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Elsevier

Libros en Ciencias de la Vida

  • Genetic Advances in Inborn Errors of Immunity

    • 1 Edición
    • Volumen 117
    • Inglés
    Genetic advances in inborn errors of immunity, published as Volume 117 of the serial Advances in Genetics, provides a comprehensive and up‑to‑date overview of the rapidly evolving genetic landscape underlying inborn errors of immunity (IEI). Bringing together authoritative contributions from leading experts, this volume examines how advances in genomics, molecular diagnostics, and functional immunology have transformed the understanding, classification, and clinical management of primary immunodeficiency disorders. The chapters span severe monogenic conditions to complex, polygenic phenotypes, highlighting both mechanistic insights and translational implications. Collectively, the volume serves as an essential reference for researchers and clinicians seeking to understand how genetic discoveries are reshaping immunology and precision medicine.

  • Essentials of Stem Cell Biology

    • 4 Edición
    • Robert Lanza + 1 más
    • Inglés
    Essentials of Stem Cell Biology, Fourth Edition is designed for the growing community of scientists, researchers, practitioners, and students embracing the latest advancements in stem cells. This comprehensive book, a collaboration of 7 editors and over 200 pioneering scholars and scientists, provides a thorough understanding of adult and embryonic stem cells. It combines fundamental concepts with cutting-edge research in specific organ systems, ensuring a robust foundation for anyone entering the field. Beyond the basics, the book delves into early development and the differentiation of ectoderm, mesoderm, and endoderm.It covers methods, applications to human diseases, regulation, ethics, and patient perspectives, leaving no stone unturned in the stem cell domain.

  • GANs in Medical Diagnostics and Classification

    • 1 Edición
    • Abhishek Kumar + 1 más
    • Inglés
    GANs in Medical Diagnostics and Classification explores the role of Generative Adversarial Networks (GANs) in addressing underdiagnosed and overlooked health challenges. The book bridges cutting-edge AI research with real-world medical applications, presenting interdisciplinary insights into how GANs enhance diagnostics, treatment precision, and disease surveillance across domains such as antimicrobial resistance, rare genetic disorders, and environmental health risks. It also examines ethical, policy, and accessibility dimensions of AI in healthcare. By combining technical depth with practical case studies, this volume equips medical researchers, AI engineers, and healthcare professionals with actionable knowledge to tackle silent epidemics using GAN-based tools.

  • Gallin and Ognibene's Principles and Practice of Clinical Research

    • 5 Edición
    • John I. Gallin + 2 más
    • Inglés
    Gallin and Ognibene’s Principles and Practice of Clinical Research, Fifth Edition provides the definitive text on clinical research as written by internationally recognized experts from the National Institutes of Health, the US Food and Drug Administration, academia, and global researchers. This new edition contains more than 30 new authors and 9 new chapters. Topics covered emphasize the role of informatics in clinical research, incorporating clinical outcome assessment into endpoints for decision-making, inclusion of diverse and vulnerable research subjects, patient advocacy groups, rare disease research, preparing research for pandemics, public health emergencies, research opportunities for surgeons, and content on preclinical animal studies.For the international researcher, two new chapters detail international clinical research experiences in South Africa, India, and Pakistan. As with the previous edition, the new release provides readers with summary questions and answers after each chapter.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 136
    • Inglés
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Aging and Troponin

    Clinical Implications and Uses Beyond Diagnosis
    • 1 Edición
    • Gary Tse + 3 más
    • Inglés
    Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Sections cover the technical aspects of troponin assays, comparing traditional and high-sensitivity assays and exploring point-of-care testing advancements.The book also examine age-related changes and intra- and inter-individual variability in troponin levels, focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity, and discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice.

  • Biology of Aging Accelerators

    Fundamentals, Hallmarks and Therapeutic Interventions
    • 1 Edición
    • Sandeep Kumar Singh + 1 más
    • Inglés
    Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions explores how biological, genetic, and environmental factors affect cellular and systemic homeostasis and lead to accelerated aging. The book begins with a historical perspectives, highlighting the growth in immune system deterioration, chronic illness, and social issues. It then examines the hallmarks of aging, including primary, antagonistic, and integrative characteristics that may or may not be contributors. Subsequent chapters explore basic concepts and key accelerators in human biology, the role of biological clocks, and mechanisms of aging accelerators such as cellular senescence, DNA damage, and mitochondrial dysfunction.The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator and provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life.

  • Human-AI-Cognitive Intelligence Software, System, and Services for Quality Assurance

    Theories and Methods with Systems Thinking for Behaviour Change in the Medical Decision-Making Pathway
    • 1 Edición
    • Pantea Keikhosrokiani
    • Inglés
    Habit-based Behavior Change Medical Information Support System and Artificial Intelligence: Theories, Methods, and Data Analytics Approach provides a guideline to design and implement Habit-based Behavior Change Support Systems (HBCSS) which can change patient’s unhealthy habits to prevent the development of diseases. It presents theories, methods, management, and data analytics approach required to design, implement, and prescribe the use of HBCSS for several diseases’ management.It discusses topics such as theories of behavior change, ontologies and knowledge management, data mining, privacy and security, descriptive and prescription analytics. In addition, it discusses how to measure habit-change, future directions of the field, and case studies based on real-world examples.It is a valuable resource for clinicians, researchers, students, and member of the biomedical and medical fields who want to learn more about the use of medical systems to improve patients’ health.

  • Glial Mechanisms in Sleep and Circadian Biology

    • 1 Edición
    • Marcos G. Frank
    • Inglés
    Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep. It seamlessly links glial cell activity to the multi-system processes that affect sleep. Experts in the field discuss how glial cells influence the sleep-wake cycle, the accumulation and discharge of sleep drive, the timing of sleep and wake across the 24-hour day, and how glial cells may govern important sleep functions (e.g., brain plasticity and metabolism). This is a book that could well change scientists’ and practitioners’ traditional beliefs about the factors underlying sleep.Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.

  • The Role of Machine Learning and Artificial Intelligence in Revolutionizing Healthcare

    • 1 Edición
    • Prashant Kesharwani + 1 más
    • Inglés
    Revolutionizing Healthcare: The Role of Machine Learning and Artificial Intelligence describes the complexity of healthcare data that necessitates the expanding use of artificial intelligence (AI). This book offers an explicit accounting of vital aspects on artificial intelligence in healthcare, discussing perspectives of the technologies explored based on findings outlined in highly organized tables, illustrative figures, and flow charts. It brings together novel applications of artificial intelligence in healthcare and helps readers define major gaps in knowledge that can lead to significant scientific discoveries.In addition, the book covers computational drug design, genomic data mining, nanomedicines, medical devices, cosmeceuticals, biosensors, genome counseling, quality control, clinical trials, and cybersecurity. Researchers, students, and scientists will find the book provides foundational and practical knowledge, along with the most advanced AI applications in healthcare.

  • Empowering Health through Lifestyle Medicine

    The Essential Guide for Preventing and Managing Chronic Disease
    • 1 Edición
    • John Anthony Stevens
    • Inglés
    Empowering Health through Lifestyle Medicine: The Essential Guide for Preventing and Managing Chronic Disease combines the most updated and available research with personal insights and experience, using the Lifestyle Medicine 6 pillar framework. The book engages readers not only in the description and efficacy of LM but also in its knowledge and discussions on concepts and behaviors for managing nutrition, physical activity, stress, mental health, and how our interactions with the environment can create a healthier, happier life. It will encourage clinicians to engage their patients more often, and more practically, with lifestyle medicine, while also helping consumers engage with their clinicians.With a goal of helping clinicians and healthcare related professionals prevent and manage lifestyle-related illnesses for life, this evidenced-based book can be used by anyone in healthcare. It is also ideal for those researching illness prevention and chronic disease management to improve health research practice and patient outcomes.

  • Geographic Atrophy in Age-related Macular Degeneration

    • 1 Edición
    • Jay Chhablani + 1 más
    • Inglés
    Geographic Atrophy in Age-related Macular Degeneration provides a comprehensive resource on this flourishing discipline, focusing on accurate diagnosis, imaging features, clinical trials, differential diagnoses, and both established and emerging treatment options. The book details diagnostic processes using techniques such as visual acuity tests, dilated eye exams, fundus photography, optical coherence tomography (OCT), and fluorescein angiography, emphasizing the importance of early detection. It also differentiates geographic atrophy from other retinal conditions with similar symptoms, such as dystrophies, equipping practitioners with the knowledge for accurate diagnosis.Additional... it explores traditional management approaches like antioxidant supplements, lifestyle changes, and low vision aids, alongside novel treatments such as complement inhibitors, cell-based therapies, and gene therapy, to inform clinicians about the latest advancements and research in patient care. With the recent FDA approval for GA treatment, there has been significant interest in the retina community. This rapidly growing field necessitates a new book on geographic atrophy in age-related macular degeneration to address gaps in existing literature and provide up-to-date, comprehensive information.

  • Fluid Dynamics of Viral Transmission

    • 1 Edición
    • Mehrzad Shams + 1 más
    • Inglés
    Fluid Dynamics of Viral Transmission is an essential exploration into the transmission dynamics of COVID-19, focusing specifically on the airborne spread of respiratory aerosols carrying infectious viruses. In light of the recent global pandemic, it offers crucial insights into the complex interaction between fluid dynamics and viral transmission and provides practical solutions for minimizing risks in indoor environments. The book delves into CFD simulations, optimizing ventilation systems, air filtration strategies, and spatial layout modifications. It evaluates mitigation measures such as mask-wearing, physical distancing, and occupancy limits, aiming to equip readers with the knowledge to create safer indoor spaces. This book is ideal for public health officials, policymakers, healthcare professionals, engineers, researchers, and academics in fluid mechanics, computational fluid dynamics, epidemiology, and virology.

  • Current Advances in Cancer Stem Cells and Neoplasia Research

    • 1 Edición
    • Hirendra Banerjee
    • Inglés
    "Cancer, Volume 8" in the "Stem Cell Innovation in Health and Disease" series explores the rapidly evolving role of stem cells in cancer treatment. As cancer continues to impose a heavy global health burden, stem cell therapies are being recognized for their regenerative potential and ability to enhance recovery following aggressive therapies. Hematopoietic stem cell (HSC) transplantation is already a standard, FDA-approved treatment for hematologic cancers such as leukemia, myeloma, and lymphoma. These cells help regenerate healthy blood cells post-treatment. In addition, mesenchymal stem cells (MSCs) and neural stem cells (NSCs) are showing promise in preclinical models as therapeutic carriers, capable of homing to tumor sites and delivering anti-cancer agents such as nanoparticles, siRNAs, and small-molecule drugs. Recent clinical advancements include differentiation therapy, where stem cells are used to induce cancer cells to become non-cancerous. Two completed phase I clinical trials have demonstrated innovative applications: one using NSCs to convert a prodrug into a toxic compound within tumors, and another using MSCs engineered with viral enzymes to activate cytotoxic drugs directly at the tumor site. MSCs have also helped reduce graft-versus-host disease (GVHD), a major complication of stem cell transplants. This volume is divided into two main sections: understanding stem cell roles in cancer biology, and translating stem cell innovations into clinical practice. It features cutting-edge research, including organoid models, genetic editing, and iPSC technologies. Together, these insights offer a timely review of the field’s progress and its real-world potential to reshape cancer therapy.

  • Human Reproduction

    From basics to Biotechnology
    • 1 Edición
    • Marc yeste
    • Inglés
    Human Reproduction: From Basics to Biotechnology is a complete reference for anyone in the field of life, health, and biomedical sciences. The book provides an overview of basics in human reproduction to advanced knowledge of the field, including some evidence from other mammalian species that complement our current knowledge on the anatomy and physiology of the male and female reproductive tract and gametes. This resource covers the most used assisted reproductive techniques and technical advances, human reproduction and infertility disorders, their diagnosis and available treatment options.

  • Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine

    • 1 Edición
    • Cheng Xue + 3 más
    • Inglés
    Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine provides a comprehensive exploration into the molecular signatures and clinical implications of urine biomarkers, providing invaluable insights for clinicians, researchers, and healthcare professionals. From historical perspectives to cutting-edge technologies, this reference presents an updated understanding of urine biomarkers' role across diverse bodily systems. With sections devoted to fundamental concepts, molecular signatures, and clinical applications, readers gain a deep understanding of urine biomarkers' significance in disease diagnosis and personalized medicine.Each chapter explores specific body systems, including renal, urological, cardiovascular, and respiratory, uncovering the diagnostic potential of urine biomarkers in various conditions like cancer, cardiovascular diseases, and neurological disorders. Highlighted are the latest advances in technology, challenges, and future directions, keeping readers abreast of the rapidly evolving landscape of urine biomarker research. Real-world case studies illustrate practical applications, enhancing comprehension and facilitating knowledge transfer to clinical practice.

  • Thiamine Pyrophosphate (TPP)-Dependent Enzymes

    • 1 Edición
    • Volumen 736
    • Inglés
    Thiamine Pyrophosphate (TPP)-Dependent Enzymes, Volume 736 in the Methods in Enzymology series covers this diverse group of ubiquitous enzymes with timely chapters on Methods for Studying ThDP-dependent Mycobacterial MenDs (SEPHCHC Synthases), Mammalian 2-hydroxyacyl-CoA lyases, discovery and assays, Anti-infective target 1-deoxy-d-xylulose-5... synthase (DXS) and drug design for enzyme inhibition, Expression, Purification, and Mechanistic Studies of DXP synthases from Deinococcus radiodurans, Plasmodium falciparum, and Plasmodium vivax, Comparison of the catalysis of ThPP-dependent enzymes AHAS, ALS, and DXS, and much more.Additional sections cover Plant and fungal acetohydroxyacid synthases (AHAS): Methods for heterologous expression, kinetic characterization, and structural analysis, Biochemical and Structural characterization of novel ‘split-gene’ archeal transketolases, 4-Hydroxybenzoylform... decarboxylase enzymes from Rhodococcus jostii RHA1 and Pseudomonas fluorescens Pf-5: characterization and involvement in bacterial lignin degradation, Engineering of phosphoketolase from Bifidobacterium adolescentis for increased activity on non-phosphorylated substrates and application in a cell-free reaction system for ATP regeneration, Repurposing TPP-dependent enzymes with anodic oxidation for the conversion of aldehydes to enantioenriched carboxylic acids, and much more.

  • The Metabolon

    • 1 Edición
    • Volumen 739
    • Inglés
    Methods in Enzymology series: The Metabolon, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Morbidity Prevention in Aging

    The Role of Salutogenesis Amidst Crises
    • 1 Edición
    • Nestor Asiamah + 3 más
    • Inglés
    Morbidity Prevention in Aging: The Role of Salutogenesis Amidst Crises addresses the urgent need to rethink disease prevention strategies for an aging population. The book begins by exploring how age-friendly environments support health-seeking behaviors. The next section focuses on developing personal skills such as resilience and self-efficacy for maintaining health during crises. Section III examines the reorientation of health services to support preventive care, including community care and diet promotion, while Section IV addresses the creation of policies that facilitate health-promoting interventions and integrate prevention strategies. Community engagement and empowerment in promoting health is emphasized in the fifth section.The book concludes by providing a framework for understanding disease prevention amidst crises, focusing on diverse racial, cultural, and socioeconomic experiences and ensuring equitable opportunities for lifelong disease prevention. This groundbreaking book emphasizes a salutogenic approach that focuses on factors promoting health rather than merely treating diseases. It provides a comprehensive framework for understanding how to maintain health and prevent diseases across the lifespan, even amidst challenges such as wars, climate change, and industrial hazards.

  • Shared Research Resources

    Best Practices in Management and Administration
    • 1 Edición
    • Andrew Vinard + 2 más
    • Inglés
    Shared Research Resources: Best Practices in Management and Administration brings together best practices and case studies from research institutions around the world. Covering all areas of management, with examples and applications specific to the research environment, this is the perfect reference to build managerial skills. The first part is dedicated to introducing Shared Research Resources (SRR) management. The second part covers all aspects of staffing. Part three contains complete coverage of operations, including service development, instrument procurement, marketing, management software, customer support, safety, maintenance and repair. Part four is dedicated to fiscal management, budgeting, and reporting.Part five covers strategic management. Part six is devoted to the sustainability of the core facility. The final part covers assessment, including annual reports, program reviews, and audits. This book is a complete reference targeted at SRR managers and staff who need to keep updated with current best practices and case studies. It is also important reading for research institution managers and function leaders.

  • Perianal Crohn’s Disease

    Diagnosis and Treatment
    • 1 Edición
    • Bolin Yang + 2 más
    • Inglés
    Perianal Crohn’s Disease: Diagnosis and Treatment includes the latest knowledge, concepts, first-hand theoretical views, and clinical experience of clinical frontline experts in the field of inflammatory bowel disease. The book systematically describes disease phenotypes, clinical features, examination methods, diagnoses, and treatments. It takes a scientific, practical, and systematic account of both common and rare conditions associated with Perianal Crohn’s Disease, offering informative content, clinical case information, cutting-edge viewpoints, and current, authoritative research findings. The book contains a depth of current clinical experience, including the use of photographs to support examples of conditions, methods, and techniques. In addition, it provides clear ideas and a wealth of clinical information for the clinical diagnosis and management of perianal Crohn's disease.

  • Animal Models of Disease Part F

    • 1 Edición
    • Volumen 212
    • Inglés
    Animal Models of Disease, Part F, Volume 212 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.

  • Technology-Assisted Physical Gait Rehabilitation

    How Robotics, Data Science, and Neuroscience are Changing Modern Physical Therapy
    • 1 Edición
    • Tomislav Baček + 3 más
    • Inglés
    Technology-Assisted Physical Gait Rehabilitation: How Robotics, Data Science, and Neuroscience are Changing Modern Physical Therapy explores computational modeling techniques, robotic assistance, data science, and other technological tools and how they can be jointly used in driving and guiding physical gait therapy in impairments such as stroke, traumatic brain injury, and incomplete spinal cord injury. This book gathers experts in robotics, human biomechanics, physical therapy, neuroscience, engineering, and medicine, presenting their ongoing work and discusses their views of the future direction of technology-assisted gait therapy, showcasing the latest advancements in the interdisciplinary and multidisciplinary field of technology-assisted gait therapy and strives to outline the developments in the coming years that are needed/likely to make the next big breakthrough in the field.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 137
    • Inglés
    Advances in Applied Microbiology presents the latest developments and innovative research in applied microbiology, covering topics such as microbial biotechnology, environmental applications, industrial processes, and medical advancements. It offers valuable insights into the practical uses of microorganisms in solving real-world challenges, making it an essential resource for researchers, professionals, and students in microbiology and related fields.

  • Advances in Biomembranes and Lipid Self-Assembly

    • 1 Edición
    • Volumen 44
    • Inglés
    Advances in Biomembranes and Lipid Self-Assembly, Volume 43 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Content in this new release covers Engineered probiotics for producing phosphoinositol-sn-l... as biosurfactant modulators: Their hydropathy, in potentiating surface tension and scaffold properties into model emulsions.

  • Diabetic Neuropathy

    • 1 Edición
    • Shahidul Islam
    • Inglés
    "Recent Therapeutic Targets for the Prevention and Management of Diabetic Complications: Neuropathy" covers recent research and therapeutic approaches of this diabetic complication for the management of diabetes. It is a detailed reference to understand the pathogenesis of diabetes to alleviate the overall complications of neuropathy to improve patient care. It is uniquely focused on the different aspects of neuropathy with a focus on the molecular and biological pathways (therapeutic target) to detect an early diagnosis to better manage the disease and improve patient care. The book is useful to anyone in the field particularly those who do research investigations, and day-to-day practice in the area of diabetes.

  • Biosimilars in Cancer

    • 1 Edición
    • Ranjita Shegokar + 1 más
    • Inglés
    Biosimilars in Cancer is a comprehensive resource on the role of biosimilars in treating various cancer types. The book offers a succinct yet thorough overview of current trends in oncology, covering 21 different cancers from liver to breast cancer. Chapters provide detailed insights into trends, fundamental facts, and practical and clinical data, making it an invaluable tool for academics and practitioners. The book empowers researchers and clinicians to enhance understanding and improve patient outcomes through the effective use of biosimilars in oncology. Targeted primarily at pharmaceutical researchers, biomedical scientists, and clinicians, it supports the growing oncology biosimilars market.In addition, the book provides critical insights for those involved in cancer diagnostics and clinical trials, helping them stay ahead in this rapidly progressing field.

  • Cell Death Part F

    • 1 Edición
    • Volumen 211
    • Inglés
    Cell Death: Part F, Volume 211 presents the latest advances and comprehensive reviews in the rapidly evolving field of cell death. This volume explores Methods to Assess BAX Conformation, Activation, Translocation, and Mitochondrial Outer Membrane Permeabilization, Proximity biotin labelling identification of Bcl-2 protein interactions in live cells, Bimolecular fluorescence complementation assays for investigating Bcl-2 family protein interactions, Assessing apoptotic sensitivity in primary mouse B cells by BH3 profiling, Liposome permeabilization assays to monitor pore formation by cell death proteins, Flow Cytometry Assessment of Mitochondrial Membrane Potential, Biomass, and ROS in OXPHOS-Dependent and Glycolytic Cancer Cells during Cell Death Induction, and much more.Additional chapters cover Assessment of Viability Versus Cell Death: What is What?, Flow cytometry-based drug response profiling of primary B-precursor ALL cells in co-culture with bone marrow-derived stromal cells, An in vitro model of efferocytosis in macrophage foam cells to probe lipid-driven dysregulation of dead cell clearance, Measuring tumor cell killing using in vivo bioluminescence imaging, and more.

  • Geostatistical Approaches to Environmental and Public Health Issues

    • 1 Edición
    • Deepak Kumar + 4 más
    • Inglés
    Geostatistical Approaches to Environmental and Public Health Issues discusses how geostatistical techniques can be leveraged to better understand and respond to pressing environmental and public health challenges. The book showcases how techniques like kriging, spatial regression, Bayesian modeling, and space-time analysis offer powerful, nuanced insights into these issues. Emphasizing stochastic, non-deterministic approaches, it highlights the importance of modeling uncertainty in both environmental and health domains. Through case studies and research-driven chapters, sections demonstrate how integrating geospatial and statistical methods can enhance our understanding of where, why, and how events occur—ultimately improving the precision of health interventions and environmental policies.By aligning cutting-edge statistical approaches with the geospatial dimensions of health and environmental data, this book fills a critical gap in the literature and supports more targeted, data-driven decision-making in the face of global uncertainty. It bridges methodological innovation with applied research, making it an essential resource for scientists, policymakers, and public health practitioners.

  • Electrocardiography of Laboratory Animals

    • 3 Edición
    • Meg M. Sleeper + 1 más
    • Inglés
    Electrocardiography of Laboratory Animals, Third Edition, provides the latest information on critical topics such as safety electrocardiography, toxicology, safety pharmacology, and telemetry, ensuring that readers are well-equipped with the knowledge required for accurate ECG interpretation in preclinical studies. The book begins with the fundamental principles of electrocardiography and its applications in drug safety evaluation but then covers electrocardiography in a wide range of laboratory animals, including rodents, guinea pigs, rabbits, cats, dogs, and various non-human primates such as marmosets, cynomolgus monkeys, rhesus monkeys, baboons, and chimpanzees.Addition... it reviews the ECG characteristics of minipigs, nanopigs, and micropigs. The text also includes chapters on telemetry and echocardiography in preclinical safety studies, as well as discussions on important parameters like PR (PQ), QRS, and QT intervals. The book concludes with chapters on cardiac assays, biomarkers, stem cells, and cardiovascular medical devices, providing a holistic view of cardiovascular research. It is an essential resource for biological and medical researchers, veterinarians, zoologists, and students.

  • Understanding Molecular Processes using Electrochemical Methods

    • 1 Edición
    • Ashis Kumar Satpati + 1 más
    • Inglés
    Understanding Molecular Processes using Electrochemical Methods offers a detailed compendium of techniques for molecular analysis. The book considers step and sweep techniques, scanning electrochemical microscopy, spectroelectrochemic... techniques, electrochemiluminesc... and scanning probe techniques while also exploring COSMOL multiphysics simulation, electroanalysis in biomedical and clinical applications, and future prospects for electrochemical techniques. Chapters focus on evaluating redox reactions, biological interactions, kinetics, quorum sensing, biofilm formation, surface modification and more molecular aspects. This volume offers a deep-dive into the fundamental principles behind the latest electrochemical techniques, equipping researchers with practical guidance for their own experiments.Users will find this to be an ideal reference for researchers working across a range of disciplines including molecular biology, bioanalytical chemistry, biomedical science, and translational medicine.

  • Bio-Click Chemistry

    Expanding Horizons Beyond the Click
    • 1 Edición
    • Flavia Zacconi + 2 más
    • Inglés
    Bio-Click Chemistry: Expanding Horizons Beyond the Click delves into the dynamic intersection of biocatalysis and click chemistry, providing a comprehensive exploration of these rapidly evolving fields. This book offers in-depth insights into both historical perspectives and the latest advancements, ensuring readers gain a thorough understanding of fundamental principles, practical applications, and future directions. Readers will discover the versatile applications of biocatalysis and click chemistry in pharmaceuticals, biotechnology, biology, biomedicine, nanomedicine, and materials science, equipping researchers, educators, and industry professionals with the tools and techniques needed to foster innovation and real-world impact. Furthermore, the book investigates the emerging trends, challenges, and opportunities in biocatalysis and click chemistry, empowering readers to stay ahead of the curve and drive transformative developments in chemical synthesis and enzymatic engineering. This indispensable guide is designed for researchers, educators, and industry professionals dedicated to advancing their work and exploring new frontiers in chemical synthesis and biocatalytic processes.

  • The Potential of Extracellular Vesicles from Plant and Animal Sources for Improving Human Beauty and Health

    • 1 Edición
    • Khalid Rehman Hakeem + 2 más
    • Inglés
    The Potential of Extracellular Vesicles from Plant and Animal Sources for Improving Human Beauty and Health is a comprehensive resource that consolidates the latest research on the mechanisms of extracellular vesicles (EVs) and their applications in the cosmetic industry. The book explores a range of topics, including the latest techniques in isolation and characterization of EVs, safety considerations, methods, and challenges associated with large-scale production, and recent advancements in biomedical applications. The therapeutic potential of EVs for age-related neurological conditions and autoimmune skin diseases is investigated, as well as the application of EVs for skincare, hair loss and anti-aging products.The book considers EVs from a variety of sources, including humans, plants, animals and bacteria, highlighting their major differences. It also includes a discussion of market trends and the global impact for EV products in cosmetic and anti-aging industries. With growing interest in the role of extracellular vesicles in enhancing health and beauty, this book provides invaluable insights to researchers working in this field, equipping them with the knowledge to leverage EVs for innovative cosmetic applications and natural solutions.

  • PACAP

    From Discovery to Function
    • 1 Edición
    • David Vaudry + 1 más
    • Inglés
    PACAP: From Discovery to Function in Health and Disease serves as a comprehensive review covering all aspects of PACAP and its receptors, from expression to function in healthy tissues and disease models. The book introduces the biochemical, pharmacological and signaling properties of PACAP before exploring the biological actions of PACAP in normal health and pathological conditions. It considers PACAP in relation to various aspects, including pain, stress, brain injury, tumor cells and neurodegenerative disease. Effect on peripheral organs is also covered, from the gastrointestinal tract and cardiovascular system to immune cells and bones, among others. Therapeutic potential is also explored. This is a volume in the Molecular Mediators in Health and Disease book series, and provides a complete analysis of PACAP and the latest research in the field. Thus it is an ideal guide for researchers interested in PACAP and its impact across health and disease.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 136
    • Inglés
    Advances in Applied Microbiology provides a comprehensive overview of the latest research, innovations, and practical applications in the field of microbiology. Covering a broad spectrum of topics, this book explores recent advances in microbial biotechnology, environmental and industrial microbiology, medical and food microbiology, and emerging technologies. Each chapter highlights significant developments, challenges, and future directions, making it an invaluable resource for researchers, students, and professionals seeking to stay updated on the dynamic landscape of applied microbiology. With contributions from leading experts, this volume offers insights into the vital roles microorganisms play in various sectors, including health, agriculture, industry, and the environment.

  • Computational and Experimental Approaches in Protein Engineering and Design

    • 1 Edición
    • Aditya Kumar Padhi + 1 más
    • Inglés
    Computational and Experimental Approaches in Protein Engineering and Design offers a one-stop resource for students, researchers, and practitioners. Cutting-edge techniques in AI and machine learning applications are expertly covered in the book, empowering readers with the tools they need to tackle modern challenges in biotechnology and therapeutics. Step-by-step protocols provide readers with actionable guidance to transition smoothly from computational modelling to laboratory implementation. The inclusion of real-world case studies makes the theoretical concepts relatable and actionable and immediately applicable to solving complex problems, such as producing protein-based vaccines for immunotherapy.The book’s focus on synthetic biology positions it at the forefront of innovation, appealing to a broad audience, from those involved in tissue engineering to those exploring next-generation therapeutics. With its forward-looking approach, emphasizing machine-learning-dri... protein design and nanobody engineering, this book is an indispensable resource for researchers preparing to navigate the future of biotechnology.

  • Nano Meets Micro

    Revolutionizing Medicine through Microfluidic Devices
    • 1 Edición
    • Fatemeh Hataminia + 1 más
    • Inglés
    Nano Meets Micro: Revolutionizing Medicine through Microfluidic Devices explores the transformative potential of integrating nanotechnology with microfluidics to revolutionize medical diagnostics, treatment, and personalized medicine. The book provides a detailed examination of how these cutting-edge technologies are making healthcare more precise, efficient, and personalized. Sections highlight nanomedicine and microfluidics, highlighting their importance in healthcare and their intersection with advanced healthcare solutions. It covers traditional and emerging fabrication techniques for microfluidic devices, the design and synthesis of nanoparticles, and the integration of nanomedicine into microfluidic systems. Examples and case studies illustrate how these technologies are used in drug delivery, disease diagnosis, and rapid diagnostics.With a strong focus on future implications, the book discusses emerging trends and potential advances in microfluidics and nanotechnology, including the integration of artificial intelligence and data analytics. It addresses the challenges and future directions in the commercialization of nanomedicine and microfluidic devices, providing a roadmap for translating laboratory innovations into clinical applications.

  • Molecular Tools and Infectious Disease Epidemiology

    • 2 Edición
    • Betsy Foxman + 1 más
    • Inglés
    Molecular Tools and Infectious Disease Epidemiology, Second Edition examines the opportunities and methodologic challenges in the application of modern molecular genetic and biologic techniques to infectious disease epidemiology. The application of these techniques dramatically improves the measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. This book presents the key points of consideration when integrating molecular biology and epidemiology.Section... discuss how using molecular tools in epidemiologic research affects program design and conduct, consider the ethical concerns that arise in molecular epidemiologic studies, and provide a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory, and in the field. The book is recommended for graduate and advanced undergraduate students studying infectious disease epidemiology and molecular epidemiology; and for the epidemiologist wishing to integrate molecular techniques into their studies.

  • Clinical Atlas of Gonioscopy

    • 1 Edición
    • Chunyan Qiao + 3 más
    • Inglés
    Clinical Atlas of Gonioscopy comprehensively and systematically covers all aspects of gonioscopy: from basic knowledge and common manifestations to characteristic signs of different diseases, and the application of gonioscopy in the laser and surgical treatment of glaucoma. Including over a thousand high-quality images, it helps clinicians explore the diverse and fascinating world of the anterior chamber angle, and deepens their understanding of the pathogenesis, classification, diagnosis, differential diagnosis, treatment and follow-ups of glaucoma.

  • Gestational Diabetes Mellitus

    Epidemiology, Clinical Practice and Evidence-Based Guidelines
    • 1 Edición
    • Moshe Hod + 6 más
    • Inglés
    Gestational Diabetes Mellitus: Epidemiology, Clinical Practice and Evidence-Based Guidelines is an invaluable resource for healthcare professionals seeking to understand the latest developments in GDM. Over the past 20 years, significant progress has been made in the study of its epidemiology, mechanisms, diagnosis, management, and prevention. This book delves into these advancements, offering insights that are crucial for both researchers and clinicians. It explores potential therapeutic solutions to enhance patient care, and is essential reading for obstetricians, endocrinologists, diabetes researchers, maternal health specialists, and pediatric endocrinologists, as well as specialty fellows, residents, postdoctoral fellows, and graduate students in these fields.

  • Capsule Endoscopy in Pediatric Patients from Theory to Practice

    • 1 Edición
    • Thomas M. Attard
    • Inglés
    Capsule Endoscopy in Pediatric Patients from Theory to Practice is a practical and authoritative guide that empowers pediatric gastroenterologists, physicians, and trainees to navigate the complexities of Video Capsule Endoscopy (VCE) in children. With a focus on bridging knowledge gaps and providing practical insights, this book offers updated information on understanding and utilizing VCE in the pediatric population. The book covers the background and technical aspects of VCE, including guidance on setting up a pediatric VCE service and an overview of indications and limitations. It delves into practical aspects such as preprocedural preparation, artifact reduction techniques, and management of capsule retention. By exploring VCE in various disease conditions such as inflammatory bowel disease, gastrointestinal bleeding, hereditary polyposis syndromes, and chronic abdominal pain, readers gain a comprehensive understanding of diagnosis, surveillance, and management. Special content elements, including key terms, case studies, and a timeline of recent advances, enhance the learning experience. This essential resource empowers readers to optimize patient care, make informed decisions, and confidently navigate the realm of VCE in children.

  • Structural Biology of Ubiquitination

    From Mechanisms to Interventions
    • 1 Edición
    • Navaneet Chaturvedi + 1 más
    • Inglés
    Structural Biology of Ubiquitination: From Mechanisms to Interventions provides an in-depth exploration of the structural and biophysical principles governing ubiquitination and their implications in diseases such as cancer and neurodegeneration. The book seamlessly integrates experimental insights with advanced computational methods, including AI-driven drug discovery, molecular modeling, and biophysical simulations, offering a comprehensive toolkit for researchers and clinicians. By bridging fundamental science with translational applications, the book empowers readers to design targeted therapeutics, understand disease mechanisms at the molecular level, and accelerate progress toward personalized medicine.

  • Dry Eye Disease

    A Clinical Handbook
    • 1 Edición
    • James Stuart William Wolffsohn + 2 más
    • Inglés
    Dry Eye Disease: A Clinical Handbook illuminates the translation of cutting-edge research on dry eye disease into practical situations, allowing clinical diagnosis and management of the condition using the latest evidence-based methods. It first presents research on the core pathophysiological features of dry eye disease, including tear film instability, hyperosmolarity, inflammation, and ocular surface damage. Thereafter, it champions a patient-centered approach to dry eye management, emphasizing the necessity of classifying the ocular surface disease(s) most relevant to each case. It discusses global disease distribution and the role of non-modifiable risk factors like age, sex, and ethnicity. Additionally, the book describes tools for monitoring symptoms over time and assessing subtle signs of the disease. Readers will find practical methods for improving patient outcomes both in clinical settings and at home.

  • Intelligent IoT-based Diagnostic and Assistive Systems for Neurological Disorders

    • 1 Edición
    • Hanif Heidari + 1 más
    • Inglés
    Intelligent IoT-based Diagnostic and Assistive Systems for Neurological Disorders discusses the latest developed methods in IoT and its applications in neurological disorders that emphasize end-user requirements. Intelligent IoT is used to explore the intersection between medicine, data science, biomedical engineering, and healthcare systems. A comprehensive overview of modelling and analyzing the requirements of people with neurological disorders is presented in this book. Signals and images of biological activity are collected and analyzed based on patient specifications to facilitate more accurate diagnosis and treatment. The book also discusses cutting-edge AI methods for IoT devices designed to treat neurological conditions.

  • Applications of Microfluidics Device Technology

    • 1 Edición
    • Volumen 226
    • Inglés
    Microfluidics is a rapidly expanding field that is recognized as a powerful platform for accelerating biological science research and innovation. It has the potential to reduce the cost and reagent consumption by enabling the precise manipulation of a small amount of fluids through microchannel ranging from ten to hundreds micrometres in size. It is a multidisciplinary domain, which integrates molecular analysis, molecular biology, and microelectronics. It has demonstrated practical applications in the design and fabrication of systems capable of processing low volumes of fluids while enabling multiplexing, automation, and high-throughput screening. Since its emergence in early 1980s, microfluidics has significantly contributed in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies. Microfluidic chips comprise intricate networks of microchannels and chambers designed to manipulate fluids at the microscale. This volume highlights the applications of microfluidics in the detection and analysis of infectious diseases caused by bacteria, viruses, fungi, and protozoa. It also explores the use of microfluidic technologies in the diagnosis and study of non-infectious diseases, including cardiovascular disorders, cancer, metabolic diseases, and neurological conditions. It also covered single-cell analysis, high-throughput drug screening, cell sorting, and both preclinical and clinical applications. It also used in role of microfluidics in organ culture, regenerative medicine, and personalized healthcare. It also addresses ethical and regulatory issues in the development and use of microfluidic devices. This volume is designed to serve as valuable resource for students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand microfluidics and apply microfluidics technology/devices in various fields. It provides a strong foundation to help the extension of microfluidics knowledge and accelerate research, innovation, technology and practical applications.

  • Super-Resolution Nanoscopy for Protein Imaging

    • 1 Edición
    • Varun Vyas
    • Inglés
    Super-Resolution Nanoscopy for Protein Imaging decodes the intricate world of protein visualization using cutting-edge nanoscopic techniques. This comprehensive guide is crafted to equip master students, PhD candidates, and early-stage researchers with essential knowledge and practical insights into advanced protein imaging technologies. The book covers foundational principles, innovative methodologies, and real-world applications, providing a complete resource for mastering the complexities of protein imaging. This book offers a unique compilation of diverse nanoscopic methods, overcoming the limitation of technique-specific texts currently available.By collecting scattered information into a single volume, it delivers an in-depth exploration of imaging techniques, from Atomic Force Microscopy (AFM) to Electron Microscopy (EM), and Single Molecule Fluorescence Imaging. Each section delves into instrumentation, sample preparation, data analysis, and the latest developments, making it an indispensable reference for understanding how to visualize proteins in their natural environments.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 135
    • Inglés
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Value-Based Healthcare in the Digital Age

    Economic Efficiency and Transformation
    • 1 Edición
    • Miltiadis Lytras + 2 más
    • Inglés
    Value-Based Healthcare in the Digital Age: Economic Efficiency and Transformation addresses the transformation in global healthcare that has been driven by digital innovation, economic efficiency, and value-based care. The book provides comprehensive frameworks that integrate health economics, digital transformation, and patient-centered value delivery. Facing rising costs, aging populations, and chronic diseases, the healthcare sector also sees opportunities in AI, machine learning, blockchain, and IoT for smarter, more efficient delivery. Users will find an exploration of the economic implications of these technologies, offering strategies to align them with value-based care principles, optimize resources, and improve patient outcomes.For academics, policymakers, and healthcare professionals, this book bridges theory and practice with cutting-edge research and real-world case studies. It equips readers with the knowledge and frameworks to navigate the evolving healthcare landscape, emphasizing global perspectives and diverse technological applications, ultimately driving innovation and economic sustainability in healthcare delivery.

  • The Phylogenetic Pathways

    Research, Protocols and Applications
    • 1 Edición
    • Muzafar Riyaz + 1 más
    • Inglés
    The Phylogenetic Pathways: Tracing Evolution Across Time and Species embarks on a captivating journey that unveils the mysteries of evolutionary history and genetic ancestry. Delve into the fascinating realm of molecular phylogenetics and phylogenomics, where cutting-edge research and ancient genetic clues converge. Unravelling the enigmatic paradoxes that lie at the heart of the evolutionary process, this book takes readers on an exploration of genetic relationships spanning millions of years. From the origins of life to the branching paths of diverse species, readers will discover how scientists reconstruct the evolutionary tree of life using DNA. Through compelling storytelling and accessible explanations, the book introduces readers to the revolutionary field of phylogenetics, showcasing the powerful tools and methodologies used to decipher evolutionary patterns. It explores the frontiers of phylogenomics, where state-of-the-art genomic technologies illuminate the intricate tapestry of life's history. The book inspires curiosity, deepens the understanding of life's connections, and sheds light on the mysteries of the phylogenetic paradox, making it a must-read for anyone interested in the living world.

  • COVID-19 in New York City

    Public Health Crisis and its Aftermath
    • 1 Edición
    • Rainer W.G. Gruessner
    • Inglés
    COVID-19 in New York City: A Five-Year Account presents a comprehensive account of the pandemic, from how events unfolded, how circumstances were handled, and how New Yorkers learned to better manage a similarly deadly pandemic in the future. The book documents the period from when the first case was diagnosed in New York City, addressing the medical, political, social, psychological, business, and environmental aspects, as well as the changes in behavior and lifestyle. The author shares his birds eye view of the city through a comprehensive investigation of the events, and the impact of the current and future implications for all readers.This book serves as a guide for anyone interested in how to handle and cope with a future deadly pandemic or similar disaster and is written by a physician and advocate for science who was living in New York City during the pandemic.

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