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Elsevier

Libros en Neurociencia

  • Multiple Sclerosis

    A Mechanistic View
    • 1 Edición
    • Alireza Minagar
    • Inglés
    Multiple Sclerosis: A Mechanistic View provides a unique view of the pathophysiology of multiple sclerosis (MS) and related disorders. As the only book on the market to focus on the mechanisms of MS rather than focusing on the clinical features and treatment of the disease, it describes the role of genetic and environmental factors in the pathogenesis of MS, the role of specific cells in the pathophysiology of the disease, and the pathophysiology of inflammatory and neurodegenerative disorders related to MS. The book provides discussion of neurodegeneration and neuroregeneration, two critical emerging areas of research, as well as detailed discussion of the mechanisms of action of the approved and investigational drugs for treatment of MS and the emerging role of magnetic resonance spectroscopy (MRI) in investigations into MS. It is the only book on the market to offer comprehensive coverage of the known mechanisms of MS and related diseases, and contains contributions from physicians and researchers who are worldwide experts in the field of study.

  • Neurocutaneous Syndromes

    • 1 Edición
    • Volumen 132
    • Monica P. Islam + 1 más
    • Inglés
    Neurocutaneous Syndromes provides the most updated and comprehensive resource on the disorders that lead to the growth of tumors in various parts of the body, those caused by the abnormal development of cells in an embryo and characterized by the presence of tumors in various parts of the body and eyes, including the nervous system, and by certain differences in the skin. The most common neurocutaneous syndromes include, neurofibromatosis, Sturge-Weber syndrome, tuberous sclerosis, ataxia-telangiectasi... and von Hippel-Lindau disease. Symptoms vary widely and while present early may not express until later in life. As molecular medicine and genetic science is continuing to impact our understanding of neurocutaneous syndromes, this book also includes the latest molecular and genetic science.

  • Occupational Neurology

    • 1 Edición
    • Volumen 131
    • Inglés
    Occupational Neurology a volume in the Handbook of Clinical Neurology Series, provides a comprehensive overview of the science, clinical diagnosis, and treatment for neurotoxin related neurological and psychiatric disorders. This timely collection provides not only a complete scientific reference on the chemical origin of this class of neurological and psychiatric disorders, but also a practical guide to diagnosis and treatment challenges and best practices. Handbook of Clinical Neurology Series The first volume of the Handbook of Clinical Neurology under the editorship of George Bruyn and Pierre Vinken was published in 1968. In 1982, the series was brought to an interim conclusion with the publication of the cumulative index volume (Volume 44). By that stage, the Handbook had come to represent one of the largest scientific works ever published. It enjoys a high reputation in specialist media circles throughout the world. After the series was concluded in 1982, it was realized that an update of the material was imperative. Accordingly, a revised series was planned and published over the following years, concluding with the publication of another cumulative index to both series (Volume 76-78) in 2002. Since then, George Bruyn has passed away and Pierre Vinken has retired, but the need for a further new series, incorporating advances in the field, again become necessary. Professors Michael J. Aminoff, François Boller and Dick F. Swaab have with enthusiasm taken on the responsibility of supervising the preparation of a third series, the first volumes of which were published in 2003. Now, more than 130 volumes after the first published, the Handbook of Clinical Neurology series continues to have an unparalleled reputation for providing the latest foundational research, diagnosis, and treatment protocols essential for both basic neuroscience research and clinical neurology.

  • Domain Specificity of Creativity

    • 1 Edición
    • John Baer
    • Inglés
    Recent research findings have challenged the idea that creativity is domain-general. Domain Specificity of Creativity brings together the research information on domain specificity in creativity -- both the research that supports it and answers to research arguments that might seem to challenge it. The implications for domain specificity affect how we move forward with theories of creativity, testing for creativity, and teaching for creativity. The book outlines what these changes are and how creativity research and applications of that research will change in light of these new findings.

  • Exercise-Cognition Interaction

    Neuroscience Perspectives
    • 1 Edición
    • Terry McMorris
    • Inglés
    Exercise-Cognition Interaction: Neuroscience Perspectives is the only book on the market that examines the neuroscientific correlation between exercise and cognitive functioning. The upsurge in research in recent years has confirmed that cognitive-psychology theory cannot account for the effects of exercise on cognition, and both acute and chronic exercise effect neurochemical and psychophysiological changes in the brain that, in turn, affect cognitive functioning. This book provides an overview of the research into these effects, from theoretical research through current studies that emphasize neuroscientific theories and rationales. It addition, users will find a thorough examination of the effects of exercise interventions on cognitive functioning in special populations, including the elderly, children, and those suffering from a variety of diseases, including schizophrenia, diabetes, and an array of neurological disorders. With contributions from leading researchers in the field, this book will be the go-to resource for neuroscientists, psychologists, medical professionals, and other researchers who need an understanding of the role exercise plays in cognitive functioning.

  • Movement Disorders in Childhood

    • 2 Edición
    • Harvey S. Singer + 3 más
    • Inglés
    Movement Disorders in Childhood, Second Edition, provides the most up-to-date information on the diseases and disorders that affect motor control, an important area of specialization within child neurology. Over the past several decades, advances in genetics, neuroimaging, neurophysiology, and other areas of neuroscience have provided new understanding of the underlying etiologies and mechanisms of these conditions as well as new opportunities for more accurate diagnosis and effective treatment. This new edition builds upon the success of the first edition, with comprehensive scientific and clinical updates of all chapters. In addition, there are new chapters on hereditary spastic paraplegia, quantitative motor assessments, autoimmune disorders, and movement disorders in the developmental neuropsychiatric disorders ADHD, OCD, and autism. Additional materials are provided on the latest in drug treatments, computer based strategies for genetic diagnosis, and helpful videos for phenomenology.

  • Computational Neurostimulation

    • 1 Edición
    • Volumen 222
    • Inglés
    Computational Neurostimulation, the latest volume in the Progress in Brain Research series provides an introduction to a nascent field with contributions from leading researchers. In addition, it addresses a very timely and relevant issue which has long been known to require more treatment.

  • New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System – Part B

    • 1 Edición
    • Volumen 221
    • Inglés
    New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System - Part B is the latest volume from Progress in Brain Research focusing on new trends in basic and clinical research of glaucoma. This established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields.

  • Nicotine Use in Mental Illness and Neurological Disorders

    • 1 Edición
    • Volumen 124
    • Inglés
    Nicotine Use in Mental Illness and Neurological Disorders, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into nicotine use in mental illness and neurological disorders. It reviews current knowledge and understanding, also provides a starting point for researchers and practitioners entering the field.

  • Emotions, Technology, Design, and Learning

    • 1 Edición
    • Sharon Y. Tettegah + 1 más
    • Inglés
    Emotions, Technology, Design, and Learning provides an update to the topic of emotional responses and how technology can alter what is being learned and how the content is learned. The design of that technology is inherently linked to those emotional responses. This text addresses emotional design and pedagogical agents, and the emotions they generate. Topics include design features such as emoticons, speech recognition, virtual avatars, robotics, and adaptive computer technologies, all as relating to the emotional responses from virtual learning.

  • The Neuronal Codes of the Cerebellum

    • 1 Edición
    • Detlef Heck
    • Inglés
    The Neuronal Codes of the Cerebellum provides the most updated information on what is known on the topics of the cerebellum’s anatomy and single cell physiology, two areas where there has been a gap in knowledge regarding the specific codes it uses to process information internally and convey commands to other brain regions. This has created difficulties for researchers and clinicians looking to develop an understanding of the mechanisms by which it contributes to behavior and how its dysfunction causes neurological symptoms. Focused on findings related to the neuronal code used by cerebellar neurons for the representation of behavioral and sensory processes, this edited volume will aid scientists in overcoming that knowledge gap, also serving as the first resource to broadly address the different aspects of spike coding in the cerebellum that focuses on spike train analysis.

  • Biomechanics and Motor Control

    Defining Central Concepts
    • 1 Edición
    • Mark L. Latash + 1 más
    • Inglés
    Biomechanics and Motor Control: Defining Central Concepts provides a thorough update to the rapidly evolving fields of biomechanics of human motion and motor control with research published in biology, psychology, physics, medicine, physical therapy, robotics, and engineering consistently breaking new ground. This book clarifies the meaning of the most frequently used terms, and consists of four parts, with part one covering biomechanical concepts, including joint torques, stiffness and stiffness-like measures, viscosity, damping and impedance, and mechanical work and energy. Other sections deal with neurophysiological concepts used in motor control, such as muscle tone, reflex, pre-programmed reactions, efferent copy, and central pattern generator, and central motor control concepts, including redundancy and abundance, synergy, equilibrium-point hypothesis, and motor program, and posture and prehension from the field of motor behavior. The book is organized to cover smaller concepts within the context of larger concepts. For example, internal models are covered in the chapter on motor programs. Major concepts are not only defined, but given context as to how research came to use the term in this manner.

  • New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System Part A

    • 1 Edición
    • Volumen 220
    • Inglés
    New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System is the latest volume from Progress in Brain Research focusing on new trends in basic and clinical research of glaucoma. This established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields.

  • Performance Psychology

    Perception, Action, Cognition, and Emotion
    • 1 Edición
    • Markus Raab + 4 más
    • Inglés
    This book integrates findings from across domains in performance psychology to focus on core research on what influences peak and non-peak performance. The book explores basic and applied research identifying cognition-action interactions, perception-cognition interactions, emotion-cognition interactions, and perception-action interactions. The book explores performance in sports, music, and the arts both for individuals and teams/groups, looking at the influence of cognition, perception, personality, motivation and drive, attention, stress, coaching, and age. This comprehensive work includes contributions from the US, UK, Canada, Germany, and Australia.

  • Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels

    • 1 Edición
    • Volumen 123
    • Inglés
    This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current knowledge and understanding and provides a starting point for researchers and practitioners entering the field.

  • The Choroid Plexus and Cerebrospinal Fluid

    Emerging Roles in CNS Development, Maintenance, and Disease Progression
    • 1 Edición
    • Josh Neman + 1 más
    • Inglés
    The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in CNS Development, Maintenance, and Disease Progression combines new and established work to allow for cross-disciplinary discussion and showcase newfound excitement surrounding the choroid plexus and cerebrospinal fluid (CSF). This book is of great utility to neuroscientists interested in biological questions about cancer, multiple sclerosis, Alzheimer’s, choroid plexus, or CSF research, and especially for researchers looking to expand their research into later stages of their disease of interest, such as metastasis. No other resource is currently available which addresses these issues in this fashion. The focus on the choroid plexus provides a practical resource on modeling clinical issues influenced by this brain region for researchers from students to principal investigators.

  • Omic Studies of Neurodegenerative Disease - Part B

    • 1 Edición
    • Volumen 122
    • Inglés
    Omic Studies of Neurodegenerative Disease: Part B is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields. The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research.

  • Sex Differences in the Central Nervous System

    • 1 Edición
    • Rebecca M. Shansky
    • Inglés
    Sex Differences in the Central Nervous System offers a comprehensive examination of the current state of sex differences research, from both the basic science and clinical research perspectives. Given the current NIH directive that funded preclinical research must consider both females and males, this topic is of interest to an increasing percentage of the neuroscience research population. The volume serves as an invaluable resource, offering coverage of a wide range of topics: sex differences in cognition, learning, and memory, sex hormone signaling mechanisms, neuroimmune interactions, epigenetics, social behavior, neurologic disease, psychological disorders, and stress. Discussions of research in both animal models and human patient populations are included.

  • The Linguistic Cerebellum

    • 1 Edición
    • Peter Mariën + 1 más
    • Inglés
    The Linguistic Cerebellum provides a comprehensive analysis of this unique part of the brain that has the most number of neurons, each operating in distinct networks to perform diverse functions. This book outlines how those distinct networks operate in relation to non-motor language skills. Coverage includes cerebellar anatomy and function in relation to speech perception, speech planning, verbal fluency, grammar processing, and reading and writing, along with a discussion of language disorders.

  • Modeling Neuropsychiatric Disorders in Laboratory Animals

    • 1 Edición
    • Kurt Leroy Hoffman
    • Inglés
    Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research.

  • Omic Studies of Neurodegenerative Disease - Part A

    • 1 Edición
    • Volumen 121
    • Inglés
    Omic Studies of Neurodegenerative Disease: Part A is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields. The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research.

  • Handbook of Aging and the Social Sciences

    • 8 Edición
    • Linda George + 1 más
    • Inglés
    Handbook of Aging and the Social Sciences, Eighth Edition, presents the extraordinary growth of research on aging individuals, populations, and the dynamic culmination of the life course, providing a comprehensive synthesis and review of the latest research findings in the social sciences of aging. As the complexities of population dynamics, cohort succession, and policy changes modify the world and its inhabitants in ways that must be vigilantly monitored so that aging research remains relevant and accurate, this completely revised edition not only includes the foundational, classic themes of aging research, but also a rich array of emerging topics and perspectives that advance the field in exciting ways. New topics include families, immigration, social factors, and cognition, caregiving, neighborhoods, and built environments, natural disasters, religion and health, and sexual behavior, amongst others.

  • Neurobiology of Language

    • 1 Edición
    • Gregory Hickok + 1 más
    • Inglés
    Neurobiology of Language explores the study of language, a field that has seen tremendous progress in the last two decades. Key to this progress is the accelerating trend toward integration of neurobiological approaches with the more established understanding of language within cognitive psychology, computer science, and linguistics. This volume serves as the definitive reference on the neurobiology of language, bringing these various advances together into a single volume of 100 concise entries. The organization includes sections on the field's major subfields, with each section covering both empirical data and theoretical perspectives. "Foundational" neurobiological coverage is also provided, including neuroanatomy, neurophysiology, genetics, linguistic, and psycholinguistic data, and models.

  • The Neurology of Consciousness

    Cognitive Neuroscience and Neuropathology
    • 2 Edición
    • Steven Laureys + 2 más
    • Inglés
    The second edition of The Neurology of Consciousness is a comprehensive update of this ground-breaking work on human consciousness, the first book in this area to summarize the neuroanatomical and functional underpinnings of consciousness by emphasizing a lesional approach offered by the study of neurological patients. Since the publication of the first edition in 2009, new methodologies have made consciousness much more accessible scientifically, and, in particular, the study of disorders, disruptions, and disturbances of consciousness has added tremendously to our understanding of the biological basis of human consciousness. The publication of a new edition is both critical and timely for continued understanding of the field of consciousness. In this critical and timely update, revised and new contributions by internationally renowned researchers—edited by the leaders in the field of consciousness research—provide a unique and comprehensive focus on human consciousness. The new edition of The Neurobiology of Consciousness will continue to be an indispensable resource for researchers and students working on the cognitive neuroscience of consciousness and related disorders, as well as for neuroscientists, psychologists, psychiatrists, and neurologists contemplating consciousness as one of the philosophical, ethical, sociological, political, and religious questions of our time.

  • Emergency Neuro-Otology: Diagnosis and Management of Acute Dizziness and Vertigo, An Issue of Neurologic Clinics

    • 1 Edición
    • Volumen 33-3
    • David E. Newman-Toker
    • Inglés
    The focus of this publication on Neuro-Otology in Neurologic Clinics is on the patient presenting for urgent or emergent care with a chief complaint of new, previously-undiagnos... dizziness or vertigo. Intent is to emphasize throughout the issue five primary components of initial diagnosis and management: (1) Epidemiology, differential diagnosis, and disease definitions; (2) Bedside clinical features that differentiate dangerous from benign causes; (3) Appropriate use of advanced diagnostic tests (including imaging, vestibular tests) and consultations; (4) Application of early treatments (manipulative, pharmacologic, rehabilitative); and (5) Acute disposition strategies, including determining need for admission and urgency of follow-up. Articles have a consistent architecture to highlight key points: 1) Case Scenario (with a representative case example; videos are presented with many of these); 2) Prevalence & Pathomechanisms; 3) Definitions & Diagnostic Criteria; 4) Bedside & Laboratory Diagnostic Tests; 5) Acute Treatment Options (including manipulative, pharmacologic, rehabilitative); and 6) Triage & Disposition (including referrals and follow-up). The articles are presented with four major parts: Overall approach to acute dizziness and vertigo; Episodic vertigo and dizziness; Acute, continuous vertigo and dizziness; and Case unknowns. Among the topics covered are: Bedside evaluation; Transient ischemic attacks; Vestibularl neuritis and labyrinthitis; Stroke; Novel approach to diagnosing the acutely dizzy patient. David Newman-Toker leads this publication with associate editors renown in their fields - Kevin Kerber, William J. Meurer, Rodney Omron, and Jonathan Edlow.

  • Orbit and Neuro-ophthalmic Imaging, An Issue of Neuroimaging Clinics

    • 1 Edición
    • Volumen 25-3
    • Juan E. Gutierrez
    • Inglés
    Orbit and Neuro-ophthalmic Imaging is explored in this important Neuroimaging Clinics issue. Articles include: Imaging indication, protocols, anatomy, and pitfalls; Orbital ultrasonography and optical coherence tomography – what radiologists need to know; Advanced imaging techniques for the retina and visual pathway; Imaging of optic neuropathy and chiasmatic disorder; Imaging of post-chiasmatic disorder and higher cortical visual dysfunction; Imaging of diseases of the ocular motor pathway; Imaging of orbital trauma and emergent non-traumatic conditions; Imaging of ocular prosthesis and orbital reconstruction flaps; Imaging of pediatric ophthalmologic conditions; and more!

  • Evolution of Vulnerability

    Implications for Sex Differences in Health and Development
    • 1 Edición
    • David C. Geary
    • Inglés
    Biologists have known for decades that many traits involved in competition for mates or other resources and that influence mate choice are exaggerated, and their expression is influenced by the individuals’ ability to tolerate a variety of environmental and social stressors. Evolution of Vulnerability applies this concept of heightened sensitivity to humans for a host of physical, social, psychological, cognitive, and brain traits. By reframing the issue entirely, renowned evolutionary psychologist David C. Geary demonstrates this principle can be used to identify children, adolescents, or populations at risk for poor long-term outcomes and identify specific traits in each sex and at different points in development that are most easily disrupted by exposure to stressors. Evolution of Vulnerability begins by reviewing the expansive literature on traits predicted to show sex-specific sensitivity to environmental and social stressors, and details the implications for better assessing and understanding the consequences of exposure to these stressors. Next, the book reviews sexual selection—mate competition and choice—and the mechanisms involved in the evolution of condition dependent traits and the stressors that can undermine their development and expression, such as poor early nutrition and health, parasites, social stress, and exposure to man-made toxins. Then it reviews condition dependent traits (physical, behavioral, cognitive, and brain) in birds, fish, insects, and mammals to demonstrate the ubiquity of these traits in nature. The focus then turns to humans and covers sex-specific vulnerabilities in children and adults for physical traits, social behavior, psychological wellbeing, and brain and cognitive traits. The sensitivity of these traits is related to exposure to parasites, poor nutrition, social maltreatment, environmental toxins, chemotherapy, and Alzheimer’s disease, among others. The book concludes with an implications chapter that outlines how to better assess vulnerabilities in children and adults and how to more fully understand how, why, and when in development some types of environmental and social stressors are particularly harmful to humans.

  • Essential Clinically Applied Anatomy of the Peripheral Nervous System in the Limbs

    • 1 Edición
    • Paul Rea
    • Inglés
    Essential Clinically Applied Anatomy of the Peripheral Nervous System in the Limbs is designed to combine the salient points of the anatomy of the PNS with typical pathologies affecting the nerves of the upper and lower limbs. The book is a quick reference guide for those studying and treating neuromuscular disease such as neurologists, neurosurgeons, neuroradiologists, and clinical neurophysiologists. Readers will find easy-to-access facts about the anatomy of the nerves in the limbs, coupled with clinically applied scenarios relevant to that area being discussed, as well as clinical findings on examination. The book's purpose is to provide the reader with a succinct presentation of the relevant anatomy of the PNS in the limbs and how it is directly applicable to day-to-day clinical scenarios. It presents the reader with an easily accessible format to clinically applied PNS anatomy that is perfect for quick reference. Chapters review the nerves of the upper and lower limbs, and the origins, course, distribution and relevant pathologies affecting each. These pathologies present typical injuries to the nerves of the PNS, as well as clinical findings on examination and treatments.

  • Neurology, An Issue of Primary Care: Clinics in Office Practice

    • 1 Edición
    • Volumen 42-2
    • Paula Gregory
    • Inglés
    This issue of Primary Care: Clinics in Office Practice, edited by Dr. Paula Gregory, is devoted to Neurology. Articles in this issue include: Dementia; Guillain Barre Syndrome; Multiple Sclerosis; Migraine and Migraine Variants: Keys to Diagnosis and Management; Medication and Toxin-Induced Neurological Syndrome; Approach to the Patient with Parkinson's Disease; Neurootologic Disease: Presentation, Diagnosis, and Management; Epilepsy: Current Evidence-Based Paradigms for Diagnosis and Treatment; Vertigo and the Dizzy Patient; and Sports-related Traumatic Brain Injury.

  • Cerebrovascular Diseases: Controversies and Challenges, An Issue of Neurologic Clinics

    • 1 Edición
    • Volumen 33-2
    • William J. Powers
    • Inglés
    Cerebrovascular disease results in huge health expenditures, multiple recurring physician visits, and a great number of surgical and non-surgical treatments along with research into causes and prevention. This issue addresses therapies, early therapies, diagnoses, and prevention. Topics include: Endovascular Treatment of Acute Ischemic Stroke; Acute Treatment of Blood Pressure after Ischemic Stroke and Intracerebral Hemorrhage; Diagnostic Evaluation for Non-traumatic Intracerebral Hemorrhage; Prevention of Recurrent Stroke in Patients with Patent Foramen Ovale; Management of Asymptomatic Carotid Stenosis; Stenting or Endarterectomy for Patients with Symptomatic Carotid Stenosis; The Therapeutic Value of Laboratory Testing for Hypercoagulable States in Secondary Stroke Prevention; Diagnosis and Treatment of Carotid and Vertebral Artery Dissection; Recurrent Stroke while on Anti-platelet Therapy; Anti-platelet and Anti-coagulant Therapy after Intracerebral Hemorrhage; Diagnosis and Treatment of Isolated Central Nervous System Angiitis/Vasculitis; Statins for Aneurysmal Subarachnoid Hemorrhage; Expansion of IV-tPA eligibility beyond NINDS and ECASS III criteria; and Treatment of Unruptured Arteriovenous Malformations. William J Powers MD, renowned for his clinical work with Stroke and Research in Cerebral blood flow and metabolism, and stroke treatment and prevention, leads this issue of Neurologic Clinics, with authors renown in the field.

  • Drug Design and Discovery in Alzheimer’s Disease

    • 1 Edición
    • Atta-ur Rahman + 1 más
    • Inglés
    Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of β-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery.

  • Trigeminocardiac Reflex

    • 1 Edición
    • Tumul Chowdhury + 1 más
    • Inglés
    Trigeminocardiac Reflex is a comprehensive tutorial reference to the science, diagnosis, and possible treatment of the trigeminocardiac reflex (TCR) that is usually initiated when the trigeminal nerve is disturbed during intercranial surgery. Since first reported in 1999 by co-Editor Bernhard Schaller, the research focused on TCR is expanding. While its instance is rare, new discoveries are not only increasing diagnosis, but also providing more effective treatment protocols. This text is ideal as a reference for clinical and research neurologists, as a general introduction for clinical presentation, and as a foundation for new research.

  • MRI/DTI Atlas of the Rat Brain

    • 1 Edición
    • George Paxinos + 4 más
    • Inglés
    MRI/DTI Atlas of the Rat Brain offers two major enhancements when compared with earlier attempts to make MRI/DTI rat brain atlases. First, the spatial resolution at 25µm is considerably higher than previous data published. Secondly, the comprehensive set of MRI/DTI contrasts provided has enabled the authors to identify more than 80% of structures identified in The Rat Brain in Stereotaxic Coordinates.

  • The Neuropsychiatric Complications of Stimulant Abuse

    • 1 Edición
    • Volumen 120
    • Inglés
    This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on the neuropsychiatric complications of stimulant abuse.

  • The Prefrontal Cortex

    • 5 Edición
    • Joaquin Fuster
    • Inglés
    The Prefrontal Cortex, Fifth Edition, provides users with a thoroughly updated version of this comprehensive work that has historically served as the classic reference on this part of the brain. The book offers a unifying, interdisciplinary perspective that is lacking in other volumes written about the frontal lobes, and is, once again, written by the award-winning author who discovered "memory cells," the physiological substrate of working memory. The fifth edition constitutes a comprehensive update, including all the major advances made on the physiology and cognitive neuroscience of the region since publication in 2008. All chapters have been fully revised, and the overview of prefrontal functions now interprets experimental data within the theoretical framework of the new paradigm of cortical structure and dynamics (the Cognit Paradigm), addressing the accompanying social, economic, and cultural implications.

  • Netter’s Cranial Nerve Collection

    • 1 Edición
    • Frank H. Netter
    • Inglés
    Netter’s Cranial Nerve Collection brings together classic illustrations of these clinically important nerves by Frank H. Netter, MD, combined with illustrated cross-sections and dissection videos to provide clarity to this intricate and difficult area of anatomy.

  • Neurology of Sexual and Bladder Disorders

    • 1 Edición
    • Volumen 130
    • David B. Vodusek + 1 más
    • Inglés
    The neurology of sex and bladder disorders requires specialized knowledge and represents a challenge for clinical neurologists focused on the neurological condition. Sex and bladder disorders are often related to more general neurological disorders like Parkinson’s disease and multiple sclerosis, and often the sex and bladder disorders are passed to specialists in urology. Neurology of Sexual and Bladder Disorders: Handbook of Clinical Neurology is a focused, yet comprehensive overview that provides complete tutorial reference to the science, diagnosis and treatment of sex and bladder disorders from a neurologic perspective.

  • Brain Lipids in Synaptic Function and Neurological Disease

    Clues to Innovative Therapeutic Strategies for Brain Disorders
    • 1 Edición
    • Jacques Fantini + 1 más
    • Inglés
    Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders.

  • Spinal Infections, An Issue of Neuroimaging Clinics

    • 1 Edición
    • Volumen 25-2
    • E. Turgut Tali
    • Inglés
    Spinal Infections is explored in this important Neuroimaging Clinics issue. Articles include: Pathologic approach to spinal cord infections; Pediatric spinal infection and inflammation; Pediatric and adult spinal Tb: imaging and pathophysiology; Pyogenic spinal infections; Spinal brucellosis; Viral infection of the spinal cord and roots; Parasitic and rare spinal infections; Overview of complications and sequeala in spinal infections; Neurosurgical approach to spinal infections; Image guided interventions in spinal infections; Pathological basis of pyogenic, nonpyogenic, and other spondylitis and discitis, and more!

  • Image-Guided Neurosurgery

    • 1 Edición
    • Alexandra J. Golby
    • Inglés
    Image-Guided Neurosurgery provides readers with an update on the revolutionary improvements in imaging and visualization relating to neurosurgery. From the development of the pneumoencephalogram, to the operating microscope, to cross sectional imaging with CT and later MRI, to stereotaxy and neuronavigation, the ability to visualize the pathology and surrounding neural structures has been the driving factor leading surgical innovation and improved outcomes. The book provides a comprehensive reference on the application of contemporary imaging technologies used in neurosurgery. Specific techniques discussed include brain biopsies, brain tumor resection, deep brain stimulation, and more. The book is ideal for neurosurgeons, interventional radiologists, neurologists, psychiatrists, and radiologists, as well as technical experts in imaging, image analysis, computer science, and biomedical engineering.

  • Waking and the Reticular Activating System in Health and Disease

    • 1 Edición
    • Edgar Garcia-Rill
    • Inglés
    Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the “activating” properties of the RAS. In health, the RAS provides the basis against which we assess the external world, and in disease it distorts that world and shatters our self-image. This book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment should be. Dr. Garcia-Rill, along with contributions from leading specialists, discusses the understanding of the RAS as a system not only modulating waking, but also in charge of survival mechanisms such as fight vs flight responses and reflexes. The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinson’s disease. The book reviews the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in certain neurological and psychiatric disorders.

  • Nerves and Nerve Injuries

    Vol 1: History, Embryology, Anatomy, Imaging, and Diagnostics
    • 1 Edición
    • R. Shane Tubbs + 5 más
    • Inglés
    Nerves and Nerve Injuries is the first comprehensive work devoted to the nerves of the body. An indispensable work for anyone studying the nerves or treating patients with nerve injuries, these books will become the ‘go to’ resource in the field. The nerves are treated in a systematic manner, discussing details such as their anatomy (both macro- and microscopic), physiology, examination (physical and imaging), pathology, and clinical and surgical interventions. The authors contributing their expertise are international experts on the subject. The books cover topics from detailed nerve anatomy and embryology to cutting-edge knowledge related to treatment, disease and mathematical modeling of the nerves. Nerves and Nerve Injuries Volume 1 focuses on the history of nerves, embryology, anatomy, imaging, and diagnostics. This volume provides a greatly detailed overview of the anatomy of the peripheral and cranial nerves as well as comprehensive details of imaging modalities and diagnostic tests.

  • Nerves and Nerve Injuries

    Vol 2: Pain, Treatment, Injury, Disease and Future Directions
    • 1 Edición
    • R. Shane Tubbs + 5 más
    • Inglés
    Nerves and Nerve Injuries is a must-have for clinicians and researchers dealing with the Peripheral Nervous System and neuropathy. An indispensable work for anyone studying the nerves or treating patients with nerve injuries, these books will become the ‘go to’ resource in the field. The nerves are treated in a systematic manner, discussing details such as their anatomy (both macro- and microscopic), physiology, examination (physical and imaging), pathology, and clinical and surgical interventions. The authors contributing their expertise are international experts on the subject. The books cover topics from detailed nerve anatomy and embryology to cutting-edge knowledge related to treatment, disease and mathematical modeling of the nerves. Nerves and Nerve Injuries Volume 2 focuses on pain, treatment, injury, disease and future directions in the field. This volume also addresses new information regarding neural interfaces, stem cells, medical and surgical treatments, and medical legal issues following nerve injury.

  • Sensorimotor Rehabilitation

    At the Crossroads of Basic and Clinical Sciences
    • 1 Edición
    • Volumen 218
    • Inglés
    This volume of Progress in Brain Research focuses on Sensorimotor Rehabilitation.

  • Stellate Cells in Health and Disease

    • 1 Edición
    • Chandrashekhar Gandhi + 1 más
    • Inglés
    Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology.

  • TRP Channels as Therapeutic Targets

    From Basic Science to Clinical Use
    • 1 Edición
    • Arpad Szallasi
    • Inglés
    TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings.

  • Headache and Migraine Biology and Management

    • 1 Edición
    • Seymour Diamond + 4 más
    • Inglés
    There are two crucial issues in the treatment and management of headache patients: More than 50% of individuals experiencing headache have only been treated symptomatically, with no appropriate diagnosis established; and history and neurologic examination are essential to establishing a diagnosis, and thus selecting appropriate therapy. Headache and Migraine Biology and Management is a practical text that addresses these issues, featuring contributions from expert clinical authors. The book covers in detail topics including chronic and episodic migraine, post-traumatic headache, sinus headache, cluster headache, tension headache, and others. Chapters are also dedicated to treatment subjects, including psychiatric and psychological approaches, medication overuse, inpatient treatment, and pediatric issues. This book is an ideal resource for researchers and clinicians, uniting practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs. This resource is useful to those who want to understand headache biology, treat and manage symptoms, and for those performing research in the headache field.

  • Diseases of the Nervous System

    • 1 Edición
    • Harald Sontheimer
    • Inglés
    The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system.

  • Epilepsy and Brain Tumors

    • 1 Edición
    • Herbert B. Newton + 1 más
    • Inglés
    Patients with brain tumor-related epilepsy (BTRE) suffer from two serious pathologies simultaneously – a brain tumor and a secondary form of epilepsy. Although there has been remarkable progress in BTRE research in recent years, it remains an on-going challenge for clinicians and continues to stimulate much debate in the scientific community. This volume is the first to be completely dedicated to BTRE, and in doing so it explores issues faced by the health care team as well as some of the novel and promising directions that future research may take. Epilepsy and Brain Tumors is not only a complete reference on BTRE but also a practical guide based on clinical experiences, with a comprehensive collection of presentations from international experts who share some of the latest discoveries and their approaches to tackling a wide range of difficult and complex issues.

  • Guide to Research Techniques in Neuroscience

    • 2 Edición
    • Matt Carter + 1 más
    • Inglés
    Neuroscience is, by definition, a multidisciplinary field: some scientists study genes and proteins at the molecular level while others study neural circuitry using electrophysiology and high-resolution optics. A single topic can be studied using techniques from genetics, imaging, biochemistry, or electrophysiology. Therefore, it can be daunting for young scientists or anyone new to neuroscience to learn how to read the primary literature and develop their own experiments. This volume addresses that gap, gathering multidisciplinary knowledge and providing tools for understanding the neuroscience techniques that are essential to the field, and allowing the reader to design experiments in a variety of neuroscience disciplines.

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