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Elsevier

Libros en Farmacología

  • Encyclopedia of Separation Science

    • 1 Edición
    • Colin F. Poole + 2 más
    • Inglés
    The Encyclopedia of Separation Science is the most comprehensive resource available on the theory, techniques, and applications of separation science. The work presents information on three levels. The first volume contains Level 1, which provides a broad overview of the theory of the 12 main categories of separation techniques. Volumes 2-4 (Level 2) expand coverage with detailed theoretical and technical descriptions of particular techniques. The remaining Volumes 5-9 (Level 3) cover applications of these techniques from the micro to the macro, and also from the analytical laboratory bench to large-scale industrial processes. Volume 10 consists mainly of the index. Initial access to the online version offering extensive hypertext linking and advanced search tools is available with purchase. Ongoing access is maintained for a minimum annual fee. The Encyclopedia of Separation Science is the first truly comprehensive work covering the whole of separation theory, methods, and techniques. This encyclopedia will be invaluable to researchers and professionals across a wide range of areas in academia and industry. Enclyclopedia of Separation Science is available online via ScienceDirect offering enhanced features such as extensive cross-referencing and dynamic linking. For more information please (http://www.info.sci... click here.)

  • Progress in Medicinal Chemistry

    • 1 Edición
    • Volumen 37
    • Inglés
    This volume reviews recent advances in five important areas of medicinal chemistry which will be of interest both to chemists and to scientists of other disciplines engaged in medicines research and development. Included are accounts of successful drug discovery programmes, disease targets of unmet medical need, and recent progress in new technologies which are considered by many to hold the key to future developments in medicinal chemistry.The style and organisation of chapters follow a similar pattern to previous volumes but references, where appropriate, now include website addresses of the World Wide Web.

  • Adenosine Receptors and Parkinson's Disease

    • 1 Edición
    • Hiroshi Kase + 2 más
    • Inglés
    This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease.

  • Encyclopedia of Violence, Peace, and Conflict

    • 1 Edición
    • Lester R. Kurtz
    • Inglés
    The Encyclopedia of Violence, Peace, and Conflict, a three-volume set written by more than 200 eminent contributors from around the world, takes advantage of increasing, worldwide awareness in the public, private, commercial, and academic sectors about manifestations of violence in all segments of society. While the contributors do not use these volumes to make specific arguments, they do describe and clarify the developments in thought that have led to current theories about and positions on violence and peace. Our reviewers consistently note that while many in-depth studies of war, peace, and aggression exist, the attendant specialization keeps scholars from learning about related fields. No publication competing with the Encyclopedia of Violence, Peace, and Conflict can satisfy their need for a vast introductory work to such a diverse and socially-important field. This major work includes more than 190 multidisciplinary articles with over 1,000 cross-references and more than 2,000 bibliography entries for further reading which are arranged alphabetically for easy access.

  • Membrane Permeability: 100 Years Since Ernest Overton

    • 1 Edición
    • Volumen 48
    • Inglés
    Membrane permeability is fundamental to all cell biology and subcellular biology. The cell exists as a closed unit. Import and export depend upon a number of sophisticated mechanisms, such as active transport, endocytosis, exocytosis, and passive diffusion. These systems are critical for the normal housekeeping physiological functions. However, access to the cell is also taken advantage of by toxic microbes (such as cholera or ptomaine) and when designing drugs. Ernest Overton, one of the pioneers in lipid membrane research, put forward the first comprehensive theory of lipid membrane structure. His most quoted paper on the osmotic properties of cells laid the foundation for the modern concepts of membrane function, most notably important in anesthesia. This book is designed to celebrate the centennial anniversary (in the first chapter) of Overton's work. Subsequent chapters present readers with up-to-date concepts of membrane structure and function and the challenge they pose for new explorations.

  • Progress in Medicinal Chemistry

    • 1 Edición
    • Volumen 36
    • Inglés

  • Advances in Pharmacology

    • 1 Edición
    • Volumen 46
    • Inglés
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Annual Reports in Medicinal Chemistry

    • 1 Edición
    • Volumen 33
    • David Robertson + 5 más
    • Inglés
    Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expectedto provide the basis for entirely new future therapies.

  • Progress in Medicinal Chemistry

    • 1 Edición
    • Volumen 35
    • Inglés
    Eminent scientists at the cutting edge of pharmacology and medicinal chemistry research provide us with yet another excellent addition to this famous series. The focus on bacterial resistance mechanisms serves to highlight an important area of unmet medical need requiring the attention of medicinal chemists. Five topical subjects are reviewed: the biosynthesis, metabolism and function of Vitamin D3 and the potential application of its analogues in bone disorders and immune-related diseases; the therapeutic potential of neurokinin antagonists; opioid receptor antagonists; the mechanisms of bacterial resistance; and a survey of recent advances in cannabinoid research. This volume will deservedly take its place in clinical and industrial pharmaceutical libraries, and will prove invaluable to medicinal chemists.

  • Asthma

    Basic Mechanisms and Clinical Management
    • 3 Edición
    • Peter J. Barnes + 2 más
    • Inglés
    Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become the reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field.

  • Cytokines

    • 1 Edición
    • Anthony R. Mire-Sluis + 1 más
    • Inglés
    This book provides comprehensive coverage of the cytokines from a pharmacological approach. The chapters are presented in a consistent format allowing easy cross-reference, with sample diagrams and a summary table of essential facts for each chapter at the end of the book.Cytokines is unique in stressing cytokine biology and the application of research data to provide disease therapy. With 33 detailed and up-to-date chapters about individual cytokines, this comprehensive reference will provide both clinicians and researchers in immunology and pharmacology with invaluable information.

  • Advances in Pharmacology

    • 1 Edición
    • Volumen 44
    • Inglés
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Stable Isotopes in Pharmaceutical Research

    • 1 Edición
    • Volumen 26
    • T.R. Browne
    • Inglés
    Stable isotope techniques offer advantages in safety, sensitivity, specificity, and economy for many types of pharmaceutical investigations when compared to conventional techniques. Nevertheless, pharmaceutical researchers are slow to embrace stable isotope techniques.This book assembles in one place comprehensive reviews of the many applications of stable isotopes and the background material necessary to understand the application. This approach is a deliberate attempt to encourage the usage of stable isotopes in pharmaceutical research. A bonus to the reader is the high standard of contributions from a very talented and diverse group of investigators.

  • A Manual of Adverse Drug Interactions

    • 5 Edición
    • J.P. Griffin + 1 más
    • Inglés
    For twenty years this book, now in its 5th edition, has provided information on adverse drug interactions that is unrivalled in coverage and scholarship.Adverse drug reactions, many of them ascribable to interactions with other drugs or with chemical substances in food or the environment, are thought to cause or complicate one in twenty of hospital admissions.The book is conveniently divided into two parts: Part 1 comments on drug interactions and their mechanisms, on a pharmacokinetic and pharmacodynamic level, while Part 2 consists of drug interaction tables, divided and subdivided into categories of disorders, and the drugs used in the treatment of these disorders.If safety in drugs is to improve, education of prescribers is vitally important. This book, with its up-to-date and coordinated approach, serves that purpose well. The real threat, as the authors remind us, is the ignorance of practitioners, not the drug itself. The volume is therefore an essential addition to the shelves of those responsible for the prescription of drugs, in order to prevent a potential backlash when used in combination with other drugs or chemical substances.

  • Advances in Cancer Research

    Cumulative Subject Index
    • 1 Edición
    • Volumen 73
    • Inglés
    Academic Press proudly presents this Cumulative Subject Index covering Volumes 50-72 of Advances in Cancer Research. In one comprehensive source, the interested reader can find references to specific articles on topics such as breast cancer, prostate cancer, Kaposi's sarcoma, Burkitt's lymphoma, leukemias, oncogenes, transcription factors, tumor genetics, p53, T-cell receptors, and drug resistance. This cumulative index will serve not only as a complete overview of the major topics published in Advances in Cancer Research, but also as an indicator of the progress made in cancer research over the last ten years.

  • Catecholamines: Bridging Basic Science with Clinical Medicine

    • 1 Edición
    • Volumen 42
    • Inglés
    This volume in Advances in Pharmacology focuses on all aspects of catecholamine research, from very basic to medical. It is broad based and covers many areas within physiology and medicine.

  • Drug-Drug Interactions: Scientific and Regulatory Perspectives

    • 1 Edición
    • Volumen 43
    • Inglés
    Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.

  • Hormones and Signaling

    • 1 Edición
    • Volumen 1
    • Bert W. O'Malley + 6 más
    • Inglés
    Hormones and Signaling focuses on the mechanism of gene regulation at the cellular level. It also covers the way hormones act to modulate gene regulation and animal development.

  • Heparin-Binding Proteins

    • 1 Edición
    • H. Edward Conrad
    • Inglés
    This book describes the complex structures of heparins and heparan sulfates (heparinoids) and how they are generated by their biosynthetic pathways. The book also details the methodologies for studying these structures and their cellular metabolism. Heparin-Binding Proteins introduces the general nature of interactions between heparinoids and proteins, and presents the role for these structures in their interactions with the proteins of the hemostatic mechanisms, fibroblasts growth factors, superoxide dismutase, and lipoproteins.

  • XIVth International Symposium on Medicinal Chemistry

    • 1 Edición
    • Volumen 28
    • F. Awouters
    • Inglés
    Vaso-occlusive disorders including unstable angina, myocardial infarction, transient ischemic attacks, stroke and peripheral artery disease remain the major sources of morbidity and mortality in western civilization. Platelet activation and resulting platelet aggregation play a major role in the pathogenesis of these thromboembolic diseases. Recognition of the contribution of platelets to the pathophysiology of cardiovascular disease has provided impetus for the continued search for new antiplatelet agents. Hence, over the past two decades many strategies have been evaluated in the search for efficacious mechanisms to reduce platelet function. The medical need for more efficacious antithrombotic drugs and the growing understanding of the role of platelets in vascular injury have catalyzed the extensive evaluation of novel approaches to control platelet function. Along these lines, the volume therefore provides an in-depth assessment of ongoing clinical trials, new and clinically established agents, and other developments in this rapidly developing field.

  • Diuretic Agents

    Clinical Physiology and Pharmacology
    • 1 Edición
    • Donald W. Seldin + 1 más
    • Inglés
    The only comprehensive work to cover all aspects of diuretic agents, the book discusses the pharmacology and toxicology of diuretic agents as well as the physiological effects. Experts in the field present the principles and experimental approaches for the study of interactions between pharmacologic compounds in relation to specific target organs. Diuretic Agents contains information on the mechanisms of action and application of diuretics, and details FDA regulations and pharmaceutical industry guidelines.

  • Progress in Medicinal Chemistry

    • 1 Edición
    • Volumen 34
    • Inglés
    There are five main subject areas in this volume in the series on medicinal chemistry. The first is a review of the understanding of Alzheimer's disease and the development of drugs for its treatment; the second, looking at recent efforts in modifying a naturally occuring anticancer (campothecin) for chemotherapy; the third covers the problem of getting a drug to a specific site within the context of phosphates and phosphonates; a survey of sterilization using aldehydes for the destruction of microbes both inside and outside the human body is reviewed in the fourth; and the last chapter is an account of the progress made in the biologically active enantiomer for complex synthetic asymmetric drug molecules.

  • Apoptotis: Pharmacological Implications and Therapeutic Opportunities

    • 1 Edición
    • Volumen 41
    • Inglés
    Programmed cell death (PCD) has become a topic of widespread interest and experimentation over the past decade. Written by experts in the field,Apoptosis: Pharmacological Implications and Therapeutic Opportunities concentrates on presenting an overview of PCD pathways as they are currently understood, and strives to identify important unanswered questions as well as other therapeutic possibilities suggested by recent biochemical discoveries. Understanding the biochemical pathways that participate in the cell death process has become an important goal in developmental biology, neurobiology, cardiology, and infectious disease research. The control of apoptosis has also become a major area of investigation in the field of cancer biology.Apoptosis: Pharmacological Implications and Therapeutic Opportunities contains an overview for those with a general interest in apoptosis, and provides discussions of sufficient depth to be useful for specialists in the field.

  • Advances in Drug Research

    • 1 Edición
    • Volumen 29
    • Inglés
    This volume continues the trend for Advances in Drug Research of shorter, but more frequent volumes. In line with the tradition of the series, chapters on general themes are interspersed with chapters on specific drug classes and targets.

  • New Cosmetic Science

    • 1 Edición
    • T. Mitsui
    • Inglés
    Cosmetic science covers the fields from natural sciences to human and social sciences, and is an important interdisciplinary element in various scientific disciples. New Cosmetic Science is a completely updated comprehensive review of its 35 year old counterpart Cosmetic Science. New Cosmetic Science has been written to give as many people as possible a better understanding of the subject, from scientists and technologists specializing in cosmetic research and manufacturing, to students of cosmetic science, and people with a wide range of interests concerning cosmetics.The relationship between the various disciplines comprising cosmetic science, and cosmetics, is described in Part I. In addition to discussing the safety of cosmetics, the "Usefulness of Cosmetics", rapidly becoming an important theme, is described using research examples. The latest findings on cosmetic stability are presented, as are databases, books and magazines, increasingly used by cosmetic scientists. Part II deals with cosmetics from a usage viewpoint, including skin care cosmetics, makeup cosmetics, hair care cosmetics, fragrances, body cosmetics, and oral care cosmetics. Oral care cosmetics and body cosmetics are presented with product performance, types, main components, prescriptions and manufacturing methods described for each item.This excellent volume enlightens the reader not only on current cosmetics and usage, but indicates future progress enlarging the beneficial effects of cosmetics. Products with better pharmaceutical properties (cosmeceuticals), working both physically and psychologically, are also highlighted.

  • Advances in Pharmacology

    • 1 Edición
    • Volumen 39
    • Inglés
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Primer on Cerebrovascular Diseases

    • 1 Edición
    • Bo K. Siesjo + 4 más
    • Inglés
    Primer on Cerebrovascular Diseases is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, and presents the information in a comprehensive and easily accessible manner. The book also contains valuable information on practical applications of basic research.

  • The Kinin System

    • 1 Edición
    • Stephen G. Farmer
    • Inglés
    Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef'... DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases.

  • The Eye's Aqueous Humor: From Secretion to Glaucoma

    • 1 Edición
    • Volumen 45
    • Inglés
    This volume presents a basic consensus of how the aqueous humor is formed and exits through the trabecular meshwork and canal of Schlemm. It presents a timely update to current knowledge of the molecular transport mechanisms which underlie aqueous humor dynamics. In addition, it provides a concise description of the clinical approaches used for assessing these basic transport processes. The book emphasizes the phenomenon of the diurnal rhythm of aqueous humor formation, from both the clinical and molecular points of view. This phenomenon provides the major indication that aqueous humor secretion is regulated.

  • International Review of Neurobiology

    • 1 Edición
    • Volumen 39
    • Inglés
    Since 1959, International Review of Neurobiology has been a well known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes.

  • Drugs and Human Lactation

    A Comprehensive Guide to the Content and Consequences of Drugs, Micronutrients, Radiopharmaceuticals and Environmental and Occupational Chemicals in Human Milk
    • 2 Edición
    • A. Astrup-Jensen + 12 más
    • P.N. Bennett
    • Inglés
    Now in its second edition, Drugs and Human Lactation is a comprehensive guide to the content and consequences of xenobiotics and micronutrients in human milk, and remains by far the most thorough and extensive work available on this subject. The excellent methodology used for the compilation of the 1st edition has been retained.It begins with an outline of the processes by which substances enter milk during its formation, the effects of drugs on the milk production process, the main determinants of drug excretion into milk and their disposition in the child. There follows an analysis of current data on 234 individual drugs, describing the extent of their passage into human milk, and assessing the risk to the suckling infant. Vitamins and essential trace elements, and radiopharmaceuticals are similarly reviewed. Also included is an account of the factors that influence the passage of environmental and occupational chemicals into milk. The result is a complete overview of what is known and proven, with clear pointers to matters which require further study, and brings the various subject areas up to date. Risks, uncertainties and false alarms which exist have been defined in such a way that they can be avoided.Once again, Drugs and Human Lactation provides a comprehensive guide to the content and consequences of substances in milk. The volume will provide a rational basis for making therapeutic decisions in women who seek to breast-feed.Reproduc... Immunology on the first edition: ...a superbly written compendium of reliable information and sensible conclusions and recommendations.

  • In Vitro Methods in Pharmaceutical Research

    • 1 Edición
    • Jose V. Castell + 1 más
    • Inglés
    In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies.

  • Advances in Pharmacology

    • 1 Edición
    • Volumen 37
    • Inglés
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Phosphodiesterase Inhibitors

    • 1 Edición
    • Inglés
    Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting.

  • Neural Networks in QSAR and Drug Design

    • 1 Edición
    • James Devillers
    • Inglés
    Comprehensive and impeccably edited, Neural Networks in QSAR and Drug Design is the first book to present an all-inclusive coverage of the topic. The book provides a practice-oriented introduction to the different neural network paradigms, allowing the reader to easily understand and reproduce the results demonstrated. Numerous examples are detailed, demonstrating a variety of applications to QSAR and drug design.The contributors include some of the most distinguished names in the field, and the book provides an exhaustive bibliography, guiding readers to all the literature related to a particular type of application or neural network paradigm. The extensive index acts as a guide to the book, and makes retrieving information from chapters an easy task. A further research aid is a list of software with indications of availablility and price, as well as the editors scale rating the ease of use and interest/price ratio of each software package. The presentation of new, powerful tools for modeling molecular properties and the inclusion of many important neural network paradigms, coupled with extensive reference aids, makes Neural Networks in QSAR and Drug Design an essential reference source for those on the frontiers of this field.

  • Advances in DNA Sequence-Specific Agents

    • 1 Edición
    • Volumen 2
    • J.B. Chaires
    • Inglés
    DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molec... interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of Advances in DNA Sequence Specific Agents. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA.This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.

  • Advances in Drug Research

    • 1 Edición
    • Volumen 28
    • Inglés
    This volume continues the trend for Advances in Drug Research of shorter, but more frequent volumes. In line with the tradition of the series, chapters on general themes are interspersed with chapters on specific drug classes and targets.

  • Antidiabetic Agents: Recent Advances in their Molecular and Clinical Pharmacology

    • 1 Edición
    • Volumen 27
    • Inglés
    Volume 27, the first thematic volume in the Series, provides an overview of present knowledge with regard to the pharmacological and clinical aspects of antidiabetic drugs. It aims to stimulate further consideration of possible concepts in the development of new antidiabetic drugs.

  • Guidebook on Molecular Modeling in Drug Design

    • 1 Edición
    • N. Claude Cohen
    • Inglés
    Specially designed computer software is revolutionizing procedures for structured or rational drug design and discovery. The Guidebook on Molecular Modeling in Drug Design serves as a manual for the analysis ofmolecular structure and the correlation of these structures with pharmacological reactions. Intended as an introductory guide for advanced students and professionals with an interest in computer-assisted modeling for drug design and discovery, this bookwill also be of interest to medicinal and organic chemists, pharmaceutical researchers, pharmacologists, and biochemists who want to gain further insight into this rapidly advancing field.Molecular modeling is assuming an important role in the understanding of three-dimensional aspects in the specificity of drug-receptor interactions at the molecular level. This research area has become a well-established discipline in pharmaceutical research. It has created unprecedented opportunities in assisting medicinal chemists in the design of new therapeutic agents. Advances made in computer hardware and in theoretical medicinal chemistry have brought high-performance computing and graphics tools within reach of most academic and industrial laboratories, facilitating the development of useful approaches to rational drug design.The Guidebook on Molecular Modeling in Drug Design serves as a manual for the analysis of the molecular structure of biological molecules and drugs and the correlation of these structures with pharmacological actions. Intended as a guide for advanced students and professionals with an interest in computer-assisted modeling for drug design and discovery, this book will also be of interest to medicinal and organic chemists, pharmaceutical researchers, pharmacologists, and biochemists who want to gain further insight into this rapidly advancing field.

  • Progress in Medicinal Chemistry

    • 1 Edición
    • Volumen 33
    • Inglés

  • Doing What Works in Brief Therapy

    A Strategic Solution Focused Approach
    • 1 Edición
    • Ellen K. Quick
    • Inglés
    The first of its kind, Doing What Works in Brief Therapy is a guidebook to strategic solution focused therapy, a model which combines the principles and techniques of the Mental Research Institute's brief strategic therapy and the Brief Family Therapy Center's solution focused therapy. The book explains how the strategic emphasis on clarification of the problem and interruption of what does not work can complement and enhance the solution-focused emphasis on amplification of what does work. The text reviews the theory and presents specific treatment techniques. Case examples illustrate how the model has been used in brief, intermittent, and single-session therapy in a managed care setting. Brief psychotherapy doesn't have to result in chronic frustration for the therapist or superficial, second-rate care for the client. This book presents an approach that is upbeat, practical, and eminently workable in managed care. The reader learns to focus on critical issues with exquisite precision and to construct creative, individualized interventions that amplify what works and interrupt what does not.

  • Handbook of Perception and Action

    Perception
    • 1 Edición
    • Wolfgang Prinz + 1 más
    • Inglés
    This volume combines the classical fields of perception research with the major theoretical attitudes of today's research, distinguishing between experience- versus performance-related approaches, transformational versus interactional approaches, and approaches that rely on the processing versus discovery of information. Perception is separated into two parts. The first part deals with basic processes and mechanisms, and discusses early vision and later, yet still basic, vision. The second covers complex achievements with accounts of perceptual constancies and the perception of patterns, objects, events, and actions.

  • The SV40 Replicon Model for Analysis of Anticancer Drugs

    • 1 Edición
    • Robert M. Snapka
    • Inglés
    This book provides the most up-to-date review of the simian virus 40 (SV40) minichromosome as a model for the mammalian chromosome in studies of DNA replication. It focuses on disruption of DNA replication by anticancer drugs and DNA-damaging agents. There is a strong emphasis on the unique advantages of SV40 as an experimental system for the analysis of these classes of anticancer drug mechanisms. The new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication are covered in detail to aid readers in designing and interpreting similar experiments.

  • Advances in Pharmacology

    • 1 Edición
    • Volumen 35
    • Inglés
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Drug Receptor Subtypes and Ingestive Behaviour

    • 1 Edición
    • Steven J. Cooper + 1 más
    • Inglés
    Neural Mechanisms of ingestive behaviour has long been one of the most intensively investigaged areas within neuroscience. Drug studies have been introduced to develop anti-obesity compounds and, more recently, to identify nerotransmitters which might be involved in the control of ingestive behaviour. The current focus within this field is towards neurotransmitter receptors as it has become known that there are multiple receptor subtypes for each identified neurotransmitter. The study of drug receptor subtypes and ingestive behaviour is growing very rapidly, and has become quite complex. Drug Receptor Subtypes and Ingestive Behaviour is designed to guide students and investigators through a number of different neurotransmitter systems and provide them with the latest information on the identities of receptor subtypes most relevant in the study of ingestive behaviour. As such, it will prove enormously useful to all engaged in studies on appetite and obesity treatment.

  • Biochemistry, Molecular Biology, and Therapeutic Implications

    Nitric Oxide: Biochemistry, Molecular Biology, And Therapeutic Implications
    • 1 Edición
    • Volumen 34
    • Inglés
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types.

  • Advances in Heterocyclic Chemistry

    • 1 Edición
    • Volumen 64
    • Inglés
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.

  • Immunopharmacology of Respiratory System

    • 1 Edición
    • Stephen T. Holgate
    • Inglés
    Immunopharmacology represents the boundary between the immune system and chemical mediators of the inflammatory and neuroendocrine responses. The subject as applied to the respiratory system embraces most of the common non-malignant lung diseases of which asthma and allied disorders are the most prevalent. An understanding of the underlying mechanisms of the disorders provides rationale for prevention and drug treatment as well as creating opportunities for novel drug development. Immunopharmacology of Respiratory System embraces all of these principles and should enable the reader to become rapidly updated in an area of medical importance.

  • Advances in Pharmacology

    • 1 Edición
    • Volumen 33
    • Inglés
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Annual Reports in Medicinal Chemistry

    • 1 Edición
    • Volumen 30
    • James A. Bristol
    • Inglés
    Praise for the Series:"This series is one of the very few annual publications which justify the title of an absolute must for the pharmacologist, chemist, or physician who is interested in the chemistry of drug development."--Enzym... book is strongly recommended for researchers, teachers, students, administrators - in short, anyone whose interests impinge on medicinal chemistry. In view of the work's documented reference value, it is a must for inlusion in the scientist's personal library."--Journal of Medicinal Chemistry"All topics are covered in sufficient depth, with extensive references, to allow either the specialist or the novice to be informed of the latest developments in a particular area of medicinal chemistry."--Norman Gilman, Hoffmann-La Roche, Inc, in the JOURNAL OF PHARMACEUTICAL SCIENCESAdvances in Medicinal Chemistry continues to provide timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

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