición
    • Carlo Sala + 1 más
    • Inglés
    Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms.

  • Controversies In Diabetic Neuropathy

    • 1 Edición
    • Volumen 127
    • Inglés
    This latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.

  • Neuropathology of Drug Addictions and Substance Misuse Volume 3

    General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions
    • 1 Edición
    • Victor R. Preedy
    • Inglés
    Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances.

  • New Horizons in Neurovascular Coupling: A Bridge Between Brain Circulation and Neural Plasticity

    • 1 Edición
    • Volumen 225
    • Inglés
    New Horizons in Neurovascular Coupling: A Bridge Between Brain Circulation and Neural Plasticity is the latest volume in the Progress in Brain Research series that focuses on new trends and developments in neurovascular coupling. This established international series examines major areas of basic and clinical research within the neurosciences, as well as popular and emerging subfields. This volume takes an integrated approach to review and summarize some of the most recent progress reported on the connection between brain circulation and neural plasticity.

  • The Inner Ear

    Including Otoneurology, Otosurgery, and Problems in Modern Warfare
    • 1 Edición
    • Joseph Fischer + 1 más
    • Inglés
    The Inner Ear: Including Otoneurology, Otosurgery, and Problems in Modern Warfare covers the anatomical, physiological and the central pathways of the inner ear. This book is composed of 15 chapters that particularly consider the pathologic anatomy of the various forms of labyrinthine diseases. The first three chapters deal with the clinical anatomy and physiological features of the inner ear. The next chapter examines certain conditions that can be observed during induced and abnormal excitability of the labyrinth. These topics are followed by considerable chapters on various forms of labyrinthine diseases, including otosclerosis, inflammatory diseases, intracranial complications, congenital diseases, neoplasms, facial palsy, vascular lesions, and war trauma. A chapter evaluates the potential use of sulfa drugs in chemotherapy for inner ear cases. Another chapter surveys the role of the inner ear in the aeronautics and the functional tests for aviation fitness. The last chapter discusses the effects of atmospheric pressure changes on the ear. This book will be of value to otologists, otoneurologists, and otosurgeons.

  • Neurology Secrets

    • 6 Edición
    • Eli M. Mizrahi + 1 más
    • Inglés
    Part of the bestselling Secrets Series, the updated sixth edition of Neurology Secrets continues to provide an up-to-date, concise overview of the most important topics in neurology today. It serves as a comprehensive introduction for medical students, physician assistants, and nurse practitioners, and is also a handy reference and refresher for residents and practitioners. Lists, tables, and clear illustrations throughout expedite review, while the engaging Secrets Series format makes the text both enjoyable and readable. New lead editors, Drs. Kass and Mizrahi, join this publication from a leading neurology program to lend a fresh perspective and expert knowledge.

  • Brain Metastases from Primary Tumors, Volume 3

    Epidemiology, Biology, and Therapy of Melanoma and Other Cancers
    • 1 Edición
    • M. A. Hayat
    • Inglés
    Brain Metastases from Primary Tumors Volume Three: Epidemiology, Biology, and Therapy of Melanoma and Other Cancers provides a comprehensive overview of the metastasis of cancer, the main cause of approximately 90% of cancer associated deaths, yet the mechanisms governing this clinically important process remain poorly understood. Melanoma is the third most common diagnosis among patients with brain metastases, after lung and breast cancer. Approximately 75% of patients with metastatic melanoma develop brain metastases during the course of their disease. Although tumorigenesis of melanoma remains poorly understood, recent advances in gene expression profiling have revealed molecular mechanisms of this deadly disease. In addition, high-throughput gene expression has many advantages over techniques in cancer transcriptomic studies and has led to the discovery of numerous diagnostic, prognostic, and therapeutic targets, which are also detailed in this book. The book discusses the link between primary tumors and brain metastasis of melanoma, including molecular mechanisms, treatment options, prognosis, and general applications. Comprehensive chapters discuss systemic therapy, integrin inhibitors, stereotaxic radiosurgery, and more, making this book a great resource for neurooncologists, neurosurgeons, neurologists, and cancer researchers.

  • Animal Models for Medications Screening to Treat Addiction

    • 1 Edición
    • Volumen 126
    • Richard L Bell + 1 más
    • Inglés
    Animal Models for Medications Screening to Treat Addiction, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.

  • Handbook of Neuro-Oncology Neuroimaging

    • 2 Edición
    • Herbert B. Newton
    • Inglés
    Remarkable progress in neuro-oncology due to increased utilization of advanced imaging in clinical practice continues to accelerate in recent years. Refinements in magnetic resonance imaging (MRI) and computed tomography (CT) technology, and the addition of newer anatomical, functional, and metabolic imaging methods, such as MRS, fMRI, diffusion MRI, and DTI MRI have allowed brain tumor patients to be diagnosed much earlier and to be followed more carefully during treatment. With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this second edition of the Handbook of Neuro-Oncology Neuroimaging is so relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuro-Imaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the first edition, and in addition will feature several new important chapters covering diverse topics such as advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. It will also serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.

  • The Auditory System and Human Sound-Localization Behavior

    • 1 Edición
    • John van Opstal
    • Inglés
    The Auditory System and Human Sound-Localization Behavior provides a comprehensive account of the full action-perception cycle underlying spatial hearing. It highlights the interesting properties of the auditory system, such as its organization in azimuth and elevation coordinates. Readers will appreciate that sound localization is inherently a neuro-computational process (it needs to process on implicit and independent acoustic cues). The localization problem of which sound location gave rise to a particular sensory acoustic input cannot be uniquely solved, and therefore requires some clever strategies to cope with everyday situations. The reader is guided through the full interdisciplinary repertoire of the natural sciences: not only neurobiology, but also physics and mathematics, and current theories on sensorimotor integration (e.g. Bayesian approaches to deal with uncertain information) and neural encoding.

  • Neuropathology of Drug Addictions and Substance Misuse Volume 2

    Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects
    • 1 Edición
    • Victor R. Preedy
    • Inglés
    Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. Each section provides data on the general, molecular and cellular, and structural and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention, and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad material and substances.

  • Adult Neurogenesis in the Hippocampus

    Health, Psychopathology, and Brain Disease
    • 1 Edición
    • Juan J. Canales
    • Inglés
    Neurogenesis in the adult brain has emerged as one of the most dynamic and rapidly moving fields in modern neuroscience research. The implications of adult neurogenesis for health and well-being are wide-ranging, with findings in this area having distinct relevance for treatment and rehabilitation in neurology and psychopathology. Adult Neurogenesis in the Hippocampus addresses these implications by providing an up-to-date account on how neurogenesis in the adult hippocampus contributes to critical psychological and physiological processes, such as learning and memory, and how it is modified by life experiences, such as aging, environmental enrichment, exercise, and dieting. The book also provides the most current reviews of how adult hippocampal neurogenesis influences the pathogenesis of mood disorders, addiction, and key neurological disorders. This book is the ideal resource for researchers and advanced graduates seeking focused knowledge on the role of adult neurogenesis in brain health and disease.

  • Introduction to EEG- and Speech-Based Emotion Recognition

    • 1 Edición
    • Priyanka A. Abhang + 2 más
    • Inglés
    Introduction to EEG- and Speech-Based Emotion Recognition Methods examines the background, methods, and utility of using electroencephalogram... (EEGs) to detect and recognize different emotions. By incorporating these methods in brain-computer interface (BCI), we can achieve more natural, efficient communication between humans and computers. This book discusses how emotional states can be recognized in EEG images, and how this is useful for BCI applications. EEG and speech processing methods are explored, as are the technological basics of how to operate and record EEGs. Finally, the authors include information on EEG-based emotion recognition, classification, and a proposed EEG/speech fusion method for how to most accurately detect emotional states in EEG recordings.

  • Systems Neuroscience in Depression

    • 1 Edición
    • Thomas Frodl
    • Inglés
    Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry.

  • Autoimmune Neurology

    • 1 Edición
    • Volumen 133
    • Inglés
    Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders.

  • Stress: Concepts, Cognition, Emotion, and Behavior

    Handbook of Stress Series, Volume 1
    • 1 Edición
    • George Fink
    • Inglés
    Stress: Concepts, Cognition, Emotion, and Behavior: Handbook in Stress Series, Volume 1, examines stress and its management in the workplace and is targeted at scientific and clinical researchers in biomedicine, psychology, and some aspects of the social sciences. The audience is appropriate faculty and graduate and undergraduate students interested in stress and its consequences. The format allows access to specific self-contained stress subsections without the need to purchase the whole nine volume Stress handbook series. This makes the publication much more affordable than the previously published four volume Encyclopedia of Stress (Elsevier 2007) in which stress subsections were arranged alphabetically and therefore required purchase of the whole work. This feature will be of special significance for individual scientists and clinicians, as well as laboratories. In this first volume of the series, the primary focus will be on general stress concepts as well as the areas of cognition, emotion, and behavior.

  • Neuropathology of Drug Addictions and Substance Misuse Volume 1

    Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids
    • 1 Edición
    • Victor R. Preedy
    • Inglés
    Neuropathology of Drug Addictions and Substance Misuse, Volume One: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids, Opioids and Emerging Addictions provides the latest research in an area that shows that the neuropathological features of one addiction are often applicable to those of others. The book also details how a further understanding of these commonalties can provide a platform for the study of specific addictions in greater depth, all in an effort to create new modes of understanding, causation, prevention, and treatment. The three volumes in this series address new research and challenges, offering comprehensive coverage on the adverse consequences of the most common drugs of abuse, with each volume serving to update the reader’s knowledge on the broader field of addiction, while also deepening our understanding of specific addictive substances. Volume One addresses tobacco, alcohol, cannabinoids, and opioids, with each section providing data on the general, molecular/cellular, and structural/functiona... neurological aspects of a given substance, along with a focus on the adverse consequences of addictions.

  • Fundamentals of Brain Network Analysis

    • 1 Edición
    • Alex Fornito + 2 más
    • Inglés
    Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization.

  • Gliomas

    • 1 Edición
    • Volumen 134
    • Inglés
    Researchers’ knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book’s discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers. Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care.

  • Genes, Environment and Alzheimer's Disease

    • 1 Edición
    • Orly Lazarov + 1 más
    • Inglés
    Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease.

  • Pharmacological Mechanisms and the Modulation of Pain

    • 1 Edición
    • Volumen 75
    • Inglés
    Pharmacological Mechanisms and the Modulation of Pain, the newest volume in the Advances in Pharmacology series, presents the pharmacological mechanisms and the modulation of pain. With a variety of chapters and the best authors in the field, this volume is an essential resource for pharmacologists, immunologists, and biochemists alike.

  • Chemosensory Transduction

    The Detection of Odors, Tastes, and Other Chemostimuli
    • 1 Edición
    • Frank Zufall + 1 más
    • Inglés
    Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals.

  • Intracellular Consequences of Amyloid in Alzheimer's Disease

    • 1 Edición
    • Michael R. D'Andrea
    • Inglés
    Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.

  • Making a Scientific Case for Conscious Agency and Free Will

    • 1 Edición
    • William R. Klemm
    • Inglés
    Making a Scientific Case for Conscious Agency and Free Will makes a series of arguments that certain human behaviors are impossible to explain in the absence of free will, and that free will emerges from materialistic processes of brain function. It outlines future directions for neuroscience studies that can harness emerging technologies and tools for systems-level analysis. All humans have the sensation that they consciously will certain things to happen and that, in the absence of external constraints, they are free to choose from among alternatives. This notion of free will is deemed obvious by the average person based on common experience. Free will is frequently defended with arguments stemming from social, legal, philosophical, and religious perspectives. But these arguments appeal to consequences—not causes—of choices and decisions. In the past 3 decades, debate has raged within the scientific community over whether free will is in fact an illusion. Because free will would require conscious agency, the supporting corollary is that consciousness itself cannot do anything and is merely an observer rather than an actor.

  • Essential Clinically Applied Anatomy of the Peripheral Nervous System in the Head and Neck

    • 1 Edición
    • Paul Rea
    • Inglés
    Essential Clinically Applied Anatomy of the Nerves in the Head and Neck presents the reader with an easy access format to clinically-applied peripheral nervous system (PNS) anatomy. Perfect for a quick reference to essential details. The chapters review nerves of the head and neck, the origin(s), course, distribution and relevant pathologies affecting each are given, where relevant. The pathologies present typical injuries to the nerves of the PNS, as well as clinical findings on examination and treatments. It details modern clinical approaches to the surgery and other treatments of these nerve pathologies, as applicable to the clinical scenario.

  • Fundamental Statistical Principles for the Neurobiologist

    A Survival Guide
    • 1 Edición
    • Stephen W. Scheff
    • Inglés
    Fundamental Statistical Principles for Neurobiologists introduces readers to basic experimental design and statistical thinking in a comprehensive, relevant manner. This book is an introductory statistics book that covers fundamental principles written by a neuroscientist who understands the plight of the neuroscience graduate student and the senior investigator. It summarizes the fundamental concepts associated with statistical analysis that are useful for the neuroscientist, and provides understanding of a particular test in language that is more understandable to this specific audience, with the overall purpose of explaining which statistical technique should be used in which situation. Different types of data are discussed such as how to formulate a research hypothesis, the primary types of statistical errors and statistical power, followed by how to actually graph data and what kinds of mistakes to avoid. Chapters discuss variance, standard deviation, standard error, mean, confidence intervals, correlation, regression, parametric vs. nonparametric statistical tests, ANOVA, and post hoc analyses. Finally, there is a discussion on how to deal with data points that appear to be "outliers" and what to do when there is missing data, an issue that has not sufficiently been covered in literature.

  • Complications in Neuroanesthesia

    • 1 Edición
    • Hemanshu Prabhakar
    • Inglés
    Complications in Neuroanesthesia focuses on complications that may arise related to neuroanesthesia practice and discusses its various causes. Each complication is written as a separate chapter, and the pathophysiology and mechanisms of each complication, as well as measures for diagnosis, treatment and prevention are discussed. Towards the end of the book, several case scenarios are provided to the readers that challenge readers to diagnose the possible complication for each case. Chapters include brain and spinal cord problems, cardiovascular and hematological problems, and nerve and muscle problems. Written in a standard format, Complications in Neuroanesthesia provides quick and easy access to understanding problems in neuroanesthesia. It provides insight into all possible complications occurring during perioperative management of neurosurgical and neurologic patients. It is useful for trainees, clinicians, and researchers in the fields of neurosurgery, neurocritical care, and neurology by providing an understanding of preventable mishaps that may occur in neurosurgical or neurologic patients.

  • Neuroimaging Personality, Social Cognition, and Character

    • 1 Edición
    • John R Absher + 1 más
    • Inglés
    Neuroimaging Personality, Social Cognition, and Character covers the science of combining brain imaging with other analytical techniques for use in understanding cognition, behavior, consciousness, memory, language, visual perception, emotional control, and other human attributes. Multidimensional brain imaging research has led to a greater understanding of character traits such as honesty, generosity, truthfulness, and foresight previously unachieved by quantitative mapping. This book summarizes the latest brain imaging research pertaining to character with structural and functional human brain imaging in both normal individuals and those with brain disease or disorder, including psychiatric disorders.By reviewing and synthesizing the latest structural and functional brain imaging research related to character, this book situates itself into the larger framework of cognitive neuroscience, psychiatric neuroimaging, related fields of research, and a wide range of academic fields, such as politics, psychology, medicine, education, law, and religion.

  • Insights to Neuroimmune Biology

    • 2 Edición
    • Istvan Berczi
    • Inglés
    Insights to Neuroimmune Biology, Second Edition discusses the systemic regulatory network, coordination, organization, and interpretation of the rapidly accumulating knowledge on the topic of neuroimmune biology, with an ultimate goal of helping readers understand the function of higher organisms, including man, in their entire complexity. This publication provides assessments and interpretations of accumulated experimental evidence, enabling the scientific community to keep abreast of essential advancements of existing knowledge as we search for greater understanding of the biology of higher organisms.

  • Perception of Pixelated Images

    • 1 Edición
    • Talis Bachmann
    • Inglés
    Perception of Pixelated Images covers the increasing use of these images in everyday life as communication, socialization, and commerce increasingly rely on technology. The literature in this book is dispersed across a wide group of disciplines, from perception and psychology to neuroscience, computer science, engineering, and consumer science. The book summarizes the research to date, answering such questions as, What are the spatial and temporal limits of perceptual discrimination of pixelated images?, What are the optimal conditions for maximizing information extracted from pixelated images?, and How does the method of pixelation compromise or assist perception?

  • The Neuronal Cytoskeleton, Motor Proteins, and Organelle Trafficking in the Axon

    • 1 Edición
    • Volumen 131
    • Inglés
    The Neuronal Cytoskeleton, Motor Proteins, and Organelle Trafficking in the Axon, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in neuronal cells, and includes sections on such topics as actin transport in axons and neurofilament transport.

  • Neuroscience of Pain, Stress, and Emotion

    Psychological and Clinical Implications
    • 1 Edición
    • Magne Arve Flaten + 1 más
    • Inglés
    Neuroscience of Pain, Stress, and Emotion: Psychological and Clinical Implications presents updated research on stress, pain, and emotion, all key research areas within both basic and clinical neuroscience. Improved research understanding of their interaction is ultimately necessary if clinicians and those working in the field of psychosomatic medicine are to alleviate patient suffering. This volume offers broad coverage of that interaction, with chapters written by major researchers in the field. After reviewing the neuroscience of pain and stress, the contents go on to address the interaction between stress and chronic/acute pain, the role of different emotions in pain, neurobiological mechanisms mediating these various interactions, individual differences in both stress and pain, the role of patient expectations during treatment (placebo and nocebo responses), and how those relate to stress modulation. While there are books on the market which discuss pain, stress, and emotion separately, this volume is the first to tackle their nexus, thus appealing to both researchers and clinicians.

  • Laterality

    Exploring the Enigma of Left-Handedness
    • 1 Edición
    • Clare Porac
    • Inglés
    Left-handedness has been connected to many different conditions, traits, and abilities. This is especially true for pathological syndromes, such as schizophrenia, along with learning disabilities and autism. The published research on handedness is vast and frequently contradictory, often raising more questions than providing answers. Questions such as: Is handedness genetic? Can handedness be changed? Are there consequences to training someone to switch handedness? Are there positive traits associated with left-handedness like creativity? Are there negative traits associated with left-handedness like trouble reading maps? Is it abnormal to do some things right-handed and other things left-handed? Are the brains of left-handers different from the brains of right-handers? Laterality: Exploring the Enigma of Left-Handedness examines the research conducted over the past 50 years with special emphasis on twenty-first century research on handedness and translates this literature into an accessible and readable form. Each chapter is based on a question or questions covering diverse topics such as genetic and biological origins of handedness, familial and hormonal influences on handedness, and the effects of a majority right-handed world on the behaviors of left-handers.

  • Cuban Blindness

    Diary of a Mysterious Epidemic Neuropathy
    • 1 Edición
    • Gustavo C. Román
    • Inglés
    On May 4, 1993, Cuba asked the international health community and the World Health Organization (WHO) to find the cause of a mysterious epidemic of blindness that was spreading uncontrollably. Contradictory hypotheses confronted the team of scientists on this mission. Is the epidemic the result of a plot to topple Castro, as the Cubans believe? Or exposure to radioactivity or an unidentified nerve toxin accidentally released by the Russian Army withdrawing from Cuba?Cuban Blindness: Diary of a Mysterious Epidemic Neuropathy is a firsthand account of the epidemic of blindness and the hardships of life in Cuba at the time of the "special period" that followed the collapse of the Soviet Union and the tightening of the US embargo. Dr. Román—who was at the time Chief of Neuroepidemiology at the US National Institutes of Health—was a participant in this scientific mission and describes the neurological symptoms experienced by the victims of this epidemic disease, and narrates the epidemiologists’ detective work struggling to solve the mystery. This book combines neuroscience and scientific discovery with political intrigue, finally bringing the reader to the unexpected solution provided by a WWII survivor of Changi POW Camp in Singapore. Cuban Blindness: Diary of a Mysterious Epidemic Neuropathy is a description of the neuroepidemiological study undertaken to identify the cause of the epidemic neurological disease that affected Cuba in 1993-1994.

  • Endocannabinoids

    • 1 Edición
    • Volumen 125
    • Inglés
    Endocannabinoids, the latest volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into the neurobiology of migraines. It reviews the current knowledge and understanding in the field, and provides a starting point for researchers and practitioners entering the field.

  • Axons and Brain Architecture

    • 1 Edición
    • Kathleen Rockland
    • Inglés
    Several excellent monographs exist which deal with axons. These, however, focus either on the cellular and molecular biology of axons proper or on network organization of connections, the latter with only an incidental or abstract reference to axons per se. Still relatively neglected, however, is the middle ground of terminations and trajectories of single axons in the mammalian central nervous system. This middle level of connectivity, between networks on the one hand and local, in vitro investigations on the other, is to some extent represented by retrograde tracer studies and labeled neurons, but there have so far been many fewer of the complementary anterograde studies, with total visualization of the axonal arborization. The present volume brings together in one source an interrelated treatment of single axons from the perspective of microcircuitry and as substrates of larger scale organization (tractography). Especially for the former area - axons in microcircuitry - an abundance of published data exists, but these are typically in specialty journals that are not often accessed by the broader community. By highlighting and unifying the span from microcircuitry to tractography, the proposed volume serves as a convenient reference source and in addition inspires further interactions between what currently tend to be separate communities. The volume also redresses the imbalance between in vitro/local connectivity and long-distance connections. Focusing on mammalian systems, Part 1 of this book is devoted to anatomical investigations of connections at the single axon level, drawing on modern techniques and classical methods from the 1990s. A particular emphasis is on broad coverage of cortical and subcortical connections from different species, so that common patterns of divergence, convergence, and collateralization can be easily appreciated. Part 2 addresses mechanisms of axon guidance, as these seem particularly relevant to pathways and branching patterns. Part 3 covers axon dynamics and functional aspects; and Part 4 focuses on tractography, notably including comparisons between histological substrates and imaging.

  • Atlas of the Human Brain

    • 4 Edición
    • Juergen K Mai + 2 más
    • Inglés
    The fourth edition of Atlas of the Human Brain presents the anatomy of the brain at macroscopic and microscopic levels, featuring different aspects of brain morphology and topography. This greatly enlarged new edition provides the most detailed and accurate delineations of brain structure available. It includes features which assist in the new fields of neuroscience – functional imaging, resting state imaging and tractography. Atlas of the Human Brain is an essential guide to those working with human brain imaging or attempting to relate their observations on experimental animals to humans. Totally new in this edition is the inclusion of Nissl plates with delineation of cortical areas (Brodmann’s areas), the first time that these areas have been presented in serial histological sections.

  • Atlas of Early Zebrafish Brain Development

    A Tool for Molecular Neurogenetics
    • 2 Edición
    • Dr. Thomas Mueller + 1 más
    • Inglés
    Atlas of Early Zebrafish Brain Development: A Tool for Molecular Neurogenetics, Second Edition, remains the only neuroanatomical expression atlas of important genetic and immunohistochemical markers of this vertebrate model system. It represents a key reference and interpretation matrix for analyzing expression domains of genes involved in Zebrafish brain development and neurogenesis, and serves as a continuing milestone in this research area. This updated volume provides in-situ hybridized and immunostained preparations of complete series of brain sections, revealing markers of the fundamental stages in the life history of neuronal cells in very high quality preparations and photographic plates. Specific additions to this edition include documentation on the distribution of neurons expressing GABA, dopamine and serotonin, material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon, new theories on the early organization of the telencephalon and thalamus, and integration of a comparative perspective on the mid- and hindbrain.

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