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Elsevier

Libros en Neurociencia

  • Aspects of Knowing

    Epistemological Essays
    • 1 Edición
    • Inglés
    AcknowledgementsCont... Introduction: The art of precise epistemology Stephen HetheringtonPart A. Epistemology as scientific?2. A problem about epistemic dependence Tim Oakley3. Accounting for commitments: A priori knowledge, ontology, and logical entailments Michaeli... Michael4. Epistemic bootstrappingPeter Forrest5. More praise for Moore’s proofRoger White6. Lotteries and the Close Shave principle John Collins7. Skepticism, self-knowledge, and responsibilityDavid Macarthur8. A reasonable contextualism (or, Austin reprised)A. B. Dickerson9. Questioning contextualism Brian WeathersonPart B. Understanding knowledge?10. Truthmaking and the Gettier problemAdrian Heathcote11. Is knowing having the right to be sure?André Gallois12. Knowledge by intention? On the possibility of agent’s knowledge Anne Newstead13. Gettier’s theoremJohn Bigelow14. Knowledge that works: A tale of two conceptual models Stephen Hetherington

  • The Neurobiology of Painting

    International Review of Neurobiology
    • 1 Edición
    • Volumen 74
    • F. Clifford Rose + 3 más
    • Inglés
    The book presents a basis for the interaction of the brain and nervous system with painting, music and literature, and a discussion of art from multiple facets – such as anatomy, migraine, illusion and evolutionary biology. The book explores several aspects of the neurobiology of painting, including evolutionary neurobiology, sensation vs. perception, the visual brain and how the mind works, and also explores the affects of brain disorders and trauma on artist, with a concluding chapter on Frida Kahlo and the spinal cord injury that influenced her painting.

  • Catatonia in Autism Spectrum Disorders

    • 1 Edición
    • Volumen 72
    • Dirk Marcel Dhossche
    • Inglés
    The study of catatonia in Autism Spectrum Disorders is a novel and controversial topic. Catatonia is a motor disorder characterized by stereotypy, rigidity, mutism, and posturing. These motor signs are also characteristic of autism. The interest in the relation between autism and catatonia stems from clinical observations that autistic and catatonic symptoms overlap, that some people with autism develop full-blown catatonia, and that anti-catatonic treatments bring relief in some of those patients. Catatonia in Autism Spectrum Disorders explores the question of if the two syndromes have a common pathophysiology. It also examines whether the successful treatment of catatonia be applied to patients with both autism and catatonia. The book concludes with blueprints for the assessment, treatment, and future study of catatonia in Autism Spectrum Disorders. These blueprints aim to increase early recognition and treatment of catatonia in patients with autism, show the urgency of controlled treatment trials and increased collaborative and interdisciplinary research into the co-occurrence of these two enigmatic disorders.

  • The Neurobiology of C. elegans

    • 1 Edición
    • Volumen 69
    • Inglés
    The Neurobiology of C. elegans assembles together a series of chapters describing the progress researchers have made toward solving some of the major problems in neurobiology with the use of this powerful model organism. The first chapter is an introduction to the anatomy of the C. elegans nervous system. This chapter provides a useful introduction to this system and will help the reader who is less familiar with this system understand the chapters that follow. The next two chapters on learning, conditioning and memory and neuronal specification and differentiation, summarize the current state of the C. elegans field in these two major areas of neurobiology. The remaining chapters describe studies in C. elegans that have provided particularly exciting insights into neurobiology.

  • Mental Models and the Mind

    Current developments in Cognitive Psychology, Neuroscience and Philosophy of Mind
    • 1 Edición
    • Volumen 138
    • Carsten Held + 2 más
    • Inglés
    "Cognitive psychology," "cognitive neuroscience," and "philosophy of mind" are names for three very different scientific fields, but they label aspects of the same scientific goal: to understand the nature of mental phenomena. Today, the three disciplines strongly overlap under the roof of the cognitive sciences. The book's purpose is to present views from the different disciplines on one of the central theories in cognitive science: the theory of mental models. Cognitive psychologists report their research on the representation and processing of mental models in human memory. Cognitive neuroscientists demonstrate how the brain processes visual and spatial mental models and which neural processes underlie visual and spatial thinking. Philosophers report their ideas about the role of mental models in relation to perception, emotion, representation, and intentionality. The single articles have different and mutually complementing goals: to introduce new empirical methods and approaches, to report new experimental results, and to locate competing approaches for their interpretation in the cross-disciplinary debate. The book is strongly interdisciplinary in character. It is especially addressed to researchers in any field related to mental models theory as both a reference book and an overview of present research on the topic in other disciplines. However, it is also an ideal reader for a specialized graduate course.

  • Human Neuroanatomy

    • 1 Edición
    • James R. Augustine
    • Inglés
    Human Neuroanatomy provides a thorough and comprehensive overview of the human brain and spinal cord for medical and graduate students as well as residents in the clinical neurosciences. Standing on the shoulders of training from outstanding scientist-teacher mentors and based on more than 30 years of experience teaching about the brain and spinal cord to medical and graduate students, this single authored text presents everything the reader would need as they begin their study of the nervous system. At the same time the experienced neuroscientist will find much useful and valuable information in these pages that is based almost exclusively on studies in experimental primates and observations in humans. Every effort has been made to present the complexities of the nervous system as simply and clearly as possible. The careful reader will discover a clarity and depth of coverage that makes the reading both instructional and enjoyable. Topics are presented logically and the text in an easy-to-read style. The accompanying line drawings emphasize important concepts in a clear and uncluttered manner. Topics presented: Neurons, glial cells, degeneration, regeneration, axonal transport Review of the development of the human nervous system Overview of the anatomy of the spinal cord, brain stem and forebrain General sensory paths (pain, temperature, touch, pressure, proprioception) Special sensory systems (auditory, vestibular, visual, olfactory and gustatory) Eye movements and visual reflexes Comprehensive presentation of the regions involved in motor activity including the clinical manifestation of injuries to these motor areas Limbic system, hypothalamus and the autonomic nervous system Lobes of the brain, clinically important cortical areas and the results of lesions in these areas Blood supply to the spinal cord, brain stem, and brain including classical brain stem syndromes The meninges and the ventricular system Numerous helpful clinical correlations that emphasize the practical application of basic anatomical information

  • Handbook of Neuroemergency Clinical Trials

    • 1 Edición
    • Wayne M. Alves + 1 más
    • Inglés
    During the 1990’s, scientific advances in understanding the mechanisms and pathophysiology of acute central nervous system injury were offset by a history of disappointing results from Phase III clinical trials of novel neuroprotective drugs. Numerous novel compounds were “tested,” and seemingly fell by the wayside. This book is intended to focus on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. The authors explore the issues facing research in this area and the strategies that might lead to future success in this critical area of unmet medical need. It represents a compendium of information gained from over 20 years of clinical trial experience in areas of acute neurology and neurosurgery. From the knowledge of clinical assessment using standardized tools, to the intricate design of difficult hyper-acute neuroemergencies trials, the reader will benefit from the authors’ perspectives.

  • Handbook of Brain Tumor Chemotherapy

    • 1 Edición
    • Herbert B. Newton
    • Inglés
    Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including “targeted” agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art of chemotherapy development and clinical treatment of patients with this devastating disease.Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy.

  • The Biology of the Eye

    • 1 Edición
    • Volumen 10
    • Jorge Fischbarg
    • Inglés
    Acknowledgement This book is the result of a collective effort. Due to an oversight, mention of three of the contributors who played an especially decisive role in bringing the work to fruition was omitted from the book. They should share fully in the intellectual credits accruing from this publication. I would therefore like to acknowledge and thank the following for their outstanding contributions to editing the work: Dr. Morten Dornonville la Cour (MD, Dr. Med. Sci.) solicited and edited the chapters on retina, RPE, choroid, vitreous, immunology, and sclera. Dr. la Cour is a Lecturer, Eye Department, Copenhagen University Hospital, specializes in vitreoretinal surgery, and frequently lectures in the international scene. A trained mathematician, he has done research in retinal pigment epithelial physiology in the laboratories of Drs. Thomas Zeuthen and Sheldon Miller. Dr. Friedrich P.J. Diecke and Dr. Elliott M. Kanner also provided invaluable editorial assistance. Dr Diecke, who was formerly Professor and Chairman of the Department of Physiology, UMDNJ-New Jersey Medical School, is a Professor Emeritus at that institution. His research has concentrated on membrane transport mechanisms in lens epithelial cells, corneal endothelial cells and peripheral nerve and on the regulation of vascular smooth muscle contraction. Dr. Elliott M. Kanner was born in Canada in 1970. He graduated from Yale University in 1992 with a BS/MS degree in Molecular Biophysics and Biochemistry. He received his PhD degree from the Rockefeller University in 1999 and his MD degree from Weill/Cornell in 2001. He is currently an Ophthalmology resident at Columbia University. Jorge Fischbarg, December 2005 This book explores the many recent novel ideas about the eye in a systematic and synthetic way. It includes both basic sciences and applications towards clinical research. Chapters include both anatomical and functional descriptions of the different ocular tissues and treatments of a few subjects of practical importance for ophthalmologists. This book is intended for students in basic biomedical science interested in the eye, as well as ophthalmologists a comprehensive source on recent developments in ocular research.

  • Auditory Spectral Processing

    • 1 Edición
    • Volumen 70
    • Manuel S. Malmierca + 1 más
    • Inglés
    All natural auditory signals, including human speech and animal communication signals, are spectrally and temporally complex, that is, they contain multiple frequencies and their frequency composition, or spectrum, varies over time. The ability of hearers to identify and localize these signals depends on analysis of their spectral composition. For the overwhelming majority of human listeners spoken language is the major means of social communication, and this communication therefore depends on spectral analysis. Spectral analysis begins in the cochlea, but is then elaborated at various stages along the auditory pathways in the brain that lead from the cochlea to the cerebral cortex. The broad purpose of Auditory Spectral Processing is to provide a comprehensive account of the way in which spectral information is processed in the brain and the way in which this information is used by listeners to identify and localize sounds.

  • The Somatotrophic Axis in Brain Function

    • 1 Edición
    • Fred Nyberg
    • Inglés
    The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being reduced in depression.This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science.

  • Gene Therapy of the Central Nervous System: From Bench to Bedside

    • 1 Edición
    • Michael G. Kaplitt + 1 más
    • Inglés
    Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis.

  • Neuroanatomy of the Oculomotor System

    • 1 Edición
    • Volumen 151
    • Jean A. Büttner-Ennever
    • Inglés
    This volume in the Progress in Brain Research series features reviews on the functional neuroanatomy and connectivity of the brain areas involved in controlling eye movements. Oculomotor control of the eyes is now the subject of many research projects and advances in this field are relevant to understanding motor control in general.

  • Neuroimaging Part A

    • 1 Edición
    • Volumen 66
    • Inglés
    Consisting of two separate volumes, Neuroimaging provides a state-of-the-art review of a broad range of neuroimaging techniques applied to both clinical and research settings. The breadth of the methods covered is matched by the depth of description of the theoretical background. Part A focuses on the cutting edge of research methodologies, providing a foundation for both established and evolving techniques. These include voxel-based morphometry using structural MRI, functional MRI, perfusion MRI, diffusion tensor imaging, near-infrared spectroscopy and the technique of combining EEG and fMRI studies. Two chapters are devoted to describing methods for studying brain responses and neural models, focusing on functional connectivity, effective connectivity, dynamic causal modeling, and large-scale neural models. The important role played by brain atlases in facilitating the study of normal and diseased brain populations is described in one chapter, and the concept of neuroimaging data bases as a future resource for scientific discovery is elucidated in another. The two parts of Neuroimaging complement each other providing in-depth information on a broad range of routine and cutting edge techniques that is not available in any other text. This book is superbly written and beautifully illustrated by contributors working at the top of their chosen specialty.

  • Basic Neurochemistry

    Molecular, Cellular and Medical Aspects
    • 7 Edición
    • Scott Brady + 5 más
    • Inglés
    Basic Neurochemistry: Molecular, Cellular and Medical Aspects, a comprehensive text on neurochemistry, is now updated and revised in its Seventh Edition. This well-established text has been recognized worldwide as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for graduate and postgraduate students and instructors in the neurosciences. It is an excellent source of information on basic biochemical processes in brain function and disease for qualifying examinations and continuing medical education.

  • Handbook of Categorization in Cognitive Science

    • 1 Edición
    • Henri Cohen + 1 más
    • Inglés
    Categorization, the basic cognitive process of arranging objects into categories, is a fundamental process in human and machine intelligence and is central to investigations and research in cognitive science. Until now, categorization has been approached from singular disciplinary perspectives with little overlap or communication between the disciplines involved (Linguistics, Psychology, Philosophy, Neuroscience, Computer Science, Cognitive Anthropology). Henri Cohen and Claire Lefebvre have gathered together a stellar collection of contributors in this unique, ambitious attempt to bring together converging disciplinary and conceptual perspectives on this topic."Categorizatio... is a key concept across the range of cognitive sciences, including linguistics and philosophy, yet hitherto it has been hard to find accounts that go beyond the concerns of one or two individual disciplines. The Handbook of Categorization in Cognitive Science provides just the sort of interdisciplinary approach that is necessary to synthesize knowledge from the different fields and provide the basis for future innovation." Professor Bernard Comrie, Department of Linguistics, Max Planck Institute for Evolutionary Anthropology, Germany"Anyone concerned with language, semantics, or categorization will want to have this encyclopedic collection."Professo... Eleanor Rosch, Dept of Psychology, University of California, Berkeley, USA

  • Neuroimaging Part B

    • 1 Edición
    • Volumen 67
    • Inglés
    Comprised of two separate volumes, Neuroimaging provides a state-of-the-art review of a broad range of neuroimaging techniques applied to both clinical and research settings. The breadth of the methods covered is matched by the depth of description of the theoretical background. Part B covers the application of neuroimaging in both research and clinical settings for the study of anxiety disorders, dementia, depression, schizophrenia, functional somatic syndromes, stroke, and multiple sclerosis using a range of neuroimaging modalities including CT, PET, SPECT, DTI, structural MRI and fMRI. One chapter is devoted to the study of brain development using structural MRI, and one chapter to the study of pediatric neurobehavioral disorders using fMRI. One of the most exciting recent applications of neuroimaging to the area of genetics is covered, and with the theory and application of neuroreceptor imaging in psychiatry, forms the final two chapters. The two parts of Neuroimaging complement each other providing in-depth information on a broad range of routine and cutting edge techniques that is not available in any other text. This book is superbly written and beautifully illustrated by contributors working at the top of their chosen specialty.

  • Autonomic Dysfunction After Spinal Cord Injury

    • 1 Edición
    • Volumen 152
    • Lynne C. Weaver + 1 más
    • Inglés
    Autonomic dysfunction is a major and poorly understood consequence of spinal cord injury. It is a cause of very serious disability and requires much more research. It should be a focus of treatment strategies. This book will be of interest to anyone involved in research and treatment of spinal cord injury since it helps to explain the tremendously negative impact on the body caused by cord injury that is not as obvious as paralysis and loss of sensation. It contains a compilation of what is known about bladder, cardiovascular, bowel and sexual dysfunction after spinal cord injury, as it relates to the changes within the autonomic nervous system control of these functions.The book begins with a description of the time course of autonomic dysfunctions and their ramifications from the first hours after a spinal cord injury to the more stable chronic states. The next section contains three chapters that address anatomical findings that may provide some of the foundation for autonomic dysfunctions in many of the systems. The system-specific chapters then follow in four sections. Each section begins with a chapter or two defining the clinical problems experienced by people with cord injury. The following chapters present research, basic and clinical, that address the autonomic dysfunctions.

  • Development of the Nervous System

    • 2 Edición
    • Dan H. Sanes + 2 más
    • Inglés
    Development of the Nervous System, Second Edition has been thoroughly revised and updated since the publication of the First Edition. It presents a broad outline of neural development principles as exemplified by key experiments and observations from past and recent times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. The original, artist-rendered drawings from the First Edition have all been redone and colorized to so that the entire text is in full color. This new edition is an excellent textbook for undergraduate and graduate level students in courses such as Neuroscience, Medicine, Psychology, Biochemistry, Pharmacology, and Developmental Biology.

  • Atlas of Ambulatory EEG

    • 1 Edición
    • Bernard S. Chang + 2 más
    • Inglés
    Atlas of Ambulatory EEG covers the areas of clinical neurophysiology, an atlas that comprehensively depicts normal, abnormal, and artifactual findings from actual ambulatory EEG recordings in a convenient and easily accessible format. As the use of ambulatory EEG has increased in recent years, the need for a concise atlas of ambulatory EEG has grown significantly, since ambulatory EEG tracings are subject to their own unique issues and artifacts, often not discussed in standard EEG atlases. This book begins with several chapters that introduce the history, technology, and clinical utility of ambulatory EEG. The bulk of the atlas consists of a page-by-page display of high-quality ambulatory EEG excerpts that are easy to review and come with short annotations describing the relevant findings. Atlas of Ambulatory EEG is a critical resource for anyone involved in the interpretation of ambulatory EEG studies.

  • Models of Seizures and Epilepsy

    • 1 Edición
    • Asla Pitkänen + 2 más
    • Inglés
    An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research.

  • Cortical Function: a View from the Thalamus

    • 1 Edición
    • Volumen 149
    • V. A. Casagrande + 2 más
    • Inglés
    Almost all of the messages that are received by the cerebral cortex from the environment or from the body's internal receptors come through the thalamus and much current thought about perceptual processing is based on sensory pathways that relay in the thalamus. This volume focuses on three major areas: the role of thalamocortical communication in cognition and attention; the role of the thalamus in communication between cortical areas; the hypothesis that much or all of the information relayed by thalamus, even to classical, pure "sensory" areas of cortex, represents a corollary message being sent simultaneously to motor centers. It presents a broad overview of important recent advances in these areas.

  • Cognitive Systems - Information Processing Meets Brain Science

    • 1 Edición
    • Richard G.M. Morris + 2 más
    • Inglés
    Cognitive Systems - Information Processing Meets Brain Science presents an overview of the exciting, truly multidisciplinary research by neuroscientists and systems engineers in the emerging field of cognitive systems, providing a cross-disciplinary examination of this cutting-edge area of scientific research. This is a great example of where research in very different disciplines touches to create a new emerging area of research. The book illustrates some of the technical developments that could arise from our growing understanding of how living cognitive systems behave, and the ability to use that knowledge in the design of artificial systems. This unique book is of considerable interest to researchers and students in information science, neuroscience, psychology, engineering and adjacent fields.

  • The Neuromodulators

    • 1 Edición
    • Volumen 64
    • Ronald J. Bradley + 2 más
    • Inglés
    Glutamate and GABA are the main information carrying neurotransmitters in the brain. Their action is modulated by a further series of small molecules called neuromodulators. The major neuromodulators in the brain are acetylcholine (both muscarinic and nicotinic), dopamine, norepinephrine, epinephrine and serotonin. These have an enormous range of functions in a wide variety of brain mechanisms. This book attempts to give a general overview of this field with a section devoted to each of these. Each section starts with anatomy, both structural and functional. The various types of receptors for these agents are described and then the effects of stimulating these receptors. These receptors trigger a variety of electrical reactions that generally involve potassium, sodium or calcium channels. Also reviewed are other receptors that trigger a wide variety of post-synaptic signaling cascades that influence a large number of neuronal functions including receptor sensitivity, synaptic plasticity and gene manipulation. Finally the relevance of these systems to disease states is detailed. There are many reviews of individual neuromodulators but this is the only book where one author attempts to cover the whole field.

  • MRI Atlas of Human White Matter

    • 1 Edición
    • Susumu Mori + 3 más
    • Inglés
    Recent advances in modern imaging techniques that can be used non-invasively for the visualization of the human brain have greatly enhanced the knowledge of brain anatomy and the understanding of its relationship to brain function. A unique new MRI modality, called diffusion tensor imaging (DTI) allows the three-dimensional study of the large white matter (WM) fiber bundles at macroscopic resolution (millimeter scale). MRI Atlas of Human White Matter provides a three-dimensional and two-dimensional in vivo atlas of various white matter tracts in the human brain. The images are based on diffusion tensor imaging and various tracts are reconstructed three-dimensionally from the data. Following an introduction and description of the methodology (Chapters 1 and 2), the 3D anatomy of individual tracts is delineated in Chapter 3. Chapter 4 consists of a series of color-coded orientation maps to delineate white matter anatomy in a slice-by-slice manner, in which the structures are extensively annotated. This richly illustrated Atlas is a valuable resource for students studying white matter anatomy and researchers working in brain research and radiology. This book also provides the structural assignment, which will assist neuroradiologists when interpreting diffusion tensor images in routine clinical studies.

  • Multiple Sclerosis As A Neuronal Disease

    • 1 Edición
    • Stephen Waxman
    • Inglés
    This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities.

  • International Review of Neurobiology

    • 1 Edición
    • Volumen 63
    • Ronald J. Bradley + 2 más
    • Inglés
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • Neurobiology of Attention

    • 1 Edición
    • Laurent Itti + 2 más
    • Inglés
    A key property of neural processing in higher mammals is the ability to focus resources by selectively directing attention to relevant perceptions, thoughts or actions. Research into attention has grown rapidly over the past two decades, as new techniques have become available to study higher brain function in humans, non-human primates, and other mammals. Neurobiology of Attention is the first encyclopedic volume to summarize the latest developments in attention research.An authoritative collection of over 100 chapters organized into thematic sections provides both broad coverage and access to focused, up-to-date research findings. This book presents a state-of-the-art multidisciplinary perspective on psychological, physiological and computational approaches to understanding the neurobiology of attention. Ideal for students, as a reference handbook or for rapid browsing, the book has a wide appeal to anybody interested in attention research.

  • Handbook of Stress and the Brain Part 1: The Neurobiology of Stress

    • 1 Edición
    • Volumen 15
    • Thomas Steckler + 2 más
    • Inglés
    The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry.Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality.

  • Handbook of Stress and the Brain Part 2: Stress: Integrative and Clinical Aspects

    • 1 Edición
    • Volumen 15
    • Thomas Steckler + 2 más
    • Inglés
    The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry.Part 2 treats the complexity of short-term and long-term regulation of stress responsivity, the role of stress in psychiatric disorders as based on both preclinical and clinical evidence, and the current status with regard to new therapeutic strategies targetting stress-related disorders.

  • Movement Disorders

    Genetics and Models
    • 1 Edición
    • Mark S. LeDoux
    • Inglés
    The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.

  • Dopamine

    • 1 Edición
    • Volumen 21
    • S.B. Dunnett + 3 más
    • Inglés
    Dopamine is a major neurotransmitter of the brain involved in the control of movement, emotion, and cognition; disturbance in dopamine function is associated with disorders like Parkinson’s disease, schizophrenia and attention deficit hyperactivity disorder. This volume of the Handbook of Chemical Neuroanatomy provides a series of in depth critical reviews of our present understanding of the most important aspects of dopamine’s organisation and disturbed function in the animal and human brain.

  • The Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1 Edición
    • Volumen 45
    • Inglés
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work.

  • Magnetic Resonance in Epilepsy

    Neuroimaging Techniques, Second Edition
    • 2 Edición
    • Ruben Kuzniecky + 1 más
    • Inglés
    Remarkable advances in imaging have increased the importance of MRI for diagnostic, treatment and management of epilepsy. Neuroimaging of patients with epilepsy no longer simply deals with the technology and interpretation of images but also with issues of brain metabolism, energetics, cognition and brain dysfunction. The first edition of Magnetic Resonance in Epilepsy came into clinical practice in 1995 with a revolutionary idea; that is, MR is as important as EEG in the clinical management of patients with epilepsy. The second edition of Magnetic Resonance in Epilepsy, the only comprehensive text in the field of epilepsy neuroimaging, reviews fundamental concepts and new advances in MR technology, computerized analysis, MR spectroscopy, DWI and other neuroimaging techniques such as PET, SPECT and MEG application to the study of patients with epileptic disorders.

  • Advances in the Study of Behavior

    • 1 Edición
    • Volumen 34
    • Peter J.B. Slater + 5 más
    • Inglés
    The aim of Advances in the Study of Behavior is to serve scientists engaged in the study of animal behavior, including psychologists, neuroscientists, biologists, ethologists, pharmacologists, endocrinologists, ecologists, and geneticists. Articles in the series present critical reviews of significant research programs with theoretical syntheses, reformulation of persistent problems, and/or highlighting new and exciting research concepts. Volume 34 is purely eclectic and illustrates the breadth of behavior research. Contents include sexual conflict among insects, the evolution of sexual cannibalism, odor processing and activity patterns in honeybees, hormone secretion in vertebrates, bird song organization, food transfer in primates, game theory approaches to mutualism, as well as neural mechanisms of learning and memory and how these change during infant development.

  • Human Brain Proteome

    • 1 Edición
    • Volumen 61
    • Inglés
    Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic technologies and their application to studying neurological disorders such as Alzheimer’s disease, alcoholism, trauma/stroke, Huntington's disease, and Parkinson's disease. With numerous illustrations to explain the concepts, it provides a comprehensive review on the topic.

  • Creating Coordination in the Cerebellum

    • 1 Edición
    • Volumen 148
    • Chris I. De Zeeuw + 1 más
    • Inglés
    Creating Coordination in the Cerebellum provides a multidisciplinary collection of chapters on the cerebellum with topics covering the entire spectrum from development and molecular neurobiology, cell physiology and plasticity to motor control, system physiology, functional imaging and pathology. The book not only presents novel discoveries obtained with recently developed technologies, but also gives new general concepts in global issues of cerebellar development and functions. By doing so it sets the standard for cerebellar research of the 21st century.

  • Emission Tomography

    The Fundamentals of PET and SPECT
    • 1 Edición
    • Miles N. Wernick + 1 más
    • Inglés
    PET and SPECT are two of today’s most important medical-imaging methods, providing images that reveal subtle information about physiological processes in humans and animals. Emission Tomography: The Fundamentals of PET and SPECT explains the physics and engineering principles of these important functional-imaging methods. The technology of emission tomography is covered in detail, including historical origins, scientific and mathematical foundations, imaging systems and their components, image reconstruction and analysis, simulation techniques, and clinical and laboratory applications. The book describes the state of the art of emission tomography, including all facets of conventional SPECT and PET, as well as contemporary topics such as iterative image reconstruction, small-animal imaging, and PET/CT systems. This book is intended as a textbook and reference resource for graduate students, researchers, medical physicists, biomedical engineers, and professional engineers and physicists in the medical-imaging industry. Thorough tutorials of fundamental and advanced topics are presented by dozens of the leading researchers in PET and SPECT. SPECT has long been a mainstay of clinical imaging, and PET is now one of the world’s fastest growing medical imaging techniques, owing to its dramatic contributions to cancer imaging and other applications. Emission Tomography: The Fundamentals of PET and SPECT is an essential resource for understanding the technology of SPECT and PET, the most widely used forms of molecular imaging.

  • The Rat Brain in Stereotaxic Coordinates - The New Coronal Set

    • 5 Edición
    • George Paxinos + 1 más
    • Inglés
    The preceding editions made The Rat Brain in Stereotaxic Coordinates the second most cited book in science. This Fifth Edition is the result of years of research providing the user with the drawings of the completely new set of coronal sections, now from one rat, and with significantly improved resolution by adding a third additional section level as compared to earlier editions. Numerous new nuclei and structures also have been identified. The drawings are presented in two color, providing a much better contrast for use. The Fifth Edition continues the legacy of this major neuroscience publication and is a guide for all students and scientists who study the rat brain.

  • Development, Dynamics and Pathology of Neuronal Networks: From Molecules to Functional Circuits

    • 1 Edición
    • Volumen 147
    • J. van Pelt + 5 más
    • Inglés
    This book is about neuronal networks within the brain. With roughly 100 billion nerve cells the human brain contains about 3.2 million kilometers of 'wires' to make a million billion of connections between these nerve cells. Nerve cells exchange electrical and chemical signals through these connections and the dynamical patterns of electrical/chemical signals are the basis of all our thinking, memories, consciousness, and control of our behaviour. How do these networks develop their specific connectivity, what are the patterns of electrical activity that serve such a fundamental role in our cognitive abilities, how can it go wrong in these networks resulting in different types of brain pathologies, such as mental retardation, Alzheimer’s disease, epilepsy or schizophrenia? These questions are among the most fundamental ones in neuroscience and are addressed in this volume. The chapters in this book cover both state-of-the-art broad reviews and in-depth studies of topics selected in order to bridge different levels of neurobiological organization, from the molecular, cellular, neural network to the cognitive level. An excellent example of such a 'red thread' is given by the chapters devoted to the visual system, illustrating the advanced state of understanding of network development, plasticity and functioning of the visual system. Other chapters illustrate how scientific advances are driven by technical developments as shown for multi-electrode recording and life imaging techniques that enable the study of electrical activity simultaneously in many nerve cells.

  • International Review of Neurobiology

    • 1 Edición
    • Volumen 62
    • Ronald J. Bradley + 2 más
    • Inglés
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • From Neuroscience to Neurology

    Neuroscience, Molecular Medicine, and the Therapeutic Transformation of Neurology
    • 1 Edición
    • Stephen Waxman
    • Inglés
    The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders.

  • DNA Arrays in Neurobiology

    • 1 Edición
    • Volumen 60
    • Inglés
    DNA array technology is a technique for studying gene expression by comparing samples of different genes. The result is an enormous amount of data that must be carefully analyzed in order for it to be useful and meaningful. This book examines both data analysis and techniques for ensuring optimal experimental conditions. The array approach has applications in a number of model systems, including development, learning and drug abuse. In addition, the technique has applications in a number of neurological disorders such as Alzheimer's disease, schizophrenia, multiple sclerosis, and neurological cancers.

  • Principles of Hormone/Behavior Relations

    • 1 Edición
    • Donald W. Pfaff + 2 más
    • Inglés
    This text introduces underlying principles of the endocrine regulation of behavior in animals and humans. Every chapter begins by stating a principle, followed by specific examples of hormone actions derived from scientific experiments and clinical observations, and concludes with a few challenging unanswered questions. The reference source Hormones, Brain & Behavior identified this field as rapidly expanding within neurobiology and endocrinology. Now, this well-illustrated and referenced text will serve students from undergraduate school to medical school as they learn this new discipline.

  • Introduction to Psychoneuroimmunology

    • 1 Edición
    • Jorge H. Daruna
    • Inglés
    Psychoneuroimmunolog... investigates the relationships between behavior, psychosocial factors, the nervous, endocrine, and immune systems, and disease. Each system affects the others, enhancing and/or inhibiting processes elsewhere in the body. Research in this field has grown tremendously in recent years as science better understands the checks and balances of these interdisciplinary systems and processes. Introduction to Psychoneuroimmunolog... provides the first introductory text for this complex field.Beginning with a discussion of immune system basics, Introduction to Psychoneuroimmunolog... explores endocrine-immune modulation, neuro-immune modulation, the relationship between stress, contextual change, and disease, as well as infection, allergy, immune activity and psychopathology, and immune function enhancement. This text provides a sound introduction to the field and will serve as a valuable overview to what is otherwise a complex interdisciplinary subject at the junction of molecular biology, genetics, the neurosciences, immunology, cell biology, endocrinology, pharmacology, biochemistry, and the behavioral sciences.

  • The Neuroendocrine Immune Network in Ageing

    • 1 Edición
    • Volumen 4
    • R.H. Straub + 1 más
    • Inglés
    The book describes the mechanisms involved in the maintenance of neuroendocrine-immun... interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immun... response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity.

  • Representation in Mind

    New Approaches to Mental Representation
    • 1 Edición
    • Volumen 1
    • Hugh Clapin + 2 más
    • Inglés
    'Representation in Mind' is the first book in the new series 'Perspectives on Cognitive Science' and includes well known contributors in the areas of philosophy of mind, psychology and cognitive science.The papers in this volume offer new ideas, fresh approaches and new criticisms of old ideas. The papers deal in new ways with fundamental questions concerning the problem of mental representation that one contributor, Robert Cummins, has described as "THE problem in philosophy of mind for some time now". The editors' introductory overview considers the problem for which mental representation has been seen as an answer, sketching an influential framework, outlining some of the issues addressed and then providing an overview of the papers. Issues include: the relation between mental representation and public, non-mental representation; misrepresentation; the role of mental representations in intelligent action; the relation between representation and consciousness; the relation between folk psychology and explanations invoking mental representations

  • Neuromimetic Semantics

    Coordination, quantification, and collective predicates
    • 1 Edición
    • Harry Howard
    • Inglés
    This book attempts to marry truth-conditional semantics with cognitive linguistics in the church of computational neuroscience. To this end, it examines the truth-conditional meanings of coordinators, quantifiers, and collective predicates as neurophysiological phenomena that are amenable to a neurocomputational analysis. Drawing inspiration from work on visual processing, and especially the simple/complex cell distinction in early vision (V1), we claim that a similar two-layer architecture is sufficient to learn the truth-conditional meanings of the logical coordinators and logical quantifiers. As a prerequisite, much discussion is given over to what a neurologically plausible representation of the meanings of these items would look like. We eventually settle on a representation in terms of correlation, so that, for instance, the semantic input to the universal operators (e.g. and, all)is represented as maximally correlated, while the semantic input to the universal negative operators (e.g. nor, no)is represented as maximally anticorrelated. On the basis this representation, the hypothesis can be offered that the function of the logical operators is to extract an invariant feature from natural situations, that of degree of correlation between parts of the situation. This result sets up an elegant formal analogy to recent models of visual processing, which argue that the function of early vision is to reduce the redundancy inherent in natural images. Computational simulations are designed in which the logical operators are learned by associating their phonological form with some degree of correlation in the inputs, so that the overall function of the system is as a simple kind of pattern recognition. Several learning rules are assayed, especially those of the Hebbian sort, which are the ones with the most neurological support. Learning vector quantization (LVQ) is shown to be a perspicuous and efficient means of learning the patterns that are of interest. We draw a formal parallelism between the initial, competitive layer of LVQ and the simple cell layer in V1, and between the final, linear layer of LVQ and the complex cell layer in V1, in that the initial layers are both selective, while the final layers both generalize. It is also shown how the representations argued for can be used to draw the traditionally-recogn... inferences arising from coordination and quantification, and why the inference of subalternacy breaks down for collective predicates. Finally, the analogies between early vision and the logical operators allow us to advance the claim of cognitive linguistics that language is not processed by proprietary algorithms, but rather by algorithms that are general to the entire brain. Thus in the debate between objectivist and experiential metaphysics, this book falls squarely into the camp of the latter. Yet it does so by means of a rigorous formal, mathematical, and neurological exposition – in contradiction of the experiential claim that formal analysis has no place in the understanding of cognition. To make our own counter-claim as explicit as possible, we present a sketch of the LVQ structure in terms of mereotopology, in which the initial layer of the network performs topological operations, while the final layer performs mereological operations. The book is meant to be self-contained, in the sense that it does not assume any prior knowledge of any of the many areas that are touched upon. It therefore contains mini-summaries of biological visual processing, especially the retinocortical and ventral /what?/ parvocellular pathways; computational models of neural signaling, and in particular the reduction of the Hodgkin-Huxley equations to the connectionist and integrate-and-fire neurons; Hebbian learning rules and the elaboration of learning vector quantization; the linguistic pathway in the left hemisphere; memory and the hippocampus; truth-conditional vs. image-schematic semantics; objectivist vs. experiential metaphysics; and mereotopology. All of the simulations are implemented in MATLAB, and the code is available from the book’s website.

  • Time-to-Contact

    • 1 Edición
    • Volumen 135
    • Heiko Hecht + 1 más
    • Inglés
    Time-to-contact is the visual information that observers use in fundamental tasks such as landing an airplane or hitting a ball. Time-to-contact has been a hot topic in perception and action for many years and although many articles have been published on this topic, a comprehensive overview or assessment of the theory does not yet exist. This book fills an important gap and will have appeal to the perception and action community. The book is divided into four sections. Section one covers the foundation of time-to-contact, Section two covers different behavioral approaches to time-to-contact estimation, Section three focuses on time-to-contact as perception and strategy, and Section four covers time-to-contact and action regulation.

  • Primer on the Autonomic Nervous System

    • 2 Edición
    • Phillip A. Low
    • Inglés
    The Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls the body, particularly in response to stress. It represents the largest collection of world-wide autonomic nervous system authorities ever assembled in one book. It is especially suitable for students, scientists and physicians seeking key information about all aspects of autonomic physiology and pathology in one convenient source. Providing up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun, this book is a must-have for any neuroscientist’s bookshelf!

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