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Elsevier

Libros en Neurociencia

  • The Physiology of Synapses

    • 1 Edición
    • John Carew Eccles
    • Inglés
    The Physiology of Synapses covers the considerable advances in understanding the complex physiology of synapses. This book is divided into 16 chapters that emphasize the mechanism of synaptic transmission. The first chapters describe the structural and physiological features of chemically transmitting synapses. The subsequent chapters deal with the excitatory postsynaptic responses to presynaptic impulse and the release of transmitter by presynaptic impulses. These topics are followed by discussions of the impulse generation by the excitatory postsynaptic potential; the postsynaptic electrical events produced by chemically transmitting inhibitory synapses; the ionic mechanism generating the inhibitory postsynaptic potential. The last chapters consider the mechanism of inhibitory transmitter substances, pathways responsible for postsynaptic inhibitory action, and the trophic and plastic properties of synapses. This book will prove useful to physiologists, neurologists, and researchers.

  • Cognitive Development

    The Child's Acquisition of Diagonality
    • 1 Edición
    • David R. Olson
    • David S. Palermo
    • Inglés
    Cognitive Development: The Child's Acquisition of Diagonality is an empirical and rational enquiry into the child's development of a conceptual system relating to the concept of the diagonal during the age range three to six years. A detailed examination will be made of why a young child has difficulty with such a problem, and what occurs during development that removes this difficulty. In the context of these empirical arguments, the book considers such theoretical questions as the nature of intellectual skills and conceptual or symbolic knowledge, as well as the role of experience and instruction in their development. The study concludes with a description of the child's reconstruction of the diagonal in terms of what at least poses as a general model of perceptual and intellectual development, and accounts for, among other things, man's increasing ability to apprehend and theorize about the motion of the stars. It shows that it is the elaboration of the child's perceptual knowledge in the context of his performatory attempts in such cultural media as language and geometry that accounts for his ability to copy a diagonal in particular and his intellectual development in general.

  • Developmental Neuropsychobiology

    • 1 Edición
    • William T Greenough + 1 más
    • Inglés
    Developmental Neuropsychobiology is a compendium of papers that deals with developmental neuroscience and developmental psychology, as well as the broad range of approaches toward brain-behavior development. One paper reviews the embryonic mechanisms including the pattern formation that develops in a single fertilized egg, particularly focusing on limb innervation as a special case of pattern formation. Another paper discusses the regulation of nerve fiber elongation during embryogenesis. One author analyzes the pathways and changing connections in the nervous system of the insect: he shows that manipulating neural organization by grafting results in the ability of the transplanted sensory cells to find the proper central connections. Another paper reviews the sex differences in developmental plasticity of behavior and the brain. These differences point to the vulnerability of males during development to incidences of autism, dyslexia, or cerebral palsy compared to females. One paper also examines alternative perceptions of parent- offspring relationships. This collection can prove helpful for researchers, students, and academicians involved in the disciplines of biological or psychological sciences.

  • Clinical Anesthesia in Neurosurgery

    • 1 Edición
    • Elizabeth A. M. Frost
    • Inglés
    Clinical Anesthesia in Neurosurgery, Second Edition, integrates the evolution of the field of neuroanesthesia with the major areas of neurosurgical activity to give the reader the required perspective and requisite information to help in laying the foundation for future advances as well as describing the current state of the art. The book contains 25 chapters organized into five parts. Part I presents studies on cerebral physiology and evaluation. Topics covered include cerebral circulation and metabolism, intraoperative neurophysiologic monitoring, and central nervous system effects of anesthetic agents. Part II covers neurosurgical and related procedures, such as posterior cranial fossa surgery, surgery of the spine, and peripheral nerve surgery. Part III examines central nervous system trauma including spinal cord trauma and cardiovascular effects of severe head injury. Part IV takes up postoperative and intensive care, including postanesthetic care, neurosurgical intensive care, and parenteral nutrition while Part V deals with the medical criteria and legal aspects of brain death.

  • Progress in Behavior Modification

    Volume 4
    • 1 Edición
    • Michel Hersen + 2 más
    • Inglés
    Progress in Behavior Modification, Volume 4, is a multidisciplinary serial publication that encompasses the contributions of psychology, psychiatry, social work, speech therapy, education, and rehabilitation. This serial aims to meet the need for a review publication that undertakes to present yearly in-depth evaluations that include a scholarly examination of theoretical underpinnings, a careful survey of research findings, and a comparative analysis of existing techniques and methodologies. The discussions center on a wide spectrum of child and adult disorders. The present volume opens with a chapter on behavioral treatment for obesity. This is followed by separate chapters on applications of reinforcement techniques in the areas of pollution control and energy conservation, job performance and unemployment, community self-government, racial integration, and others; and behavior modification in community settings. Subsequent chapters deal with demand characteristics in behavior modification; the clinical utility of biofeedback procedures; and the technology of training parents in behavior therapy. The final chapter reviews the rationale and empirical support for the extinction approach of implosive (flooding) therapy.

  • Neuroendocrine Perspectives

    Volume 3
    • 1 Edición
    • Eugenio E. Müller + 1 más
    • Inglés
    Neuroendocrine Perspectives, Volume 3 provides information on amine and peptide biochemistry. This book discusses the availability of specific biochemical and histochemical techniques that have greatly advanced knowledge of central nervous system neurotransmitter and neuropeptide systems. Organized into nine chapters, this volume begins with an overview of the structure of corticotropin releasing hormone. This text then examines the possible role of the cerebrospinal fluid in the regulation of pituitary function. Other chapters consider the importance of cerebrospinal fluid as a route for the hypothalamic regulation of pituitary function. This book discusses as well the available information concerning the neuroendocrine mechanisms involved in the onset of female puberty in primate and subprimate species. The final chapter deals with pineal indole metabolism and its controlling mechanisms as well as information on the interactions of the pineal hormones with neuroendocrine-repro... axis. This book is a valuable resource for pharmacologists, research workers, and students.

  • Neuro-Ophthalmology

    • 1 Edición
    • R. Lindsay Rea
    • Inglés
    Neuro-Ophthalmology provides information pertinent to the neuro-ophthalmologic... examination of the eye. This book discusses the anatomy and function of the eye as well as its various diseases. Organized into 17 chapters, this book begins with an overview of the various equipment and methods used in the examination of the eye, including the Snellen's test type, a 13 dioptre lens, and electric ophthalmoscope. This text then discusses the principal reactions of the normal pupil, including the direct light reflex, reflex to accommodation, the spino-pupillary reflex, the psychical reflex, the orbicularis reflex, and the oculo-sensory reflex. Other chapters consider the anatomy of the muscles and nerves of the eye as well as it adnexa. This book discusses as well the condition of optic atrophy and its various types. The final chapter deals with the distinction between headache and neuralgia. This book is a valuable resource for ophthalmic surgeons and ophthalmologists.

  • Progress in Neurology and Psychiatry

    An Annual Review
    • 1 Edición
    • E. A. Spiegel
    • Inglés
    Progress in Neurology and Psychiatry: An Annual Review, Volume 22 covers the significant advances in the understanding of neurophysiology, neuro-ophthalmology, and psychiatry. This volume is organized into four sections encompassing 33 chapters that also deal with the neurological aspects of pain and motor disorders. The first part discusses the fundamentals of neuroanatomy, general and regional neurophysiology, neuropathology, and the pharmacological aspects of the central nervous system. The second part examines the diagnosis, symptoms, and clinical features of neurological disorders. This part also explores the anatomical aspects of neuro-ophthalmology, otoneurology, and pediatric neurology. The third part reviews the surgical treatments for various neuro-related problems, including trauma, brain tumors, pain, and motor disorders. The fourth part considers the application of clinical psychiatry to the diagnosis and treatment of mental and emotional disorders, both in children and adults. This book will prove useful to neurologists, clinicians, pediatricians, and psychiatrists.

  • Neuroendocrinology

    Volume II
    • 1 Edición
    • Luciano Martini + 1 más
    • Inglés
    Neuroendocrinology, Volume II, is the second in a two-volume treatise designed to provide a survey of all aspects of the rapidly expanding science of neuroendocrinology. Only in recent years have the relations between the nervous system and the endocrine system come under intensive scrutiny, but their interactions have already been shown to be multiple and diverse. This diversity is reflected in the range of subjects covered. There are chapters on neural control of endocrine function; the effects of hormones on the brain; brain-endocrine interrelations during various phases of development; and the comparative aspects of neuroendocrine integration. The relation of brain chemistry to endocrine function, the effect of drugs on neuroendocrine mechanisms, and the new discipline of clinical neuroendocrinology have also been considered. Not only neurophysiologists and endocrinologists, but pharmacologists, zoologists, biochemists, psychologists, and those in clinical medicine will find the treatise of interest. Parts of neuroendocrinology have been discussed in other works, but this is the first treatise in which an attempt has been made to cover all ramifications of neuroendocrinology. This book can be used both as a text for advanced students and as a reference source.

  • Biochemical Factors Concerned in the Functional Activity of the Nervous System

    First International Meeting of the International Society for Neurochemistry, Strasbourg, 1967
    • 1 Edición
    • D. Richter
    • Inglés
    Biochemical Factors Concerned in the Functional Activity of the Nervous System presents the biological aspects concerned in the functional activity of the nervous system. This book covers several interesting topics concerning the central nervous system, including phospholipids, RNA synthesis, nerve impulse flow, and nerve growth factor. Comprised of 213 chapters, this book begins with an overview of the electron micrographs of calcium–ATP–phosphol... complexes. This text then examines the biochemical and histochemical studies on sectioned rat spinal cords, which demonstrated two types of monoamine-reducing drugs. Other chapters consider the diversity of antagonistic relations between the thiamine derivatives and vitamin B6, which is manifested by changes in the glutamate–GABA, histidine–histamine, tryptophan–serotonin... and tyrosine–noradrenali... systems. This book discusses as well the influence of a conditioned avoidance training experience on the incorporation of radioactive uridine into the RNA of mouse brain. The final chapter deals with the amino acid-incorporating activity of cerebral polyribosomes. This book is a valuable resource for biochemists, neurologists, pharmacologists, and biophysicists.

  • Dale's Principle and Communication between Neurones

    Based on a Colloquium of the Neurochemical Group of the Biochemical Society, Held at Oxford University, July 1982
    • 1 Edición
    • Neville N. Osborne
    • Inglés
    Dale's Principle and Communication Between Neurones is based on a colloquium of the Neurochemical Group of the Biochemical Society, held at Oxford University, July 1982. This book focuses on communication between neurones by means of chemical signals. The book contains an introductory chapter by V. P. Whittaker and nine further chapters on various aspects of the chemical communication processes between neurones. Topics covered include chemical communication between excitable cells; the neuroendocrine division of the nervous system; evidence for a neurone having the capacity to use two chemicals in the same process; and non-synaptic interneuronal communication. Each article is based on the excellent lectures given by the main authors and the discussion which ensued in the one-day colloquium held in Oxford. The final chapter is a specially invited contribution by Drs. Polak and Varndell, who agreed to produce an article on their new method of localising transmitter-like molecules at the electron-microscopic level.

  • The Release of Catecholamines from Adrenergic Neurons

    • 1 Edición
    • David M. Paton
    • Inglés
    The Release of Catecholamines from Adrenergic Neurons covers the advances in understanding the mechanism of catecholamine release and other neurotransmitters from adrenergic neurons. This book is organized into four sections encompassing 18 chapters. The opening section surveys biochemical studies of the mechanism and regulation of nerve stimulation. This section examines the role of calcium, prostaglandins, and presynaptic adrenoceptors and muscarine receptors in catecholamine release. The next section describes the modification of catecholamine release by several drugs, including adrenergic neuron blocking agents, narcotic analgesics, opioid peptides, lysergic acid diethylamide, anesthetics, alcohols, and adenosine and adenine nucleotides. These topics are followed by discussions of catecholamine release induced by cations and other drugs, such as nicotinic agonists, calcium ionophores, veratridine, scorption venom, and phenethylamines. The final section deals with the biochemical assessment of peripheral adrenergic activity and the clinical pharmacology of adrenergic neuron blocking agents. This book is intended for pharmacologists, neurologists, researchers, and advanced students.

  • Neuropathology

    Brussels, 21-28 July 1957
    • 1 Edición
    • L. Van Bogaert + 1 más
    • Inglés
    Neuropathology, Volume IV presents the proceedings of the First International Congress of Neurological Sciences, held in Brussels, Belgium, on July 21–28, 1957. This book provides information pertinent to the fundamental aspects of neuropathology. Organized into 84 chapters, this compilation of papers begins with an overview of the problem of multiple sclerosis and its relationship to leucodystrophies. This text then explains the two major histopathological manifestations of the injury caused by the rabies virus in the central nervous system. Other chapters consider the successful identification and isolation of a biologically active compound, which depends to a large extent on the availability of a quantitative bioassay. This book discusses as well the clinical manifestations, pathogenesis, and treatment of multiple sclerosis. The final chapter deals with the study of nucleic acids as well as histochemistry as a method of histological inquiry. This book is a valuable resource for neuropsychiatrists, biochemists, physicians, and scientists.

  • Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses

    Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27-29, 1981
    • 1 Edición
    • P. Lechat + 2 más
    • Inglés
    Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses presents the proceedings of a IUPHAR Satellite Symposium in conjunction with the eighth International Congress of Pharmacology held in Paris, France on July 27-29, 1981. The book contains papers on the effects of aminopyridines on ionic currents in excitable membranes; the effects of aminopyridines on synaptic transmission; and the effects of aminopyridines on the release of chemical transmitters. The text also presents papers on some differences in the blockade of potassium permeabilities by apamin and the aminopyridines; the miscellaneous actions of aminopyridines and related compounds; and the effects of aminopyridines on the skeletal, smooth and cardiac muscle. The clinical applications of aminopyridines and further miscellaneous actions of aminopyridines and related compounds are also considered.

  • Case Presentations in Neurology

    • 1 Edición
    • G. S. Venables + 2 más
    • Inglés
    Case Presentations in Neurology presents a selection of case histories demonstrating how patients with often quite simple problems may present and to bring out aspects of their diagnosis and management. All the patients presented to the Department of Neurology including those with more obscure diagnoses. The book consists of 12 exercises, each of six cases broadly corresponding to the style of the MRCP (UK) written case history papers. Each case is set out with the history and physical findings given first. There follows either a series of questions or true/false statements on one side of the page which the reader should attempt before continuing on to the answer section on the other side. There then follows a short discussion about each case and a single reference. This book is intended for those doctors studying for higher professional qualifications such as the MRCP, although it may be of interest and use to medical students approaching their final examinations.

  • Neurogenic Heart Lesions

    • 1 Edición
    • I. S. Zavodskaya + 2 más
    • Inglés
    Neurogenic Heart Lesions reviews the main publications concerned with the problem of neurogenic lesions of the heart. The book describes the methods for producing experimental neurogenic lesions, as well as the pharmacological analysis of the participation of the sympathetic nervous system and its transmitters in the development of neurogenic lesions of the myocardium. The text also discusses the changes in energy metabolism and in functional conditions of the myocardium caused by neurogenic lesions; and the pharmacoprophylaxis and pharmacotherapy of the biochemical changes produced by neurogenic lesions of the myocardium. Pharmacologists, pathologists, and other clinicians and physicians concerned with the new achievements in the field of cardiology will find the book invaluable.

  • Steroid Hormone Regulation of the Brain

    Proceedings of an International Symposium Held at the Wenner-Gren Center, Stockholm, 27-28 October 1980
    • 1 Edición
    • Kjell Fuxe + 2 más
    • Inglés
    Steroid Hormone Regulation of the Brain focuses on the advancement of knowledge of the properties of brain steroid receptors and steroid target nerve cells, including the actions of gonadal steroids, adrenocortical steroids, and androgenic steroids on the brain. The selection features the work of authors who have inspiringly conducted extensive studies on the action of steroid hormones. The book starts with discussions that point out that steroid hormones not only function through intracellular steroid receptors, but possibly through steroid membrane actions as well. Studies to support this claim are presented. As to the action of steroid hormones on presynaptic transmitter mechanisms, the book suggests that adrenocortical and gonadal steroids can create alterations in noradrenaline, adrenaline, and dopamine levels and turnover within the hypothalamus and preoptic area. The effects of catecholestrogens on the brain are also elaborated. A contribution to this paper stresses that estrogens have antidopaminergic action in the extrapyramidal system. This idea is identified through a series of behavioral experiments and measurements of the levels of striatal acetylcholine. This selection is recommended to scientists interested in studying the effect of hormones on the brain.

  • Neurobiology and Behavior

    • 1 Edición
    • A. O. Dennis Willows
    • Inglés
    The Mollusca, Volume 8: Neurobiology and Behavior, Part 2, provides an overview of the state of knowledge in molluscan neurobiology and behavior. It is part of a multivolume treatise that covers the areas of structure and function, metabolic biochemistry, molecular biomechanics, environmental biochemistry, physiology, ecology, reproduction and development, neurobiology and behavior, and evolution. The Mollusca is intended to serve a range of disciplines—zoology, biochemistry, physiology, and paleontology. It will prove useful to researchers and to all others with interests in mollusks. The book contains four chapters and begins with a discussion of neural control of cephalopod behavior. Subsequent chapters deal with the neuroanatomy of selected gastropod species; molluscan membranes, gates, and channels; and molluscan transmitters and modulators.

  • Aspects of Neural Ontogeny

    • 1 Edición
    • A. F. W. Hughes
    • Inglés
    Aspects of Neural Ontogeny focuses on the interaction between the nervous system and peripheral organs during development, including history and development of neurons and the functions of nerves and muscles. The book first offers information on the development of neurons, including formation and growth of nerve fibers; growth cone and the extension of nerve fibers; history of the neuron theory; and path of nerve fibers. The manuscript then elaborates on the innervation of the tetrapod limb and the center and periphery. Discussions focus on the relationships between the ventral horn and muscles of the limb; experimental studies on limb plexus and limb nerves; and relationships between spinal nerves and limb muscles. The publication takes a look at the ontogeny of behavior, as well as pattern of motility, spontaneous movements, tetrapod limb, and experimental studies. The book is a dependable reference for readers interested in neural ontogeny.

  • Neurochemistry of the Retina

    Proceedings of the International Symposium on the Neurochemistry of the Retina Held in Athens, Greece, August 28 - September 1, 1979
    • 1 Edición
    • Nicolas G. Bazan + 1 más
    • Inglés
    Neurochemistry of the Retina covers the proceedings of the International Symposium on the Neurochemistry of the Retina held in Athens, Greece, on August 28 – September 1, 1979. This book mainly focuses on the retina and its neurochemistry. This text is divided into eight major parts. The first part discusses the composition, metabolism, and biogenesis of membrane components. This book then explains the biochemical approaches to the study of visual cells and their relationship with the pigment epithelium, photorector shedding, and circadian rhythm. Chemical transmission of nerve signals is also tackled. This text also looks into the biochemical aspects of photoreceptor structure and function; cyclic nucleotides; and biochemical and pharmacological approaches to study the entire retina. This book concludes by explaining the neurochemical studies in retinal diseases and future research and prospective of the subject. This publication will be invaluable to ophthalmologists and students of ophthalmology.

  • Nervous System Theory

    An Introductory Study
    • 1 Edición
    • K. N. Leibovic
    • Inglés
    Nervous System Theory: An Introductory Study focuses on the nervous system theory, stressing the means for understanding the nature of the biological system rather than the elaboration of mathematical theories. This book begins with a discussion on single-cell responses, followed by a discussion of sensory information processing that leads into models of perceptual processes and their possible neural bases. This text concludes with some general principles and theoretical investigations relating to units that make up a nervous system, through a sensory pathway and central structures. The peripheral stimuli that explain the operations of the brain are also described. This publication is a good reference for neurologists, medical practitioners, and researchers conducting work on the nervous system theory.

  • Computers and Computations in the Neurosciences

    • 1 Edición
    • P. Michael Conn
    • Inglés
    Methods in Neurosciences, Volume 10: Computers and Computations in the Neurosciences discusses the use of computers in the neurosciences. The book deals with data collection, analysis, and modeling, with emphasis on the use of computers. Section I involves data collection using a personal microcomputer system. One paper presents a tutorial on using a PC-based motor control composed of an electronic circuit to adjust the motion of a light microscope stage through a software program. Other papers discuss computer methods in nuclei cartography and a computer-assisted quantitative receptor autoradiography in studying receptor density distribution. Section II deals with data analysis and some computer programs for kinetic modeling of gene expression in neurons. The book also discusses a computerized analysis of opioid receptor heterogeneity by ligand binding in test animals using computerized programs instead of employing manual or graphical methods. Computerized curve-fitting allows the researcher to utilize a more precise mathematical model to describe the binding of one ligand to one class of sites. Section III evaluates data modeling and simulations and describes the practicality of using computers to design model ion channels. Another paper discusses a graphical interaction program called MEMPOT to simulate an electrophysiological investigation of the properties of the membrane potential in stimulated cells. The book also presents a quantitative data gathered from computer simulation of the factors that affect neuronal density per measured sections. The book is suitable for microbiologists, biochemists, neuroscientists, and researchers in the field of medical research, as well as for advanced computer programmers in medical research work.

  • Pain Syndromes in Neurology

    Butterworths International Medical Reviews
    • 1 Edición
    • Howard L. Fields
    • Inglés
    Pain Syndromes in Neurology deals with the diagnosis and treatment of painful conditions associated with dysfunction of the peripheral or central nervous system. It discusses advances in three areas: first, the normal anatomy and physiology of pain; second, the pathophysiology of damaged sensory neurons; and third, the diagnosis and treatment of patients with neuropathic pain. The book begins with a discussion of neural mechanisms relevant to pain perception along with a brief review of neuropathic pain. This is followed by separate chapters on hyperalgesia following cutaneous injury; the importance of peripheral processes in the etiology of neuropathic and radiculopathic pain; and mechanisms by which sympathetic efferent fibers contribute to the occurrence of pain. Subsequent chapters cover the diagnosis and treatment of reflex sympathetic dystrophy; pain in generalized neuropathies; surgical treatment of pain; clinical features and management of postherpetic neuralgia; diagnosis of cancer pain syndromes; and drugs in the management of chronic pain.

  • Visual and Oculomotor Functions

    Advances in Eye Movement Research
    • 1 Edición
    • Volumen 5
    • G. d'Ydewalle + 1 más
    • Inglés
    A collection of contemporary work in various areas of eye-movement research with an emphasis on physiological aspects is presented in this book. The contributions are divided into six sections: I. saccadic eye movements; II. smooth pursuit and motion perception; III. eye movements in pathology and clinical settings; IV. neurophysiology of eye movements; V. optokinetic nystagmus; and VI. methods. This volume provides updated information on the most recent research on eye movements carried out mainly in Europe.

  • Topical Reviews in Neurosurgery

    Volume 1
    • 1 Edición
    • J. M. Rice Edwards
    • Inglés
    Topical Reviews in Neurosurgery, Volume 1 focuses on neurosurgery, a medical specialty concerned with the prevention, diagnosis, treatment, and rehabilitation of disorders that affect any portion of the nervous system. This book discusses the advances in computed tomography, vascular surgery in neurological disorders, and carotid endarterectomy. The extracranial-intracr... anastomosis, etiology of chronic subdural hematoma, radical surgery in the treatment of craniopharyngiomas, and syringomyelia are also covered. Other topics include the sensory neural deafness; aneurysmal hemorrhage; detection of carotid stenosis; bypass procedures; and completed stroke in the carotid territory. This publication likewise considers the middle cerebral aneurysms; cell kinetics of glioma; and pathophysiology of enlargement of chronic subdural hematomas. This publication is a good source for neurosurgeons and medical students interested in neurosurgery.

  • Biochemistry of Brain

    • 1 Edición
    • Sudhir Kumar
    • Inglés
    Biochemistry of Brain is a collection of articles dealing with the developments in the biochemistry of the brain. This book gives a comprehensive and critical discussion of important developments in studies concerning the above subject. This text discusses the structure, function, and metabolism of glycosphingolipids, which are related to the study of sphingolipid storage diseases. Inborn defects of metabolism are found in Gaucher's and Fabry's disease, which are characterized by lipid accumulation in the brain. Another paper reviews the chemical and genetics of critically lysosomal hydrolase deficiencies that can cause the storage of sphingolipids. This book then explains the role of myelin basic protein in lipids in vivo that the weak bonding of the protein is not a major component of myelin stability. Another paper discusses the procedures for isolating subfractions of myelin and myelin-related membranes, with some attention given on the alterations in the subfractionation of myelin in pathological hypomyelinating and demyelinating conditions. Another article discusses the biochemical and enzymatic composition of lysosomes and the biosynthesis, intracellular transport, storage, and the degradation of lysosomal constituents. This collection of papers will benefit scientists doing research in microbiology, microchemistry, molecular genetics, and neurochemistry.

  • Neuropeptide Analogs, Conjugates, and Fragments

    Methods in Neurosciences, Vol. 13
    • 1 Edición
    • P. Michael Conn
    • Inglés
    Methods in Neurosciences, Volume 13: Neuropeptide Analogs, Conjugates, and Fragments covers the synthesis and characterization of peptide analogs, conjugates, and fragments, their use as ligands for receptors, and their role in the development and use of antisera. The book discusses techniques such as novel synthetic approaches; biotinylation; purification and characterization; radioligand techniques and assay development; use of agonists and antagonists; distinguishing receptor subtypes; conjugation to carrier proteins; antiidiotypic antibody development; and radiolabeling. Neuroscientists, biochemists, neurochemists, and pharmacologists will find the book useful.

  • Trophic Regulation of the Basal Ganglia

    Focus on Dopamine Neurons
    • 1 Edición
    • K. Fuxe + 2 más
    • Inglés
    Trophic Regulation of the Basal Ganglia: Focus on Dopamine Neurons examines neurotransmitters. The book first discusses the role of fibroblast growth factor-2 (FGF-2) and ganglioside GM1 and the trophic regulation of the basal ganglia. Biochemical and histochemical studies on the cellular localization of FGF-2; mapping of FGF-2 and its receptors in the basal ganglia postnatally and adulthood; and mapping of the ganglioside GM1 distribution in the basal ganglia are presented. The text also explains glucocorticoid and estrogen effects on the nigrostriatal and mesolimbic dopaminergic systems; factors associated to dopaminergic cell death in Parkinson's disease; and compensatory mechanisms at dopamine D-2 receptors. The book also describes the effects of brain-derived neurotrophic factor on injured dopaminergic neurons; role of gangliosides and trophic factors in brain repair; and features of the trophic action of polyamines. The text also underscores the presence of interleukin-1 in the central nervous system; neuropeptides synthesis in astrocytes; and astrocytic kynurenines as modulators of dopaminergic function in the rat basal ganglia. The selection is a good source of information for readers wanting to study neurotransmitters.

  • Contributions to Contemporary Neurology

    A Tribute to Joseph Michael Foley
    • 1 Edición
    • Robert B. Daroff + 1 más
    • Inglés
    Contributions to Contemporary Neurology features articles presented at the scientific meeting at the March 1986 gala evening affair held in Cleveland, Ohio in honor of neurologist Joseph Michael Foley's seventieth birthday and his impending transition to Professor Emeritus at Case Western University. This book is organized into 20 chapters written by 41 contributors. It starts with the biography of Foley and ends with his curriculum vitae. In between the biographies and curriculum vitae are basic and clinical articles written by professionals closely associated with Foley throughout his illustrious career. This book will be of interest to those interested in learning about the life and career of neurologist Joseph Michael Foley.

  • Neurosciences Research

    Volume 4
    • 1 Edición
    • S Ehrenpreis + 1 más
    • Inglés
    Neuroscience Research, Volume 4 covers papers on a varied group of studies, ranging from synaptic transmission and local anesthetic action to the immobility reflex ("animal hypnosis") and control of food intake. The book presents papers on the mechanisms of synaptic transmission; the acetylcholine system and neural development; and the site of action and active form of local anesthetics. The text also includes papers on biological rhythms and their control in neurobehavioral perspective; neurophysiologic studies of the immobility reflex ("animal hypnosis" and the hepatic receptors and the neurophysiological mechanisms controlling feeding behavior. Neuroscientists, physiologists, and psychiatrists will find the book useful.

  • Methods in Neurotransmitter and Neuropeptide Research

    • 1 Edición
    • Volumen 11
    • S.H. Parvez + 2 más
    • Inglés
    This two-part book provides the most advanced biochemical and histochemical analytical methods on neurotransmitters, neuromodulators, and neuropeptides described by international specialists. The biochemical methods include liquid chromatography/elect... liquid chromatography/fluor... and chemiluminescence detection, gas chromatography or liquid chromatography with mass spectrometry, and immunoassays.Morphol... and physiological methods are also described, including immunohistochemistry... in situ hybridization, in vivo microdialysis, electrophysiological analysis, microwave irradiation, electrophysiological analysis, micro-anatomical dissection, peptide sequence analysis, quantitative autoradiographic analysis, and isolated CNS preparations. The neurotransmitters and neuropeptides include catecholamines, indoleamines, histamine, polyamines, and various neuropeptides, and their related enzymes. The book is the most comprehensive, advanced and versatile volume on the biochemical, morphological and physiological analysis of neurotransmitters and neuropeptides.

  • Comparative Neurochemistry

    Proceedings of the Fifth International Neurochemical Symposium
    • 1 Edición
    • Derek Richter
    • Inglés
    Comparative Neurochemistry, a collection of papers presented at the Fifth International Symposium of Comparative Neurochemistry, held at St. Wolfgang, Austria in 1962, deals with variations in neurochemical mechanisms in different animal species. The book integrates the data derived from comparative studies in different disciplines and assesses their significance in relation to the understanding of nervous mechanisms in animals, including human. The papers are grouped into sections, which cover general topics on functional organization in different species; lipids, proteins, and ribonucleic acid; amino acids in different species; energy metabolism and function; neurosecretory mechanisms; and comparative neuropharmacology. The text will be of interest to biologists, zoologists, pharmacologists, chemists, neurologists, and researchers in the pharmaceutical and chemical industries.

  • Microsurgery

    Applied to Neurosurgery
    • 1 Edición
    • M. G. Yaşargil
    • Inglés
    Microsurgery Applied to Neurosurgery focuses on microsurgical approaches to cerebrospinal lesions, including plastic surgery, suturing techniques, instruments for microsurgery, and microsurgical operations. The manuscript first offers information on the history of microsurgery and the operating microscope. Discussions focus on bipolar electric coagulation, plastic surgery, peripheral nerves, clinical application, binocular diploscope, automatic microscope stand, sterile covering of the microscope, and magnification. The text also elaborates on the instruments for microsurgery and suturing techniques. The publication takes a look at experimental microsurgical operations in animals and reconstructive and constructive surgery of the cerebral arteries in man. The manuscript also ponders on intracranial tumors and transnasal-transsphe... approach to the pituitary gland. Topics include transsphenoidal approach, suboccipital transmeatal approach, spinal tumors, and preoperative radiological study. The manuscript is a dependable reference for health professionals and readers interested in microsurgery.

  • Clinical Neuroendocrinology

    • 1 Edición
    • G. M. Besser + 1 más
    • Inglés
    Clinical Neuroendocrinology, Volume II discusses neuroendocrine science and its application to the analysis of human physiology and behavior. This book stresses the importance of the interrelationships between central and peripheral signals, neurotransmitters and neuromodulators, and target glands and peripheral tissues to ensure coordination of somatic and behavioral development and function. The ""centralist"" concepts of the importance of brain hormones are revised in this text, emphasizing that neurohumoral factors isolated from brain tissues, and initially considered to be primarily involved in the central nervous system regulation of the endocrine system, also exist outside the brain and spinal cord. This volume is valuable to neuroendocrinologist... but is also a good source for those involved in basic and clinical research and patient management.

  • Neurological Emergencies

    • 1 Edición
    • S.D. Shorvon
    • Inglés
    Neurological Emergencies presents a comprehensive guide on the initial assessment and early treatment of patients with neurological emergencies. It discusses the diagnosis, emergency investigations, and handling of coma patients. It addresses the management of focal supratentorial lesion. Some of the topics covered in the book are the diffuse neurological or systemic disturbance; emergency resuscitation; diagnosis and treatment of transtentorial herniation; diagnosis and treatment of acute viral encephalitis; raised intracranial pressure; diagnosis and treatment of non-viral infective encephalitis; viral meningitis; meningovascular syphilis; diagnosis and treatment of cerebral abscess; diagnosis and treatment of intracranial subdural empyema; and diagnosis and treatment of cerebral venous thrombosis. The diagnosis and treatment ofstroke is fully covered. An in-depth account of the difference between haemorrhage and infarction is provided. The diagnosis of subarachnoid haemorrhage is completely presented. A chapter is devoted to the prevention of more cranial bleeding.

  • Receptors in the Human Nervous System

    • 1 Edición
    • F. A. O. Mendelsohn + 1 más
    • Inglés
    Receptors in the Human Nervous System is a synthesis of the results of receptor mapping by leaders in the field. In addition to a comprehensive discussion of the distribution and possible interactions of the receptors of different neuroactive substances, this book also contains an abundance of pictorial representations of receptor distributions. High-quality photographs of one receptor are often juxtaposed with photographs of the distribution of a different receptor or receptor subtype for the consideration of possible interactions between different systems. The book surveys the distribution of receptor subtypes for the classical monoamine transmitters (acetylcholine, adrenaline, noradrenaline and serotonin) as well as the distribution of receptors for the excitatory and inhibitory amino acids, (glutamate, GABA and benzodiazepines) as well as the opioid peptides, angiotensen and other neuropeptides. The distribution of multiple types of serotonin receptors is given in detail, and the codistribution of receptors in the cortex is discussed. The book is directed toward researchers in the field of chemical neuroanatomy, as well as pharmacologists, neurophysiologists, and neuroscientists.

  • Diagnostic Reference Index of Clinical Neurology

    • 2 Edición
    • Pasquale F. Finelli
    • Inglés
    Diagnostic Reference Index of Clinical Neurology aims to give the busy clinician a fast, easy-to-use guide to the core neurological literature published from 1980 to 1986. This book is divided into two sections, key words and references. The keywords section consists of neuroscience terms and each main entry is followed by reference citation numbers and corresponding references. This index, unlike the usual computerized systems for literature retrieval, is structured around clinical problems and uses the approach and terminology of a practicing neurologist. The contents were sources from the full text of articles that were published in critical core of fourteen major international English-language journals in medicine and neurology. This book will be of interest to neurology students and to practicing clinical neurologists.

  • Presynaptic Receptors and Neuronal Transporters

    Official Satellite Symposium to the IUPHAR 1990 Congress Held in Rouen, France, on 26–29 June 1990
    • 1 Edición
    • S.Z. Langer + 2 más
    • Inglés
    Advances in the Biosciences, Volume 82: Presynaptic Receptors and Neuronal Transporters documents the proceedings of the Official Satellite Symposium to the IUPHAR 1990 Congress held in Rouen, France on June 26-29, 1990. The first part of this book deals with the extensive and still increasing list of presynaptic release-modulating auto and heteroreceptors, emphasizing the various subtypes of presynaptic receptors that are characterized by functional studies, both in vitro and in vivo, using a number of experimental approaches. The next chapters are devoted to the molecular pharmacology of presynaptic receptors, of which can interfere with G proteins and modify the activity of adenylate cyclase, guanylate cyclase, or protein kinase C. The purification and molecular biology of transporter systems, including cloning and sequencing of the neuronal sodium-ion coupled GABA transporter are also discussed. This compilation concludes with insights on the function of presynaptic receptors and neuronal transporters both in the periphery and in the CNS, as well as their ubiquitous locations and physiological roles. This publication is a good reference for students and individuals researching on the presynaptic autoreceptors and neurotransmitters.

  • Neurobiology of Steroids

    • 1 Edición
    • Volumen 22
    • P. Michael Conn + 1 más
    • Inglés
    Steroid hormones are unique compounds in that they are active at the interface of peripheral endocrine events and neural mechanisms. Thus their effects present an important peripheral signaling system to alter brain function. This volume presents state-of-the-art and classical techniques for the study of steroid hormones and their receptors and their effects and actions.

  • Neural Modeling and Neural Networks

    • 1 Edición
    • F. Ventriglia
    • Inglés
    Research in neural modeling and neural networks has escalated dramatically in the last decade, acquiring along the way terms and concepts, such as learning, memory, perception, recognition, which are the basis of neuropsychology. Nevertheless, for many, neural modeling remains controversial in its purported ability to describe brain activity. The difficulties in "modeling" are various, but arise principally in identifying those elements that are fundamental for the expression (and description) of superior neural activity. This is complicated by our incomplete knowledge of neural structures and functions, at the cellular and population levels. The first step towards enhanced appreciation of the value of neural modeling and neural networks is to be aware of what has been achieved in this multidisciplinary field of research. This book sets out to create such awareness. Leading experts develop in twelve chapters the key topics of neural structures and functions, dynamics of single neurons, oscillations in groups of neurons, randomness and chaos in neural activity, (statistical) dynamics of neural networks, learning, memory and pattern recognition.

  • The Molecular Biology of Neurological Disease

    Butterworths International Medical Reviews
    • 1 Edición
    • Roger N. Rosenberg + 1 más
    • Inglés
    The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

  • Neural Models of Plasticity

    Experimental and Theoretical Approaches
    • 1 Edición
    • John H. Byrne + 1 más
    • Inglés
    Neural Models of Plasticity: Experimental and Theoretical Approaches is an outgrowth of a conference that was held at Woods Hole, Massachusetts, in the spring of 1987. The purpose of that conference was to review recent developments in both areas and to foster communication between those researchers pursuing theoretical approaches and those pursuing more empirical approaches. Contributions have been solicited from individuals who represent both ends of the spectrum of approaches as well as those using a combination of the two. These indicate that our knowledge of the plastic capabilities of the nervous system is accelerating rapidly due to rapid advances in the understanding of basic subcellular and molecular mechanisms of plasticity, and because of the computational capabilities and plastic properties that emerge from neural networks and assemblies. The book contains 19 chapters and opens with a study on the role of the neuromodulator in associative learning of the marine mollusk Hermissend. Subsequent chapters examine topics such as learning and memory in Aplysia; the Hebb rule for synaptic plasticity; olfactory processing and associative memory in the mollusk Limax maximus; simulation of a classically conditioned response; and the neural substrates of memory, focusing on the role of the hippocampus.

  • Atlas of the Prenatal Mouse Brain

    • 1 Edición
    • Uta B. Schambra + 1 más
    • Inglés
    The Atlas of the Prenatal Mouse Brain is the latest addition to Academic Press' list of atlases for neuroscientists and neuroscience students. It fills an urgent need for a comprehensive atlas of the developing mouse brain for use in studies of both normal and abnormal development. High-quality photomicrographs of brain sections are depicted in sagittal, coronal, and horizontal planes for four gestational age groups. Each photomicrograph is accompanied by a fully labeled, precision-drawn diagram for easy identification of brain structures. Researchers and students using normal, transgenic, or mutant mouse preparations in developmental neurobiology, neurotoxicology, and biotechnology will welcome this meticulously assembled and accessible guide.

  • The Neuropsychology of Consciousness

    • 1 Edición
    • A. D. Milner + 1 más
    • Inglés
    The Neuropsychology of Consciousness is based on a symposium entitled “Consciousness and Cognition: Neuropsychological Perspectives” held at the University of St Andrews, September 1990. The intention was to assemble a group of the major researchers at the forefront of this field. The starting point for the symposium and for the book was the widespread realization that in several areas of human cognition (e.g. visual perception, memory, language comprehension, and attention), the severe and profound impairments due to brain damage that have been described over the past 150 years are often not absolute. In particular, the use of indirect methods of testing may reveal unsuspected preservation of capacities that are undetected by more traditional direct methods. The book opens with a discussion of the epidemic of dissociations and how well the phenomena within either neuropsychology or within normal human experimental psychology map onto each other. This is followed by separate chapters on topics such as blindsight, covert visual processing in patients, face recognition and awareness following brain injury, and the relationship between the study of attention and the understanding of consciousness.

  • Biological Markers in Psychiatry and Neurology

    Proceedings of a Conference Held at the Ochsner Clinic, New Orleans, on May 8-10, 1981
    • 1 Edición
    • Earl Usdin + 1 más
    • Inglés
    Biological Markers in Psychiatry and Neurology is a collection of papers that details the advancement in the understanding of the biological markers that stems from psychiatric and neurological pathologies. The text first covers topics about various biological markers, such as neurochemical, enzymatic, membrane, receptors, endocrine, and physiological. Next, the selection examines the relationship between alcohol abuse and biological papers. The next part covers the genetic aspects of biological markers. The text also deals with use of tomography and modeling theory. The book will be of great use to students, researchers, and practitioners of neurology and psychiatry. Psychologists will also benefit from the text.

  • An Introduction to the Study of the Nervous System

    • 2 Edición
    • E. E. Hewer + 1 más
    • Inglés
    An Introduction to the Study of the Nervous System covers topics about the minute structure and functions of the nervous system. The book discusses the minute and gross anatomy of the various parts of the nervous system; the degenerative and regenerative changes following section of the nerves; and the descending and ascending tracts of the spinal cord. The text then describes the cerebellar connections; the deep connections of the cranial nerves; and the microscopic structure of the cortex of the cerebellum and of the cerebrum. The distribution, source, circulation and absorption, pressure, and normal composition of the cerebrospinal fluid and the parts and functions of the autonomic nervous system are also considered. The book further tackles the normal physiology of the sensory and motor paths; the results of interference with the general sensory path at various levels; and the visual path and interference therewith. The text also discusses the cochlear and olfactory paths and the interference therewith and the levels of integration and mechanism of coordinated muscular movement. Students taking courses related to neurology will find the book useful.

  • Methods in Behavioral Pharmacology

    • 1 Edición
    • Volumen 10
    • F. van Haaren
    • Inglés
    Methods in Behavioral Pharmacology is unique in offering a complete description and critical evaluation of most, if not all, methods available to study the effects of drugs on behavior. It stands apart in that it is not limited to the analysis of a particular class of pharmacological agents in a limited number of paradigms. Methods in Behavioral Pharmacology covers all paradigms without reference to specific pharmacological compounds.The book provides a comprehensive overview of the methodology used to study the behavioral effects of legal and illegal drugs. It also provides an in-depth presentation of dependent variables, their quantification and a critical evaluation of their advantages and disadvantages. An excellent work, contributed to by well-known experts in the different fields of behavioral pharmacology.

  • Neurotrauma

    Treatment, Rehabilitation, and Related Issues
    • 1 Edición
    • Michael E. Miner + 1 más
    • Inglés
    Neurotrauma features the papers presented at the Second Houston Conference on Neurotrauma in Texas held in May 1985. These papers cover discussions on patients who have both brain and spinal cord injuries and acute care treatment and investigations of brain injury, as well as rehabilitation strategies and approaches. This second edition is organized into four parts. The first part deals with the treatment of less-than-severe head injury, barbiturate-induced coma, closed head injuries, and severely brain-injured patients. The second part focuses on the evaluation of physiological and anatomical recovery of brain injury patients, while the third part discusses the management of patients with combined head and spinal cord injury. The final part focuses on rehabilitation issues that include nonpharmacological management, the impact of traumatic brain injury on sexuality, and ethical aspects of lifesaving therapeutic strategies. This book may be of interest to persons dealing with studies on the treatment of brain and spinal cord injuries.

  • Neurobiology of Motor Programme Selection

    New Approaches to the Study of Behavioural Choice
    • 1 Edición
    • J. Kien + 2 más
    • Inglés
    The traditional view of motor systems as a linear chain of elements switched on and off by command neurons has become increasingly difficult to maintain in the face of accumulating evidence against the existence of command elements. So far, however, the general formulation of an alternative approach has been lacking. This book, by summarising the evidence against the linear approach to motor systems, argues forcefully against it. Analyses are presented of motor systems ranging from the lobster stomatogastric system through molluscan systems, leech movement, insect singing and locomotion, fish and amphibian behaviour, to goal-directed a movements in primates and volitional movements in humans. Comparison of these motor systems reveal the existence of some general principles underlying motor control and behavioural choice such that motor systems appear generally to be parallel, distributed processing networks. By discussing the treatment of motor systems in terms of parallel distributed processing systems, this book presents in concentrated form an alternative to the earlier view of motor systems. As such, the book is a must for all neuroscientists interested in the organisation of motor systems and the neuronal substrates of behavioural choice.

  • Interleukin-1 in the Brain

    • 1 Edición
    • Nancy J. Rothwell
    • Inglés
    Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration.

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