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Elsevier

Libros en Ciencias de la Vida

  • Essays on Developmental Biology Part B

    • 1 Edición
    • Volumen 117
    • Paul Wassarman
    • Inglés
    In 2016 Current Topics in Developmental Biology (CTDB) will celebrate its 50th or “golden” anniversary. To commemorate the founding of CTDB by Aron Moscona (1921-2009) and Alberto Monroy (1913-1986) in 1966, a two-volume set of CTDB (volumes 116 and 117), entitled Essays on Development, will be published by Academic Press/Elsevier in early 2016. The volumes are edited by Paul M. Wassarman, series editor of CTDB, and include contributions from dozens of outstanding developmental biologists from around the world. Overall, the essays provide critical reviews and discussion of developmental processes for a variety of model organisms. Many essays relate the history of a particular area of research, others personal experiences in research, and some are quite philosophical. Essays on Development provides a window onto the rich landscape of contemporary research in developmental biology and should be useful to both students and investigators for years to come.

  • Adenoviral Vectors for Gene Therapy

    • 2 Edición
    • David T. Curiel
    • Inglés
    Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

  • Stress: Concepts, Cognition, Emotion, and Behavior

    Handbook of Stress Series, Volume 1
    • 1 Edición
    • George Fink
    • Inglés
    Stress: Concepts, Cognition, Emotion, and Behavior: Handbook in Stress Series, Volume 1, examines stress and its management in the workplace and is targeted at scientific and clinical researchers in biomedicine, psychology, and some aspects of the social sciences. The audience is appropriate faculty and graduate and undergraduate students interested in stress and its consequences. The format allows access to specific self-contained stress subsections without the need to purchase the whole nine volume Stress handbook series. This makes the publication much more affordable than the previously published four volume Encyclopedia of Stress (Elsevier 2007) in which stress subsections were arranged alphabetically and therefore required purchase of the whole work. This feature will be of special significance for individual scientists and clinicians, as well as laboratories. In this first volume of the series, the primary focus will be on general stress concepts as well as the areas of cognition, emotion, and behavior.

  • Friends and Partners

    The Legacy of Franklin D. Roosevelt and Basil O’Connor in the History of Polio
    • 1 Edición
    • David W. Rose
    • Inglés
    Friends and Partners: The Legacy of Franklin D. Roosevelt and Basil O’Connor in the History of Polio presents the story of two men, one the President of the United States, the other an ambitious attorney, who became the "architects of the fight against polio." With unfettered access to the March of Dimes Archives, this book explores the friendship and partnership that ensured the end of polio in the US, with exclusive pictures and documentation. The book describes the founding and history of Franklin D. Roosevelt’s (FDR) polio colony in Warm Springs, Georgia, and the early years of the March of Dimes as established by FDR in 1938 as the National Foundation for Infantile Paralysis. Other little-known aspects of the partnership are also included, such as O’Connor’s participation in FDR’s "Brain Trust," the President’s birthday ball fundraisers during the Great Depression, the March of Dimes during World War II, and O’Connor’s simultaneous leadership of the American Red Cross. Finally, the book explores, in detail, how O’Connor used the legacy of FDR after his death in 1945 to promote the philosophy of "freedom from disease" to achieve the goal of ending polio through the March of Dimes. Friends and Partners: The Legacy of Franklin D. Roosevelt and Basil O’Connor in the History of Polio will appeal to researchers, students, and policy makers in public health and medicine as well as all those interested in learning more about this pivotal period in history.

  • Essays on Developmental Biology Part A

    • 1 Edición
    • Volumen 116
    • Inglés
    In 2016 Current Topics in Developmental Biology (CTDB) will celebrate its 50th or “golden” anniversary. To commemorate the founding of CTDB by Aron Moscona (1921-2009) and Alberto Monroy (1913-1986) in 1966, a two-volume set of CTDB (volumes 116 and 117), entitled Essays on Development, will be published by Academic Press/Elsevier in early 2016. The volumes are edited by Paul M. Wassarman, series editor of CTDB, and include contributions from dozens of outstanding developmental biologists from around the world. Overall, the essays provide critical reviews and discussion of developmental processes for a variety of model organisms. Many essays relate the history of a particular area of research, others personal experiences in research, and some are quite philosophical. Essays on Development provides a window onto the rich landscape of contemporary research in developmental biology and should be useful to both students and investigators for years to come.

  • Neuropathology of Drug Addictions and Substance Misuse Volume 1

    Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids
    • 1 Edición
    • Victor R. Preedy
    • Inglés
    Neuropathology of Drug Addictions and Substance Misuse, Volume One: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids, Opioids and Emerging Addictions provides the latest research in an area that shows that the neuropathological features of one addiction are often applicable to those of others. The book also details how a further understanding of these commonalties can provide a platform for the study of specific addictions in greater depth, all in an effort to create new modes of understanding, causation, prevention, and treatment. The three volumes in this series address new research and challenges, offering comprehensive coverage on the adverse consequences of the most common drugs of abuse, with each volume serving to update the reader’s knowledge on the broader field of addiction, while also deepening our understanding of specific addictive substances. Volume One addresses tobacco, alcohol, cannabinoids, and opioids, with each section providing data on the general, molecular/cellular, and structural/functiona... neurological aspects of a given substance, along with a focus on the adverse consequences of addictions.

  • Gaseous Air Pollutants and Plant Metabolism

    • 1 Edición
    • M. J. Kozioł + 1 más
    • Inglés
    Gaseous Air Pollutants and Plant Metabolism mainly talks about plants and air pollution. The publication of this book is inspired by a symposium on plants and pollution, which generated great interest among the personnel related to the field. The book begins with a brief background on air pollution and continues with a discussion on different types, effects, and solutions to the pollution. The book also features studies about the gaseous air pollution in North America, China, and Japan. The chapters that follow explore the different effects of pollution on chloroplasts, respiration, biochemistry, plant, and plant cells. The text is a valuable reference to undergraduates or postgraduates of chemistry and its related studies.

  • Fundamentals of Brain Network Analysis

    • 1 Edición
    • Alex Fornito + 2 más
    • Inglés
    Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization.

  • Cardiac MRI in Diagnosis, Clinical Management, and Prognosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

    • 1 Edición
    • Aiden Abidov + 2 más
    • Inglés
    Cardiac MRI in Diagnosis, Clinical Management and Prognosis of Arrhythmogenic Right Ventricular Cardiomyopathy / Dysplasia provides up-to-date information regarding the most effective diagnostic protocols and CMR sequences for the evaluation of patients with suspected or known ARVC/D. It includes CMR protocol summaries and clinical algorithms presented as flow diagrams, many of which have never been previously published. The book contains case reports from the practice and database of Dr. Frank I. Marcus, world renowned ARVC/D expert; as well as input from imaging experts from a large academic center with unique RV pathology imaging experience. This title is the perfect pocket companion for cardiologists, pediatric cardiologists, cardiac imaging and electrophysiology specialists as well as cardiology researchers.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 73
    • Inglés
    Advances in Clinical Chemistry, Volume 73, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Women and Positive Aging

    An International Perspective
    • 1 Edición
    • Lisa Hollis-Sawyer + 1 más
    • Inglés
    Women and Positive Aging: An International Perspective presents the noted research in the fields of psychology, gerontology, and gender studies, reflecting the increasingly popular and pervasive positive aging issues of women in today’s society from different cohorts, backgrounds, and life situations. Each section describes a bridge between the theoretical aspects and practical applications of the theory that is consistent with the scientist-practition... training model in psychology, including case studies and associated intervention strategies with older women in each chapter. In addition to incorporating current research on aging women’s issues, each section provides the reader with background about the topic to give context and perspective.

  • Proteomic Profiling and Analytical Chemistry

    The Crossroads
    • 2 Edición
    • Pawel Ciborowski + 1 más
    • Inglés
    Proteomic Profiling and Analytical Chemistry: The Crossroads, Second Edition helps scientists without a strong background in analytical chemistry to understand principles of the multistep proteomic experiment necessary for its successful completion. It also helps researchers who do have an analytical chemistry background to break into the proteomics field. Highlighting points of junction between proteomics and analytical chemistry, this resource links experimental design with analytical measurements, data analysis, and quality control. This targeted point of view will help both biologists and chemists to better understand all components of a complex proteomic study. The book provides detailed coverage of experimental aspects such as sample preparation, protein extraction and precipitation, gel electrophoresis, microarrays, dynamics of fluorescent dyes, and more. The key feature of this book is a direct link between multistep proteomic strategy and quality control routinely applied in analytical chemistry. This second edition features a new chapter on SWATH-MS, substantial updates to all chapters, including proteomic database search and analytical quantification, expanded discussion of post-hoc statistical tests, and additional content on validation in proteomics.

  • Breast Cancer Screening

    Making Sense of Complex and Evolving Evidence
    • 1 Edición
    • Nehmat Houssami + 1 más
    • Inglés
    Breast Cancer Screening: Making Sense of Complex and Evolving Evidence covers broad aspects of breast cancer screening specifically focusing on current evidence, emerging evidence, and issues that will be critical for future breast screening practice such as tailored screening and shared decision-making in breast screening. The scope of the book is relevant to a global audience. This book provides balanced perspectives on this increasingly controversial topic, using scientific evidence to explain the evolution of knowledge relating to breast cancer screening. Breast Cancer Screening covers the key points related to this debate including the context of increasingly complex and conflicting evidence, divergent opinions on the benefits and harms of breast screening, and variability in screening practice and outcomes across settings around the world.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 91
    • Inglés
    First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews on all areas of interest in contemporary parasitology. The series includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications. The 2014 impact factor is 6.226.

  • Gliomas

    • 1 Edición
    • Volumen 134
    • Inglés
    Researchers’ knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book’s discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers. Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care.

  • Silicon Carbide Biotechnology

    A Biocompatible Semiconductor for Advanced Biomedical Devices and Applications
    • 2 Edición
    • Stephen E. Saddow
    • Inglés
    Silicon Carbide Biotechnology: A Biocompatible Semiconductor for Advanced Biomedical Devices and Applications, Second Edition, provides the latest information on this wide-band-gap semiconductor material that the body does not reject as a foreign (i.e., not organic) material and its potential to further advance biomedical applications. SiC devices offer high power densities and low energy losses, enabling lighter, more compact, and higher efficiency products for biocompatible and long-term in vivo applications, including heart stent coatings, bone implant scaffolds, neurological implants and sensors, glucose sensors, brain-machine-interf... devices, smart bone implants, and organ implants. This book provides the materials and biomedical engineering communities with a seminal reference book on SiC for developing technology, and is a resource for practitioners eager to identify and implement advanced engineering solutions to their everyday medical problems for which they currently lack long-term, cost-effective solutions.

  • Biotransformation of Agricultural Waste and By-Products

    The Food, Feed, Fibre, Fuel (4F) Economy
    • 1 Edición
    • Palmiro Poltronieri + 1 más
    • Inglés
    Biotransformation of Agricultural Waste and By-Products in the 4F Economy: The Food, Feed, Fiber, Fuel (4F) Economy presents an evaluation of plant species better exploitable for a particular transformation. As crops are already covering large parts of cultivable soils, is it is not conceivable to try to extend the cultures beyond the limit of available soils, but a further increase in productivity is not easy to obtain. The book discusses advances in technology and plants design which support the exploitation and valorization of vegetable and fruit by-products through fermentation (feed-batch liquid fermentation, solid-state fermentation) in bio-based bio-chemicals/biofue... production. Pathways in the biosynthesis of fibers, sugars, and metabolites are provided with a focus on the lifecycle of bacteria, yeasts, and even plant species. The text analyzes cellular structures and the organization of cell walls in order to show which polysaccharides offer more favorable fermentative processes and which are detrimental.

  • Biomechanics of the Female Pelvic Floor

    • 1 Edición
    • Lennox Hoyte + 1 más
    • Inglés
    Biomechanics of the Female Pelvic Floor, Second Edition, is the first book to specifically focus on this key part of women’s health, combining engineering and clinical expertise. This edited collection will help readers understand the risk factors for pelvic floor dysfunction, the mechanisms of childbirth related injury, and how to design intrapartum preventative strategies, optimal repair techniques, and prostheses. The authors have combined their expertise to create a thorough, comprehensive view of female pelvic floor biomechanics in order to help different disciplines discuss, research, and drive solutions to pressing problems. The book includes a common language for the design, conduct, and reporting of research studies in female PFD, and will be of interest to biomechanical and prosthetic tissue engineers and clinicians interested in female pelvic floor dysfunction, including urologists, urogynecologists, maternal fetal medicine specialists, and physical therapists.

  • Advances in Food and Nutrition Research

    • 1 Edición
    • Volumen 77
    • Inglés
    Advances in Food and Nutrition Research recognizes the integral relationship between the food and nutritional sciences, bringing together outstanding and comprehensive reviews that highlight this relationship. The book contains contributions that detail scientific developments in the broad areas of food science and nutrition, providing those in academia and industry with the latest information on emerging research in these constantly evolving sciences.

  • The Cytology of Effusions

    Pleural, Pericardial and Peritoneal and of Cerebrospinal Fluid
    • 2 Edición
    • A. I. Spriggs + 1 más
    • Inglés
    The Cytology of Effusions: Pleural, Pericardial and Peritoneal and of Cerebrospinal Fluid, Second Edition provides information pertinent to the cytology of effusion in various conditions. This book discusses the cytology of cerebrospinal fluid wherein the appropriate methods for studying this material are much the same as for serous fluids. Organized into nine chapters, this edition begins with an overview of the differential cell count from a serous fluid. This text then presents the nomenclature and descriptions of cells of serous effusions. Other chapters consider the cytological examinations of pleural or peritoneal fluid, which often shed light on the diagnosis in leukemias and lymphomas. This book discusses as well the general features of malignant effusions that may suggest the diagnosis. The final chapter deals with the distinction between polymorphonuclear and lymphocytic types of meningeal exudate made from an examination of the cerebrospinal fluid. This book is a valuable resource for pathologists and clinicians.

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1 Edición
    • Volumen 41
    • Inglés
    Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.

  • Nonsense Mutation Correction in Human Diseases

    An Approach for Targeted Medicine
    • 1 Edición
    • Fabrice Lejeune + 2 más
    • Inglés
    Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD). It presents the mechanism of action and rationale associated with each strategy to correct nonsense mutations with the results of clinical trials to further support this basis. In addition, the book shows how it may be possible to combine several of these strategies to ultimately improve the efficiency of correction, also suggesting the future goals and objectives to improve treatment modalities in this evolving sphere of personalized medicine.

  • G Protein-Coupled Receptors

    Signaling, Trafficking and Regulation
    • 1 Edición
    • Volumen 132
    • Inglés
    G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in G-Protein-Coupled Receptors, and includes sections on such topics signaling, trafficking and regulation.

  • Nitric Oxide and Signaling in Plants

    • 1 Edición
    • Volumen 77
    • Inglés
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 77th volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology.

  • Genes, Environment and Alzheimer's Disease

    • 1 Edición
    • Orly Lazarov + 1 más
    • Inglés
    Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease.

  • Tumor Immunology

    • 1 Edición
    • Volumen 130
    • Inglés
    Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. This volume focuses on tumor immunology.

  • Chemokines

    • 1 Edición
    • Volumen 570
    • Inglés
    Chemokines, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in chemokines, and includes sections on such topics as chemokine detection using receptors, tracking cellular responses to chemokines, recognition of GAG-bound chemokines, and the production of chemokine receptor complexes for structural and biophysical studies.

  • Epi-Informatics

    Discovery and Development of Small Molecule Epigenetic Drugs and Probes
    • 1 Edición
    • Jose Medina-Franco
    • Inglés
    Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes.

  • Nanotechnology Tools for the Study of RNA

    • 1 Edición
    • Volumen 139
    • Inglés
    This volume of Progress in Molecular Biology and Translational Science introduces emerging strategies of studying RNA structure and function using nanotechnological tools. The volume aims to provide the readers with a novel view and give them opportunities to think about how to incorporate the new technologies into their own research.

  • Advances in Genetics

    • 1 Edición
    • Volumen 93
    • Inglés
    Advances in Genetics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

  • Industrial Oil Crops

    • 1 Edición
    • Thomas McKeon + 3 más
    • Inglés
    Industrial Oil Crops presents the latest information on important products derived from seed and other plant oils, their quality, the potential environmental benefit, and the latest trends in industrial uses. This book provides a comprehensive view of key oil crops that provide products used for fuel, surfactants, paints and coatings, lubricants, high-value polymers, safe plasticizers and numerous other products, all of which compete effectively with petroleum-derived products for quality and cost. Specific products derived from oil crops are a principle concern, and other fundamental aspects of developing oil crops for industrial uses are also covered. These include improvement through traditional breeding, and molecular, tissue culture and genetic engineering contributions to breeding, as well as practical aspects of what is needed to bring a new or altered crop to market. As such, this book provides a handbook for developing products from renewable resources that can replace those currently derived from petroleum. Led by an international team of expert editors, this book will be a valuable asset for those in product research and development as well as basic plant research related to oil crops.

  • Pharmacological Mechanisms and the Modulation of Pain

    • 1 Edición
    • Volumen 75
    • Inglés
    Pharmacological Mechanisms and the Modulation of Pain, the newest volume in the Advances in Pharmacology series, presents the pharmacological mechanisms and the modulation of pain. With a variety of chapters and the best authors in the field, this volume is an essential resource for pharmacologists, immunologists, and biochemists alike.

  • The Diverse Faces of Bacillus Cereus

    • 1 Edición
    • Vincenzo Savini
    • Inglés
    The Diverse Faces of Bacillus cereus elucidates all characteristics of this microorganism, from its environmental and ecologic relevance, to its veterinary involvement, its clinical settings, most common B. cereus associated food poisoning episodes, and the newest airway disease pictures mimicking the inhalation of anthrax. Due to its environmental distribution, B. cereus may cause serious, even fatal human diseases. The organism shows many diverse faces, as it is not only a veterinary pathogen, but also used as a biocontrol agent to control vegetable decay due to its natural antimicrobial properties. Once considered as a mere colonizer or contaminant, Bacillus cereus is nowadays acquiring increasing importance as an agent of nosocomial infections. The book's target audience is familiar with this opportunistic pathogen and will benefit from this clear compendium on the classical and molecular techniques and procedures that may be adopted or followed to correctly identify this intriguing multi-faceted microorganism.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 94
    • Inglés
    Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology, and includes recent research on the roles of fungal communities in soil nutrient recycling, the microbial nitrogen cycle in soil, and the inter-kingdom associations between soil bacteria, fungi, and mycorrhizal fungi.

  • Ion Channels as Therapeutic Targets, Part A

    • 1 Edición
    • Volumen 103
    • Inglés
    Ion Channels as Therapeutic Targets is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

  • International Review of Cell and Molecular Biology

    • 1 Edición
    • Volumen 323
    • Inglés
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. The series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists.

  • Hsp90 in Cancer: Beyond the Usual Suspects

    • 1 Edición
    • Volumen 129
    • Inglés
    Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression.

  • Molecules to Medicine with mTOR

    Translating Critical Pathways into Novel Therapeutic Strategies
    • 1 Edición
    • Kenneth Maiese
    • Inglés
    Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin.

  • Thin Film Coatings for Biomaterials and Biomedical Applications

    • 1 Edición
    • Hans J Griesser
    • Inglés
    Thin Film Coatings for Biomaterials and Biomedical Applications discusses the latest information on coatings, including their historic use by scientists who are looking to improve the properties and biological responses of the material-host interface. Thin films, in particular, are becoming more widely researched and used as an alternative to traditional sprayed coatings because they have a more uniform structure and therefore greater stability. This book provides readers with a comprehensive guide to thin film coatings and their application in the biomaterials field. Part One of the book details the fundamentals of thin films for biomedical application, while Part Two looks at the special properties of thin films, with a final section reviewing functional thin films and their usage in biomedical applications.

  • Clinical Trials

    Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines
    • 2 Edición
    • Tom Brody
    • Inglés
    Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials.

  • Methods of Hydrobiology

    (Freshwater Biology)
    • 1 Edición
    • Jürgen Schwoerbel
    • Inglés
    Methods of Hydrobiology discusses the study of life of organism in water. It also discusses the science of inland waters, called limnology. The focuses of learning are animals, plants, and bacteria that live in water. The main object of the book is to review and evaluate the methods utilised to gather data on the characteristics of water dwellers. The topics of bacteriology are also covered. The fields of bacteriology that will be covered are hydrobacteriology, hydrobotany, and hydrozoology. The means of measurement and calculation applied by production biology are discussed. The text begins with a discussion of the types of water and their description. This is followed by a qualitative analysis of the phytoplankton. A separate chapter is devoted to the means for running water investigation. Another section of the book focuses on the procedures in the biological evaluation of underground water. The book will provide useful information to marine biologist, botanist, zoologist, microbiologist, students, and researches in the field of biological sciences.

  • Collaborative Genomics Projects: A Comprehensive Guide

    • 1 Edición
    • Margi Sheth + 2 más
    • Inglés
    Collaborative Genomics Projects: A Comprehensive Guide contains operational procedures, policy considerations, and the many lessons learned by The Cancer Genome Atlas Project. This book guides the reader through methods in patient sample acquisition, the establishment of data generation and analysis pipelines, data storage and dissemination, quality control, auditing, and reporting. This book is essential for those looking to set up or collaborate within a large-scale genomics research project. All authors are contributors to The Cancer Genome Atlas (TCGA) Program, a NIH- funded effort to generate a comprehensive catalog of genomic alterations in more than 35 cancer types. As the cost of genomic sequencing is decreasing, more and more researchers are leveraging genomic data to inform the biology of disease. The amount of genomic data generated is growing exponentially, and protocols need to be established for the long-term storage, dissemination, and regulation of this data for research. The book's authors create a complete handbook on the management of research projects involving genomic data as learned through the evolution of the TCGA program, a project that was primarily carried out in the US, but whose impact and lessons learned can be applied to international audiences.

  • The Innate Immune Response to Noninfectious Stressors

    Human and Animal Models
    • 1 Edición
    • Massimo Amadori
    • Inglés
    The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation.

  • Chemosensory Transduction

    The Detection of Odors, Tastes, and Other Chemostimuli
    • 1 Edición
    • Frank Zufall + 1 más
    • Inglés
    Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals.

  • Intracellular Consequences of Amyloid in Alzheimer's Disease

    • 1 Edición
    • Michael R. D'Andrea
    • Inglés
    Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.

  • Pharmacy Practice in Developing Countries

    Achievements and Challenges
    • 1 Edición
    • Ahmed Fathelrahman + 2 más
    • Inglés
    Pharmacy Practice in Developing Countries: Achievements and Challenges offers a detailed review of the history and development of pharmacy practice in developing countries across Africa, Asia, and South America. Pharmacy practice varies substantially from country to country due to variations in needs and expectations, culture, challenges, policy, regulations, available resources, and other factors. This book focuses on each country’s strengths and achievements, as well as areas of weakness, barriers to improvement and challenges. It sets out to establish a baseline for best practices, taking all of these factors into account and offering solutions and opportunities for the future. This book is a valuable resource for academics, researchers, practicing pharmacists, policy makers, and students involved in pharmacy practice worldwide as it provides lessons learned on a global scale and seeks to advance the pharmacy profession.

  • Electronic Noses and Tongues in Food Science

    • 1 Edición
    • Maria Luz Rodriguez Mendez
    • Inglés
    Electronic Noses and Tongues in Food Science describes the electronic products of advanced chemical and physical sciences combined with intuitive integration of microprocessors, advanced bioinformatics and statistics. These include, for example, voltammetric, bio-electronic, piezoelectric platforms made from a variety of components including, nanoparticles, enzyme biosensors, heavy metals, graphite-epoxy composites, metal oxide semiconductors, microelectrodes, microfluidic channels, pre-manufactured gas sensors, redox enzymes and others and is an ideal resource for understanding and utilizing their power in Food Science settings. Devices used to analyse one particular food item can theoretically be adapted for other food items or components. This does not just mean the re-deploying the physical platforms but also the mode of bioinformatic and statistical analysis. This includes artificial neural networks (ANN), linear discriminant analysis (LDA), partial least squares (PLS), principal component analysis (PCA) etc. In other words, there is cross transference of chemistry, physics, concepts, techniques, findings and approaches from one food to another. Electronic noses and tongues are two of these devices but are advancing in application and importance. This book provides examples of the use of electronic noses and tongues to characterise components that contribute to sensory or compositional profiles, from ripening to harvesting and from storage of raw materials to packaging and consumption. These devises are suitable for high-throughput analysis, quality control or to determine the nature and extent of spoilage and adulteration, and have also been used to ascertain the geographical origins of food and mixtures.

  • Ionic Liquids in Lipid Processing and Analysis

    Opportunities and Challenges
    • 1 Edición
    • Xuebing Xu + 2 más
    • Inglés
    This book serves as a reference for those interested in state-of-the-art research on the science and technology of ionic liquids (ILs), particularly in relation to lipids processing and analysis. Topics include a review of the chemistry and physics of ILs as well as a quantitative understanding of structure-activity relationships at the molecular level. Further, chapter authors examine the molecular basis of the toxicity of ILs, the prediction of the properties of ILs, and the rationale and steps toward a priori design of ionic liquids for task-defined applications. Emerging research in developing lipid-inspired ILs and their prospective use in drug formulation is described. Among the highlights are the latest advances in IL-mediated biocatalysis and biotransformation, along with lipase production, purification, and activation.

  • Essential Clinically Applied Anatomy of the Peripheral Nervous System in the Head and Neck

    • 1 Edición
    • Paul Rea
    • Inglés
    Essential Clinically Applied Anatomy of the Nerves in the Head and Neck presents the reader with an easy access format to clinically-applied peripheral nervous system (PNS) anatomy. Perfect for a quick reference to essential details. The chapters review nerves of the head and neck, the origin(s), course, distribution and relevant pathologies affecting each are given, where relevant. The pathologies present typical injuries to the nerves of the PNS, as well as clinical findings on examination and treatments. It details modern clinical approaches to the surgery and other treatments of these nerve pathologies, as applicable to the clinical scenario.

  • The Membranes of Cells

    • 3 Edición
    • Philip L. Yeagle
    • Inglés
    The Membranes of Cells, Third Edition, provides a basic guide to biomembranes, connecting researchers to the numerous fields of biology. The new edition offers a complete update of content based on new understandings in the field. Foundational content for graduate students, researchers, professors, and undergraduate students across the sciences is provided, succinctly covering all of the basic information needed for lipids and membranes.

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