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Elsevier

Libros en Ciencias de la Vida

  • Unveiling the History of Transplantation

    An Illustrated Review of the Boundaries, Fantasies and Realities
    • 1 Edición
    • Shi Chen
    • Inglés
    Unveiling the History of Transplantation: An Illustrated Review of the Boundaries, Fantasies and Realities covers the key international figures involved in organ transplantation and related fields. It includes a discussion of the contributions of many Nobel Prize winners in Physiology and Medicine. The book introduces the whole process of transplantation and the latest research progress of cell, tissue, and organ transplantation: from initial exploration to maturity and on to widespread application. A key feature of this resource is that it includes a large number of unique historical photos and material related to organ transplantation as collected by the author from libraries worldwide.

  • mRNA Therapeutics

    Foundations, Innovations, and Clinical Applications
    • 1 Edición
    • Anya Hillery
    • Inglés
    mRNA Therapeutics: Foundations, Innovations and Clinical Applications aims to provide a comprehensive text that covers all aspects of mRNA therapeutics, from the foundational science that underpins this disruptive new drug class, through the scientific and technological breakthroughs crucial for therapeutic success, to the current clinical applications and the innovative advances driving future directions. The book begins with foundational knowledge covering mRNA biology, the immune system, and vaccines. The second section addresses the major challenges associated with mRNA as a therapeutic modality, and the molecular engineering innovations and delivery technologies that have allowed these hurdles to be largely overcome. The third section describes the current and future clinical applications of mRNA therapeutics that are transforming, or are poised to transform, medicine and health. This includes the use of mRNA vaccines for COVID-19 and other infectious diseases, as well as mRNA's role in revolutionizing cancer immunotherapy, covering immunostimulants, cancer vaccines including personalized neoantigen vaccines, and CAR T cell technologies. Additional chapters describe the use of mRNA therapeutics for protein replacement therapy and gene-editing, as well as newer mRNA constructs, including self-amplifying mRNA. The final section addresses the safety and regulatory considerations of mRNA therapeutics, along with broader cultural issues including vaccine hesitancy, global vaccine inequality, and pandemic preparedness. Currently, mRNA texts either provide personal accounts from key players involved in COVID-19 vaccine development, with limited scientific depth, or focus on highly specialized, more esoteric applications of mRNA in advanced molecular biology. This book aims to bridge this gap by providing a scientifically rigorous and wide-ranging exploration of mRNA's role in therapeutics. This pioneering textbook serves as a vital addition to the academic canon, providing an essential tool for the current and next generation of students, scientists, researchers and professionals in a wide variety of related disciplines including molecular biology, biomedical engineering, pharmaceutical science, oncology, and the health sciences.

  • Metabolomics of Bladder Cancer

    An Emerging Application
    • 1 Edición
    • Vishwajeet Singh + 1 más
    • Inglés
    Metabolomics of Bladder Cancer: An Emerging Application offers insights into the latest research methodologies and potential therapeutic applications. The book examines how applied research on the discovery of metabolomic biomarkers with prognostic and predictive value is needed to stratify patients into different risk groups, minimizing overtreatment and the risk of drug resistance development. In eight chapters, the book gives an in-depth analysis of recent findings in both fundamental and applied research, with a focus on the metabolomics approach and its potential for identifying major metabolic pathways that characterize various diseases and physiological states.It intuitively leads from the discovery of biomarkers for bladder cancer, to the metabolisms of glutamine and fatty acids and finalizes with a chapter on the metabolic effect of cancer therapy. Overall, this book is a comprehensive and insightful resource for researchers, clinicians, and academic professionals interested in the latest developments in bladder cancer research.

  • Artificial Intelligence for Drug Product Lifecycle Applications

    • 1 Edición
    • Alberto Pais + 3 más
    • Inglés
    Artificial Intelligence for Drug Product Lifecycle Applications explains the use of artificial intelligence (AI) in drug discovery and development paths, including the clinical and postapproval phases. This book gives methods for each of the drug development steps, from the fundamentals to postapproval drug product. AI is a synergistic assembly of enhanced optimization strategies with particular applications in pharmaceutical development and advanced tools for promoting cost-effectiveness throughout the drug lifecycle. Specifically, AI brings together the potential to improve drug approval rates, reduce development costs, get medications to patients faster, and help patients comply with their treatments.Accelerat... pharmaceutical development and drug product approval rates will enable larger profits from patent-protected market exclusivity. This book offers the tools and knowledge to create the right AI strategy to extend the landscape of AI applications across the drug lifecycle. It is especially useful for pharmaceutical scientists, health care professionals, and regulatory scientists, as well as advanced students and postgraduates actively involved in pharmaceutical product and process development involving the use of artificial intelligence in drug delivery applications.

  • Self-powered Sensors

    A Path to Wearable Electronics
    • 1 Edición
    • Rajesh Kumar Dhanaraj + 4 más
    • Inglés
    Self-powered Sensors: A Path to Wearable Electronics features recent developments in chemical, photonic, pharmaceutical, microbiological, biomimetic, and bio-inspired approaches for MEMS/NEMS and medicinal self-powered sensors. Unconventional nanomaterial sensors driven by self-sufficient energy are given a contemporary review, with a focus on the categorization of energy sources and comparisons of research involving self-powered solar, piezoresistive, triboelectric, and thermodynamic technologies. This book also focuses on the different techniques, materials, comparisons of fabrication of self-powered sensors as well as thermoelectric self-powered sensors and its implantable applications.

  • Forest Fungi

    Biodiversity, Conservation, Mycoforestry and Biotechnology
    • 1 Edición
    • Ahmed M. Abdel Azeem + 3 más
    • Inglés
    Forest Fungi: Biodiversity, Conservation, Mycoforestry and Biotechnology explores sustainable option aspects of forest fungal research, from the selection of hosting plants, isolation, identification, fermentation, identification of secondary metabolites, omics-tools for better understanding the plant–fungus Interactions. Forests are the world’s greatest repository of terrestrial biomass, soil carbon and biodiversity. They provide a variety of provisioning, supporting, regulatory and cultural ecosystem services, which are crucial for the survival of human beings. Fungi play key roles in forest ecosystems as mutualists, saprobes and pathogens.

  • Biomechatronics

    • 2 Edición
    • Marko B. Popovic
    • Inglés
    Biomechatronics is rapidly becoming one of the most influential and innovative research directions defining the 21st century. The second edition Biomechatronics provides a complete and up-to-date account of this advanced subject at the university textbook level. This new edition introduces two new chapters – Animals Biomechatronics and Plants Biomechatronics – highlighting the importance of the rapidly growing world population and associated challenges with food production. Each chapter is co-authored by top experts led by Professor Marko B. Popovic, researcher and educator at the forefront of advancements in this fascinating field. Starting with an introduction to the historical background of Biomechatronics, this book covers recent breakthroughs in artificial organs and tissues, prosthetic limbs, neural interfaces, orthotic systems, wearable systems for physical augmentation, physical therapy and rehabilitation, robotic surgery, natural and synthetic actuators, sensors, and control systems. A number of practice prompts and solutions are provided at the end of the book. The second edition of Biomechatronics is a result of dedicated work of a team of more than 30 contributors from all across the globe including top researchers and educators in the United States (Popovic, Lamkin-Kennard, Herr, Sinyukov, Troy, Goodworth, Johnson, Kaipa, Onal, Bowers, Djuric, Fischer, Ji, Jovanovic, Luo, Padir, Tetreault), Japan (Tashiro, Iraminda, Ohta, Terasawa), Sweden (Boyraz), Turkey (Arslan, Karabulut, Ortes), Germany (Beckerle and Wiliwacher), New Zealand (Liarokapis), Switzerland (Dobrev), and Serbia (Lazarevic).

  • The Immunology of the Cat

    • 1 Edición
    • Ian R. Tizard
    • Inglés
    The Immunology of the Cat makes available the first single-source, comprehensive review of the feline immune system, reporting on all immunologic aspects of diseases of the cat and its relatives and relating recent basic science to important clinical issues. The book opens with the evolution, domestication, and development of the cat then provides detailed information on immunity to infectious diseases, feline allergic diseases, the top feline autoimmune diseases, and feline immunodeficiencies. Content examines feline vaccines, hypersensitivity, cancer, nutrition, and the aged cat. Professionals in veterinary research and practice will appreciate complete information on all aspects of feline immunology in one essential resource.

  • Anandamide in Health and Disease

    • 1 Edición
    • Bernard Le Foll
    • Inglés
    Anandamide in Health and Disease, a volume in the Molecular Mediators in Health and Disease: How Cells Communicate series, is a complete reference on the roles of anandamide in health and disease states. Following the characteristics of the series, this book provides a comprehensive overview of the effects of the mediator on human health.The book is divided into two parts, the first of which provides background information on biology, regulation, synthesis and degradation and modulation of anandamide. The second part is dedicated to covering the role of anandamide in various diseases. A comprehensive panel of authors cover several somatic and psychiatric disorders, such as anxiety disorders, mood disorders, psychosis and substance use disorders. Additionally, the role of anandamide across epilepsy, Alzheimer's disease, and digestive conditions is explored.Anandamide in Health and Disease is the perfect reference for bioscience researchers seeking to understand anandamide pharmacology, biochemistry, cellular, and molecular biology. Clinicians may also be interested in better understanding the wide-ranging health effects of the mediator.

  • Ectoparasitic Diseases

    • 1 Edición
    • James H. Diaz
    • Inglés
    Ectoparasitic Diseases provides information on the diagnosis, treatment, and prevention of ectoparasitic conditions caused by arthropods of medical importance. The book discusses the manner in which arthropod ectoparasites threaten human health by bodily infestations, covering specific ectoparasites and the vector-borne infectious diseases transmitted by each. Chapters offer definitions, epidemiology, diagnosis, clinical manifestations, therapeutic treatments, and preventive measures. In addition, the book examines the public health, socioeconomic, and psychological impact from ectoparasitic infections.This book offers comprehensive coverage to researchers, practitioners, and advanced students studying ectoparasitic vector-borne diseases.

  • Bacterial Carbonic Anhydrases

    • 1 Edición
    • Volumen 55
    • Inglés
    Bacterial Carbonic Anhydrases, Volume 55 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Overview on bacterial CA genetic families, Bacterial α-CAs, Bacterial β-CAs, Bacterial γ-CAs, Bacterial ι-CAs, Sulfonamide bacterial CA inhibitors, Non-sulfonamide bacterial CA inhibitors, Helicobacter pylori CA inhibition, Neisseria gonorrhea CA inhibition, Vancomycin resistant enterococci CA inhibition, Pseudomonas aeruginosa CA inhibition, Mycobacterium tuberculosis CA inhibition, and Challenges for developing bacterial CA inhibitors as novel antibiotics.

  • Natural Biomaterials for Tissue Engineering

    • 1 Edición
    • Naveen Kumar + 6 más
    • Inglés
    Natural Biomaterials for Tissue Engineering is a comprehensive reference that provides in-depth principles for supporting and enabling knowledge during the tissue production process, focusing on different cell systems. The tissue fabrication process is illustrated with specific examples for more than 30 tissues, which may soon lead to new tissue engineering therapies. The section coverage includes an overall introduction, decellularization protocols specific to each tissue, characterization, materials and methods, cell seeding process, preclinical evaluation in laboratory animals, clinical applications, limitations, conclusion, and future challenges. Readers may turn to this up-to-date coverage for a widespread understanding of regenerative medicine, which will be useful to students and experts alike.

  • Food-borne Delivery Systems of Functional Substances for Precision Nutrition

    • 1 Edición
    • Volumen 112
    • Inglés
    Food-Borne Delivery Systems of Functional Substances for Precision Nutrition, Volume 112 highlights new advances in the field, with this new volume presenting interesting chapters on a range of topics, including Biological activity, limitations, and steady-state delivery of functional substances for precision nutrition, Nanoparticles delivery systems of functional substances for precision nutrition, Micelles delivery systems of functional substances for precision nutrition, Microgel delivery systems of functional substances for precision nutrition, Emulsions delivery systems of functional substances for precision nutrition, and Microencapsule delivery systems of functional substances for precision nutrition, and much more.Other chapters focus on Liposomes' delivery systems of functional substances for precision nutrition, Hydrogel delivery systems of functional substances for precision nutrition, Vesicle delivery systems of functional substances for precision nutrition, and Future development trend of food-borne delivery systems of functional substances for precision nutrition.

  • Equine Welfare in Clinical Practice

    • 1 Edición
    • Virginia Wensley Koch
    • Inglés
    Equine veterinarians frequently encounter behavior and welfare problems, but they generally focus only on the physical issues affecting their patients because they lack the training to address psychological, behavioral, or other welfare issues. This book is meant to remedy that lack. As the primary source of medical information for horse owners, veterinarians need to address the unmet need for medical professionals to deal with equine mental health problems through treatment or referral. Science tells us that mental health determines an animal’s welfare status. The public considers veterinarians to be animal welfare experts, so clinicians need to become familiar with animal welfare science. Knowledge of equine behavior science is important in assessing welfare, and even more importantly, the appropriate handling of horses requires behavioral expertise. Clients prefer veterinarians who handle patients with gentleness, and using persuasion instead of force improves equine welfare, handler safety, and practitioner effectiveness. Veterinarians who understand and can educate their clients in equine welfare and in safe and appropriate care and handling techniques will increase their business success and improve the lives of their clients and patients.The book’s topics are addressed by internationally recognized experts and are most important for those whose formal veterinary education neglected to cover animal psychology, behavior modifi cation, and animal welfare, but they also provide current information and useful practical tips for those already familiar with equine behavior/welfare science. Topics include practical welfare assessment; how horses learn (both good and bad habits); safe, appropriate, and fear-free training and handling techniques for both adult horses and foals; how equine behavior is affected by diet (and the microbiome), by the differences between horse and human senses and cognition, and by enrichment; differentiating medical from behavioral problems; and preventing and treating behavioral problems (including stereotypies). It describes the Equine Behavior Assessment and Research Questionnaire (E-BARQ), a tool that can assist veterinarians to introduce behavior into their practices in a simple and basic manner, and it offers guidance on resolving ethical dilemmas while advancing equine welfare. The final chapter offers resources for further study and access to specialists for consultation or referral. Ultimately, the book will serve its purpose if it helps improve the lives of horses, their owners, and their veterinarians.

  • Omega-3 Fatty Acids

    A Scientific Approach to Healthy Aging and Optimized Nutrition
    • 1 Edición
    • Peter Lembke
    • Inglés
    Omega-3 Fatty Acids: A Scientific Approach to Healthy Ageing and Optimized Nutrition looks at the biochemistry of long chain fatty acids and their importance to health, well-being, and the reduction of inflammation in the body. Divided into two parts, the book first explains the history, chemical background, and physiological pathways of how EPA and DHA influence our inflammatory response and their importance as structural building blocks within our cell membranes. Readers will learn about increasing the anti-inflammatory effects from polyunsaturated-fatt... intake by combining Omega-3s and Omega-6s, as well as the differences, safety aspects, nutritional values of plant Omegas verse animal Omegas.In additions, sections will update on the benefits of different Omega fatty acids derived from various food sources such as seeds, fish, eggs, and nuts. Part Two is dedicated to healthy aging and discusses the results of numerous clinical trials and mechanisms of action that address heart, immune, bone, muscle, cognitive, and vision health. Readers will gain insight to methods of sustainable sourcing to ensure maximum benefits and optimized nutrition.

  • The Evolution of Immunotherapy Against Tumors

    An Historical Approach
    • 1 Edición
    • Domenico Ribatti
    • Inglés
    The Evolution of Immunotherapy Against Tumors: An Historical Approach summarizes the literature concerning the development of the theory of immune surveillance against tumors. It discusses the evidence for and against this theory, along with the concept of immunoediting. Finally, current approaches in anti-tumor immunotherapy will be analyzed.The immune system plays a major role in the surveillance against tumors. To avoid attack from the immune system, tumor cells develop different strategies to escape immune surveillance. Evidence of immune surveillance comes from both animal models and clinical observations. Mice with a wide variety of immunodeficiencies have a high rate of tumor incidence and are more susceptible to transplanted or chemical carcinogen-induced tumors. Immunosuppressed patients have a high incidence of tumors. However, many patients develop cancer even in the presence of an apparently normal immune system. This indicates that tumor cells can escape immune surveillance.

  • Genetics and Epigenetics of Genitourinary Diseases

    • 1 Edición
    • Seyed Mohammad Kazem Aghamir
    • Inglés
    Genetics and Epigenetics of Genitourinary Diseases aims to provide a comprehensive collection of data on genetics and epigenetics in almost all genitourinary diseases for researchers, clinicians, and graduate students.This book discusses several genetic and epigenetic changes like DNA methylation, mutations, single nucleotide polymorphisms, DNA rearrangements, chromosomal remodeling, microsatellite instability, and chromosomal instability (CIN) in genitourinary cancers.This book is split into 18 chapters, beginning with the importance of genetics and epigenetics in genitourinary diseases. It then goes on to cover the genetics and epigenetics of various diseases and tumors. Certain chapters present novel techniques of next-generation sequencing (NGS). Furthermore, RNA-Seq is discussed as a sequencing technique that uses NGS to reveal the presence and quantity of RNA in a biological sample.This book is a valuable resource for researchers, practitioners, and students in genetics and epigenetics who want to broaden their understanding of the field.

  • Rowan's Primer of EEG

    • 3 Edición
    • Lara V. Marcuse + 2 más
    • Inglés
    **Selected for 2025 Doody’s Core Titles® in Neurology**Practical... brief, and easy to understand, Rowan's Primer of EEG, 3rd Edition, teaches the difficult technical aspects of how to perform and interpret EEGs. Direct, concise text, numerous illustrations and teaching points, and an extensive video library make this up-to-date reference a valuable resource for students, residents, neurologists, and epileptologists alike.

  • Vaccines in Aquaculture

    Development, Production, and Applications
    • 1 Edición
    • Baskaralingam Vaseeharan + 1 más
    • Inglés
    Vaccines in Aquaculture: Development, Production, and Applications acknowledges the crucial part that aquatic vaccines play in disease control for the sustainable future of aquaculture. Vaccination progression has become the most important method for disease prevention and effective prophylaxis based on stimulation of the immune systems of key aquaculture species. This book provides detailed information about the evaluation, mass production, and commercialization of aquatic animal vaccines, as well as specific descriptions of the correct use of vaccines against the most important microbial diseases of aquatic animals.Written by a leading expert in aquatic animal health biotechnology, this book is systematically organized for effective delivery of its major themes. The book starts by providing an overview on aquaculture vaccine history, evolution, and characteristic features before describing the various types of vaccines and vaccination methods in the industry. Latter sections discuss aquatic vaccine development, recent developments and challenges, mass production, and commercialization. The book concludes with an examination of the challenges associated with large-scale production, commercialization, and ethical and legal considerations.

  • From Anatomy to Function of the Central Nervous System

    Clinical and Neurosurgical Applications
    • 1 Edición
    • Brandon Matteo Ascenzi
    • Inglés
    From Anatomy to Function of the Central Nervous System: Clinical and Neurosurgical Applications features neuroradiologic images that represent today, one of the most effective resources able to detect the anatomy of the nerve structures. Simultaneously featuring neuroimages, readers can study the functional aspects of the entire central nervous system with detailed captions that describe in detail how to use and interpret them. This book includes images of the brain dissected with the Klingler’s method and white matter fiber dissection. By integrating the anatomo-functional description with the synaptic organization of the CNS, this reference is useful for anyone who wants to understand how the activity of a nerve structure arises, describing its microstructure, neurotransmitter phenotype, and neural activity. It also features descriptions of pathologic conditions which result from neuroanatomical and/or neurofunctional alterations and includes neurosurgical aspects.

  • Intelligent Computing Techniques in Biomedical Imaging

    Methods, Case Studies, and Applications
    • 1 Edición
    • Bikesh Kumar Singh + 1 más
    • Inglés
    Intelligent Computing Techniques in Biomedical Imaging: Methods, Case Studies, and Applications provides comprehensive and state-of-the-art applications of Computational Intelligence techniques used in biomedical image analysis for disease detection and diagnosis. The book offers readers a stepwise approach from fundamental to advanced techniques using real-life medical examples and tutorials. The editors have divided the book into five sections, from prerequisites to case studies. Section I presents the prerequisites, where the reader will find fundamental concepts needed for advanced topics covered later in this book. This primarily includes a thorough introduction to Artificial Intelligence, probability theory and statistical learning. The second section covers Computational Intelligence methods for medical image acquisition and pre-processing for biomedical images. In this section, readers will find AI applied to conventional and advanced biomedical imaging modalities such as X-rays, CT scan, MRI, Mammography, Ultrasound, MR Spectroscopy, Positron Emission Tomography (PET), Ultrasound Elastography, Optical Coherence Tomography (OCT), Functional MRI, Hybrid Modalities, as well as pre-processing topics such as medical image enhancement, segmentation, and compression. Section III covers description and representation of medical images. Here the reader will find various categories of features and their relevance in different medical imaging tasks. This section also discusses feature selection techniques based on filter method, wrapper method, embedded method, and more. The fourth section covers Computational Intelligence techniques used for medical image classification, including Artificial Neural Networks, Support Vector Machines, Decision Trees, Nearest Neighbor Classifiers, Random Forest, clustering, extreme learning, Convolution Neural Networks (CNN), and Recurrent Neural Networks. This section also includes a discussion of computer aided diagnosis and performance evaluation in radiology. The final section of Intelligent Computing Techniques in Biomedical Imaging provides readers with a wealth of real-world Case Studies for Computational Intelligence techniques in applications such as neuro-developmental disorders, brain tumor detection, breast cancer detection, bone fracture detection, pulmonary imaging, thyroid disorders, imaging technologies in dentistry, diagnosis of ocular diseases, cardiovascular imaging, and multimodal imaging.

  • Epigenetic Regulation of Cancer-Part C

    • 1 Edición
    • Volumen 387
    • Inglés
    Epigenetic Regulation of Cancer, Part C, Volume 389 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic biomarkers in breast cancer, Contribution of epigenetics to virus-driven cancer, Cancer metabolism and epigenetics, Technologies for epigenome editing, Epigenetics and cancer stemness, Epigenetic modifications in obesity-associated cancers, Epigenetics in cf microRNA in blood of solid tumors, Integrative analysis of transcriptome, chromatin accessibility, cell surface antigen in single cell level for AML, and more.Additional chapters cover Epigenetics in lung cancer, Gene Regulatory Mechanisms underlying therapy resistance in Cancer, Role of miRNAs as epigenetic regulators of immune checkpoints in cancer immunity, Epigenetic contributions to Acute myeloid leukemia (AML), Contribution of epigenetics to chemoresistance, Epigenetic contribution to the relationship between obesity and cancer, and Epigenetic regulation in ovarian cancer.

  • Linseed

    A Multipurpose-Multisector Crop of Industrial Significance
    • 1 Edición
    • Sapna Langyan + 1 más
    • Inglés
    Linseed: A Multipurpose-Multise... Crop of Industrial Significance provides a general overview of linseed as a multipurpose-multise... crop for obtaining a number of valuable products. The book's sections present the use of linseed as food products and discuss a number of important topics, including genetic engineering and breeding advances, pre-harvest processing methods, advanced extraction and quality assessment, metabolic engineering, bioactivity, new food product development, chemistry, and functionality. The book also covers the use of linseed in the textile sector and modified linseed oil products, animal feed products, cosmetics, and personal use products, along with their industrial significance.Food waste and the challenges of linseed crop production and processing into a number of industrial products are also discussed. This book acts as a comprehensive resource for food scientists, researchers, scholars, and industrial people related to food, nutraceutical, cosmetics, pharmaceuticals, textiles, and health practitioners, especially dieticians and nutritionists.

  • Vesicle Trafficking in Eukaryotes

    • 1 Edición
    • Volumen 93
    • Inglés
    Current Topics in Membranes, Volume 93 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Receptor-mediated endocytosis in kidney cells during physiological and pathological conditions, Membrane transport and endocytosis in malaria parasites, Impact of Coat Protein on Evolution of Ilarviruses, and Membrane Contact Sites.

  • TRP Channels as Therapeutic Targets

    Advances in Basic Science and Clinical Use
    • 2 Edición
    • Arpad Szallasi
    • Inglés
    TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 123
    • Inglés
    Advances in Clinical Chemistry, Volume 123, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists.

  • Applied Multivariate Statistical Analysis in Medicine

    • 1 Edición
    • Jingmei Jiang
    • Inglés
    Applied Multivariate Statistical Analysis in Medicine provides a multivariate conceptual framework that allows readers to understand the interconnectivity and interrelations among variables, which maintains the intrinsic precision of statistical theories. With a strong focus on the fundamental concepts of multivariate statistical analysis, the book also gives insight into the applications of multivariate distribution in biomedical fields. In 14 chapters, Applied Multivariate Statistical Analysis in Medicine covers the main topics of multivariate analysis methods widely used in health science research. The content is organized progressively from fundamental concepts to sophisticated methods. It begins with basic descriptive statistics in multivariate analysis and follows with parameter estimation, in addition to the hypothesis testing of a multivariate normal distribution, which has heavy applications in biomedical fields where the relationships among approximately normal variables are of great interest. Keeping mathematics to a minimum, considerable emphasis is placed on explanations and real-world applications of core principles to maintain a good balance between introducing theory and cultivating problem-solving skills. This book is a very valuable reference text for clinicians, medical researchers, and other researchers across medical and biomedical disciplines, all of whom confront increasingly complex statistical methods during the analysis and presentation of their results.

  • Principles of Immunotherapy in Breast and Gastrointestinal Cancers

    Activity, Mechanisms of Resistance and New Sensitization Strategies
    • 1 Edición
    • Michele Ghidini
    • Inglés
    Principles of Immunotherapy in Breast and Gastrointestinal Cancers: Activity, Mechanisms of Resistance, and New Sensitization Strategies presents updated research findings on immunotherapy, with a special focus on the mechanisms of resistance of those cancer types and how to overcome them.The book discusses topics such as tumor cell-intrinsic and -extrinsic mechanisms of cancer resistance to immunotherapy; the role of currently available biomarkers; strategies to overcome therapeutic resistance; sensitizing agents for cancer resistance to cell-mediated immunotherapy; and immunotherapeutic approaches, mechanisms of resistance, and sensitizing strategies in gastroesophageal and biliopancreatic tumors and colorectal cancer.It is a valuable resource for researchers, students, and members of the biomedical and medical fields who want to learn more about resistance to immunotherapy and how to overcome it.

  • Siderophore and Related Natural Products Biosynthesis

    • 1 Edición
    • Volumen 702
    • Inglés
    Methods in Enzymology Volume 702 highlights new advances in the field, with this new volume presenting interesting topics on Siderophore and related natural products biosynthesis

  • Neurologic Channelopathies

    • 1 Edición
    • Volumen 203
    • Inglés
    Neurological Channelopathies, Volume 203 begins with an introductory overview highlighting common mechanistic themes that cut across different CNS and PNS presentations, but that also have potential for common treatment approaches, considering classification, genetics, and fundamental physiology of ion channels. Subsequent chapters present a detailed consideration of all genetic and immunological channelopathies. Each chapter considers Pathophysiological underpinnings - genetic or immunological; Clinical presentations; Diagnostic approach; and Treatment and management.In the last 15 years, a combination of detailed clinical, genetic, molecular electrophysiological... and immunological research has combined to result in a deep understanding of a subgroup of neurological diseases spanning the central and peripheral nervous system and which have become known collectively as the Neurological Channelopathies. Although it was originally considered that significant ion channel dysfunction would not be compatible with life, we now know this is often not the case, although severe disease can often be the result. Given these major advances, it is now the right time to combine this knowledge into a single HCN volume dedicated to the topics at hand.

  • Neuroscience of Coffee Part B

    • 1 Edición
    • Volumen 289
    • Inglés
    Neuroscience of Coffee, Volume 289 is a pioneering volume that delves into the intricate relationship between one of the world's most beloved beverages and the human brain. Offering a comprehensive exploration of the biochemical and physiological mechanisms underlying coffee's impact on the nervous system, this groundbreaking book transcends traditional coffee literature by focusing specifically on the neurological aspects. Chapters in this new release include Coffee and Parkinson's Disease, Coffee and Alzheimer's Disease, Coffee and Multiple Sclerosis (MS), Coffee and Amyotrophic lateral sclerosis (ALS), Exploring the Complex Relationship Between Caffeine Consumption and Schizophrenia: A Review of Epidemiological and Clinical Studies, and much more.Additional chapters explore Coffee, Antioxidants, and Brain Inflammation, Behavioral and Psychological Aspects of Coffee Consumption, From Bean to Brain: Coffee, Gray Matter, and Neuroprotection in Neurological Disorders Spectrum, and Synaptic Modulation by Coffee Compounds: Insights into Neural Plasticity.

  • Critical Heart Condition During Pregnancy

    Critical Care Obstetrics
    • 1 Edición
    • Jorge Hidalgo + 2 más
    • Inglés
    Critical Heart Condition During Pregnancy, a volume in the Critical Care Obstetrics series, provides a novel reference to educate physicians, nurses, and all allied healthcare personnel caring for pregnant women with various health compromises specific to cardiac complications. The book's chapters reflect the growing scope of critical care obstetrics and the increasing importance and recognition of the hospital structure's field. All intensivists, regardless of primary discipline, must possess a core set of critical care skills that allow them to manage critically ill patients. The authors have gathered the best evidence-based material explicitly focused on cardiac scenarios.This volume presents cardiac medical-surgical complications that any patient can present during and post-partem, such as Arrhythmias, Endocarditis, Cardiogenic Shock, heart failure, and more.

  • Environmental Challenges in Attaining Food Security

    • 1 Edición
    • Volumen 9
    • Inglés
    Environmental Challenges in Attaining Food Security, Volume Nine in the Advances in Food Security and Sustainability series, highlights new advances in the field, with this new volume presenting interesting chapter on important topics such as Exacerbation of Food Insecurity in Africa: A Consequence of the Dual Threat of COVID-19 and the Russia-Ukraine Crisis; Rising Environmental Issues: A hindrance to food security; Microplastics in Soil and Water: Unveiling Environmental Risks and Implications; Emerging Contaminants – Categorization, Effect and Treatment; The Potential Impact on Pesticides on Insect Pollinators and Their Ecological Implications, and much more.Additional chapters cover Change in geo-environmental conditions and crop productivity; Pesticide Concentration and Its Impacts: Food security Vs. Food safety; Heavy metals in soil and water: Sources, fate, toxicology and remediation; Salinity stress in Crop Plants: Effects and Eco-friendly management; Salinity Stress: Impact on Plant Growth; Micronutrient bioavailability in contaminated soil and mitigation strategies for toxicity; Decrease in Arable Land and Water; and Nano-enabled sensor modules for detection of agrochemicals in diverse soil, and water systems: Progression and future trends; Monoculture Of Crops.

  • OrthoBiologics

    • 1 Edición
    • Rachel M. Frank + 2 más
    • Inglés
    OrthoBiologics provides state-of-the-art knowledge of current biologic therapies for a variety of orthopaedic conditions in a single source. The content is presented in a straightforward manner, including defining all currently available orthobiologic options, discussing processing characteristics and appropriate clinical use, and finally, summarizing clinical applications and outcomes as well as future potential directions.In addition to covering current approaches and applications, the editors aim for this book to present “best practices” for those practicing and researching orthopaedic pathologies and orthobiologic treatments, including blood and cellular based therapies. The editors are world-renown experts in the field and this book fills a gap in the market.

  • Microbiome and Nano-Cross-Talk

    Sustainable Agriculture and Beyond
    • 1 Edición
    • Kanchan Vishwakarma + 2 más
    • Inglés
    Microbiome Nano-Cross-Talk: Sustainable Agriculture and Beyond presents a comprehensive overview of the functional aspects of multiphasic microbial and nanotechnological interactions within and between plants and their ecosystem. Recognizing that beneficial microbes are involved in plant growth promotion, this book highlights their mechanism and regulation to enhance plant’s yield and development even under stressed conditions. The merging of nanotechnology with microbiology is an essential aspect of this book. Various nanomaterials, their synthesis approaches as well as applications in agriculture have been studied extensively in past years.With a focus on focus the morphological, anatomical, biochemical, molecular and gene expression levels of plant growth promotion, the book is the first of its kind to enable scientists to unravel the different pathways and signaling cascades involved in response to this interaction and to understanding how nanomaterials regulate the plant-microbe associations. It critically examines the role of beneficial microbes in conjunction with nanoparticles in plants and the mechanisms adopted by the plants at the biochemical and molecular levels to enhance plant growth and mitigate various stresses.

  • Neuroscience of Coffee Part A

    • 1 Edición
    • Volumen 288
    • Inglés
    The Neuroscience of Coffee is a pioneering volume that delves into the intricate relationship between one of the world's most beloved beverages and the human brain. Offering a comprehensive exploration of the biochemical and physiological mechanisms underlying coffee's impact on the nervous system, this groundbreaking book transcends traditional coffee literature by focusing specifically on the neurological aspects. From deciphering the molecular intricacies of caffeine to examining the complex interactions within the nervous system, the volume provides an unprecedented insight into how coffee influences brain function, mental health, and neurodegenerative diseases. It addresses the growing interest in understanding everyday dietary choices and their neurological implications, filling a crucial gap in accessible yet detailed resources. This book not only contributes to the evolving field of neuroscience but also serves as a valuable guide for professionals, students, and informed laypersons seeking a deeper understanding of coffee's effects on brain health and overall well-being.

  • Comprehensive Hematology and Stem Cell Research

    • 1 Edición
    • Nima Rezaei
    • Inglés
    **2025 PROSE Award Category Winner in Clinical Medicine**Comprehens... Hematology and Stem Cell Research is the first major reference to cover both stem cell research and therapy as well as the range of hematological disorders they are currently used to treat and may potentially be able to treat in the future. This five volume set includes fundamentals, such as the underlying mechanisms of the blood and immune system, highlighting blood disorders and cancers of the blood, including lymphoma, leukemia, and myeloma. Other sections cover stem cell research and therapy, from harvesting stem cells to their utilization in cancer treatments.Finally, the work looks to the future and explores newer stem cell research that may lead to future treatments. This book is an excellent resource for students at the graduate and post-graduate levels, academics, and researchers in the fields hematology, immunology and oncology.

  • Natural Antioxidants to Enhance the Shelf-Life of Food

    • 1 Edición
    • Mirian Pateiro
    • Inglés
    Natural Antioxidants to Enhance the Shelf-Life of Food, Volume Two in the Developments in Food Quality and Safety series is the most up-to-date resource covering trending topics such as the analysis of toxic compounds and control of food poisoning, food fraud, traceability and authenticity, revalorization of agrifood industry, and natural antimicrobial compounds and their applications to improve the preservation of food, non-thermal processing technologies, nanotechnology in food production, and intelligent packaging and sensors for food applications. The book focuses on recent advances and strategies to use these compounds in the preservation of food.Chapters explore advances in antioxidant activity analysis, electrochemical methods, food oxidative stability, and natural antioxidants from agro-industrial by-products. Natural antioxidants from marine sources and innovations in antioxidants films and coatings are also covered. The series is edited by Dr. José Manuel Lorenzo and authored by a team of global experts in the fields of Food Quality and Safety, providing comprehensive knowledge to food industry personals and scientists.

  • Active Peptides for Skin Care

    • 1 Edición
    • Wenfeng Ding
    • Inglés
    Active Peptides for Skin Care is one of the first books on the market that specifically deals with the application of peptides in the field of skin care. The book outlines the basic background to skin and peptides, describes the technical methods for transdermal administration of peptides to exert their effects, and introduces the key issue of quality control methods commonly used to ensure the effectiveness and safety of peptides.The book also covers the mechanism of action and application cases of different efficacies of skin peptides, such as: whitening and spot removal, prolonging and repairing, anti-allergy and soothing, anti-hair loss and growth, improving wrinkles, breast enlargement and slimming, acne repair, eye care, repairing stretch marks, etc.

  • Concepts and Techniques in OMICS and System Biology

    • 1 Edición
    • Asmat Farooq + 5 más
    • Inglés
    Concepts and Techniques in OMICS and Systems Biology provides a concise and lucid account on the technical aspects of omics, system biology and their application in fields of different life science.With a strong focus on the fundamental principles understanding of metabolomics, ionomics and system biology, the book also gives an updated account on technical aspects of omics and system biology. Since both omics and systems biology fields are fast advancing filed of biological sciences, its significance and applications need to be understood from the baseline.In 10 chapters Concepts and Techniques in OMICS and Systems Biology introduces the reader to both Proteomics, Metabolomics and Ionomics, and System Biology, the technical applications, describes both the software in for proteomics as metabolomic enumeration and preludes Omics technologies and their applications.The chapters are designed in a well-defined chronology such that readers will understand the concepts and techniques involved in omics and system biology. This compilation will be ideal reading material for students, researchers and people working in the industries related to biological sciences.

  • Ecophysiology and Ocean Acidification in Marine Mollusks

    From Molecule to Behavior
    • 1 Edición
    • Youji Wang
    • Inglés
    Ecophysiology and Ocean Acidification in Marine Mollusks: From Molecule to Behavior provides an extensive overview of the latest research on the various ecophysiological effects of ocean acidification on marine mollusks. This book synthesizes historical information and recent findings on the effects of environmental change, ocean warming, and acidification on key mollusks and their life-history. It also discusses the underlying mechanisms underpinning the effects of ocean warming and acidification. Written by internationally recognized experts in the field of marine biology, this book systematically examines the effects of ocean acidification on the reproduction, growth and development, physiological metabolism, immunity, and behavior of marine mollusks.The book concludes by discussing the implications of current research, acknowledging data limitations in the field, and proposing future research directions, providing a better understanding of the potential impacts of ocean acidification on mollusks and the global aquaculture industry and inspiring new thinking for future research practices. It will be an indispensable resource for researchers, practitioners, undergraduate and graduate students, conservationists, and aquaculturists alike who are interested in marine environmental change, ecology, physiology, and marine biology.

  • Cannabis and Khat in Drug Discovery

    The Discovery Pipeline and the Endocannabinoid System
    • 1 Edición
    • Andrew G. Mtewa + 4 más
    • Inglés
    Cannabis and Khat in Drug Discovery: The Discovery Pipeline and the Endocannabinoid System provides comprehensive coverage of two important psychoactive plants: Khat and Cannabis. Initial research has found that compounds and derivatives from Cannabis and Khat are found to have promising properties that can be used for the discovery, design and development of potential drug leads against various diseases. This book extensively discusses the drug discovery and allied sciences of these compounds in the drug discovery pipeline, including basic research and computer aided modeling in ligand-drug interactions and their interactions with the endocannabinoid system. Categorized into sections including, chemical analyses and bioassays, medicinal chemistry, chemical biology and pharmacology, clinical applications, and policy and regulations, this book covers the methods and protocols involved and will be of interest to students, researchers, policymakers and all those involved in drug discovery research.

  • Physico-Chemical Aspects of Dosage Forms and Biopharmaceutics

    Recent and Future Trends in Pharmaceutics, Volume 2
    • 1 Edición
    • Amit Kumar Nayak + 1 más
    • Inglés
    Physico-Chemical Aspects of Dosage Forms and Biopharmaceutics: Recent and Future Trends in Pharmaceutics, Volume Two explores aspects of pharmaceutics with an original approach that focuses on technology, novelties and future trends. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day, so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. Readers will find practical information for conducting research in pharmaceutics that is ideal for researchers in academia and industry as well as advanced graduate students in pharmaceutics.In addition, the book discusses the most recent developments in biopharmaceutics, including important and exciting areas such as solubility of drugs, pharmaceutical granulation, routes of drug administration, drug absorption, bioavailability and bioequivalence.

  • Environmental Health Behavior

    Concepts, Determinants, and Impacts
    • 1 Edición
    • Ana Virgolino + 2 más
    • Inglés
    The unique biological capacities of humankind enabled the emergence of organized societies and sophisticated and globalized cultures. The progressive and universal recognition of science and technology as bulwarks of our species' survival, longevity, and quality of life made individual and organizational behaviors the main drivers of current (and future) human and planetary health standards.Environmen... Health Behavior: Concepts, Determinants, and Impacts, integrates two different but intertwined fields, environmental health sciences and human behavior sciences, identifying and systematizing current knowledge about human behaviors and habits, and addressing the challenge of environmental sustainability. The book takes the reader through a conceptual framework for environmental health behavior (EHB) as an emerging field of public and environmental health, positioning behavior change as the main challenge for the success of promoting sustainable human and planetary health. Its reading promotes insight into the environmental impacts of human demands and behavior, and, vice-versa, about the impacts of the environment on human behavior change. Moreover, different evidence-based strategies to promote EHB change are identified as practical tools for stakeholders involved in the challenge of promoting intergenerational well-being in balanced and sustainable human-produced and natural systems.

  • Hormones and Reproduction of Vertebrates, Volume 5

    Mammals
    • 2 Edición
    • David O. Norris + 1 más
    • Inglés
    Hormones and Reproduction of Vertebrates, Volume 5: Mammals is the fifth of five second-edition volumes representing a comprehensive and integrated overview of hormones and reproduction in fishes, amphibians, reptiles, birds, and mammals. The book includes coverage of endocrinology, neuroendocrinology, physiology, behavior, and anatomy of mammalian reproduction. It provides a broad treatment of the roles of pituitary, thyroid, adrenal, and gonadal hormones in all aspects of reproduction, as well as descriptions of major life history events. New to this edition are chapters on the evolution of viviparity, reproduction of ungulates, carnivores, and marine mammals as well as a concluding assessment of the effect of environmental influences on mammals.The initial chapters in this book broadly examine sex determination, reproductive neuroendocrinology, stress, and hormonal regulation as they relate to male and female reproductive structure and function. Subsequent chapters introduce the evolution of viviparity and examine pregnancy in eutherian mammals, parturition, pheromones, and behavioral neuroendocrinology. The book concludes with an examination of the environmental influences on hormones and reproduction of mammals, including endocrine-disrupting chemicals and climate change.

  • Fundamentals of Health Neuroscience

    • 1 Edición
    • Yi-Yuan Tang + 1 más
    • Inglés
    Health Neuroscience is a new interdisciplinary field encompassing research from cognitive, affective, and social neuroscience, health psychology, physical and mental health, and science of behavior change. This new field addresses the longstanding gap among neuroscience, health, and behavior change within the context of health promotion.Fundamenta... of Health Neuroscience explores key topics and research, including basic principles, psychological and neural processes, brain and body interactions, and gene x brain x environment interactions. This book also covers brain-based precision prevention and intervention strategies for health decisions and promotion across the lifespan. Chapters integrate the latest research findings and explores several key topics, such as: How does the brain serve both as a predictor and an outcome of health? How can people improve self-control and achieve physical and mental health effectively? What does brain plasticity and resilience tell us about optimal learning, performance, and development throughout our life? How is the sense of meaning in life affected by dopamine and reward systems in the brain?

  • Microbes, Microbial Metabolism and Mucosal Immunity

    An Overview
    • 1 Edición
    • Tanima Bose
    • Inglés
    Microbes, Microbial Metabolism and Mucosal Immunity: An Overview presents a concise and well-vetted treatise on the study of microbiome and microbial metabolites. This volume is up-to-date with the most recent developments from the last decade. It encompasses the interaction of immunity and microbes — and their metabolites — from different mucosal organs including gastrointestinal system, lung, oral cavity, eye. Along with the efficiency of the immune system in inhibiting the growth and proliferation of microbes, the volume discusses how the mediators of the immune system can be targeted to develop therapies.This book presents the latest methods, gives broad and systematic coverage of most mucosal systems and diseases, and takes a fresh perspective that looks at the functional aspects of change in the microbiome. The study of microbiome and microbial metabolites and their roles in host mucosal immunology is a rapidly developing area of research. One major way in which the microbiome influences the host is through altered metabolism. Metabolites, readily available to the host, engender significant consequences. Microbial metabolites have been shown to impact the disease processes in both proximal and distal organs, including the brain in several neurocognitive disorders.

  • Endophytic Fungi

    The Full Story of the Untapped Treasure
    • 1 Edición
    • Ahmed M. Abdel Azeem + 2 más
    • Inglés
    Endophytic Fungi: The Full Story of the Untapped Treasure covers the developments in endophytic fungal research from beginning to the end by the eminent researchers involved in the field. It sheds light on the endophytic fungal current research, challenges, and future possibilities, the trending recent topics in the plant-fungal endophytes' biodynamics for sustainable development of bioproducts and its applications are supported in large-scale biosynthesis of industrially and pharmaceutical important biomolecules.Endophy... Fungi: The Full Story of the Untapped Treasure highlights the bioprospecting and applied aspects of endophytic fungal communities from diverse hosts and discusses the practical applications of such endophytes in detail. It also reviews recent strategies on alternative sustainable sources of medicines such as secondary metabolites of fungi instead of over collection of plants under prohibiting of biodiversity conventions. The uniqueness of this book is the inclusion of updated bioinformatics-based strategies and its importance in bioactive molecules produced by endophytic fungi. The book addresses one of the most eminent issues in this field: how to translate the potential that endophytic fungi hold in stable practical application.

  • Food Waste Valorization

    Emerging Trends, Techno-economic and Environmental Considerations
    • 1 Edición
    • Olalere Olusegun Abayomi + 2 más
    • Inglés
    Food Waste Valorization: Emerging Trends, Techno-economic and Environmental Considerations covers bioactive extraction, therapeutic properties and environmental concerns related to food waste conversion to value-added products, along with advanced technological breakthroughs in the field. The book also provides concepts and theories on several facets of agro-food waste valorization and its by-products, as well as opportunities and challenges. Each chapter contains viewpoints from different fields of research such as Basic Science, Agriculture, Food Science and Engineering, Chemical Engineering, Mechanical Engineering, Environmental Science, and more, with each having a unique approach to food waste valorization as it relates to their field. This is an invaluable resource for research and development professionals in post-harvest processing and renewable energy industries, as well as the academicians.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 122
    • Inglés
    Advances in Clinical Chemistry, Volume 122, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists.

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