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Elsevier

Libros en Neurociencia

  • Sensory Systems

    Anatomy, Physiology and Pathophysiology
    • 1 Edición
    • Aage R. Moller
    • Inglés
    Sensory Systems: Anatomy, Physiology and Pathophysiology provides a comprehensive description of how human sensory systems function, with comparisons of the five senses and detailed descriptions of the functions of each of them. In addition to describing anatomy and function, the book also provides insight as to how sensory information is processed in the brain to provide the basis for communication and for our perception of our surroundings. The information is presented in a way that is suitable for individuals from diverse disciplines and educational backgrounds. It gives the clinician an understanding of the function of normal and diseased sensory systems and provides a convenient, up-to-date source of information relevant to individuals in the fields of communication and communication disorders. This book is ideal for scientists, clinical researchers, and students in neurology and neuroscience.

  • Vasopressin and Oxytocin: From Genes to Clinical Applications

    • 1 Edición
    • Volumen 139
    • D. Poulain + 2 más
    • Inglés
    The articles comprising this volume were first presented at the World Congress on Neurohypophysial Hormones held in Bordeaux, France on September 8-12, 2001. This conference brought together more than 170 scientists from 18 countries who belong to the different fields of interest representing research in the hypothalamo-neurohyp... system. Two neurohypophysial neurohormones, oxytocin and vasopressin, exert a variety of central and peripheral actions and thus involve different scientific domains, which too often, even today, do not always find the appropriate occasion to interact. This volume is composed of chapters dealing with topics varying from basic and clinical neurosciences and neuroendocrinology, to reproductive, renal, cardiovascular physiology and pathology. It encompasses all areas of current neurohypophysial research and should be of vital interest as an integrative reference volume to specialized investigators and as an excellent introductory text to students, scientists and clinicians not yet closely familiar with the field. To ensure novelty and to make sure that all topics of current importance were covered, plenary and symposium speakers as well as poster presentations concentrated on recent advances made in the last few years.

  • Plasticity in the Adult Brain: From Genes to Neurotherapy

    • 1 Edición
    • Volumen 138
    • M.A. Hofman + 5 más
    • Inglés
    In the past decade neuronal plasticity has become a major theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in worms and insects to behavioural recovery from strokes in elderly humans. For this reason the focus of interest in the present volume of Progress in Brain Research is on the topic of neuroplasticity in mature organisms, including humans. Contributions range from neurogenesis and synaptic plasticity in the adult primate brain, to neural mechanisms of learning and memory, and the influence of environmental factors and aging on the functional potential of the central nervous system. Several contributions focus on recent developments in neural regeneration and brain repair, providing challenging evidence that the use of stem cell neurotherapy may be beneficial to humans suffering from various neurological and psychiatric diseases. This volume integrates new information on the cellular and molecular mechanisms of neuroplasticity and highlights challenging future questions in this exciting and topical area of neuroscience.

  • Glucose Metabolism in the Brain

    • 1 Edición
    • Volumen 51
    • Inglés
    Regulation of glucose at the biochemical level affects every area of the brain, and has impact from cellular to behavioral brain function. It plays an important role in diseases such as diabetes, stroke, schizophrenia and drug abuse as well as in normal and dysfunctional memory and cognition. This volume represents a thorough examination of all the major issues that are relevant to glucose metabolism by brain cells in relation to disease, combining basic research and clinical findings in a single, indispensable reference.

  • Genetics of Movement Disorders

    • 1 Edición
    • Stefan M. Pulst
    • Inglés
    Hereditary or genetic diseases featuring involuntary movements constitute a major aspect of the practice of neurology, functional neurosurgery, genetics, and many areas of basic and applied neuroscience research. Describing the current knowledge on these disorders, Genetics of Movement Disorders brings together information essential for clinicians, geneticists, and neuroscientists in one source. Utilizing a convenient and accessible format, the book is designed to allow easy identification of relevant information, with the overall organization of topics following established phenotypic classifications of movement disorders such as Parkinsonian syndromes, chorea, ataxia, and major categories of diseases grouped by gene locus. This book broadly appeals to neurologists, neuroscientists, geneticists, as well as cell and molecular biologists and hematologists.

  • The Cognitive Electrophysiology of Mind and Brain

    • 1 Edición
    • Alberto Zani + 1 más
    • Inglés
    Cognitive electrophysiology is a very well established field utilizing new technologies such as bioelectric events-related potentials (ERP) and magnetic (ERF) recordings to pursue the investigation of mind and brain. Current research focuses on reviewing ERP/ERF findings in the areas of attention, language, memory, visual and auditory perceptual processing, emotions, development, and neuropsychological clinical damages. The goal of such research is basically to provide correlations between the structures of the brain and their complex cognitive functions.This book reviews the latest findings in the areas of attention, language, memory, visual and auditory perception, and brain damage research based primarily on research conducted using ERP recordings. Beyond just compiling the knowledge gained from ongoing research, the authors also identify outstanding problems in the field and predict future developments.

  • Milestones in Neurotoxicity and Neuroprotection: A Tribute to Professor Toshiharu Nagatsu

    • 1 Edición
    • M. Naoi + 4 más
    • Inglés
    This book summarizes recent advances in understanding the mechanism underlying the selective cell death of dopamine neurons in Parkinson's disease. MPTP, endogenous neurotoxins, L-DOPA, and metal were proved to induce apoptosis and necrosis in neurons. The relationship of these causal factors to the pathogenesis of Parkinson's disease was discussed to give us overviews on the role of neurotoxins in this degenerative disorder. This title further presents the intracellular signal transduction, and the related enzymes and other factors involved in dopaminergic neuronal death. Recent results on intracellular mechanism of neuroprotection are presented, suggesting that neuroprotection as a causal therapy of neurodegenerative disorders may become practical in near future. This book shows new neuroprotective agents, such as propargylamine derivatives and neurotrophins, and the intracellular mechanism to prevent the activation of apoptotic cascade in neurons. The authors of this book are active researchers participating in these subjects and the readers will find the knowledge and techniques for the study on neurotoxicity and neuroprotection, and the strategy for future research on these important subjects in clinical and basic neurology and neurosciences.The book is dedicated to Professor Toshiharu Nagatsu, a pioneer in the search for pathogenic factors in Parkinson's disease. The book is reprinted from the journal 'Neurotoxicology and Teratology', Volume 24/5.

  • Brain Mapping: The Methods

    • 2 Edición
    • Arthur W. Toga + 1 más
    • Inglés
    Investigation of the functional architecture of the human brain using modern noninvasive imaging techniques is a rapidly expanding area of research. A proper knowledge of methodology is needed to appreciate the burgeoning literature in the field. This timely publication provides an excellent catalogue of the main techniques. The authors offer an invaluable analysis of mapping strategies and techniques, providing everything from the foundations to the major pitfalls and practical applications of the modern techniques used in neuroimaging. Contains over 1000 full color pages with more than 200 color figures.

  • Neurophysiology in Neurosurgery

    A Modern Intraoperative Approach
    • 1 Edición
    • Vedran Deletis + 1 más
    • Vedran Deletis
    • Inglés
    Through real-time assessments of how the patient's nervous system is functioning throughout a surgical procedure, Neurophysiology in Neurosurgery presents vital techniques to guide surgeons in their efforts to minimize the risks of unintentional damage to healthy nervous tissue. This book provides a comprehensive overview of the most up-to-date intraoperative neurophysiological techniques and guidelines for the managment of neuroanesthesia during MEP monitoring. Neurophysiology in Neurosurgery is a valuable educational tool that describes the theoretical and practical aspects of intraoperative monitoring through example.

  • In Situ Hybridization Protocols for the Brain

    • 2 Edición
    • Volumen 47
    • Inglés
    This volume of the International Review of Neurobiology was written to assist researchers without any previous experience with in situ hybridization, allowing them to follow the protocols and expect good results. It contains all the information required for newcomers to achieve successful in situ hybridization results, and methods for improving the technique of those already utilizing it. Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction

    • 1 Edición
    • Volumen 19
    • L. Kaczmarek + 1 más
    • Inglés
    That molecular neurobiology has become a dominant part of neuroscience research can be credited to the discovery of inducible gene expression in the brain and spinal cord. This volume deals with genes, whose expression patterns in the vertebrate central nervous system were the first to be revealed and then the most extensively investigated over the last 15 years. Immediate early genes (IEG) and their protein products, especially those acting as regulators of transcription (inducible transcription factors, ITF) have proven to be very valuable tools in functional neuroanatomy and neurophysiology, as they are rapidly and transiently induced in specific neurons in response to various modes of stimulation. Thus, they have been used to map neuronal populations selectively responsive to a variety of conditions, such as sensory and learning experience, electrical stimulation of specific circuits, seizures, and neurodegeneration.Th... single volume, written by the most prominent authors in the field, brings together for the first time information about the most widely studied IEG/ITF in a whole variety of phenomena of neuronal activation. It starts with a critical appraisal of the technologies employed for the studies on gene, protein, and transcription factor activity in the nervous system. Several chapters present exhaustive examples of expression patterns of the ITF in "vocal" avian brain, mammalian brain sensory regions, areas involved in regulation of circadian rhythms, and the spinal cord. The next parts cover functional and regular aspects of individual IEG/ITF expression: c-fos in learning and memory, c-jun and others in neuropathology and neuronal stress responses, Elk-1, egr family, and CREB in neuronal plasticity and learning. This volume will be useful as a major reference on this topic. Furthermore, it attempts to unravel the seemingly overwhelming complexity of the phenomena of gene expression in the central nervous system.

  • Encyclopedia of the Human Brain

    • 1 Edición
    • Vilayanur S. Ramachandran
    • Inglés
    In the past decade, enormous strides have been made in understanding the human brain. The advent of sophisticated new imaging techniques (e.g. PET, MRI, MEG, etc.) and new behavioral testing procedures have revolutionized our understanding of the brain, and we now know more about the anatomy, functions, and development of this organ than ever before. However, much of this knowledge is scattered across scientific journals and books in a diverse group of specialties: psychology, neuroscience, medicine, etc. The Encyclopedia of the Human Brain places all information in a single source and contains clearly written summaries on what is known of the human brain. Covering anatomy, physiology, neuropsychology, clinical neurology, neuropharmacology, evolutionary biology, genetics, and behavioral science, this four-volume encyclopedia contains over 200 peer reviewed signed articles from experts around the world. The Encyclopedia articles range in size from 5-30 printed pages each, and contain a definition paragraph, glossary, outline, and suggested readings, in addition to the body of the article. Lavishly illustrated, the Encyclopedia includes over 1000 figures, many in full color. Managing both breadth and depth, the Encyclopedia is a must-have reference work for life science libraries and researchers investigating the human brain.

  • Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1 Edición
    • Volumen 41
    • Brian H. Ross
    • Inglés
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work. Volume 41 includes in its coverage chapters on multimedia learning, brain imaging, and memory, among others.

  • Hormones, Brain and Behavior

    • 1 Edición
    • Donald W. Pfaff
    • Inglés
    Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields.

  • Universes in Delicate Balance: Chemokines and the Nervous System

    • 1 Edición
    • R.M. Ransohoff + 4 más
    • Inglés
    It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of inflammation, immunity and hematopoietic development.Only recently have the two fields, neurobiology and immunology, displayed mutual interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12) and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12 and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue.This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced 'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described, as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions are separately treated in varying contexts.The field of 'neurobiology of chemokines' has not lain fallow during the last ten years. During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium and angiogenesis.Underst... human disease is the goal of much of this research. New discoveries are being made and reported at a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines and discussing the relations of chemokine science to animal models and human disease.

  • Growth and Lactogenic Hormones

    • 1 Edición
    • Volumen 2
    • L. Matera + 1 más
    • Inglés
    For more than seventy years evidence has accumulated documenting the existence of a bi-directional communication network between growth hormone and the immune system. In the past twenty years there has been a tremendous proliferation of information detailing the workings of the growth hormone and insulin-like growth factor axis. A multitude of growth factors and binding proteins have been identified. More and more evidence supporting the important role of the growth hormone IGF network in the well functioning of the normal immune system has been documented. Clearly the challenge today is not to prove, but to understand, the neuroimmune regulatory role of GLH in its entire complexity.The ultimate goal of this volume and of all the other volumes of this series is to promote the understanding of the science and to ease human suffering.

  • Brain Lipids and Disorders in Biological Psychiatry

    • 1 Edición
    • Volumen 35
    • E.R. Skinner
    • Inglés
    Leading authorities examine the possible role of brain lipids in the development of conditions such as schizophrenia, depression, Alzheimer's disease and personality disorders and violence. A better understanding of the underlying causes of these debilitating medical disorders is of utmost importance and may contribute towards a means of prevention, amelioration and cure. The book is intended to stimulate further interest and lead to increased research in this important development area.

  • Handbook of Complementary and Alternative Therapies in Mental Health

    • 1 Edición
    • Scott Shannon
    • Inglés
    Scott Shannon is an MD, president elect of the American Holistic Medical Association, and considered a national expert on holistic psychiatry. In this book he brings together a comprehensive overview of CAM treatments, with information on their effectiveness and safety for specific patient populations and for use in treating specific disorders. Modalities covered include Acupuncture, Nutritional Medicine, Herbal Medicine, Meditation, Biofeedback, Aromatherapy and others. Coverage also includes chapters on the best CAM modalities for treatment of Anxiety and PTSD, Depression, ADD, and Addictions. Each chapter will be in a similar template, beginning with a description of the treatment, its safety, compatibility with conventional treatments and/or contrindications, scientific documentation of its efficacy, discussion of which disorders it is best used for, and references.

  • Advances in the Study of Behavior

    • 1 Edición
    • Volumen 31
    • Inglés
    The aim of Advances in the Study of Behavior remains as it has been since the series began: to serve the increasing number of scientists who are engaged in the study of animal behavior by presenting their theoretical ideas and research to their colleagues and to those in neighboring fields. We hope that the series will continue its "contribution to the development of the field", as its intended role was phrased in the Preface to the first volume in 1965. Since that time, traditional areas of animal behavior have achieved new vigor by the links they have formed with related fields and by the closer relationship that now exists between those studying animal and human subjects.Advances in the Study of Behavior, Volume 31 continues to serve scientists across a wide spectrum of disciplines. Focusing on new theories and research developments with respect to behavioral ecology, evolutionary biology, and comparative psychology, these volumes foster cooperation and communications in these dense fields.

  • The Cat Primary Visual Cortex

    • 1 Edición
    • Bertram Payne + 1 más
    • Inglés
    Written by experts on the forefront of investigations of brain function, vision, and perception, the material presented is of an unparalleled scientific quality, and shows that analyses of enormous breadth and sophistication are required to probe the structure and function of brain regions. The articles are highly persuasive in showing what can be achieved by carrying out careful and imaginative experiments. The Cat Primary Visual Cortex should emerge as essential reading for all those interested in cerebral cortical processing of visual signals or researching or working in any field of vision.

  • International Review of Neurobiology

    • 1 Edición
    • Volumen 48
    • Inglés
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • Febrile Seizures

    • 1 Edición
    • Tallie Z. Baram + 1 más
    • Inglés
    Febrile Seizures is written by the most active researchers and clinicians in epilepsy research today. This book presents the latest developments in this field as well as the current state of knowledge in the following: New imaging tools and emerging data, visualizing effects of febrile seizures on the brain; New genetic methodologies; The use of animal models to permit scientific analysis of the electrophysiology and molecular biology of the seizure.

  • Neurosteroids and Brain Function

    • 1 Edición
    • Volumen 46
    • Inglés
    International Review of Neurobiology, Volume 46 presents in-depth reviews on such ground-breaking topics as assembly and intracellular trafficking of GABA A receptors, D-1 dopamine receptors, and Alzheimer's disease. This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field.

  • New Foundation of Biology

    • 1 Edición
    • Volumen 1
    • I. Berczi + 1 más
    • Inglés
    A new scientific discipline, acknowledged 65 years after its discovery, was the focus of the first Conference on Neuroimmune Biology in Canada. The papers presented at the conference, and in this volume, are dedicated to Dr. Hans Selye who is recognized as discovering the existence of a hypothalamic-pituita... axis. This axis plays an important role in the adaptation of higher animals and man to various physical, chemical, biological and emotional challenges.The conference and participants also honored Dr. Andor Szentivanyi whose opening paper, "Studies on the hypothalamic regulation of histamine synthesis", is contained in the introduction to this book. Dr. Szentivanyi has dedicated his long research career to the clarification of the role of the central nervous system in immune and inflammatory reactions, and his experimental results are presented here.With an ultimate goal to achieve a more thorough understanding of higher organisms in their entire complexity, this book, the first in the series http://serval.elsevi... Biology presents a coordinated and integrated view of the growing body of knowledge rapidly accumulating in this area.

  • The Laboratory Computer

    A Practical Guide for Physiologists and Neuroscientists
    • 1 Edición
    • John Dempster
    • Inglés
    The Laboratory Computer: A Practical Guide for Physiologists and Neuroscientists introduces the reader to both the basic principles and the actual practice of recording physiological signals using the computer. It describes the basic operation of the computer, the types of transducers used to measure physical quantities such as temperature and pressure, how these signals are amplified and converted into digital form, and the mathematical analysis techniques that can then be applied. It is aimed at the physiologist or neuroscientist using modern computer data acquisition systems in the laboratory, providing both an understanding of how such systems work and a guide to their purchase and implementation.

  • Neuro-informatics and Neural Modelling

    • 1 Edición
    • Volumen 4
    • F. Moss + 1 más
    • Inglés
    How do sensory neurons transmit information about environmental stimuli to the central nervous system? How do networks of neurons in the CNS decode that information, thus leading to perception and consciousness? These questions are among the oldest in neuroscience. Quite recently, new approaches to exploration of these questions have arisen, often from interdisciplinary approaches combining traditional computational neuroscience with dynamical systems theory, including nonlinear dynamics and stochastic processes. In this volume in two sections a selection of contributions about these topics from a collection of well-known authors is presented. One section focuses on computational aspects from single neurons to networks with a major emphasis on the latter. The second section highlights some insights that have recently developed out of the nonlinear systems approach.

  • Insect Timing

    Circadian Rhythmicity to Seasonality
    • 1 Edición
    • D.L. Denlinger + 2 más
    • Inglés
    Leading experts in the field bring together diverse aspects of insect timing mechanisms. This work combines three topics that are central to the understanding of biological timing in insects: circadian rhythms, photoperiodism, and diapause. The common theme underlining each of the contributions to this book is an understanding of the timing of events in the insect life cycle. Most daily activities (emergence, feeding, mating, egg laying, etc.) undertaken by insects occur at precise times each day. Likewise, seasonal events such as the entry into or termination from an overwintering dormancy (diapause) occur at distinct times of the year. This book documents such events and provides an up-to-date interpretation of the molecular and physiological events undergirding these activities.The study of circadian rhythms has undergone a flowering in recent years with the molecular dissection of the components of the circadian clock. Now that many of the clock genes have been identified it is possible to track daily patterns of clock-related mRNAs and proteins to link the entraining light cycles with molecular oscillations within the cell. Insect experiments have led the way in demonstrating that the concept of a "master clock" can no longer be used to explain the temporal organization within an animal. Insects have a multitude of cellular clocks that can function independently and retain their function under organ culture conditions, and they thus offer a premier system for studying how the hierarchical organization of clocks results in the overall temporal organization of the animal. Photoperiodism, and its most obvious manifestation, diapause, does not yet have the molecular underpinning that has been established for circadian rhythms, but recent studies are beginning to identify genes that appear to be involved in the regulation of diapause. Overall, the book presents the rich diversity of challenges and opportunities provided by insects for the study of timing mechanisms.

  • Batten Disease: Diagnosis, Treatment, and Research

    • 1 Edición
    • Volumen 45
    • Inglés
    This title will present all current knowledge of Batten disease from research to clinical evaluation. NCL is not well recognized in underdeveloped countries because the diagnostic technology is lacking. With the information in this volume, however, a specific diagnosis of NCL could be made. Also, specific familial mutations obtained through genetic tests may guide prenatal diagnoses for at-risk families.

  • Computing the Brain

    A Guide to Neuroinformatics
    • 1 Edición
    • Michael A. Arbib + 1 más
    • Inglés
    Computing the Brain provides readers with an integrated view of current informatics research related to the field of neuroscience. This book clearly defines the new work being done in neuroinformatics and offers information on resources available on the Web to researchers using this new technology. It contains chapters that should appeal to a multidisciplinary audience with introductory chapters for the nonexpert reader. Neuroscientists will find this book an excellent introduction to informatics technologies and the use of these technologies in their research. Computer scientists will be interested in exploring how these technologies might benefit the neuroscience community.

  • Advances in the Study of Behavior

    • 1 Edición
    • Volumen 30
    • Inglés
    Advances in the Study of Behavior, Volume 30 continues to serve scientists across a wide spectrum of disciplines. Focusing on new theories and research developments with respect to behavioral ecology, evolutionary biology, and comparative psychology, these volumes foster cooperation and communications in these dense fields. The aim of Advances in the Study of Behavior remains as it has been since the series began: to serve the increasing number of scientists who are engaged in the study of animal behavior by presenting their theoretical ideas and research to their colleagues and to those in neighboring fields. We hope that the series will continue its "contribution to the development of the field", as its intended role was phrased in the Preface to the first volume in 1965. Since that time, traditional areas of animal behavior have achieved new vigor by the links they have formed with related fields and by the closer relationship that now exists between those studying animal and human subjects.

  • Cerebral Vasospasm

    • 1 Edición
    • R. Loch Macdonald + 1 más
    • Inglés
    Bryce Weir is a high-profile, respected neurologist. Dr. Macdonald is a colleague of Dr. Weir's and is a "rising star" in the field of neurology.This book is the first to cover all aspects of cerebral vasospasm in depth. It takes the reader from the first descriptions of this puzzling and deadly phenomenon to the latest laboratory evidence explaining its pathophysiology. Packed with clinical pearls, it is a must for neurosurgeons, interventional radiologists, neurologists, and neuropathologists.

  • Functional Neurobiology of Aging

    • 1 Edición
    • Patrick R. Hof + 1 más
    • Inglés
    Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments.

  • Experimental Design

    A Handbook and Dictionary for Medical and Behavioral Research
    • 1 Edición
    • Volumen 14
    • J. Krauth
    • Inglés
    Scientists planning experiments in medical and behavioral research will find this handbook and dictionary an invaluable desk reference tool. Also recommended as a textbook for students of Experimental Design or accompanying courses in Statistics. Principles of experimental design are introduced, techniques of experimental design are described, and advantages and disadvantages of often used designs are discussed.This two-part volume, a handbook of experimental design and a dictionary providing short explanations for many terms related to experimental design, contains information that will not quickly become outdated.

  • Brain Plasticity and Epilepsy: A Tribute to Frank Morrell

    • 1 Edición
    • Volumen 45
    • Inglés
    This volume of International Review of Neurobiology integrates the latest developments in normal and abnormal neuroplasticity and epilepsy, and considers their implications for understanding the basic mechanisms of normal and pathological behaviors. The chapters are written by leaders in the field, and provide comprehensive coverage of the subject, from molecular neurobiology to behavior. This book will help neuroscientists gain a better understanding of the application of fundamental neuronal mechanisms of plastic change to problems relevant to the diagnosis, treatment, and prevention of human disease, particularly epilepsy.

  • Exploring the Thalamus

    • 1 Edición
    • S. Murray Sherman + 1 más
    • Inglés
    The thalamus is a group of cells placed centrally in the brain that serve a critical role in controlling how both sensory and motor signals are passed from one part of the cerebral cortex to another. Essentially, all information reaching the cerebral cortex and thus consciousness is relayed through the thalamus. The role of the thalamus in controlling the flow of information (such as visual, auditory, and motor) to the cortex has only recently begun to be understood. This book provides an in-depth look at the function of the thalamus and its role as relayer of information to the cerebral cortex. The authors explore how the thalamus controls messages that are passed to the cortex and they introduce the novel suggestion that the thalamus serves a critical role in controlling how messages pass from one part of the cortex to another. Exploring the Thalamus is a comprehensive, up-to-date reference for researchers. It discusses problems concerning the function and structure of the thalamus and concludes each chapter with thought-provoking questions regarding future research.

  • Channelopathies

    • 1 Edición
    • F. Lehmann-Horn + 1 más
    • Inglés
    This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease are especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.

  • Volume Transmission Revisited

    • 1 Edición
    • Volumen 125
    • L.F. Agnati + 3 más
    • Inglés
    Volume Transmission Revisited describes the mounting evidence that cells of the central nervous system are able to communicate via a host of chemical signals that flow through the extracellular space. Volume transmission (VT) constitutes a novel and complementary communication system to classical synaptic transmission. The new modality, which does not require specific connections between cells, leads to a reconsideration of the spatial relationships of neurons and glia, brings a new dimension to network modelling and is relevant to both short term interactions and long term tonic states of the brain.The reader will find 29 chapters describing many of the major discoveries in VT during the last decade.The most striking feature of this publication is the collecting together of many compelling examples of the ubiquitous nature of VT. These point to its increasing relevance from basic neuroscience research to clinical practice. Those working in other areas will find numerous invaluable examples of how leading investigators have gone about assembling evidence for VT.

  • Glutamate

    • 1 Edición
    • Volumen 18
    • J. Storm-Mathisen + 1 más
    • Inglés
    The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery. Immunogold and other high-resolution methods are used extensively. Each chapter presents new data that have not previously been reviewed. The material presented forms the basis for work directed to understanding the functional properties of excitatory synapses in greater depth, to discover mechanisms of neurological and psychiatric disorders and novel methods for treatment. Chapter 1 deals with the transmitter molecule itself, mechanisms of release and pathways for glutamate synthesis. The anatomy of glutamatergic nerve projection pathways in different brain regions is dealt with. In Chapter 2, focus is on aspartate, the enigmatic congener of glutamate, and its possible role in excitatory neurotransmission. Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10).

  • Neural Plasticity and Regeneration

    • 1 Edición
    • Volumen 128
    • F.J. Seil
    • Inglés
    While a cure for spinal cord injury remains elusive, the contents of this volume convey a sense of progress towards this goal. More has been learned about the primary and secondary consequences of spinal cord injury and more is being understood about recovery mechanisms that are intrinsic to the nervous system and that might be further encouraged. Expanding the control capacity of uninjured portions of the nervous system may be one approach to improving the functional capabilities of those afflicted with this disorder. New therapies in the form of transplantable cells that can encourage growth or myelination or prevent secondary damage or that can substitute for injured cells appear promising for future applications. Genetic and tissue engineering studies give us further hope, and under continuous development are novel drugs with greater specificity and fewer detrimental effects and improved delivery methods for such drugs. The volume is organized into six topic sections, including I) Strategies for Spinal Cord Injury Repair, II) Plasticity of the Injured Spinal Cord: Retraining Neural Circuits to Promote Motor Recovery, III) Impact of Neuroprosthetic Applications on Functional Recovery, IV) Neurotrophins and Activity-Dependent Plasticity, V) Candidate Cells for Transplantation into the Injured CNS and VI) New Directions in Regeneration Research. Both clinical and experimental animal studies are presented in the first three sections, while predominantly basic research is the focus of the second half of the book.

  • Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1 Edición
    • Volumen 40
    • Inglés
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work. Volume 40 includes in its coverage chapters on memory, categorization, implicit and explicit learning, and the effects of rewards and punishments on learning.

  • MRI Atlas of the Human Cerebellum

    • 1 Edición
    • Jeremy D. Schmahmann + 4 más
    • Inglés
    The MRI Atlas of the Human Cerebellum constitutes the most complete, detailed work on the human cerebellum to date. This definitive work provides images in the three cardinal planes (sagittal, transverse, and coronal) at closely spaced intervals of 2 millimeters. The images are derived from MRI scans of one individual and from postmortem sections of another. It is the only such atlas set within the universally accepted framework of the Talairach stereotaxic system, derived from standard landmarks in the brain. The book includes a new nomenclature system (labeling system) which is easier to use, aids in understanding the organization of the cerebellum, and is consistent with earlier work on the anatomy of the cerebellum in animals and the development of the human cerebellum in infants.Recent studies have shown that the cerebellum is involved in much more than motor coordination alone: also in higher functions including memory, language, emotion, and attention, as well as sensory discrimination. This atlas facilitates this new era of study of the cerebellum, allowing investigators to identify cerebellar structures with precision. Everyone concerned with the anatomy, function, or dysfunction of the cerebellum should have a copy.

  • Neurobiology of Addiction

    • 1 Edición
    • George F. Koob + 1 más
    • Inglés
    Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature.

  • Computational Neuroscience

    Trends in Research 2000
    • 1 Edición
    • J.M. Bower
    • Inglés
    This volume includes papers originally presented at the 8th annual Computational Neuroscience meeting (CNS'99) held in July of 1999 in Pittsburgh, Pennsylvania. The CNS meetings bring together computational neuroscientists representing many different fields and backgrounds as well as experimental preparations and theoretical approaches. The papers published here range across vast levels of scale from cellular mechanisms to cognitive brain studies. The subjects of the research include many different preparations from invertebrates to humans.In all cases the work described in this volume is focused on understanding how nervous systems compute. The research described includes subjects like neural coding and neuronal dendrites and reflects a trend towards forging links between cognitive research and neurobiology. Accordingly, this volume reflects the breadth and depth of current research in computational neuroscience taking place throughout the world.

  • Functional Neuroanatomy of the Nitric Oxide System

    • 1 Edición
    • Volumen 17
    • H.W.M. Steinbusch + 2 más
    • Inglés
    This volume of the Handbook of Neuroanatomy is concerned with nitric oxide synthase. In this volume different research areas are presented together, which adds up to the first major review volume on the localization of nitric oxide synthase in the nervous system. The subjects range from developmental aspects in vertebrates to a functional neuroanatomy of the nervous system in vertebrates. This presentation gives an impressive look on the overwhelming presence of NOS in animal organism and the significance of NO - cGMP signaling. By clearly stating the limitations of our present knowledge the book is also a stimulant for further research. This book presents for the first time an overview of NOS and NO-cGMP signaling in the retina and urogenital system. In addition the effects if injuries on the expression of NOS are summarized in a number of models, which has not been done before.The frame of the book is a classical neuroanatomic description of the localization of NOS. Several authors give detailed advice to prevent pitfalls which may occur when different methods to locate NOS are used. In addition, several chapters detail the target structures for NO while describing the localization of NOS at the same time.All these points together make this volume very timely, i.e. overviewing a decade of NO research.

  • Peptide Receptors, Part I

    • 1 Edición
    • Volumen 16
    • A. Bjorklund + 2 más
    • Inglés
    During the last few years, the pace of research in the field of neuropeptide receptors has increased steadily: new neuropeptides were discovered, and the classification of receptor subtypes has been refined. It thus appeared essential to update the information. Peptide Receptors Part I summarizes current knowledge on ten distinct peptide families.This volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry, and immunocytochemistry images. Application of these classical techniques and of new approaches such as transgenic and knock-out animals has revealed a distinct species and tissue specific variation in receptor subtypes expression and pharmacology in the mammalian central nervous system.The functional role of neuropeptides and their receptors in the CNS has been investigated thanks to the development of potent and selective receptor antagonists and agonists. The development of specific neuropeptide-related molecules will help to get a better understanding of receptor subtype physiology and neuronal distribution and may lead to innovative treatments in a variety of brain disorders.

  • Development of the Nervous System

    • 1 Edición
    • Dan H. Sanes + 2 más
    • Inglés
    Development of the Nervous System presents a broad outline of neural development principles as exemplified by key experiments and observations from past and recent times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. Original, artist-rendered drawings combined with clear, concise writing make Development of the Nervous System well suited to anyone approaching this complex field for the first time.

  • Receptor Chemistry Towards the Third Millennium

    • 1 Edición
    • Volumen 31
    • M. Gianella + 3 más
    • Inglés
    Receptor Chemistry Towards the Third Millennium is the result of papers presented at the 12th Camerino-Noordwijker... Symposium, held in Camerino, Italy in September 1999. Although much is known about the way ligands interact with receptors, which have now been isolated, characterized and cloned, many aspects still remain to be explored. In particular, differentiation into distinct subpopulations and the multiplicity of transduction processes offer more specific targets in the search for new drugs.This book will be of interest to medicinal chemists, pharmacologists, biochemists and neurologists and will also be a valuable source of reference for medical students and postgraduate students in related fields.

  • Brain Mapping: The Disorders

    The Disorders
    • 1 Edición
    • John C. Mazziotta + 2 más
    • Inglés
    Brain Mapping: The Disorders is the first comprehensive text to describe the uses of the latest brain mapping technologies in the evaluation of patients with neurological, neurosurgical and psychiatric disorders. With contributions from the leading figures in the field, this heavily illustrated text is organized by disorders of brain systems, with specific examples of how one should use current neuroimaging techniques to evaluate patients with specific cerebral disorders. Comprehensive in scope, the text discusses patient evaluations using the wide range of modern magnetic resonance imaging techniques, positron emission tomography, single photon emission computed tomography, optical intrinsic signal imaging, electroencephalograp... magnetoencephalograp... and transcranial magnetic stimulation. The third in this brain mapping series, Brain Mapping: The Disorders, is the ultimate text for anyone interested in the use of brain mapping techniques to study patients with disorders of the central nervous system.

  • Seeing

    • 1 Edición
    • Karen K. De Valois
    • Inglés
    One of the most remarkable things about seeing is how effortless this complex task appears to be. This book provides a comprehensive overview of research on the myriad complexities of this task. Coverage includes such classic topics as color, spatial, and binocular vision, areas that have seen a recent explosion of new information such as motion vision, image formation and sampling, and areas where new tools have allowed a better investigation into processes (e.g. neural representation of shape, visual attention).Seeing is a needed reference for researchers specializing in visual perception and is suitable for advance courses on vision.

  • The Wisdom of the Eye

    • 1 Edición
    • David M. Miller
    • Inglés
    The Wisdom of the Eye is a survey of the major concepts underlying many of the basic sciences related to the human eye and visual brain in one volume, using anecdotes and a minimum of highly technical language to emphasize the important points. This book presents an up-to-date treatment on how the eye and visual system work to help us see, interpret what we see, and communicate what we feel. It also examines how this description of the visual system teaches us more about ourselves.

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