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Elsevier

Libros en Ciencias de la Vida

  • Phosphatases

    • 1 Edición
    • Volumen 607
    • Inglés
    Methods in Enzymology, Volume 607: Phosphatases, the latest release in this ongoing series, highlights new advances in the field as detailed by an international board of authors. This latest release includes chapters on Empirical Valence Bond Simulations of the Evolution of Enzyme Function, QM/MM Free Energy and Kinetic Isotope Analysis of Phosphoryl Transfer in Enzymes, the Structural, Mechanism and Evolution of Phosphatases, How to Define Rapid Motions in Pumping Pyrophosphatases, The Evolution of K+-Independence in Pyrophosphatases, the Crystallization of Michaelis, Intermediate and Inhibited Complexes in Phosphatases, and an Investigation of Nucleotide Loading and Effector Binding of K-Ras.

  • Goal-Directed Decision Making

    Computations and Neural Circuits
    • 1 Edición
    • Richard W. Morris + 2 más
    • Inglés
    Goal-Directed Decision Making: Computations and Neural Circuits examines the role of goal-directed choice. It begins with an examination of the computations performed by associated circuits, but then moves on to in-depth examinations on how goal-directed learning interacts with other forms of choice and response selection. This is the only book that embraces the multidisciplinary nature of this area of decision-making, integrating our knowledge of goal-directed decision-making from basic, computational, clinical, and ethology research into a single resource that is invaluable for neuroscientists, psychologists and computer scientists alike. The book presents discussions on the broader field of decision-making and how it has expanded to incorporate ideas related to flexible behaviors, such as cognitive control, economic choice, and Bayesian inference, as well as the influences that motivation, context and cues have on behavior and decision-making.

  • Oxidants, Antioxidants, and Impact of the Oxidative Status in Male Reproduction

    • 1 Edición
    • Ralf Henkel + 2 más
    • Inglés
    Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction is an essential reference for fertility practitioners and research and laboratory professionals interested in learning about the role of reactive oxygen species in sperm physiology and pathology. The book focuses on unravelling the pathophysiology of oxidative stress mediated male infertility, recruiting top researchers and clinicians to contribute chapters. This collection of expertise delves into the physico-chemical aspects of oxidative stress, including a new focus on reductive stress. Furthermore, the inclusion of clinical techniques to determine oxidative stress and the OMICS of reductive oxidative stress are also included. This is a must-have reference in the area of oxidative stress and male reproductive function.

  • Enzymes in Food Biotechnology

    Production, Applications, and Future Prospects
    • 1 Edición
    • Mohammed Kuddus
    • Inglés
    Enzymes in Food Biotechnology: Production, Applications, and Future Prospects presents a comprehensive review of enzyme research and the potential impact of enzymes on the food sector. This valuable reference brings together novel sources and technologies regarding enzymes in food production, food processing, food preservation, food engineering and food biotechnology that are useful for researchers, professionals and students. Discussions include the process of immobilization, thermal and operational stability, increased product specificity and specific activity, enzyme engineering, implementation of high-throughput techniques, screening to relatively unexplored environments, and the development of more efficient enzymes.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 86
    • Inglés
    Advances in Clinical Chemistry, Volume 86, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Biodiversity of Fishes in Arunachal Himalaya

    Systematics, Classification, and Taxonomic Identification
    • 1 Edición
    • Achom Darshan Singh + 2 más
    • Inglés
    Biodiversity of Fishes in Arunachal Himalaya: Systematics, Classification, and Taxonomic Identification provides a detailed piscatorial resource of the fish species living in the rich mountain waterbodies of the eastern Himalayan region. It presents the latest classifications and updated taxa of fish dwelling in high-altitude cold waters, mid-altitude cold and warm waters, and warm waters in the low altitude foothill regions of the Arunachal Himalaya. The book includes the scientific and vernacular names of more than 200 fish species, as well as coloration, distributional and conservational status. It addresses increasing threats to the endemic fishes of this region, including habitat shrinkage, habitat destruction, and more. This book will be a valuable resource for biodiversity and conservation researchers, especially those specializing in ichthyo-faunal diversity. Fishery researchers and students will also find the information presented on taxonomic and classification very useful to their initiatives.

  • Breeding Sorghum for Diverse End Uses

    • 1 Edición
    • Aruna C + 3 más
    • Inglés
    Breeding Sorghum for Diverse End Uses is a comprehensive overview of all significant global efforts for the genetic improvement of sorghum, a major crop of many semi-arid nations that is suitable for a huge range of uses, from human food, to biofuels. Split into two main sections, the book initially reviews the genetic suitability of sorghum for breeding, also providing the history of the genetic improvement of the grain. Finally, other sections look at specific breeding programs that could be improved in a number of areas, including human food, animal feed and industrial usage. Readers in academics, research, plant genetics and sorghum development will find this resource of great value. In addition, it is essential reading for engineers who utilize sorghum for food, feed and industrial materials in industry.

  • Drug Delivery Nanosystems for Biomedical Applications

    • 1 Edición
    • Chandra P. Sharma
    • Inglés
    Drug Delivery Nanosystems for Biomedical Application reviews some of the most challenging nanosystems with different routes of delivery that are useful for specific drugs, from both efficacy and bioavailability points-of-view. The chapters explore how this area is developing, the present state of the field, and future developments, in particular, inorganic, metallic, polymeric, composite and lipid nanosystems and their possible evolution to clinical applications. The book is a valuable research reference for both researchers and industrial partners who are not only interested in learning about this area, but also want to gain insights on how to move towards translational research.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 104
    • Inglés
    Advances in Applied Microbiology, Volume 104, continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas, with this updated volume including chapters covering Cold Shock Responses in Salmonella, Microbial Processes in Geotechnical Engineering, Microbial Diversity and Functional Analysis, The Mycosphere and Turnover of Contaminants, and the Enhancement of Metallosphaera Sedula Bioleaching by Targeted Recombination and Adaptive Laboratory Evolution.

  • Risk Assessment for Human Metal Exposures

    Mode of Action and Kinetic Approaches
    • 1 Edición
    • Gunnar F. Nordberg + 1 más
    • Inglés
    Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA –TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication—the classic risk assessment paradigm—with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment.

  • Encyclopedia of Bioinformatics and Computational Biology

    ABC of Bioinformatics
    • 1 Edición
    • Shoba Ranganathan + 2 más
    • Inglés
    Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries.

  • Bioethanol Production from Food Crops

    Sustainable Sources, Interventions, and Challenges
    • 1 Edición
    • Ramesh C. Ray + 1 más
    • Inglés
    Bioethanol Production from Food Crops: Sustainable Sources, Interventions and Challenges comprehensively covers the global scenario of ethanol production from both food and non-food crops and other sources. The book guides readers through the balancing of the debate on food vs. fuel, giving important insights into resource management and the environmental and economic impact of this balance between demands. Sections cover Global Bioethanol from Food Crops and Forest Resource, Bioethanol from Bagasse and Lignocellulosic wastes, Bioethanol from algae, and Economics and Challenges, presenting a multidisciplinary approach to this complex topic. As biofuels continue to grow as a vital alternative energy source, it is imperative that the proper balance is reached between resource protection and human survival. This book provides important insights into achieving that balance.

  • Noninvasive Prenatal Testing (NIPT)

    Applied Genomics in Prenatal Screening and Diagnosis
    • 1 Edición
    • Lieve Page-Christiaens + 1 más
    • Inglés
    Since its introduction in 2012, cell-free (cf) DNA based Non-Invasive Prenatal Testing (NIPT) has been employed to test for fetal chromosome abnormalities, and gene mutations that lead to a variety of genetic conditions, by millions of pregnant women, in more than 90 countries worldwide. With Noninvasive Prenatal Testing (NIPT): Applied Genomics in Prenatal Screening and Diagnosis, Dr Lieve Page-Christiaens and Dr Hanns-Georg Klein have compiled the first authoritative volume on cfDNA NIPT methods and their clinical implementation.

  • Cardiovascular Thrombus

    From Pathology and Clinical Presentations to Imaging, Pharmacotherapy and Interventions
    • 1 Edición
    • On Topaz
    • Inglés
    Cardiovascular Thrombus: From Pathology and Clinical Presentations to Imaging, Pharmacotherapy and Interventions provides a comprehensive, up-to-date presentation of the research and clinical practices as related to the contemporary aspects of the diagnosis and management of cardiovascular thrombosis. The formation, identification and management of cardiovascular thrombus is of paramount importance for researchers and practicing physicians, yet it remains one of the most challenging diagnostic and clinical scenarios. This important reference connects between research, up-to-date clinical knowledge, and the technological tools available for diagnosis and management of thrombus in cardiovascular medicine. The book includes comprehensive descriptions and review of pathology, clinical presentations, diagnosis, pharmacotherapy, interventions and future trends. It is the perfect reference for basic science students and researchers in general and interventional cardiology, general and interventional radiology, vascular medicine specialists, and vascular, general and cardiac surgeons.

  • Analysis of Pesticide in Tea

    Chromatography-Mass Spectrometry Methodology
    • 1 Edición
    • Guo-Fang Pang
    • Inglés
    Analysis of Pesticide in Tea: Chromatography-Mass Spectrometry Methodology is a comprehensive book, providing serial, rapid, high-throughput analytical methods for determining more than 600 pesticides in tea. There are increasing numbers of strict limit standards for pesticide residues in edible agricultural products in countries all over the world. The threshold for pesticide residues in tea is high for international trade. At present, 17 countries and international organizations have stipulated MRL levels for over 800 pesticide residues in tea. All methods described in this book are validated by an independent, U.S.-based organization (AOAC International), and all indexes have satisfied AOAC International's criteria. China has a history of 5000 years in growing tea and is a large tea producer with 80 million people involved in tea growing. China exports tea to over 100 countries worldwide, enjoying a high reputation for quality and variety.

  • Advanced Rehabilitative Technology

    Neural Interfaces and Devices
    • 1 Edición
    • Qingsong Ai + 3 más
    • Inglés
    Advanced Rehabilitative Technology: Neural Interfaces and Devices teaches readers how to acquire and process bio-signals using biosensors and acquisition devices, how to identify the human movement intention and decode the brain signal, how to design physiological and musculoskeletal models and establish the neural interfaces, and how to develop neural devices and control them efficiently using biological signals. The book takes a multidisciplinary theme between the engineering and medical field, including sections on neuromuscular/brain signal processing, human motion and intention recognition, biomechanics modelling and interfaces, and neural devices and control for rehabilitation. Each chapter goes through a detailed description of the bio-mechatronic systems used and then presents implementation and testing tactics. In addition, it details new neural interfaces and devices, some of which have never been published before in any journals or conferences. With this book, readers will quickly get up-to-speed on the most recent and future advancements in bio-mechatronics engineering for applications in rehabilitation.

  • Darwin’s Pangenesis and Its Rediscovery Part B

    • 1 Edición
    • Volumen 102
    • Dhavendra Kumar
    • Inglés
    Darwin’s Pangenesis and its Rediscovery Part B explores Darwin's Pangenesis, an expanded cell theory and unified theory of heredity and variation from over 150 years ago that strengthened his theory of evolution and explained many phenomena of life. Now, new discoveries on circulating DNA, mobile RNAs, prions and extracellular vesicles are providing striking evidence for the chemical existence of Darwin’s imaginary gemmules. In addition, new evidence for the inheritance of acquired characters, graft hybridization, and many other phenomena that Pangenesis supposedly explains are progressing, and are hence explored in this comprehensive volume. Specific chapters in this new volume include Darwin and Mendel: The Historical Connection, Darwin’s Pangenesis and Graft Hybridization, Darwin’s Pangenesis and Medical Genetics, Darwin’s Pangenesis and Certain Anomalous Phenomena, and Natural Selection and Pangenesis: The Darwinian Synthesis.

  • Polyphenols in Plants

    Isolation, Purification and Extract Preparation
    • 2 Edición
    • Ronald Ross Watson
    • Inglés
    Polyphenols in Plants: Isolation, Purification and Extract Preparation, 2nd edition, provides a detailed insight into polyphenols that occur naturally in plants and how they can be affected during growth and development, then effectively removed and optimized for various applications in food production. Historically, plants have been the major sources for drugs and health promotion. While there are a small number of nutrients contained, the growing focus is on the very diverse, complex ring structures: polyphenols that are not nutritious. In order to study or use them in patient treatment, the polyphenols need to be isolated, identified, and purified for application and study. This book brings together experts in the field who share their ongoing examination of isolation and purification of polyphenols as well as determination of their structures and composition. Polyphenols in Plants covers a range of new topics including polyphenols in vegetable waste and agricultural byproducts, extraction methods and characterization of polyphenols, and isolation techniques in the development of new compounds and their use in cancer therapy. This book will be useful to plant scientists and dietary supplement producers, as well as scientists in the food industry and alternative medicine who are interested in the specific health benefits of various dietary extracts and other polyphenol resources.

  • Postharvest Disinfection of Fruits and Vegetables

    • 1 Edición
    • Mohammed Wasim Siddiqui
    • Inglés
    Postharvest Disinfection of Fruits and Vegetables describes available technologies to reduce microbial infection for maintaining postharvest quality and safety. The book analyzes alternative and traditional methodologies and points out the significant advantages and limitations of each technique, thus facilitating both cost and time savings. This reference is for anyone in the fresh produce industry who is involved in postharvest handling and management. It discusses, in detail, the latest disinfection approaches, low-cost treatment strategies, management and protocols to control fresh produce qualities, diseases and insect infestation.

  • Obesity

    Oxidative Stress and Dietary Antioxidants
    • 1 Edición
    • Amelia Marti del Moral + 1 más
    • Inglés
    Obesity: Oxidative Stress and Dietary Antioxidants cover the science of oxidative stress in obesity and associated conditions, including metabolic syndrome, bariatric surgery, and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are not described in isolation, but in concert with other processes, such as apoptosis, cell signaling and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is but a single component. The book is designed for nutritionists, dietitians, food scientists, physicians and clinical workers, health care workers and research scientists.

  • The Teeth of Mammalian Vertebrates

    • 1 Edición
    • Barry Berkovitz + 1 más
    • Inglés
    "The Teeth of Mammalian Vertebrates is an important reference for researchers in dentistry, comparative morphology, anthropology, and vertebrate palaeontology, and those with an interest in exploring and understanding diversity. The book provides a comprehensive and informed analysis of mammalian dentitions and highlights the importance of teeth as drivers and mirrors of evolution and diversity." - Journal of Anatomy The Teeth of Mammalian Vertebrates presents a comprehensive survey of mammalian dentitions that is based on material gathered from museums and research workers from around the world. The teeth are major factors in the success of mammals, and knowledge of tooth form and function is essential in mammalian biology. Illustrated with high-quality color photographs of skulls and dentitions, together with X-rays, CT images and histology, this book reveals the tremendous variety of tooth form and structure in mammals. Written by two internationally-reco... experts in dental anatomy, the book provides an up-to-date account of how teeth are adapted to acquiring and processing food. With its companion volume, this book provides a complete survey of the teeth of vertebrates. It is the ideal resource for students and researchers in zoology, biology, anthropology, archaeology and dentistry.

  • Lentils

    Potential Resources for Enhancing Genetic Gains
    • 1 Edición
    • Mohar Singh
    • Inglés
    Lentils: Potential Resources for Enhancing Genetic Gains describes the evolutionary aspects and agronomic potential of this important pulse with emphasis placed on wide hybridization, including molecular aspects and future breeding strategies. The existing variability among cultivated germplasm has been exploited to reach a desirable level of productivity. However, to attain further breakthroughs in increasing yield and improving stability in future cultivars, new sources of genes/alleles need to be identified and incorporated into cultivated varieties. This book provides specific use information, including wild lentil germplasm utilization, thus allowing for the selection of transgressive interspecific recombinants that can be adapted to specific environments.

  • Principles of Regenerative Medicine

    • 3 Edición
    • Anthony Atala + 3 más
    • Inglés
    Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies.

  • Retrovirus-Cell Interactions

    • 1 Edición
    • Leslie Parent
    • Inglés
    Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences.

  • Radical SAM Enzymes

    • 1 Edición
    • Volumen 606
    • Inglés
    Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more.

  • Cerebral Lateralization and Cognition: Evolutionary and Developmental Investigations of Behavioral Biases

    • 1 Edición
    • Volumen 238
    • Inglés
    Cerebral Lateralization and Cognition: Evolutionary and Developmental Investigations of Motor Biases, Volume 238, the latest release in the Progress in Brain Research series, discusses interdisciplinary research on the influence of cerebral lateralization on cognition within an evolutionary framework. Chapters of note in this release include Evolutionary Perspectives: Visual/Motor Biases and Cognition, Manual laterality and cognition through evolution: An archeological perspective, Laterality in insects, Motor asymmetries in fish, amphibians and reptiles, Visual biases and social cognition in animals, Mother and offspring lateralized social interaction across animal species, Manual bias, personality and cognition in common marmosets and other primates, and more.

  • Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies

    • 1 Edición
    • Sorin Hostiuc
    • Inglés
    Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students. As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource.

  • Neuro-oncology, An Issue of Neurologic Clinics

    • 1 Edición
    • Volumen 36-3
    • Patrick Y Wen + 1 más
    • Inglés
    This issue of Neurologic Clinics, edited by Drs. Patrick Y. Wen and Eudocia Quant Lee, will focus on Neuro-oncology. Topiocs include, but are not limited to, Epidemiology of brain tumors, Molecular pathogenesis of brain tumors, Changes in WHO classification of brain tumors, Neurologic and medical management of brain tumors, Grade 2 and 3 Gliomas, Glioblastoma, Benign brain tumors, Primary CNS lymphoma and neurologic complications of systemic lymphoma, Pediatric brain tumors, Brain metastases, Metastatic complications of cancer, Neurologic complications of radiation therapy, Neurologic complications of systemic anticancer therapies, Neurocognitive complaints in cancer patients, and Paraneoplastic syndromes.

  • Gunner Goggles Neurology

    • 1 Edición
    • Hao-Hua Wu + 1 más
    • Inglés
    The Gunner Goggles Series is the first exam prep resource written by a high-scoring peer group of medical students, ensuring the most practical and efficient study guidance. It organizes topics around the USMLE and NBME content outlines for the required shelf exams and features state-of-the-art Augmented Reality (AR) mobile application to extend learning beyond the book. This innovative series features AR opportunities throughout the text for an integrated print-mobile experience that maximizes learning and test preparation. The Gunner Goggle function allows you to scan pages for integrated AR links, unlocking animations, visuals, and 3D models that clarify complex anatomy, conditions, and concepts in a remarkably effective and unique manner. Gunner Goggles Series: Neurology is one of seven authoritative exam preparation guides that use cutting-edge AR technology to fully prepare you for the NBME clinical shelf exams, the USMLE Step 2 Clinical Knowledge (CK) exam, and successful clinical rotations.

  • Marine Mammal Ecotoxicology

    Impacts of Multiple Stressors on Population Health
    • 1 Edición
    • Maria Cristina Fossi + 1 más
    • Inglés
    Marine Mammal Ecotoxicology: Impacts of Multiple Stressors on Population Health provides tactics on how to develop a comprehensive methodology for the study of existing threats to marine mammals. By presenting a conservation-biology approach and new and emerging technologies, this work helps provide crucial knowledge on the status of marine mammal populations that not only helps readers understand the ecosystem’s health, but also instigate mitigation measures. This volume provides information that helps investigators unravel the relationships between exposure to environmental stressors (e.g., climate change, pollutants, marine litter, pathogens and biotoxins) and a range of endpoints in marine mammal species. The application of robust examination procedures and biochemical, immunological, and molecular techniques, combined with pathological examination and feeding ecology, has led to the development of health assessment methods at the individual and population levels in wild marine mammals.

  • Polyphenols: Mechanisms of Action in Human Health and Disease

    • 2 Edición
    • Ronald Ross Watson + 2 más
    • Inglés
    Polyphenols: Mechanisms of Action in Human Health and Disease, Second Edition describes the mechanisms of polyphenol antioxidant activities and their use in disease prevention. Chapters highlight the anti-inflammatory activity of polyphenols on key dendritic cells, how they modulate and suppress inflammation, and how they are inactivated or activated by metabolism in the gut and circulating blood. Polyphenols have proven effective for key health benefits, including bone health, organ health, cardiac and vascular conditions, absorption and metabolism, and cancer and diseases of the immune system. They are a unique group of phytochemicals that are present in all fruits, vegetables and other plant products. This very diverse and multi-functional group of active plant compounds contain powerful antioxidant properties and exhibit remarkable chemical, biological and physiological properties, including cancer prevention and cardio-protective activities.

  • Polyphenols: Prevention and Treatment of Human Disease

    • 2 Edición
    • Ronald Ross Watson + 2 más
    • Inglés
    Polyphenols in Prevention and Treatment of Human Disease, Second Edition authoritatively covers evidence of the powerful health benefits of polyphenols, touching on cardiovascular disease, cancer, obesity, diabetes and osteoporosis. This collection represents the contributions of an international group of experts in polyphenol research who share their expertise in endocrinology, public health, cardiology, pharmacology, agriculture and veterinary science. Researchers from diverse backgrounds will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted insights into the mechanisms of disease. This reference fills a void in research where nutritionists and alternative therapies may be applicable.

  • The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology

    • 1 Edición
    • Fernando Cobo
    • Inglés
    The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities.

  • Human Genome Informatics

    Translating Genes into Health
    • 1 Edición
    • Christophe Lambert + 2 más
    • Inglés
    Human Genome Informatics: Translating Genes into Health examines the most commonly used electronic tools for translating genomic information into clinically meaningful formats. By analyzing and comparing interpretation methods of whole genome data, the book discusses the possibilities of their application in genomic and translational medicine. Topics such as electronic decision-making tools, translation algorithms, interpretation and translation of whole genome data for rare diseases are thoroughly explored. In addition, discussions of current human genome databases and the possibilities of big data in genomic medicine are presented. With an updated approach on recent techniques and current human genomic databases, the book is a valuable source for students and researchers in genome and medical informatics. It is also ideal for workers in the bioinformatics industry who are interested in recent developments in the field.

  • Biological Emerging Risks in Foods

    • 1 Edición
    • Volumen 86
    • Inglés
    Biological Emerging Risks in Foods, Volume 86, addresses the emerging biological risks in food from a global context. Specific sections in this new release include discussions on parasites in foods as an emerging issue and antimicrobial resistance in the food chain. Specific chapters cover Norovirus: the burden of the unknown, Hepatitis E virus: a new foodborne zoonotic concern, Parasites in foods: from a neglected position to an emerging issue, Antimicrobial resistance in the food chain: an emerging global concern, Salmonella in foods: a reemerging problem, Listeria monocytogenes in foods, and Campylobacter in the food chain.

  • Fundamentals of Congenital Minimally Invasive Cardiac Surgery

    • 1 Edición
    • Vladimiro Vida + 1 más
    • Inglés
    Fundamentals of Congenital Minimally Invasive Cardiac Surgery is a first of its kind, fully-illustrated guide that is solely dedicated to the most diffused congenital minimally invasive cardiac surgery procedures. It provides detailed, step-by-step descriptions of surgical maneuvers to underline each aspect of the procedures along with full color drawings and operative pictures to enhance understanding. Each chapter fully describes the preoperative setting, the needed materials and the required technical skills that make specific congenital heart defects amenable to minimally invasive surgical treatment. This is the perfect go-to reference for pediatric and congenital cardiac surgeons, and is also a must-have guide for residents in cardiac surgery who are looking to review the technical aspects and outcomes of utilizing a minimally invasive approach for cardiac surgery.

  • The Sourcebook for Clinical Research

    A Practical Guide for Study Conduct
    • 1 Edición
    • Jeff Nelligan + 1 más
    • Inglés
    A single trial is complex, with numerous regulations, administrative processes, medical procedures, deadlines and specific protocol instructions to follow. And yet, there has existed no single-volume, comprehensive clinical research reference manual for investigators, medical institutions, and national and international research personnel to keep on the shelf as a ready reference to navigate through trial complexities and ensure compliance with U.S. Federal Regulations and ICH GCP until The Sourcebook for Clinical Research. An actionable, step-by-step guide through beginning to advanced topics in clinical research with forms, templates and checklists to download from a companion website, so that study teams will be compliant and will find all the necessary tools within this book. Additionally, the authors developed Display Posters for Adverse Events Plus Reporting and Medicare Coverage Analysis that can be purchased separately here: https://www.elsevier... Moreover, The Sourcebook for Clinical Research contains clear information and guidance on the newest changes in the industry to keep seasoned investigators and staff current and compliant, in addition to providing detailed information regarding the most complex topics. This book serves as a quick, actionable, off-the-shelf resource to keep by your side at the medical clinic.

  • Pharmacovigilance: A Practical Approach

    • 1 Edición
    • Thao Doan + 4 más
    • Inglés
    Written by experts in the field of pharmacovigilance and patient safety, this concise resource provides a succinct, easy-to-digest overview of an increasingly critical area of medical safety. Drs. Thao Doan, Cheryl Renz, Fabio Lievano, Mondira Bhattacharya, and Linda Scarazzini provide essential information for health care professionals, clinical researchers, and regulators who need a comprehensive, up-to-date source of information on the principles and practice of pharmacovigilance.

  • Mitochondria and Longevity

    • 1 Edición
    • Volumen 340
    • Inglés
    Mitochondria and Longevity, Volume 340, the latest release in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics with this release focusing on topics such as Mitochondria metabolism and aging, Mitohormesis, Mitochondrial dynamics in the aging stem cell compartment, Mitochondrial proteostasis and aging, Mitochondrial DNA mutations and aging, Mitochondrial sirtuins, NAD+, NADH and aging, Mitophagy and aging, Mitochondria, calcium transport and aging.

  • Neuroinflammation

    • 2 Edición
    • Alireza Minagar
    • Inglés
    Neuroinflammation, Second Edition, discusses the role inflammation plays in neuro-inflammatory diseases. As research in neuroinflammation has dramatically increased in recent years, this new edition covers all of the new developments and findings since the first publication nearly a decade ago. Comprehensive coverage of topics includes chapters on multiple sclerosis, optic neuritis and Susac syndrome. New chapters cover the latest research in Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury, amongst other topics. Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, brain trauma and meningitis, and it contributes to the generation of pain. Researchers are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage, through tolerance, and to modulation and repair.

  • Neuroepigenetics and Mental Illness

    • 1 Edición
    • Volumen 158
    • Bart P.F. Rutten
    • Inglés
    Neuroepigenetics and Mental Illness, Volume 158, the latest release in the Progress in Molecular Biology and Translational Science series, seeks to provide the most topical, informative, and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series seeks to provide readers with in-depth knowledge of important molecular biological aspects of organismal physiology and function, with this release focusing on Neuroepigenetics in mental illness, Neuroepigenetics of development and neurodevelopmental disorder, Neuroepigenetics of aging and age-related neurodegenerative disorders, Neuroepigenetics of prenatal psychological stress, Neuroepigenetics of the HPA axis, Neuroepigenetics of the serotonergic system, and more.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 151
    • Donald L. Sparks
    • Inglés
    Advances in Agronomy, Volume 151, continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied, and exemplary of the abundant subject matter addressed by this long-running serial.

  • Dosage Form Design Considerations

    Volume I
    • 1 Edición
    • Inglés
    Dosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries.

  • Sphingolipids in Cancer

    • 1 Edición
    • Volumen 140
    • Inglés
    Sphingolipids in Cancer, Volume 140, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Topics discussed in this updated volume include Mechanisms of ceramide-dependent cancer cell death, Sphingolipids as regulators of autophagy and endocytic trafficking, The role and function of sphingomyelin biosynthesis in the development of cancer, Neutral sphingomyelinases in cancer: Friend or foe?, Sphingolipid rendezvous at the crossroad of NAFLD and senescence, Ceramide signaling and p53 pathways, Sphingolipid regulation of RNA Biology in cancer phenotypes, The role of ceramide-1-phosphate in tumor cell survival and dissemination, and more.

  • Wearable Technology in Medicine and Health Care

    • 1 Edición
    • Raymond K. Y. Tong
    • Inglés
    Wearable Technology in Medicine and Health Care provides readers with the most current research and information on the clinical and biomedical applications of wearable technology. Wearable devices provide applicability and convenience beyond many other means of technical interface and can include varying applications, such as personal entertainment, social communications and personalized health and fitness. The book covers the rapidly expanding development of wearable systems, thus enabling clinical and medical applications, such as disease management and rehabilitation. Final chapters discuss the challenges inherent to these rapidly evolving technologies.

  • Modern Techniques for Food Authentication

    • 2 Edición
    • Da-Wen Sun
    • Inglés
    Modern Techniques for Food Authentication, Second Edition presents a comprehensive review of the novel techniques available to authenticate food products, including various spectroscopic technologies, methods based on isotopic analysis and chromatography, and other techniques based on DNA, enzymatic analysis and electrophoresis. This new edition pinpoints research and development trends for those working in research, development and operations in the food industry, giving them readily accessible information on modern food authentication techniques to ensure a safe and authentic food supply. It will also serve as an essential reference source to undergraduate and postgraduate students, and for researchers in universities and research institutions.

  • Dosage Form Design Parameters

    Volume II
    • 1 Edición
    • Inglés
    Dosage Form Design Parameters, Volume II, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries.

  • Prostate Cancer

    A Case Report
    • 1 Edición
    • Gilles Plourde
    • Inglés
    Prostate Cancer: A Case Report discusses the prevention, treatment modalities, and side effects of the medications used to treat prostate cancer. The book presents the most appropriate information, allowing patient empowerment to make informed decisions on their choice of treatments. Through the analysis of a real case report, the book also discusses the main complication associated with prostate cancer—bone metastasis—and provides information on treatment modalities for lung and liver metastasis. Diet, physical activities and the management of stress are also discussed, as is palliative care and the use of palliative sedation when other treatment modalities have failed. Cannabis, the pros and cons of euthanasia, and concerns raised by society are also covered. Esteemed author Dr. Plourde has more than 12 years’ experience working on drug safety, especially for biologic products involved in the treatment of various cancers. For more than 4 years he has suffered from prostate cancer with metastasis to the lungs and bones. During this time he has learned a lot on prostate cancer from the medical literature and from discussions with various specialists. The case report presented in this book represents his own medical history. Prostate Cancer: A Case Report provides the most relevant and up to date information on the various aspects involved in the screening, diagnosis and treatment of prostate cancer.

  • Manejo de la retinopatía diabética

    • 1 Edición
    • Caroline R. Baumal + 1 más
    • Español
    La obra analiza los factores de riesgo y la clasificación de la retinopatía diabética, además de estudiar cada modalidad de tratamiento. El título aborda los hot topic con las evidencias más recientes que guiarán al lector a través de cada opción terapéutica. Los casos clínicos que se presentan sirven para mostrar diversos aspectos del tratamiento de la retinopatía diabética complicada. Los autores han elaborado un práctico manual de ayuda para la selección de los fármacos más adecuados y que permitan obtener los mejores resultados para el paciente.

  • Darwin’s Pangenesis and Its Rediscovery Part A

    • 1 Edición
    • Volumen 101
    • Inglés
    Darwin’s Pangenesis and Its Rediscovery Part A highlights the findings of Darwin's Pangenesis, an expanded cell theory and unified theory of heredity and variation that strengthened his theory of evolution and explained many phenomena of life. Now, new advances and the discovery of circulating cell-free DNA, mobile RNAs, prions and extracellular vesicles are providing new breakthroughs, thus increasing evidence on the inheritance of acquired characters, graft hybridization, and many other phenomena that Pangenesis suggests. Sections of note in this volume include the rationale, criticisms, influence and recent molecular evidence of Darwin's Pangenesis, as well as its relation to the inheritance of acquired characters, which is often included under the blanket term "transgenerational epigenetic inheritance."

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