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Elsevier

Libros en Ciencias de la Vida

  • Advances in Microbial Food Safety

    Volume 2
    • 1 Edición
    • J Sofos
    • Inglés
    Research and legislation in food microbiology continue to evolve, and outbreaks of foodborne disease place further pressure on the industry to provide microbiologically safe products. This second volume in the series Advances in Microbial Food Safety summarises major recent advances in this field, and complements volume 1 to provide an essential overview of developments in food microbiology. Part one opens the book with an interview with a food safety expert. Part two provides updates on single pathogens, and part three looks at pathogen detection, identification and surveillance. Part four covers pathogen control and food preservation. Finally, part five focuses on pathogen control management.

  • Advances in Bacterial Pathogen Biology

    • 1 Edición
    • Volumen 65
    • Inglés
    This volume is an up-to-date overview of the physiology of selected pathogenic bacteria. Each chapter is written by experts in the field of that organism.The focus is on biochemistry and physiology but topics of clinical relevance are included.

  • Mitochondrial Function

    • 1 Edición
    • Volumen 547
    • Inglés
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. Methods to assess mitochondrial function is of great interest to neuroscientists studying chronic forms of neurodegeneration, including Parkinson's, Alzheimer's, ALS, Huntington's and other triplet repeat diseases, but also to those working on acute conditions such as stroke and traumatic brain injury. This volume covers research methods on how to assess the life cycle of mitochondria including trafficking, fusion, fission, and degradation. Multiple perspectives on the complex and difficult problem of measurement of mitochondrial reactive oxygen species production with fluorescent indicators and techniques ranging in scope from measurements on isolated mitochondria to non-invasive imaging of metabolic function.

  • Clinical Genomics

    • 1 Edición
    • Shashikant Kulkarni + 1 más
    • Inglés
    Clinical Genomics provides an overview of the various next-generation sequencing (NGS) technologies that are currently used in clinical diagnostic laboratories. It presents key bioinformatic challenges and the solutions that must be addressed by clinical genomicists and genomic pathologists, such as specific pipelines for identification of the full range of variants that are clinically important. This book is also focused on the challenges of diagnostic interpretation of NGS results in a clinical setting. Its final sections are devoted to the emerging regulatory issues that will govern clinical use of NGS, and reimbursement paradigms that will affect the way in which laboratory professionals get paid for the testing.

  • Practical Guide to Clinical Computing Systems

    Design, Operations, and Infrastructure
    • 2 Edición
    • Thomas Payne
    • Inglés
    Although informatics trainees and practitioners who assume operational computing roles in their organization may have reasonably advanced understanding of theoretical informatics, many are unfamiliar with the practical topics - such as downtime procedures, interface engines, user support, JCAHO compliance, and budgets - which will become the mainstay of their working lives. Practical Guide to Clinical Computing Systems 2nd edition helps prepare these individuals for the electronic age of health care delivery. It is also designed for those who migrate into clinical computing operations roles from within their health care organization. A new group of people interested in this book are those preparing for Clinical Informatics board certification in the US. The work provides particular differentiation from the popular first edition in four areas: 40% more content detailing the many practical aspects of clinical informatics. Addresses the specific needs of the Clinical Informatics board certification course – for which it is presently recommended by the ABPM Focus on new tech paradigms including cloud computing and concurrency – for this rapidly changing field.

  • Dietary Supplements

    Safety, Efficacy and Quality
    • 1 Edición
    • Katja Berginc + 1 más
    • Inglés
    Dietary supplements made from foods, herbs and their constituents are a rapidly growing market sector. Consumers often view food supplements as ‘natural’ and therefore safe; however, supplements are regulated as foods rather than as pharmaceuticals and so are not as closely monitored as may be necessary. With the commercial market in these products growing, this book provides essential research into their safety, efficacy and potential risk of interaction with pharmaceuticals. Following an introductory chapter, part one covers the chemical composition, manufacture and regulation of dietary supplements. Part two looks at the effectiveness of different types of dietary supplement and methods of evaluation. Finally, part three focuses on supplement safety.

  • Metagenomics for Microbiology

    • 1 Edición
    • Jacques Izard + 1 más
    • Inglés
    Concisely discussing the application of high throughput analysis to move forward our understanding of microbial principles, Metagenomics for Microbiology provides a solid base for the design and analysis of omics studies for the characterization of microbial consortia. The intended audience includes clinical and environmental microbiologists, molecular biologists, infectious disease experts, statisticians, biostatisticians, and public health scientists. This book focuses on the technological underpinnings of metagenomic approaches and their conceptual and practical applications. With the next-generation genomic sequencing revolution increasingly permitting researchers to decipher the coding information of the microbes living with us, we now have a unique capacity to compare multiple sites within individuals and at higher resolution and greater throughput than hitherto possible. The recent articulation of this paradigm points to unique possibilities for investigation of our dynamic relationship with these cellular communities, and excitingly the probing of their therapeutic potential in disease prevention or treatment of the future.

  • Diabetes and the Nervous System

    • 1 Edición
    • Volumen 126
    • Douglas W Zochodne + 1 más
    • Inglés
    This is a unique compilation, by experts worldwide, addressing how diabetes impacts the nervous system. For example, diabetic polyneuropathy, a disorder more common than MS, Parkinson’s disease, and ALS combined, is a major source of disability to diabetic persons worldwide. This book addresses diabetic polyneuropathy and how diabetes alters other parts of the nervous system.

  • Stem Cell Biology and Tissue Engineering in Dental Sciences

    • 1 Edición
    • Ajaykumar Vishwakarma + 3 más
    • Inglés
    Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration.

  • Epigenetics and Neuroplasticity - Evidence and Debate

    • 1 Edición
    • Volumen 128
    • Inglés
    The ‘epi-(Greek for ‘over’, ‘above’)genome’, with its rich cache of highly regulated, structural modifications—includ... DNA methylation, histone modifications and histone variants—defines the moldings and three-dimensional structures of the genomic material inside the cell nucleus and serves, literally, as a molecular bridge linking the environment to the genetic materials in our brain cells. Due to technological and scientific advances in the field, the field of neuroepigenetics is currently one of the hottest topics in the basic and clinical neurosciences. The volume captures some of this vibrant and exciting new research, and conveys to the reader an up-to-date discussion on the role of epigenetics across the lifespan of the human brain in health and disease.

  • Handbook of Natural Antimicrobials for Food Safety and Quality

    • 1 Edición
    • M Taylor
    • Inglés
    Natural additives are increasingly favoured over synthetic ones as methods of ensuring food safety and long shelf-life. The antimicrobial properties of both plant-based antimicrobials such as essential oils and proteins such as bacteriocins are used in, for example, edible preservative films, in food packaging and in combination with synthetic preservatives for maximum efficacy. New developments in delivery technology such as nanoencapsulation also increase the potential of natural antimicrobials for widespread use in industry. Part one introduces the different types of natural antimicrobials for food applications. Part two covers methods of application, and part three looks at determining the effectiveness of natural antimicrobials in food. Part four focuses on enhancing quality and safety, and includes chapters on specific food products.

  • The Use of CRISPR/cas9, ZFNs, TALENs in Generating Site-Specific Genome Alterations

    • 1 Edición
    • Volumen 546
    • Inglés
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers recent research and methods development for changing the DNA sequence within the genomes of cells and organisms. Focusing on enzymes that generate double-strand breaks in DNA, the chapters describe use of molecular tools to introduce or delete genetic information at specific sites in the genomes of animal, plant and bacterial cells.

  • Biomaterials and Medical Device - Associated Infections

    • 1 Edición
    • L Barnes + 1 más
    • Inglés
    Despite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation site. This book reviews the fundamentals of biomaterials and medical device related infections and methods and materials for the treatment and prevention of infection. The first part of the book provides readers with an introduction to the topic including analyses of biofilms, diagnosis and treatment of infection, pathology and topography. The second part of the book discusses a range of established and novel technologies and materials which have been designed to prevent infection.

  • Coffee in Health and Disease Prevention

    • 1 Edición
    • Victor R. Preedy
    • Inglés
    Coffee in Health and Disease Prevention presents a comprehensive look at the compounds in coffee, their reported benefits (or toxicity risks) and also explores them on a health-condition specific level, providing researchers and academics with a single-volume resource to help in identifying potential treatment uses. No other book on the market considers all the varieties of coffee in one volume, or takes the disease-focused approach that will assist in directing further research and studies. The book embraces a holistic approach and effectively investigates coffee and its specific compounds from the biochemical to the nutritional well-being of geographical populations. This book represents essential reading for researchers in nutrition, dietetics, food science, biochemistry, and public health.

  • Control of Plant Virus Diseases

    Seed-Propagated Crops
    • 1 Edición
    • Volumen 90
    • Gad Loebenstein + 1 más
    • Inglés
    The first review series in virology and published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the field. The series of eclectic volumes are valuable resources to virologists, microbiologists, immunologists, molecular biologists, pathologists, and plant researchers. Volume 90 features articles on control of plant virus diseases.

  • Implantable Electronic Medical Devices

    • 1 Edición
    • Dennis Fitzpatrick
    • Inglés
    Implantable Electronic Medical Devices provides a thorough review of the application of implantable devices, illustrating the techniques currently being used together with overviews of the latest commercially available medical devices. This book provides an overview of the design of medical devices and is a reference on existing medical devices. The book groups devices with similar functionality into distinct chapters, looking at the latest design ideas and techniques in each area, including retinal implants, glucose biosensors, cochlear implants, pacemakers, electrical stimulation therapy devices, and much more. Implantable Electronic Medical Devices equips the reader with essential background knowledge on the application of existing medical devices as well as providing an introduction to the latest techniques being used.

  • The History of the Gamma Knife

    • 1 Edición
    • Volumen 215
    • Jeremy C. Ganz
    • Inglés
    The History of the Gamma Knife presents the evolution of concepts and technology which ended in the production of the modern Gamma Knife. The story starts before the Second World War and links pioneers in Berkeley and Sweden. To the best of the author’s belief it is the first detailed, factually accurate account of the development of this important therapeutic method.

  • Brain Extracellular Matrix in Health and Disease

    • 1 Edición
    • Volumen 214
    • Inglés
    In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells.

  • Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

    • 5 Edición
    • Roger N. Rosenberg + 1 más
    • Inglés
    Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases.

  • Contemporary Insect Diagnostics

    The Art and Science of Practical Entomology
    • 1 Edición
    • Timothy J. Gibb
    • Inglés
    Contemporary Insect Diagnostics aids entomologists as they negotiate the expectations and potential dangers of the practice. It provides the reader with methods for networking with regulatory agencies, expert laboratories, first detectors, survey specialists, legal and health professionals, landscape managers, crop scouts, farmers and the lay public. This enables the practitioner and advanced student to understand and work within this network, critically important in a time when each submission takes on its own specific set of expectations and potential ramifications. Insect diagnosticians must be knowledgeable on pests that affect human health, stored foods, agriculture, structures, as well as human comfort and the enjoyment of life. The identification and protection of the environment and the non-target animals (especially beneficial insects) in that environment is also considered a part of insect diagnostics. Additionally, Integrated Pest Management recommendations must include any of a variety of management tactics if they are to be effective and sustainable. This greatly needed foundational information covers the current principles of applied insect diagnostics. It serves as a quick study for those who are called upon to provide diagnostics, as well as a helpful reference for those already in the trenches.

  • Thermal Sensors

    • 1 Edición
    • Volumen 74
    • León Islas + 1 más
    • Inglés
    Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume presents an up to date presentation of current knowledge and problems in the field of thermal receptors. This is a rapidly evolving research area and the book contains important contributions from some of the leaders in the field.

  • International Review of Cell and Molecular Biology

    • 1 Edición
    • Volumen 313
    • Kwang W. Jeon
    • Inglés
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists.

  • Movement Disorders

    Genetics and Models
    • 2 Edición
    • Mark S. LeDoux
    • Inglés
    The use of animal models is a key aspect of scientific research in numerous fields of medicine. Movement Disorders, Second Edition vigorously examines the important contributions and application of animal models to the understanding of human movement disorders, and serves as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. The book is divided into sections on Parkinson's disease, Huntington's disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration, and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.

  • Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy

    • 1 Edición
    • Gang Ho Lee + 1 más
    • Inglés
    Most books discuss general and broad topics regarding molecular imagings. However, Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy, will mainly focus on lanthanide oxide nanoparticles for molecular imaging and therapeutics. Multi-modal imaging capabilities will discussed, along with up-converting FI by using lanthanide oxide nanoparticles. The synthesis will cover polyol synthesis of lanthanide oxide nanoparticles, Surface coatings with biocompatible and hydrophilic ligands will be discussed and TEM images and dynamic light scattering (DLS) patterns will be provided. Various techniques which are generally used in analyzing the synthesized surface coated nanoparticles will be explored and this section will also cover FT­, IR analysis, XRD analysis, SQUID analysis, cytotoxicity measurements and proton relaxivity measurements. In vivo MR images, CT images, fluorescence images will be provided and Therapeutic application of gadolinium oxide nanoparticles will be discussed. Finally, future perpectives will be discussed. That is, present status and future works needed for clinical applications of lanthanide oxide nanoparticles to molecular imagings will be discussed.

  • Marine Managed Areas and Fisheries

    • 1 Edición
    • Volumen 69
    • Inglés
    Advances in Marine Biology has been providing in-depth and up-to-date reviews on all aspects of marine biology since 1963--over 40 years of outstanding coverage! The series is well known for its excellent reviews and editing. Now edited by Michael Lesser (University of New Hampshire, USA) with an internationally renowned Editorial Board, the serial publishes in-depth and up-to-date content on many topics that will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, and biological oceanography. Volumes cover all areas of marine science, both applied and basic, a wide range of topical areas from all areas of marine ecology, oceanography, fisheries management and molecular biology and the full range of geographic areas from polar seas to tropical coral reefs. This volume, with an introduction by Ray Hilborn, will present the latest views on the use of MPAs or Marine Managed Areas for fisheries management. It will contain a wide range of case studies including the Chagos archipelago, South Georgia, the Caribbean, the North Sea, Florida, Hawaii, Great Barrier Reef, California, Mediterraneanand the Phoenix Islands Protected Area. It is the intention of the editors that the volume presents a series of evidence based rather than advocacy driven contemporary reviews.

  • The Lung

    Development, Aging and the Environment
    • 2 Edición
    • Kent Pinkerton + 1 más
    • Inglés
    The second edition of The Lung: Development, Aging and the Environment provides an understanding of the multi-faceted nature of lung development, aging, and how the environment influences these processes. As an essential resource to respiratory, pulmonary, and thoracic scientists and physicians it provides an interface between the “normal” and “disease” cluster of chapters, allowing for a natural complement to each other. The interface between different lung diseases affecting the pediatric lung also adds a useful source for comparing how different lung diseases share key pathophysiological features. This same complementarity comes across in the logical line up of chapters dealing with the “normal” pediatric lung. New research, including cell-based strategies for infant lung function, epigenetics, and prenatal alcohol exposure on lung development and function are some of the important additions to this edition of this reference work.

  • Innovative Brain Tumor Therapy

    • 1 Edición
    • Gerardo Caruso + 2 más
    • Inglés
    Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.

  • Regulatory Affairs for Biomaterials and Medical Devices

    • 1 Edición
    • Stephen F. Amato + 1 más
    • Inglés
    All biomaterials and medical devices are subject to a long list of regulatory practises and policies which must be adhered to in order to receive clearance. This book provides readers with information on the systems in place in the USA and the rest of the world. Chapters focus on a series of procedures and policies including topics such as commercialization, clinical development, general good practise manufacturing and post market surveillance.

  • Bursting Neurons and Fading Memories

    An Alternative Hypothesis of the Pathogenesis of Alzheimer’s Disease
    • 1 Edición
    • Michael R. D'Andrea
    • Inglés
    Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.

  • Advances in Genetics

    • 1 Edición
    • Volumen 87
    • Inglés
    The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Volume 87 presents an eclectic mix of articles of use to all human and molecular geneticists on topics including: gene transfer, fruiting body development and the genetics of Alzheimer’s disease; and more.

  • Design and Manufacture of Pharmaceutical Tablets

    • 1 Edición
    • Reynir Eyjolfsson
    • Inglés
    Design and Manufacture of Pharmaceutical Tablets offers real world solutions and outcomes of formulation and processing challenges of pharmaceutical tablets. This book includes numerous practical examples related to actual formulations that have been validated and marketed and covers important data in the areas of stability, dissolution, bioavailibity and processing. It provides important background and theoretical information on design and manufacturing and includes a full section dedicated to design experimental methodology and statistics. In addition, this book offers a a general discussion of excipients used in proper tablet design along with practical examples related to excipients. Drug development scientists in industry and academia, as well as students in the pharmaceutical sciences will greatly benefit from the practical knowledge and case examples provided throughout this book.

  • Molecular Biology of B Cells

    • 2 Edición
    • Tasuku Honjo + 3 más
    • Inglés
    Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.

  • Translational Systems Biology

    Concepts and Practice for the Future of Biomedical Research
    • 1 Edición
    • Yoram Vodovotz + 1 más
    • Inglés
    Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money’s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation.

  • Alcohol and the Nervous System

    • 1 Edición
    • Volumen 125
    • Edith V. Sullivan + 1 más
    • Inglés
    Alcohol is the most widely used drug in the world, yet alcoholism remains a serious addiction affecting nearly 20 million Americans. Our current understanding of alcohol's effect on brain structure and related functional damage is being revolutionized by genetic research, basic neuroscience, brain imaging science, and systematic study of cognitive, sensory, and motor abilities. Volume 125 of the Handbook of Clinical Neurology is a comprehensive, in-depth treatise of studies on alcohol and the brain covering the basic understanding of alcohol's effect on the central nervous system, the diagnosis and treatment of alcoholism, and prospect for recovery. The chapters within will be of interest to clinical neurologists, neuropsychologists, and researchers in all facets and levels of the neuroscience of alcohol and alcoholism.

  • Dictionary of Toxicology

    • 3 Edición
    • Ernest Hodgson + 1 más
    • Inglés
    Dictionary of Toxicology, Third Edition presents a compendium of definitions of all current toxicological terminology. This authoritative reference illustrates and describes words, concepts, acronyms and symbols for both the toxicological theory and applied risk assessment, as well as providing guidance on the correct selection of problematic, similar and frequently-misused terms. Written by one of the world’s foremost experts in toxicology, and with each entry peer reviewed, Dictionary of Toxicology, Third Edition is an essential reference for all scientific, medical and legal professionals who work with or encounter the toxicological effects of contaminants on biological systems. New to this edition: an update on every entry and the inclusion of all terminology and concepts relating to molecular toxicology, nanotoxicology and computational toxicology.

  • Molecular Targets in Protein Misfolding and Neurodegenerative Disease

    • 1 Edición
    • Pierfausto Seneci
    • Inglés
    Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.

  • Biomolecular Modelling and Simulations

    • 1 Edición
    • Volumen 96
    • Inglés
    Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series is the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.

  • Advances in Molecular Toxicology

    • 1 Edición
    • Volumen 8
    • Inglés
    Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed.

  • Marine Carbohydrates: Fundamentals and Applications, Part B

    • 1 Edición
    • Volumen 73
    • Inglés
    Marine Carbohydrates: Fundamentals and Applications brings together the diverse range of research in this important area which leads to clinical and industrialized products. The volume, number 73, focuses on marine carbohydrates in isolation, biological, and biomedical applications and provides the latest trends and developments on marine carbohydrates. Advances in Food and Nutrition Research recognizes the integral relationship between the food and nutritional sciences and brings together outstanding and comprehensive reviews that highlight this relationship. Volumes provide those in academia and industry with the latest information on emerging research in these constantly evolving sciences.

  • Correlative Light and Electron Microscopy II

    • 1 Edición
    • Volumen 124
    • Inglés
    This new volume of Methods in Cell Biology looks at methods for analyzing correlative light and electron microscopy (CLEM). With CLEM, people try to combine the advantages of both worlds, i.e. the dynamics information obtained by light microscopy and the ultrastructure as provided by electron microscopy. This volume contains the latest techniques on correlative microscopy showing that combining two imaging modalities provides more than each technique alone. Most importantly it includes the essential protocols, including tips, tricks and images for you to repeat these exciting techniques in your own lab. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come.

  • Fed-Batch Fermentation

    A Practical Guide to Scalable Recombinant Protein Production in Escherichia Coli
    • 1 Edición
    • G G Moulton
    • Inglés
    Fed-batch Fermentation is primarily a practical guide for recombinant protein production in E. coli using a Fed-batch Fermentation process. Ideal users of this guide are teaching labs and R&D labs that need a quick and reproducible process for recombinant protein production. It may also be used as a template for the production of recombinant protein product for use in clinical trials. The guide highlights a method whereby a medium cell density - final Ods = 30-40 (A600) - Fed-batch Fermentation process can be accomplished within a single day with minimal supervision. This process can also be done on a small (2L) scale that is scalable to 30L or more. All reagents (media, carbon source, plasmid vector and host cell) used are widely available and are relatively inexpensive. This method has been used to produce three different protein products following cGMP guidelines for Phase I clinical studies.

  • Emerging Applications of Molecular Imaging to Oncology

    • 1 Edición
    • Volumen 124
    • Inglés
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume, number 124, covers emerging applications of molecular imaging to oncology, including molecular-genetic imaging, imaging the tumor microenvironment, tracking cells and vaccines in vivo, and more.

  • Chronic Renal Disease

    • 1 Edición
    • Paul L. Kimmel + 1 más
    • Inglés
    Chronic Renal Disease comprehensively investigates the physiology, pathophysiology, treatment, and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD while excluding coverage of dialysis or transplantation, which are both well detailed in other textbooks and references. Chapters in the basic science sections are devoted to the scientific underpinnings of the development and progression of CKD, including consideration of different etiologic factors. Chapters in the treatment and management sections are geared towards the most common problems faced by nephrologists in the management of CKD. Each chapter relates specific illnesses to the CKD framework instead of covering only the specific illness. Readers will learn, for example, how the management of CKD in a patient with diabetic nephropathy differs from that of other CKD patients. Chapters indicate which unique complications the reader needs to be aware of when treating a specific patient or disease. Chronic Renal Disease includes a companion web-based question and answer supplement to each chapter. This is a valuable resource to reinforce the content of the chapters. The questions are multiple-choice, clinically focused and include referenced discussions of answers. The questions can be used for medical student, resident and fellow teaching, preparation for board or maintenance of certification examinations, and clinician teaching or conference preparation.

  • Brain-Computer Interfacing for Assistive Robotics

    Electroencephalograms, Recurrent Quantum Neural Networks, and User-Centric Graphical Interfaces
    • 1 Edición
    • Vaibhav Gandhi
    • Inglés
    Brain-computer interface (BCI) technology provides a means of communication that allows individuals with severely impaired movement to communicate with assistive devices using the electroencephalogram (EEG) or other brain signals. The practicality of a BCI has been possible due to advances in multi-disciplinary areas of research related to cognitive neuroscience, brain-imaging techniques and human-computer interfaces. However, two major challenges remain in making BCI for assistive robotics practical for day-to-day use: the inherent lower bandwidth of BCI, and how to best handle the unknown embedded noise within the raw EEG. Brain-Computer Interfacing for Assistive Robotics is a result of research focusing on these important aspects of BCI for real-time assistive robotic application. It details the fundamental issues related to non-stationary EEG signal processing (filtering) and the need of an alternative approach for the same. Additionally, the book also discusses techniques for overcoming lower bandwidth of BCIs by designing novel use-centric graphical user interfaces. A detailed investigation into both these approaches is discussed.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 5 - Role in Human Diseases
    • 1 Edición
    • M. A. Hayat
    • Inglés
    Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 5 comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders. In spite of the increasing importance of autophagy in the various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases remains poorly understood. This book is an asset to newcomers as a concise overview of the diverse disease implications of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis.Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders.Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation.Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.

  • International Review of Cell and Molecular Biology

    • 1 Edición
    • Volumen 312
    • Kwang W. Jeon
    • Inglés
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists.

  • Practical Predictive Analytics and Decisioning Systems for Medicine

    Informatics Accuracy and Cost-Effectiveness for Healthcare Administration and Delivery Including Medical Research
    • 1 Edición
    • Gary D. Miner + 7 más
    • Inglés
    With the advent of electronic medical records years ago and the increasing capabilities of computers, our healthcare systems are sitting on growing mountains of data. Not only does the data grow from patient volume but the type of data we store is also growing exponentially. Practical Predictive Analytics and Decisioning Systems for Medicine provides research tools to analyze these large amounts of data and addresses some of the most pressing issues and challenges where data integrity is compromised: patient safety, patient communication, and patient information. Through the use of predictive analytic models and applications, this book is an invaluable resource to predict more accurate outcomes to help improve quality care in the healthcare and medical industries in the most cost–efficient manner.Practical Predictive Analytics and Decisioning Systems for Medicine provides the basics of predictive analytics for those new to the area and focuses on general philosophy and activities in the healthcare and medical system. It explains why predictive models are important, and how they can be applied to the predictive analysis process in order to solve real industry problems. Researchers need this valuable resource to improve data analysis skills and make more accurate and cost-effective decisions.

  • Advances in Fermented Foods and Beverages

    Improving Quality, Technologies and Health Benefits
    • 1 Edición
    • Wilhelm Holzapfel
    • Inglés
    Fermentation is used in a wide range of food and beverage applications, and the technology for enhancing this process is continually evolving. This book reviews the use of fermentation in foods and beverages and key aspects of fermented food production. Part one covers the health benefits of fermented foods. Part two includes chapters on fermentation microbiology, while part three looks at ways of controlling and monitoring the quality and safety of fermented foods. Part four covers advances in fermentation technology. Finally, part five covers particular fermented food products.

  • Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders

    • 1 Edición
    • Volumen 71
    • Inglés
    This new volume of Advances in Pharmacology presents pharmacology of the blood brain barrier, focusing on targeting CNS disorders. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

  • Z Score Neurofeedback

    Clinical Applications
    • 1 Edición
    • Robert W. Thatcher + 1 más
    • Inglés
    Neurofeedback is utilized by over 10,000 clinicians worldwide with new techniques and uses being found regularly. Z Score Neurofeedback is a new technique using a normative database to identify and target a specific individual’s area of dysregulation allowing for faster and more effective treatment. The book describes how to perform z Score Neurofeedback, as well as research indicating its effectiveness for a variety of disorders including pain, depression, anxiety, substance abuse, PTSD, ADHD, TBI, headache, frontal lobe disorders, or for cognitive enhancement. Suitable for clinicians as well as researchers this book is a one stop shop for those looking to understand and use this new technique.

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