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Elsevier

Libros en Ciencias de la Vida

  • Clinical PET/MRI

    • 1 Edición
    • Onofrio Antonio Catalano
    • Inglés
    Clinical PET/MR presents the state-of-the-art of PET/MR, guiding the reader from how to scan patients, how to read and report the studies, and how keep an eye on what is clinically relevant for a patient’s care. Each chapter starts with the clinical scenario and then moves to pertinent imaging, addressing the need of a clinical PET/MR book written by world experts in both clinical and imaging fields. It discusses the clinical application of PET/MR in diverse subspecialties such as head and neck, neurology, cardiovascular, pediatrics, chest, bone, hematology, breast, hepatobiliary pancreatic, genitourinary, gynecology, and gastrointestinal tract. This book is a valuable resource for radiologists, oncologists and members of the biomedical field who need to learn more about clinical applications of PET/MR.

  • Current Applications, Approaches and Potential Perspectives for Hemp

    Crop Management, Industrial Usages, and Functional Purposes
    • 1 Edición
    • Ivan Francisco Garcia Tejero + 1 más
    • Inglés
    Current Applications, Approaches and Potential Perspectives for Hemp: Crop Management, Industrial Usages, and Functional Purposes presents the latest in the rapidly growing interest for hemp cultivation and its sustainable applications for humans. This book gathers research and review chapters that analyze research trends and current agricultural issues. It then proposes alternative solutions and describes current and future applications for this raw material. This book will be extremely beneficial for researchers, academics, policymakers, technicians and other stakeholders interested in this crop development and its applications. Cannabis sativa is considered as a proper and alternative crop because of its wide range of applications and marketability, especially when developed for biomedical applications. Thus, many producers and technicians are trying to find relevant information about this crop development and usages in order to be considered viable in the future.

  • Neuroinflammation in Vascular Dementia

    • 1 Edición
    • Gary Rosenberg
    • Inglés
    Neuroinflammation in Vascular Dementia describes the molecular mechanisms that drive this transition to mixed pathology, along with the newer lifestyle and pharmacological approaches that can reduce the incidence of dementia. The book describes the practical aspects of neuroimaging methods, along with novel neuroimaging methods, using MRI, that are becoming important clinically. The author also discusses how the diagnosis of dementias will be greatly aided by biomarkers from neuroimaging, blood and CSF biochemistry and neuropsychological testing in the future. This information will be used in precision medicine to design treatment strategies based on the most likely causes of the disease. Dementia research has undergone dramatic growth driven by current and projected increases in the aging of the population, and thus leading to a larger number of patients with dementia by 2050. Hence, advances in neuroimaging, brain chemistry, and genetics have accelerated our understanding of diseases that lead to cognitive decline.

  • Disorders of Protein Synthesis

    • 1 Edición
    • Volumen 132
    • Rossen Donev
    • Inglés
    Disorders of Protein Synthesis, Volume 132 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Snack Foods

    Processing and Technology
    • 1 Edición
    • Suvendu Bhattacharya
    • Inglés
    Snack Foods: Processing and Technology presents the use of different raw materials, processing technologies, quality attributes of snacks, machinery requirements, and innovative thoughts for future product development. These items are discussed in 15 chapters, including recent technologies leading to the industrial production of popular snacks and healthy products. The discussion on artistic snacks and troubleshooting are the new addi>tions. This book will be of use to entrepreneurs, academic and research institutes, professionals in the field, and personnel from industries.

  • How Synthetic Drugs Work

    Insights into Molecular Pharmacology of Classic and New Pharmaceuticals
    • 1 Edición
    • Imran Kazmi + 4 más
    • Inglés
    How Synthetic Drugs Work: Insights into Molecular Pharmacology of Classic and New Pharmaceuticals provides comprehensive, structured access to robust information on molecular pharmacology for clinicians, research scientists and advanced health care students. The book covers the foundations of molecular pharmacology and the main drug classes, including detailed information on their mechanisms of action and the application of molecular pharmacology in drug development. This book is an ideal reference for graduate students and researchers in pharmacology, however, researchers in corporate settings will also benefit from the book's structured and detailed coverage of mechanisms of action of synthetic drugs.

  • An Insider's Perspective of Prostate Cancer

    Understanding Effects, Management Options and Consequences
    • 1 Edición
    • Robert Alexander (‘Frank’) Gardiner
    • Inglés
    An Insider’s Perspective of Prostate Cancer: Understanding Effects, Management Options and Consequences provides scientifically based information on the management and treatment of prostate cancer. The text is designed to be neither prescriptive nor proscriptive, providing succinct, yet comprehensive details in ‘bite size chunks’ for ready assimilation and application. Sections cover recent approaches the prostate cancer landscape has made by providing background statistical and anatomical information that is followed by relevant genetic, immunological and background data. The book then proceeds to explain the mechanisms involved with cancer development and the spread and metastases that can occur in a minority of those diagnosed. In addition to acknowledging the importance of psychological effects of diagnosis and management interventions, the undervalued benefits of exercise are also emphasized, including information on holistic management. This comprehensive approach makes this a perfect reference for up-to-date information on all aspects of prostate cancer and its management.

  • MRNA-Based Therapeutics

    • 1 Edición
    • Volumen 372
    • Inglés
    MRNA-Based Therapeutics, Volume 372 in the International Review of Cell and Molecular Biology series, covers topics surrounding the effect of different metabolic situations, their contribution to metabolic modulation, and their impact on tumor growth. Specific chapters in this release include New era of nucleic acid therapies: Clinical applications and perspectives, Messenger RNA as personalized therapy: time of truth for rare metabolic disease, Applications of Self-Replicating RNA, mRNA therapy in PKU, Advances in gene-editing technologies, mRNA delivery technologies: towards clinical translation, Advances in mRNA vaccines, and more.

  • The Neurosurgical Consult Book

    • 1 Edición
    • Risheng Xu + 2 más
    • Inglés
    Written by neurosurgery residents for neurosurgery residents and other providers, The Neurosurgical Consult Book focuses on the initial care and treatment of the neurosurgical consult patient, providing the key guidance you need when quick clinical management decisions are critical. You will learn to recognize the acuity of patient presentation and determine how to immediately triage the needs of the patient at an appropriate level of care. This portable, practical guide helps you quickly steer neurosurgical patients to medical stability and safety until a definitive treatment plan is implemented.

  • Tailor-Made Polysaccharides in Drug Delivery

    • 1 Edición
    • Amit Kumar Nayak + 1 más
    • Inglés
    Tailor-Made Polysaccharides in Drug Delivery provides extensive details on all the vital precepts, basics and fundamental aspects of tailored polysaccharides in the pharmaceutical and biotechnological industry for understanding and developing high quality products. The book offers a comprehensive resource to understand the potential of the materials in forming new drug delivery methods. It will be useful to pharmaceutical scientists, chemical engineers, and regulatory scientists and students actively involved in pharmaceutical product and process development of tailored-made polysaccharides in drug delivery applications.The utilization of natural polymeric excipients in numerous healthcare applications demand the replacement of the synthetic polymers with the natural ones due to their biocompatibility, biodegradability, economic extraction and readily availability. The reality behind the rise in importance of these natural materials is that these sources are renewable if grown in a sustainable means and they can tender incessant supply of raw materials. Amongst these natural polymers, polysaccharides are considered as excellent excipients because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of polysaccharides in drug delivery.

  • Palm Trees and Fruits Residues

    Recent Advances for Integrated and Sustainable Management
    • 1 Edición
    • Mejdi Jeguirim + 2 más
    • Inglés
    Palm Trees and Fruits Residues: Recent Advances for Integrated and Sustainable Management places the wastes of palm trees and fruit residues in the international context of sustainable development, providing sustainable applications that are detailed based on sector to help readers from specific fields identify applications. Furthermore, successful processing case studies using valorization are presented. As the expansion of palm tree fruit crops processing industries (manufacture of syrup, honey, non-alcoholic beverages, flours, confectionery products, fruit paste, etc.) is generating growing quantities of wastes in different forms, this book covers sustainable aspects. Written by an international team of contributors, this title is aimed at professionals and enterprises who aspire to develop real, high-scale industrial applications for palm tree and fruit residue valorization.

  • Radiation Oncology and Radiotherapy, Part A

    • 1 Edición
    • Volumen 172
    • Inglés
    Radiation Oncology and Radiotherapy, Part A, Volume 172 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including DNA damage quantification by the COMET assay, Immunofluorescence microscopy-assisted quantification of ATM and ATR activation in irradiated cells, Immunoblotting-based characterization of the DNA damage response, Assessment of lipid peroxidation in irradiated cells, A simple method to assess clonogenic survival of irradiated cancer cells, Quantification of beta-galactosidase activity as a marker of radiation-driven cellular senescence, Cytofluorometric assessment of cell cycle progression in irradiated cells, and more. Other sections cover Assessment of transcription inhibition as a characteristic of immunogenic cell death, Assessment of eIF2α phosphorylation during immunogenic cell death, Quantification of cytosolic DNA species by immunofluorescence and automated image analysis, Flow cytometry-assisted quantification of CALR exposure during immunogenic cell death, Interference of immunogenic anticancer therapy by artificially controlled calreticulin secretion from tumor cells, along with many additional topics of interest.

  • Advances in Food and Nutrition Research

    • 1 Edición
    • Volumen 102
    • Fidel Toldra
    • Inglés
    Advances in Food and Nutrition Research, Volume 102 provides the latest advances on the identification and characterization of emerging bioactive compounds with putative health benefits, along with up-to-date information on food science. Chapters in this new release include Stability of polyphenols in food processing, Contribution of polysaccharides from crustacean on fermented food products, Food application of pigments from extremophile microorganisms, Recent advances in the development of healthier meat products, Food proteins in blood glucose control, Milk biomarker metabolomics and its application in milk origin, safety and quality control, Food Authenticity through protein and metabolic markers, and more.

  • Neurologic Localization and Diagnosis

    • 1 Edición
    • Eli E. Zimmerman + 3 más
    • Inglés
    Written for a wide range of neurology and non-neurology clinicians and residents, Neurologic Localization and Diagnosis: Differential Diagnosis by Complaint-Based Approach is a concise, easy-to-use guide to establishing a neurologic diagnosis. This unique learning resource uses an algorithmic, complaint-based approach to localizing the condition, developing a list of differential diagnoses, and focusing further evaluation on establishing the diagnosis. Leading neurologists provide up-to-date, practical guidance for neurology residents, medical students, and neurologists, as well as nurse practitioners, physician assistants, and non-neurology physicians.

  • Neuropalliative Care

    PART I
    • 1 Edición
    • Volumen 190
    • Inglés
    Neuropalliative Care, Part One, Volume 190 covers a type of care that is given when there is no cure for the neurological disorder and the patient is in distress. It provides a scholarly background of neuropalliative care, from historic underpinnings to its practice in various geographical regions, along with best practices for specific neurological disorders. It covers the work of multi or interdisciplinary teams whose care is intended to make the patient as comfortable as possible and includes partners and families in treatment plans.

  • Beauty, Aging and AntiAging

    • 1 Edición
    • Ibrahim Vargel + 1 más
    • Inglés
    Beauty, Aging and AntiAging covers novel and updated research and treatment options regarding the effects of aging on human physiology. Beauty perception and related molecular pathways are reviewed, along with current medical and surgical approaches to aging. The first part of the book focuses on beauty, youth, aging and its effects on the human body. In the second part, various restorative treatment approaches are reviewed in detail. Particularly, invasive treatment options and molecular pathophysiology of aging are covered in this book.

  • Metagenomics to Bioremediation

    Applications, Cutting Edge Tools, and Future Outlook
    • 1 Edición
    • Vineet Kumar + 3 más
    • Inglés
    Metagenomics to Bioremediation: Applications, Cutting Edge Tools, and Future Outlook provides detailed insight into metagenomics approaches to bioremediation in a comprehensive manner, thus enabling the analysis of microbial behavior at a community level under different environmental stresses during degradation and detoxification of environmental pollutants. The book summarizes each and all aspects of metagenomics applications to bioremediation, helping readers overcome the lack of updated information on advancement in microbial ecology dealing with pollution abatement. Users will find insight not only on the fundamentals of metagenomics and bioremediation, but also on recent trends and future expectations. This book will appeal to readers from diverse backgrounds in biology, chemistry and life sciences.

  • Transporting Operations of Food Materials within Food Factories

    Unit Operations and Processing Equipment in the Food Industry
    • 1 Edición
    • Seid Mahdi Jafari + 1 más
    • Inglés
    Transporting Operations of Food Materials within Food Factories, a volume in the Unit Operations and Processing Equipment in the Food Industry series, explains the processing operations and equipment necessary for storage and transportation of food materials within food production factories. Divided into four sections, Receiving and storage facilities, Liquid food transportation, Solid and semi- solid transportation and General material handling machines in food plants, all sections emphasize basic content relating to experimental, theoretical, computational and/or applications of food engineering principles and relevant processing equipment. Written by experts in the field of food engineering in a simple and dynamic way, the book targets all who are engaged in worldwide food processing operations, giving readers comprehensive knowledge and an understanding of different transporting facilities and equipments.

  • Advances in Immunology

    • 1 Edición
    • Volumen 154
    • Frederick W. Alt
    • Inglés
    Advances in Immunology, Volume 154, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology, with this volume covering Regulatory T Cells in Infection and Factor H and Properdin and their regulation.

  • Predictive Modeling in Biomedical Data Mining and Analysis

    • 1 Edición
    • Sudipta Roy + 4 más
    • Inglés
    Predictive Modeling in Biomedical Data Mining and Analysis presents major technical advancements and research findings in the field of machine learning in biomedical image and data analysis. The book examines recent technologies and studies in preclinical and clinical practice in computational intelligence. The authors present leading-edge research in the science of processing, analyzing and utilizing all aspects of advanced computational machine learning in biomedical image and data analysis. As the application of machine learning is spreading to a variety of biomedical problems, including automatic image segmentation, image classification, disease classification, fundamental biological processes, and treatments, this is an ideal reference. Machine Learning techniques are used as predictive models for many types of applications, including biomedical applications. These techniques have shown impressive results across a variety of domains in biomedical engineering research. Biology and medicine are data-rich disciplines, but the data are complex and often ill-understood, hence the need for new resources and information.

  • Drug Delivery Systems for Metabolic Disorders

    • 1 Edición
    • Harish Dureja + 3 más
    • Inglés
    Drug Delivery Systems for Metabolic Disorders presents the most recent developments on the targeted delivery of drugs to deal with metabolic disorders in a safe, compliant and continuous way. The book covers recent developments in advanced drug delivery systems in various metabolic disorders, including disturbances in protein, lipid, carbohydrate and hormone metabolism and lysosomal and mitochondrial disorders. It provides a brief introduction to metabolic disorders, along with a focus on the current landscape and trends in understanding disease pathology using different in vitro and in vivo models required for clinical applications and developments of new therapeutics. Each subsequent chapter covers drug delivery systems dedicated to metabolic diseases caused by disturbances in protein, lipid, carbohydrate and hormone metabolism. Then, it moves on to cover lysosomal storage disorders and applications of phytopharmaceuticals in this context. This is the perfect reference for researchers in pharmaceutical science who are interested in developing new treatments for metabolic diseases.

  • Respiratory Neurobiology

    Physiology and Clinical Disorders, Part II
    • 1 Edición
    • Volumen 189
    • Inglés
    Respiratory Neurobiology: Physiology and Clinical Disorders, Part Two, Volume 189 is one of two volumes on the neurology of breathing. This volume focuses on pathologies attributable to abnormalities of the neural control of breathing, breathing problems that may occur in neurological diseases, and the neurological complications of respiratory diseases, while volume one focuses on the neurophysiology of breathing.

  • Aquaculture Pathophysiology

    Volume II. Crustacean and Molluscan Diseases
    • 1 Edición
    • Frederick S.B. Kibenge + 2 más
    • Inglés
    Aquaculture Pathophysiology, Volume II. Crustacean and Molluscan Diseases is a concise, practical reference on shellfish diseases of significant risk to aquaculture. Its value to the veterinarian, fish health biologist or extensionist, fish pathologist and fish health diagnostician is its easy reach for critical information on the diagnosis and management of significant infectious and non-infectious diseases for the major temperate, subtropical and tropical shellfish species of commercial and fisheries importance. This volume should be read in partnership with volume one on finfish diseases as the principles and approach to the diagnosis and management of aquacultured animal species are similar.This comprehensive resource is ideal for researchers, teachers, students, diagnostic laboratory scientists, aquaculture technicians, and farmers who need to be competent across both finfish and shellfish health issues.

  • Aquaculture Pathophysiology

    Volume I. Finfish Diseases
    • 1 Edición
    • Frederick S.B. Kibenge + 2 más
    • Inglés
    Aquaculture Pathophysiology, Volume I. Finfish Diseases is a diverse, practical reference on finfish diseases impacting aquaculture. It is intended for the veterinarian, fish health biologist or extensionist, fish pathologist and fish health diagnostician supporting the management of major and emerging infectious and non-infectious health risks for the key temperate, subtropical and tropical finfish species of commercial and fisheries importance. This volume should be read in partnership with volume 2 on shellfish diseases as the principles and approach to the diagnosis and management of aquacultured animal species are similar and typically researchers, teachers, students, diagnostic laboratory scientists, aquaculture technicians and farmers need to be competent across both finfish and shellfish health issues.

  • Lawrie's Meat Science

    • 9 Edición
    • Fidel Toldra
    • Inglés
    Lawries’ Meat Science, Ninth Edition continues to be a classic reference in the meat world. It has been used by numerous generations of meat professionals since its first edition in 1966. The new edition brings four new chapters and updated information related to the latest advances in meat animals breeding and technologies for meat preservation, processing, and packaging. In addition, new relevant aspects of nutritional value, quality and safety of meat as well as methodologies for authenticity and traceability are provided with a compilation of chapters written by a select group of the most experienced and knowledgeable people in the meat field. This book covers essential information and latest advances and developments, from the initial meat animal’s growth and development to the time of slaughter and to the processing technologies, packaging and distribution till consumption of its meat. Relevant aspects of its composition, nutritional value, eating quality, consumer acceptance, safety and sustainability issues are also covered.

  • Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics

    Hematologic, Renal, and Immunologic Disorders
    • 7 Edición
    • Reed E. Pyeritz + 2 más
    • Inglés
    Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics: Hematologic, Renal, and Immunologic Disorders, Seventh Edition thoroughly examines medical genetics and genomics as applied to hematologic, immunologic and endocrinologic disorders, with an emphasis on understanding the genetic mechanisms underlying these conditions, diagnostic approaches, and treatment methods. Here, genetic researchers, students and health professionals will find new and fully revised chapters on the genetics of red blood cell diseases, rhesus and other fetomaternal incompatibilities, immunodeficiency disorders, inherited complement deficiencies, celiac disease, and diabetes mellitus, as well as thyroid, parathyroid and gonad disorders, among other conditions. With regular advances in genomic technologies propelling precision medicine into the clinic, this book, which has served as the ultimate resource for clinicians integrating genetics into medical practice, continues to provide the most important information. With nearly 5,000 pages of detailed coverage, contributions from over 250 of the world’s most trusted authorities in medical genetics, and a series of 11 volumes available for individual sale, this updated edition includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies.

  • Citrus Fruit

    Biology, Technology, and Evaluation
    • 2 Edición
    • Milind Ladaniya
    • Inglés
    Citrus Fruit: Biology, Technology and Evaluation, Second Edition presents a comprehensive view of these globally important crops, from cultivars to consumer acceptability. Now fully revised and updated to address the latest technologies and advancements, along with an exploration of highly current topics, including the impacts of climate and COVID-19, the book presents fresh fruit scenarios from around the globe. Sections explore the challenge of losses, background on fresh citrus cultivars production, factors that impact fruit quality, morphology, anatomy, physiology and biochemistry of fruit, fruit maturity, grades, and physico-chemical characteristics before moving into aspects of post-harvest technology. From irradiation and quality control to the nutritive, medicinal and safety aspects, the book presents the wide range of factors that can impact successful citrus crop production, delivery and consumption. Intended as a resource for researchers and scientists dealing with the growth, development and distribution of citrus fruit, the book provides up-to-date coverage on global citrus fruit production and practices.

  • Digital Agritechnology

    Robotics and Systems for Agriculture and Livestock Production
    • 1 Edición
    • Toby Mottram
    • Inglés
    Digital Agritechnology: Robotics and Systems for Agriculture and Livestock Production describes how systems acquire and use data in livestock production and agricultural systems, and how researchers can extract and aggregate efficiencies. The origins of digital agritechnology are decades old, with robotic milkers available for over 20 years and GPS-based tractor controls existing for nearly 30. However, only a few capabilities of these sensing and control systems are used. This book addresses the need to educate agriculturists on the full usage scale of these arable and livestock systems.

  • Carotenoids: Biological Functions of Carotenoids and Apocarotenoids in Natural and Artificial Systems

    • 1 Edición
    • Volumen 674
    • Inglés
    Carotenoids: Biological Functions of Carotenoids and Apocarotenoids in Natural and Artificial Systems, Volume 674 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Ultrafast laser spectroscopic studies on carotenoids in solution and on those bound to photosynthetic pigment-protein complexes, Assessing photoprotective functions of carotenoids in photosynthetic systems of plants and green algae, Fluorescence of carotenoids: probing binding site interactions and conformational motion in carotenoproteins, Resonance Raman: A powerful tool to interrogate carotenoids in biological matrices, and much more. Other chapters in the book cover Engineering the carotenoid biosynthetic pathway to study the function of carotenoids in light-harvesting complexes, Carotenoids as proxies for variations in photosynthesis and phenology in response to environmental and climatic change, Apocarotenoid pigment biosynthesis in non-model plants, Apocarotenoid transport in plants, Screening for apocarotenoid plant growth regulators in Arabidopsis, Effects of herbivory on carotenoid biosynthesis and breakdown, Biosynthesis and action of apocarotenoid plant hormones, and much more.

  • Nanocosmeceuticals

    Innovation, Application, and Safety
    • 1 Edición
    • Malay K. Das
    • Inglés
    Cosmetics are a fast-growing segment in the global personal care industry and the application of nanocosmeceuticals are on the rise. Conventional cosmetics greatly lack specific delivery systems, prolong effects and relatively heavy doses may be necessary. One of the common complaints of consumers is rather short-term activity of cosmetics, especially in face care products.Nanocosmece... having more advanced nutrient delivery mechanisms, carry more task specific nutrients to the skin deep where it can be metabolized and used to nourish cells. It can help to increase the aesthetic appeal of a product influencing the purchase decision of a consumer. Nanocosmeceuticals: Innovation, Application and Safety highlights the trends and applications of nanotechnology in cosmeceuticals for more advance and task specific nutrients delivery and long term effects of personal care products using liposome, solid lipid nanoparticles, nanostructured lipid carriers, transferosomes, niosomes, phytosomes, nanoemulsions, silver nanoparticles, chitin nanofibrils etc. It also provides the detailed information on regulatory laws, safety and marketing aspects of cosmeceuticals.This book offers an indispensable guide for professors, researchers, students, formulation chemists as well as formulation scientists in academia and industry; beauticians and decision-makers in consumer organizations.

  • New Aspects of Meat Quality

    From Genes to Ethics
    • 2 Edición
    • Peter P. Purslow
    • Inglés
    New Aspects of Meat Quality, Second Edition continues to be the leading source of scientific information for what constitutes meat quality for consumers, marketers and producers in the 21st century. The book includes traditional measures of meat quality such as texture, water holding, color, flavor/aroma, safety/microbiology and processing characteristics as well as quality assurance schemes, organic/free range, ethical meat production, and the desirability of genetically modified organisms, amongst others. Users will find comprehensive coverage on developments in our understanding of how muscle structure affects the eating qualities of cooked meat, along with techniques for measuring, predicting and producing meat quality. In addition, the book covers how these new techniques help us minimize variability in eating quality and/or maximize value. The book's final section identifies the current qualities of consumer and public perceptions and what is sustainable, ethical, desirable and healthy in meat production and consumption.

  • Precision Medicine

    • 1 Edición
    • Volumen 190
    • David B. Teplow
    • Inglés
    Precision Medicine, Volume 190 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Evolution of Biomarkers and Strategies for Integrating the Precision Philosophy to Guide Monitoring of Individualized Autoimmunity Conditions and to Implement the Philosophy into Clinical Practice, Precision Medicine in Epilepsy, The use of ASOs for personized medicine, Adult medicine, EGFR, NF-KB signal and regulatory noncoding RNAs in cancer, Precision medicine with multi-omics strategies, deep phenotyping, and predictive analysis, The Paradox of Personalized Medicine, and more.

  • Handbook of Neuro-Oncology Neuroimaging

    • 3 Edición
    • Herbert B. Newton
    • Inglés
    With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.

  • MRI Atlas of the Infant Rat Brain

    Brain Segmentation
    • 1 Edición
    • Dusica Bajic + 2 más
    • Inglés
    MRI Atlas of the Infant Rat Brain: Brain Segmentation features an entirely new coronal, sagittal and horizontal set of tissue cut in regular 9 µm intervals with accompanying photographs of MRI data and color drawings of selected brain regions in the three planes. The use of the single brain allows for greater consistency between sections, while color masking offers advances in manual segmentation techniques with increased refinement in the definition of brain areas. Readers will benefit from uniform and consistent manual tissue segmentation of MRI data in an infant rat brain. This volume provides readers the first infant rat brain MRI atlas and a valuable resource in research analyses of the developing brain for structural and functional MRI analyses.

  • Genetics and Neurobiology of Down Syndrome

    • 1 Edición
    • Bani Bandana Ganguly
    • Inglés
    Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development.

  • System Vaccinology

    The History, the Translational Challenges and the Future
    • 1 Edición
    • Vijay Kumar Prajapati
    • Inglés
    Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy at global level in 20th-21st Century. This book will provide the in-depth knowledge of vaccine history, and development of new strategies to design efficacious and safe vaccine molecule. This book will cover the development of system vaccinology and their applications revolutionize the vaccine discovery. This will provide a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials. My purpose to write this book to educate the students and researchers with modern development in the field of vaccinology and empowering the researcher with new tools and methodology for developing potential and immunogenic vaccines. This book will be helpful to solve the curiosity of science and medical background students related with vaccinology and will be helpful to devise a new vaccine molecule to control the spread of new and emerging pathogens. Systems biology is a rapidly expanding research discipline aiming to integrate multifaceted datasets generated using state-of-the-art high- throughput technologies such as arrays and next-generation sequencing. Combined with sophisticated computational analysis we are able to interrogate host responses to infections and vaccination on a systems level, thus generating important new hypotheses and discovering unknown associations between immunological parameters.

  • Phytoconstituents and Antifungals

    • 1 Edición
    • Awanish Kumar
    • Inglés
    Phytoconstituents and Antifungals covers a wide range of specific information on various phytoconstituents, their antifungal mode and the diagnosis and management of fungal infections. The book offers encouragement and empowers readers to re-embrace their knowledge of phytoconstituents and their various antifungal activities against most opportunistic pathogenic fungi as fungal diseases cause an estimated 1.5+ million deaths annually and over one billion people suffer from severe fungal disease. In this complex scenario, it is now clear that global warming and accompanying climate changes have resulted in increased incidence of many fungal infections. On the basis of all these factors, concerns on the occurrence of a pandemic fungal origin in the near future have been raised. In this context, to stop forgetting and underestimating fungal diseases is mandatory.

  • PDE Modeling of Tissue Engineering and Regenerative Medicine

    Computer Analysis in R
    • 1 Edición
    • William E. Schiesser
    • Inglés
    PDE Modeling of Tissue Engineering and Regenerative Medicine: Computer Analysis in R presents the formulation and computer implementation of mathematical models for the forefront research areas of tissue engineering and regenerative medicine. The mathematical model discussed in this book consists of a system of eight partial differential equations (PDEs) with dependent variables. The computer-based example models are presented through routines coded in R—a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Includes detailed examples that the reader can execute on modest computers.

  • Autophagy Dysfunction in Alzheimer's Disease and Dementia

    • 1 Edición
    • Tadanori Hamano + 1 más
    • Inglés
    Autophagy Dysfunction in Alzheimer’s Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer’s. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer’s and other neurodegenerative diseases.

  • The Chromosome 22q11.2 Deletion Syndrome

    A Multidisciplinary Approach to Diagnosis and Treatment
    • 1 Edición
    • Donna M. McDonald-McGinn
    • Inglés
    The Chromosome 22q11.2 Deletion Syndrome: A Multidisciplinary Approach to Diagnosis and Treatment serves as the first comprehensive, user-friendly resource on the etiology, prognosis, and recurrence risk associated with the chromosome 22q11.2 deletion syndrome. Leading international contributors cover the background, genetics, testing methods, and pathophysiology of 22q11.2DS, placing emphasis on a strong foundation for multidisciplinary treatment strategies. Written by specialists in every applicable subspecialty, such as, cardiology, immunology, endocrinology, gastroenterology, hematology, ophthalmology, neurology, and psychiatry, among other fields. This book presents an authoritative resource with full color images that enhance concept illustration and aid in real-time decision-making. As 22q11.2 deletion syndrome has become a model for understanding rare and frequent anomalies, numerous medical issues, cognitive and behavioral phenotypes, and later onset conditions, this text will become the go to resource for clinicians, researchers, trainees, and motivated family members, in gaining a full understanding of this complex chromosomal disorder.

  • Sex and Gender Differences in Neurological Disease

    • 1 Edición
    • Volumen 164
    • Inglés
    International Review on Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Flavor

    From Food to Behaviors, Wellbeing and Health
    • 2 Edición
    • Elisabeth Guichard + 1 más
    • Inglés
    Flavor: From Food to Behaviors, Wellbeing and Health, Second Edition presents the different mechanisms of flavor perception. Broken into four parts, the first begins with coverage of flavor release in humans. Part two addresses flavor perception, from molecules to receptors and brain integration. Part three analyzes flavor perception, preferences and food intake. Finally, part four considers flavor perception and physiological status. Academics working in the areas of sensory science, food quality, nutrition and human sciences, as well as research and development professionals and nutritionists, will benefit from this important revised reference.

  • Oral Delivery of Therapeutic Peptides and Proteins

    • 1 Edición
    • Puneet Tyagi + 1 más
    • Inglés
    Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource.

  • Cannabis and the Developing Brain

    • 1 Edición
    • Miriam Melis + 1 más
    • Inglés
    Marijuana is the most commonly used psychotropic drug in the United States, after alcohol. With the legalization and decriminalization of cannabis, momentum continues to build and propelled by the reduction of stigma associated to its consumption, there is growing concern regarding the long-term impact on brain function and behavior. Cannabis and the Developing Brain aims to provide comprehensive research on the effects of cannabis during neurodevelopment stages (i.e., perinatal and adolescent ages). This book introduces readers to vivo neural circuits, molecular and cellular mechanisms affected by cannabis exposure during three different temporal windows of brain vulnerability. Second, it offers a unique insight to shared neurobiological features of cannabinoid exposure during different developmental periods. Lastly, Cannabis and the Developing Brain determines the adverse impact of developmental cannabinoid exposure on specific cognition, emotion and behaviors.

  • Twin Research for Everyone

    From Biology to Health, Epigenetics, and Psychology
    • 1 Edición
    • Adam D. Tarnoki + 3 más
    • Inglés
    Twin Research: Biology, Health, Epigenetics, and Psychology is a comprehensive, applied resource in twinning and twin studies that is grounded in the most impactful findings from twin research in recent years. While targeted to undergraduate and graduate students, this compendium will prove a valuable resource for scholars already familiar with twin studies, as well as those coming to the field for the first time. Here, more than forty experts across an array of disciplines examine twinning and twin research methodologies from the perspectives of biology, medicine, genetic and epigenetic influences, and neuroscience. Chapters provide clear instruction in both basic and advanced research methods, family and parenting aspects of twinning, twin studies as applied across various disease areas and medical specialties, genetic and epigenetic determinants of differentiation, and academic, neurological and cognitive development. The presentation of existing studies and methods instruction empowers students and researchers to apply twin-based research and advance new studies across a range of biomedical and behavioral fields, highlighting current research trends and future directions.

  • Lipids: Update on Diagnosis and Management of Dyslipidemia, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1 Edición
    • Volumen 51-3
    • Connie B. Newman + 1 más
    • Inglés
    In this issue of Endocrinology and Metabolism Clinics of North America, guest editors Drs. Connie B. Newman and Alan Chait bring their considerable expertise to the topic of Lipids: Update on Diagnosis and Management of Dyslipidemia. When untreated, dyslipidemia may have serious comorbidities; in this issue, top experts cover the evaluation and management of LDL cholesterol and high triglicerides in adults and children, providing practical information that will help physicians and other health care professionals treat their patients and improve outcomes.

  • Clinical Immunology

    • 1 Edición
    • Nima Rezaei
    • Inglés
    Clinical Immunology not only introduces the reader to the human immune system, it also covers immunology from clinical manifestation to therapeutic approaches in a wide range of conditions. Each chapter describes an introduction, the clinical manifestations, the immunopathogenesis, diagnosis, lab tests and therapeutic approaches. The book guides clinicians, researchers and students to a better understanding of the matters of immunologic-based diseases that can lead to better decision-making for patients.Because of the growing knowledge regarding the function of immune system in health and disease conditions, clinicians, researchers and students increasingly require an exclusive scientific reference to guide them on matters of immunologic-based diseases. Accordingly, despite the existence of numerous high quality references in basic and cellular/molecular immunology which deeply explain different immunologic mechanisms, there is still a knowledge gap in the field of clinical immunology.

  • Biotechnology in Healthcare, Volume 2

    Applications and Initiatives
    • 1 Edición
    • Debmalya Barh
    • Inglés
    Biotechnology in Healthcare presents up-to-date knowledge on the emerging field of biotechnology as applied to the healthcare industry. Biotechnology has revolutionized healthcare in the last two decades by developing and introducing novel diagnostics, therapeutics, and preventive measures; whether it is noncommunicable or communicable disease, primary or secondary care, or public health, it has shown its immense potential to provide a solution to the healthcare providers, physicians, and allied health care professionals.The second volume, Applications and Initiatives, contains 19 chapters focused on the applications of biotechnology related to public healthcare, hospital management, oncology, neurodegenerative and infectious diseases, regenerative medicine, IVF, clinical trials, precision food, FMGCs, PPCPs, pharmaceuticals, and smart technologies to monitor pandemic. Further, this volume also presents government initiatives and entrepreneurship challenges in healthcare biotechnology sector.This is a valuable resource for students, biotechnologists, bioinformaticians, clinicians, and members of biomedical and healthcare fields who need to understand more about the promising developments of the emerging field of biotechnology in healthcare.

  • Epigenetics and DNA Damage

    • 1 Edición
    • Volumen 33
    • Miriam Galvonas Jasiulionis
    • Inglés
    Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment. Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research.

  • A Pharmacology Primer

    Techniques for More Effective and Strategic Drug Discovery
    • 6 Edición
    • Terry P. Kenakin
    • Inglés
    A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Sixth Edition features the latest research surrounding the application of pharmacology in drug discovery in an effort to equip readers with a deeper understanding of complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for anyone involved in drug discovery. This edition has been reorganized for better flow and clarity and includes material on new technologies for screening (virtual, DNA encoded libraires, fragment-based) and a major section on phenotypic (target agnostic) screening for new leads and determination of drug targets. With full color illustrations as well as new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such a mRNA, gene therapy, antibodies and information on CRISPR and genomics.

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